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Article ; Online: High compassion predicts fewer sleep difficulties: A general population study with an 11-year follow-up.

Tolonen, Iina / Saarinen, Aino / Puttonen, Sampsa / Kähönen, Mika / Hintsanen, Mirka

2023 Volume 13, Issue 10, Page(s) e3165

Abstract: Introduction: This study investigated the cross-sectional and longitudinal associations between self-reported compassion and sleep quality.: Methods: The data came from the population-based Young Finns Study with an 11-year follow-up on compassion ... ...

Abstract	Introduction: This study investigated the cross-sectional and longitudinal associations between self-reported compassion and sleep quality. Methods: The data came from the population-based Young Finns Study with an 11-year follow-up on compassion and sleep (n = 1064). We used regression models, multilevel models, and cross-lagged panel models to analyze the data. Results: The results showed that high compassion was cross-sectionally associated with lesser sleep deficiency and fewer sleep difficulties. High compassion also predicted fewer sleep difficulties over an 11-year follow-up (adjusted for age, gender, socioeconomic position in childhood and adulthood, body mass index, health behaviors, and working conditions). This association disappeared when controlling for depressive symptoms. The predictive pathway seemed to proceed more likely from high compassion to fewer sleep difficulties than vice versa. Discussion: Compassion may buffer against sleep difficulties, possibly via reducing depressive symptoms.
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3165
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Long term antihypertensive therapy and arterial function in experimental hypertension

Kähönen, Mika

(Acta Universitatis Tamperensis : ser A ; 453)

1995

Author's details	Mika Kähönen
Series title	Acta Universitatis Tamperensis : ser A ; 453 Acta Universitatis Tamperensis Acta Universitatis Tamperensis ; ser A
Collection	Acta Universitatis Tamperensis Acta Universitatis Tamperensis ; ser A
Language	English
Size	155 S. : Ill., graph. Darst.
Publisher	Univ. of Tampere
Publishing place	Tampere
Publishing country	Finland
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Tampere, Univ., Diss., 1995
HBZ-ID	HT006707279
ISBN	951-44-3799-3 ; 978-951-44-3799-1
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Association of childhood socioeconomic status with adulthood maximal exercise blood pressure: the Cardiovascular Risk in Young Finns Study.

Kähönen, Erika / Kähönen, Emilia / Pälve, Kristiina / Hulkkonen, Janne / Kähönen, Mika / Raitakari, Olli T / Hutri, Nina / Lehtimäki, Terho / Aatola, Heikki

Blood pressure

2024 Volume 33, Issue 1, Page(s) 2323987

Abstract: Purpose: Socioeconomic status has been related to resting blood pressure (BP) levels at different stages of life. However, the association of childhood socioeconomic status (SES) and adulthood exercise BP is largely unknown. Therefore, we studied the ... ...

Abstract	Purpose: Socioeconomic status has been related to resting blood pressure (BP) levels at different stages of life. However, the association of childhood socioeconomic status (SES) and adulthood exercise BP is largely unknown. Therefore, we studied the association of childhood SES with adulthood maximal exercise BP. Materials and methods: This investigation consisted of 373 individuals (53% women) participating in the Cardiovascular Risk in Young Finns Study who had data concerning family SES in childhood (baseline in 1980, at age of 6-18 years) and exercise BP response data in adulthood (follow-up in adulthood in 27-29 years since baseline). A maximal cardiopulmonary exercise test with BP measurements was performed by participants, and peak exercise BP was measured. Results: In stepwise multivariable analysis including childhood risk factors and lifestyle factors (body mass index, systolic BP, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, insulin, fruit consumption, vegetable consumption, and physical activity), lower family SES in childhood was associated with higher maximal exercise BP in adulthood (β value ± SE, 1.63 ± 0.77, Conclusions: These findings suggest that lower childhood family SES is associated with higher maximal exercise BP in adulthood.
MeSH term(s)	Humans ; Female ; Child ; Adolescent ; Male ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Blood Pressure ; Finland ; Social Class ; Heart Disease Risk Factors ; Exercise ; Hypertension ; Cholesterol
Chemical Substances	Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1170048-8
ISSN	1651-1999 ; 1651-2480 ; 0803-7051 ; 0803-8023
ISSN (online)	1651-1999 ; 1651-2480
ISSN	0803-7051 ; 0803-8023
DOI	10.1080/08037051.2024.2323987
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Article ; Online: The associations of depressive symptoms and perceived stress with arterial health in adolescents.

Toivonen, Emmi / Lee, Earric / Leppänen, Marja H / Laitinen, Tomi / Kähönen, Mika / Lakka, Timo A / Haapala, Eero A

Physiological reports

2024 Volume 12, Issue 6, Page(s) e15986

Abstract: Cardiovascular and mental diseases are among the most important global health problems, but little is known on the associations between mental and arterial health in adolescents. Therefore, we investigated the associations of arterial health with ... ...

Abstract	Cardiovascular and mental diseases are among the most important global health problems, but little is known on the associations between mental and arterial health in adolescents. Therefore, we investigated the associations of arterial health with depressive symptoms and perceived stress in adolescents. A total of 277 adolescents, 151 boys, 126 girls, aged 15-17 years participated in the study. Depressive symptoms were assessed using the Beck Depression Inventory and perceived stress by the Cohen Perceived Stress Scale. Arterial health was assessed by measures from carotid ultrasonography (carotid intima-media thickness, Young's Elastic Modulus, carotid artery distensibility, stiffness index), impedance cardiography (pulse wave velocity, cardio-ankle vascular index), and pulse contour analysis (reflection index, stiffness index). The data were analyzed using linear regression models adjusted for age and sex. Depressive symptoms or perceived stress were not associated with indices of arterial health in the whole study group (β = -0.08 to 0.09, p > 0.05), in boys (β = -0.13 to 0.10, p > 0.05) or in girls (standardized regression coefficient β = -0.16 to 0.08, p > 0.05). We found no associations of depressive symptoms and perceived stress with arterial health in adolescents. These observations suggest that the association between mental and arterial health problems develop in later life.
MeSH term(s)	Male ; Female ; Humans ; Adolescent ; Depression ; Carotid Intima-Media Thickness ; Pulse Wave Analysis ; Carotid Arteries/diagnostic imaging ; Stress, Psychological ; Vascular Stiffness ; Risk Factors ; Psychological Tests ; Self Report
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15986
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Article ; Online: Accumulating Sedentary Time and Physical Activity From Childhood to Adolescence and Cardiac Function in Adolescence.

Haapala, Eero A / Leppänen, Marja H / Lee, Earric / Savonen, Kai / Laukkanen, Jari A / Kähönen, Mika / Brage, Soren / Lakka, Timo A

Journal of the American Heart Association

2024 Volume 13, Issue 6, Page(s) e031837

Abstract: Background: Increased physical activity (PA) may mitigate the negative cardiovascular health effects of sedentary behavior in adolescents. However, the relationship of PA and sedentary time from childhood with cardiac function in adolescence remains ... ...

Abstract	Background: Increased physical activity (PA) may mitigate the negative cardiovascular health effects of sedentary behavior in adolescents. However, the relationship of PA and sedentary time from childhood with cardiac function in adolescence remains underexplored. Therefore, we investigated the associations of cumulative sedentary time and PA from childhood to adolescence with cardiac function in adolescence. Methods and results: Participants were 153 adolescents (69 girls) who were aged 6 to 8 years at baseline, 8 to 10 years at 2-year follow-up, and 15 to 17 years at 8-year follow-up. Cumulative sedentary time and PA exposure between baseline and 2-year follow-up and between baseline and 8-year follow-up were measured using a combined accelerometer and heart rate monitor. Cardiac function was assessed using impedance cardiography at 8-year follow-up. The data were analyzed using linear regression analyses adjusted for age and sex. Cumulative moderate to vigorous PA (standardized regression coefficient [β]=-0.323 [95% CI, -0.527 to -0.119]) and vigorous PA (β=-0.295 [95% CI, -0.508 to -0.083]) from baseline to 8-year follow-up were inversely associated with cardiac work at 8-year follow-up. Conversely, cumulative sedentary time had a positive association (β=0.245 [95% CI, 0.092-0.398]). Cumulative vigorous PA from baseline to 8-year follow-up was inversely associated with cardiac work index at 8-year follow-up (β=-0.218 [95% CI, -0.436 to 0.000]). Conclusions: Higher levels of sedentary time and lower levels of PA during childhood were associated with higher cardiac work in adolescence, highlighting the importance of increasing PA and reducing sedentary time from childhood.
MeSH term(s)	Female ; Humans ; Adolescent ; Sedentary Behavior ; Exercise/physiology ; Cardiovascular Physiological Phenomena ; Data Collection
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031837
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Article ; Online: Evaluation of the QRS score for diagnosing coronary artery disease in women: A Finnish cardiovascular study.

Beyene, Serkalem D / Nikus, Kjell C / Lehtimäki, Terho J / Kähönen, Mika A P / Viik, Jari J

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

2022 Volume 27, Issue 4, Page(s) e12968

Abstract: Background: Exercise electrocardiography is a widely used diagnostic modality for diagnosing coronary artery disease. This method has been used for both sexes; however, its diagnostic accuracy in women is limited.: Methods: The study analyzed 332 ... ...

Abstract	Background: Exercise electrocardiography is a widely used diagnostic modality for diagnosing coronary artery disease. This method has been used for both sexes; however, its diagnostic accuracy in women is limited. Methods: The study analyzed 332 women participating in the Finnish Cardiovascular Study. Among 332 women, 125 with angiographically proven coronary artery disease (mean age 62.1 ± 9.5 years), 91 with a low likelihood of coronary artery disease (mean age 47.3 ± 13.5 years), and 116 without angiographically proven coronary artery disease (mean age 56.3 ± 9.9 years) were analyzed. The Q, R, S, and ST-segment changes and QRS score were determined by subtracting the Q, R, S, and ST-segment amplitudes immediately after the maximal exercise changes from their rest values (Δ). Receiver operating characteristic curve analysis was performed to evaluate the overall diagnostic performance of the parameters for predicting coronary artery disease. Results: The areas under the receiver operating characteristic curve between coronary artery disease and low likelihood of coronary artery disease groups for the QRS score and ΔSTV5, ΔQaVF, and ΔRaVF were 0.75, 0.73, 0.71, and 0.71, respectively. These areas were lower (0.62, 0.57, 0.60, and 0.60, respectively) between the groups with and without angiographically proven coronary artery disease. QRS score demonstrated the highest sensitivity at 80% specificity (61.5%) and the highest specificity at 80% sensitivity (57.6%). Conclusions: This study suggests that the QRS and ST-segment depression have a moderate diagnostic ability to predict coronary artery disease in women. Q and R waves in lead aVF showed good diagnostic ability.
MeSH term(s)	Adult ; Aged ; Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Electrocardiography/methods ; Exercise Test/methods ; Female ; Finland ; Humans ; Male ; Middle Aged ; ROC Curve ; Sensitivity and Specificity
Language	English
Publishing date	2022-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1325530-7
ISSN	1542-474X ; 1082-720X
ISSN (online)	1542-474X
ISSN	1082-720X
DOI	10.1111/anec.12968
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Article ; Online: A new blood based epigenetic age predictor for adolescents and young adults.

Aanes, Håvard / Bleka, Øyvind / Dahlberg, Pål Skage / Carm, Kristina Totland / Lehtimäki, Terho / Raitakari, Olli / Kähönen, Mika / Hurme, Mikko / Rolseth, Veslemøy

Scientific reports

2023 Volume 13, Issue 1, Page(s) 2303

Abstract: Children have special rights for protection compared to adults in our society. However, more than 1/4 of children globally have no documentation of their date of birth. Hence, there is a pressing need to develop biological methods for chronological age ... ...

Abstract	Children have special rights for protection compared to adults in our society. However, more than 1/4 of children globally have no documentation of their date of birth. Hence, there is a pressing need to develop biological methods for chronological age prediction, robust to differences in genetics, psychosocial events and physical living conditions. At present, DNA methylation is the most promising biological biomarker applied for age assessment. The human genome contains around 28 million DNA methylation sites, many of which change with age. Several epigenetic clocks accurately predict chronological age using methylation levels at age associated GpG-sites. However, variation in DNA methylation increases with age, and there is no epigenetic clock specifically designed for adolescents and young adults. Here we present a novel age Predictor for Adolescents and Young Adults (PAYA), using 267 CpG methylation sites to assess the chronological age of adolescents and young adults. We compared different preprocessing approaches and investigated the effect on prediction performance of the epigenetic clock. We evaluated performance using an independent validation data set consisting of 18-year-old individuals, where we obtained a median absolute deviation of just below 0.7 years. This tool may be helpful in age assessment of adolescents and young adults. However, there is a need to investigate the robustness of the age predictor across geographical and disease populations as well as environmental effects.
MeSH term(s)	Child ; Humans ; Young Adult ; Adolescent ; Epigenesis, Genetic ; Aging/genetics ; CpG Islands/genetics ; DNA Methylation ; Biomarkers ; Epigenomics/methods
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29381-7
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Article ; Online: Neighbourhood deprivation in childhood and adulthood and risk of arterial stiffness: the Cardiovascular Risk in Young Finns study.

Kähönen, Erika / Korpimäki, Satu / Juonala, Markus / Kähönen, Mika / Lehtimäki, Terho / Hutri-Kähönen, Nina / Raitakari, Olli T / Kivimäki, Mika / Vahtera, Jussi

Blood pressure

2023 Volume 32, Issue 1, Page(s) 2220037

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Humans ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cohort Studies ; Finland/epidemiology ; Vascular Stiffness ; Pulse Wave Analysis ; Heart Disease Risk Factors
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1170048-8
ISSN	1651-1999 ; 1651-2480 ; 0803-7051 ; 0803-8023
ISSN (online)	1651-1999 ; 1651-2480
ISSN	0803-7051 ; 0803-8023
DOI	10.1080/08037051.2023.2220037
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Article ; Online: Childhood family environment predicting psychotic disorders over a 37-year follow-up - A general population cohort study.

Saarinen, Aino / Keltikangas-Järvinen, Liisa / Dobewall, Henrik / Sormunen, Elina / Lehtimäki, Terho / Kähönen, Mika / Raitakari, Olli / Hietala, Jarmo

Schizophrenia research

2023 Volume 258, Page(s) 9–17

Abstract: Background: Childhood adverse effects and traumatic experiences increase the risk for several psychiatric disorders. We now investigated whether prospectively assessed childhood family environment per se contributes to increased risk for psychotic ... ...

Abstract	Background: Childhood adverse effects and traumatic experiences increase the risk for several psychiatric disorders. We now investigated whether prospectively assessed childhood family environment per se contributes to increased risk for psychotic disorders in adulthood, and whether these family patterns are also relevant in the development of affective disorders. Methods: We used the Young Finns Data (n = 3502). Childhood family environment was assessed in 1980/1983 with previously constructed risk scores: (1) disadvantageous emotional family atmosphere (parenting practices, parents' life satisfaction, parents' mental disorder, parents' alcohol intoxication), (2) adverse socioeconomic environment (overcrowded apartment, home income, parent's employment, occupational status, educational level), and (3) stress-prone life events (home movement, school change, parental divorce, death, or hospitalization, and child's hospitalization). Psychiatric diagnoses (ICD-10 classification) over the lifespan were collected up to 2017 from the national registry of hospital care. Non-affective psychotic disorder and affective disorder groups were formed. Results: Frequent stress-prone life events predicted higher likelihood of non-affective psychotic disorders (OR = 2.401, p = 0.001). Adverse socioeconomic environment or emotional family atmosphere did not predict psychotic disorders. Only disadvantageous emotional family atmosphere predicted modestly higher likelihood of affective disorders (OR = 1.583, p = 0.013). Conclusions: Our results suggest that childhood family environment and atmosphere patterns as such contribute to the risk for developing adulthood mental disorders with relative disorder specificity. The results emphasize the importance of both individual and public health preventive initiatives, including family support interventions.
MeSH term(s)	Humans ; Child ; Cohort Studies ; Follow-Up Studies ; Psychotic Disorders/epidemiology ; Parents ; Mood Disorders
Language	English
Publishing date	2023-06-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2023.06.008
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Article ; Online: Ambulatory daytime blood pressure versus tonometric blood pressure measurements in the laboratory: effect of posture.

Värri, Emmi / Suojanen, Lauri / Koskela, Jenni K / Choudhary, Manoj K / Tikkakoski, Antti / Kähönen, Mika / Nevalainen, Pasi I / Mustonen, Jukka / Pörsti, Ilkka

Blood pressure monitoring

2023 Volume 28, Issue 4, Page(s) 199–207

Abstract: Objective: To compare blood pressure (BP) in tonometric radial artery recordings during passive head-up tilt with ambulatory recordings and evaluate possible laboratory cutoff values for hypertension.: Methods: Laboratory BP and ambulatory BP were ... ...

Abstract	Objective: To compare blood pressure (BP) in tonometric radial artery recordings during passive head-up tilt with ambulatory recordings and evaluate possible laboratory cutoff values for hypertension. Methods: Laboratory BP and ambulatory BP were recorded in normotensive (n = 69), unmedicated hypertensive (n = 190), and medicated hypertensive (n = 151) subjects. Results: Mean age was 50.2 years, BMI 27.7 kg/m 2 , ambulatory daytime BP 139/87 mmHg, and 276 were male (65%). As supine-to-upright changes in SBP ranged from -52 to +30 mmHg, and in DBP from -21 to +32 mmHg, the mean values of BP supine and upright measurements were compared with ambulatory BP. The mean(supine+upright) systolic laboratory BP was corresponding to ambulatory level (difference +1 mmHg), while mean(supine+upright) DBP was 4 mmHg lower ( P < 0.05) than ambulatory value. Correlograms indicated that laboratory 136/82 mmHg corresponded to ambulatory 135/85 mmHg. When compared with ambulatory 135/85 mmHg, the sensitivity and specificity of laboratory 136/82 mmHg to define hypertension were 71.5% and 77.3% for SBP, and 71.7% and 72.8%, for DBP, respectively. The laboratory cutoff 136/82 mmHg classified 311/410 subjects similarly to ambulatory BP as normotensive or hypertensive, 68 were hypertensive only in ambulatory, while 31 were hypertensive only in laboratory measurements. Conclusion: BP responses to upright posture were variable. When compared with ambulatory BP, mean(supine+upright) laboratory cutoff 136/82 mmHg classified 76% of subjects similarly as normotensive or hypertensive. In the remaining 24% the discordant results may be attributed to white-coat or masked hypertension, or higher physical activity during out-of-office recordings.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; Blood Pressure ; Hypertension/diagnosis ; Blood Pressure Determination/methods ; Masked Hypertension ; Blood Pressure Monitoring, Ambulatory ; Posture
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1324472-3
ISSN	1473-5725 ; 1359-5237
ISSN (online)	1473-5725
ISSN	1359-5237
DOI	10.1097/MBP.0000000000000651
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