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  1. Article ; Online: The Role of 68Ga FAPI-04 and 18F-FDG PET/CT in Detecting Liver Metastases in Different Types of Cancer.

    Kaplan, İhsan / Kepenek, Ferat / Güzel, Yunus / Can, Canan / Kömek, Halil

    Nuklearmedizin. Nuclear medicine

    2023  Volume 62, Issue 4, Page(s) 252–259

    Abstract: Objective: We compared the diagnostic accuracies of : Materials and methods: This retrospective study included 63 patients with liver lesions who underwent : Results: Of the 63 total patients, 34 (54%) were female, and the mean age was 61 (30-92) ... ...

    Title translation Die Rolle von 68Ga-FAPI-04 und 18F-FDG-PET/CT beim Nachweis von Lebermetastasen bei verschiedenen Krebsarten.
    Abstract Objective: We compared the diagnostic accuracies of
    Materials and methods: This retrospective study included 63 patients with liver lesions who underwent
    Results: Of the 63 total patients, 34 (54%) were female, and the mean age was 61 (30-92) years. There were 582 LMs in 51 patients and 35 benign liver lesions in 20 (12 patients had only benign and 8 both benign and malignant lesions). Of the 582 LMs, 472 (81.1%) evidenced
    Conclusion: 68
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Gallium Radioisotopes ; Liver Neoplasms/diagnostic imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; 68Ga-FAPI ; Gallium Radioisotopes
    Language English
    Publishing date 2023-08-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2030804-8
    ISSN 2567-6407 ; 0029-5566
    ISSN (online) 2567-6407
    ISSN 0029-5566
    DOI 10.1055/a-2127-7699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 68 GA-FAPI-04 PET/CT Versus 18 F-FDG PET/CT in Imaging of Malignant Mixed Germ Cell Testicular Tumor.

    Kaplan, İhsan / Can, Canan / Güzel, Yunus / Alabalik, Ulaş / Kömek, Halil

    Clinical nuclear medicine

    2023  Volume 48, Issue 4, Page(s) e195–e197

    Abstract: Abstract: 18 F-FDG PET/CT imaging was performed for restaging in in a 16-year-old boy who was operated on for right testicular tumor and was diagnosed with malignant mixed germ cell tumor. Mild FDG uptake was observed in 2 nodules in both lungs and ... ...

    Abstract Abstract: 18 F-FDG PET/CT imaging was performed for restaging in in a 16-year-old boy who was operated on for right testicular tumor and was diagnosed with malignant mixed germ cell tumor. Mild FDG uptake was observed in 2 nodules in both lungs and retroperitoneal lymph node in the abdomen. 68 Ga-FAPI (fibroblast activation protein inhibitor) 04 PET/CT showed moderate uptake of FAPI in lung nodules and retroperitoneal lymph node. In this case, 68 Ga-FAPI-04 PET/CT was shown to be superior to 18 F-FDG PET/CT in the evaluation of malignant mixed germ cell testicular tumor metastases.
    MeSH term(s) Male ; Humans ; Adolescent ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Neoplasms, Germ Cell and Embryonal
    Chemical Substances 68Ga-FAPI ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium-68 (98B30EPP5S)
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Prognostic Value of

    Agüloğlu, Nurşin / Akyol, Murat / Kömek, Halil / Katgı, Nuran

    Molecular imaging and radionuclide therapy

    2022  Volume 31, Issue 2, Page(s) 104–113

    Abstract: Objectives: This study makes a retrospective examination of exploring the prognostic value of : Methods: A retrospective examination was made of patients diagnosed with lung adenocarcinoma who underwent : Results: Metabolic tumor volume, modified ... ...

    Abstract Objectives: This study makes a retrospective examination of exploring the prognostic value of
    Methods: A retrospective examination was made of patients diagnosed with lung adenocarcinoma who underwent
    Results: Metabolic tumor volume, modified Glasgow prognostic score and locally advanced disease were identified as independent prognostic parameters for PFS (p=0.004, p=0.029, p=0.016, respectively). A univariate Cox regression analysis revealed albumin/alkaline phosphatase and tumor size to be significant parameters for prognosis (p=0.033, p=0.043, respectively). A multivariate Cox regression analysis revealed that none of the parameters were predictive or OS.
    Conclusion: The parameters of
    Language English
    Publishing date 2022-06-30
    Publishing country Turkey
    Document type Journal Article
    ISSN 2146-1414
    ISSN 2146-1414
    DOI 10.4274/mirt.galenos.2022.24650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Perirenal Infiltration of Signet Ring Cell Colon Carcinoma Shown by 68Ga-FAPI PET/CT.

    Güzel, Yunus / Kaplan, İhsan / Kepenek, Ferat / Söğütçü, Nilgün / Kömek, Halil

    Clinical nuclear medicine

    2022  Volume 47, Issue 7, Page(s) e509–e512

    Abstract: Abstract: A soft tissue lesion surrounding the left kidney was detected in 18F-FDG PET/CT performed with suspicion of recurrence in a patient who was operated for descending colon cancer and showed mild FDG uptake. Intense fibroblast activation protein- ... ...

    Abstract Abstract: A soft tissue lesion surrounding the left kidney was detected in 18F-FDG PET/CT performed with suspicion of recurrence in a patient who was operated for descending colon cancer and showed mild FDG uptake. Intense fibroblast activation protein-specific inhibitor (FAPI) uptake in the perirenal soft tissue was observed in 68Ga-FAPI-04 PET/CT. Tru-cut biopsy of the left perirenal lesion revealed signet ring cell colon carcinoma metastasis. This case demonstrated that 68Ga-FAPI-04 PET/CT could be a promising radiopharmaceutical for the evaluation of signet ring cell colon carcinomas.
    MeSH term(s) Carcinoma, Signet Ring Cell/diagnostic imaging ; Colon ; Fluorodeoxyglucose F18 ; Humans ; Positron Emission Tomography Computed Tomography ; Quinolines
    Chemical Substances 68Ga-FAPI ; Quinolines ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Case with

    Kömek, Halil / Gündoğan, Cihan / Etem, Hülya / Can, Canan

    Molecular imaging and radionuclide therapy

    2021  Volume 30, Issue 3, Page(s) 201–204

    Abstract: A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy ... ...

    Abstract A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwent
    Language English
    Publishing date 2021-10-13
    Publishing country Turkey
    Document type Journal Article
    ISSN 2146-1414
    ISSN 2146-1414
    DOI 10.4274/mirt.galenos.2021.69926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Metabolic and volume-based parameters of (18F)FDG PET/CT for primary mass and axillary lymph node metastasis in patients with invasive ductal carcinoma: a retrospective analysis in relation to molecular subtype, axillary lymph node metastasis and immunohistochemistry and inflammatory markers.

    Can, Canan / Komek, Halil

    Nuclear medicine communications

    2019  Volume 40, Issue 10, Page(s) 1051–1059

    Abstract: Objective: To evaluate metabolic and volume-based parameters of 18-Fluorodeoxyglucose positron emission tomography/computed tomography ((F)FDG PET/CT) for primary mass and axillary lymph node (ALN) metastasis in relation to molecular subtype, and ... ...

    Abstract Objective: To evaluate metabolic and volume-based parameters of 18-Fluorodeoxyglucose positron emission tomography/computed tomography ((F)FDG PET/CT) for primary mass and axillary lymph node (ALN) metastasis in relation to molecular subtype, and immunohistochemistry and inflammatory markers in patients with invasive ductal carcinoma.
    Methods: A total of 129 patients (mean±SD age: 49.2±13.0 years) with invasive ductal breast cancer who had (F)FDG PET/CT imaging prior to chemotherapy or surgery were included in this single-center retrospective study. Data on patient age, molecular subtype, ALN metastasis status, inflammatory markers, immunohistochemistry markers and (F)FDG PET/CT imaging parameters for primary mass and ALN were recorded.
    Results: ALN metastasis was evident in 52.7% of patients and associated with significantly higher median diameter (P=0.027), MTV (P<0.001) and TLG (P<0.001). NLR was positively correlated with all primary mass (p ranged from 0.041 to 0.001) and ALN (P ranged from 0.026 to <0.001) PET parameters. PET parameters did not change with respect to molecular subtype or immunohistochemistry markers. Primary mass and ALN metastasis PET parameters showed significant positive correlations for TLG (r=0.274, P=0.001) and SUVmax (r=0.358, P<0.001).
    Conclusion: In conclusion, our findings in a retrospective cohort of invasive ductal breast cancer patients revealed primary mass PET parameters to significantly differ with respect to ALN metastasis status and NLR levels, but not according to molecular subtype or immunohistochemistry markers. Accordingly, our findings highlight the value of acquisition of preoperative PET/CT imaging and role of both metabolic and volume-based parameters in predicting aggressiveness of the tumor as correlated with presence of ALN metastasis and high NLR.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/diagnostic imaging ; Carcinoma, Ductal, Breast/metabolism ; Carcinoma, Ductal, Breast/pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Immunohistochemistry ; Inflammation/metabolism ; Lymphatic Metastasis ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Tumor Burden
    Chemical Substances Biomarkers, Tumor ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2019-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 68Ga-FAPI PET/CT Versus 68Ga-DOTATATE PET/CT in the Evaluation of a Patient With Neuroendocrine Tumor.

    Kömek, Halil / Gündoğan, Cihan / Can, Canan

    Clinical nuclear medicine

    2021  Volume 46, Issue 5, Page(s) e290–e292

    Abstract: Abstract: 68Ga-FAPI (fibroblast activation protein-specific inhibitor) PET/CT was performed in a 56-year-old man with multiple liver masses, which were confirmed grade 2 well-differentiated neuroendocrine tumors with liver Tru-Cut biopsy. With 68Ga- ... ...

    Abstract Abstract: 68Ga-FAPI (fibroblast activation protein-specific inhibitor) PET/CT was performed in a 56-year-old man with multiple liver masses, which were confirmed grade 2 well-differentiated neuroendocrine tumors with liver Tru-Cut biopsy. With 68Ga-DOTATE PET/CT, primary tumor in the pancreas, multiple metastases in the liver and metastatic portocaval lymph node were detected. In 68Ga-FAPI PET/CT imaging performed for comparison, it was seen that metastatic lesions in the liver were distinguished much better because of low background activity, and the primary tumor and metastatic lymph node were clearly selected. This case suggested that FAPI-bounded radionuclides may be useful in the evaluation and targeted therapy of neuroendocrine tumors.
    MeSH term(s) Biopsy ; Humans ; Male ; Middle Aged ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/pathology ; Organometallic Compounds ; Positron Emission Tomography Computed Tomography ; Quinolines
    Chemical Substances 68Ga-FAPI ; Organometallic Compounds ; Quinolines ; gallium Ga 68 dotatate (9L17Y0H71P)
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Case Reports ; Comparative Study ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Contribution of 5th minute and 2nd hour images to standard imaging in (

    Can, Canan / Komek, Halil

    Annals of nuclear medicine

    2019  Volume 34, Issue 3, Page(s) 163–173

    Abstract: Objective: To investigate the superiority or contribution of 5th minute pelvic and 2nd hour whole body Gallium68-prostate-specific membrane antigen-HBED-CC [(: Materials and methods: A total of 63 patients diagnosed with PCa who underwent (: ... ...

    Abstract Objective: To investigate the superiority or contribution of 5th minute pelvic and 2nd hour whole body Gallium68-prostate-specific membrane antigen-HBED-CC [(
    Materials and methods: A total of 63 patients diagnosed with PCa who underwent (
    Results: The mean age of the patients was 69.81 ± 8.78 (min/max: 51/91) years. In the 5th minute images, prostate gland and bed were easier to evaluate, because of low bladder activity. However, lymph node evaluation was more difficult due to high vascular activity. In the prostate gland, lymph nodes and bone metastases, both SUVmax values and TBR rates increased with time from the 5th minute (p < 0.001). At the 2nd hour, some lesions became more visible, while decreased activity was observed in some lesions. However, none of the patients required a change in the stage or treatment.
    Conclusion: In conclusion, the 5th minute pelvic images in (
    MeSH term(s) Aged ; Aged, 80 and over ; Antigens, Surface/metabolism ; Bone Neoplasms/diagnostic imaging ; Edetic Acid/analogs & derivatives ; Edetic Acid/chemical synthesis ; Edetic Acid/pharmacokinetics ; Gallium Radioisotopes/chemistry ; Glutamate Carboxypeptidase II/metabolism ; Humans ; Lymph Nodes/diagnostic imaging ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography/standards ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/pharmacokinetics
    Chemical Substances Antigens, Surface ; Gallium Radioisotopes ; Radiopharmaceuticals ; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (35998-29-9) ; Edetic Acid (9G34HU7RV0) ; FOLH1 protein, human (EC 3.4.17.21) ; Glutamate Carboxypeptidase II (EC 3.4.17.21)
    Language English
    Publishing date 2019-12-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1146984-5
    ISSN 1864-6433 ; 0914-7187
    ISSN (online) 1864-6433
    ISSN 0914-7187
    DOI 10.1007/s12149-019-01428-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The prognostic role of whole-body volumetric 68 GA-DOTATATE PET/computed tomography parameters in patients with gastroenteropancreatic neuroendocrine tumor treated with 177 LU-DOTATATE.

    Kepenek, Ferat / Kömek, Halil / Can, Canan / Kaplan, İhsan / Altindağ, Serdar / Gündoğan, Cihan

    Nuclear medicine communications

    2023  Volume 44, Issue 6, Page(s) 509–517

    Abstract: Objective: The aim of this study is to evaluate the prognostic role of Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and quantitative 68 Ga-DOTATATE PET/computed tomography parameters such as maximum standardized uptake value (SUVmax), mean ... ...

    Abstract Objective: The aim of this study is to evaluate the prognostic role of Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and quantitative 68 Ga-DOTATATE PET/computed tomography parameters such as maximum standardized uptake value (SUVmax), mean SUV (SUVmean), DOTATATE tumor volume (DTV), total lesion DOTATATE (TLD) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) treated with 177 Lu-DOTATATE.
    Material and method: Our retrospective study included 21 patients with GEP-NETs treated with 177 Lu-DOTATATE between January 2017 and January 2022. SUVmax, SUVmean, SUVmax/spleenSUVmax (SUVmax/Sx), DTV, TLD, SUVmean/spleenSUVmean (SUVmean/Sm), TLD/Sm values were calculated and recorded for all patients before and after 177 Lu-DOTATATE treatment.
    Results: A total of 319 metastases were detected in the patients included in the study, and a total of 68 target lesions were selected. In univariant Cox regression analysis, TLD/Sm percent change (∆TLD/Sm) was found to be statistically significant on overall survival (OS) ( P  = 0.044). The 3-year survival in nonresponders was 50% ( P  = 0.034) based on ∆SUVmax/Sx values, 50% ( P  = 0.002) based on RECIST values, 50% based on ∆TDTV + new lesion values ( P  = 0.033), and according to ∆TTLD + new lesion values, it was 66% ( P  = 0.030).
    Conclusion: In our study, we showed that SUVmax/Sx, RECIST, ∆TDTV + new lesion, and ∆TTLD + new lesion parameters can predict OS in the evaluation of response to treatment.
    MeSH term(s) Humans ; Prognosis ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/radiotherapy ; Neuroendocrine Tumors/pathology ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Positron-Emission Tomography ; Organometallic Compounds
    Chemical Substances copper dotatate CU-64 ; Gallium-68 (98B30EPP5S) ; Organometallic Compounds
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Role of volumetric parameters obtained from

    Güzel, Yunus / Kömek, Halil / Can, Canan / Kaplan, İhsan / Akdeniz, Nadiye / Kepenek, Ferat / Gündoğan, Cihan

    Annals of nuclear medicine

    2023  Volume 37, Issue 9, Page(s) 517–527

    Abstract: Objective: The aim of this study was to determine the prognostic role of volumetric parameters and Pro-PET scores obtained from : Materials and methods: The study included 71 patients who underwent simultaneous PSMA and : Results: The median age ... ...

    Abstract Objective: The aim of this study was to determine the prognostic role of volumetric parameters and Pro-PET scores obtained from
    Materials and methods: The study included 71 patients who underwent simultaneous PSMA and
    Results: The median age of the patients included herein was 71 years (56-89) and the median prostate-specific antigen (PSA) level was 16.4 (0.01-1852 ng/dL). According to the Kaplan-Meier survival analysis, TTV-P ≥ 78.5, TTL-P ≥ 278.8, TTV-F ≥ 94.98, TTL-G ≥ 458.3, TTV-P + F ≥ 195.45, TTL-G + P ≥ 855.78, lymph node (L)TV-FDG ≥ 3.4, LFDG-SUVmax ≥ 3.2, LFDG-SUVmean ≥ 2.25, LFDG-SUVpeak ≥ 2.55, and bone (B)TV-F ≥ 51.15 values were found to be prognostic factors in predicting short OS. Multivariate Cox regression analysis showed that a Vscore ≥ 3 (95% confidence interval [CI]: 7.069-98.251, p < 0.001) and TTL-G + P ≥ 855.78 (95% CI: 4.878-1037.860, p = 0.006) were found to be independent prognostic factors in predicting short OS.
    Conclusion: Volumetric parameters and Pro-PET scores obtained from
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Prostatic Neoplasms, Castration-Resistant/diagnostic imaging ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Positron-Emission Tomography ; Prognosis ; Retrospective Studies
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-06-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1146984-5
    ISSN 1864-6433 ; 0914-7187
    ISSN (online) 1864-6433
    ISSN 0914-7187
    DOI 10.1007/s12149-023-01854-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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