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  1. AU="Köster, Frank"
  2. AU="Horbay, Rostyslav"
  3. AU="Akdemir, Selim E"
  4. AU="Riviello, James J"
  5. AU="S, Bahja"
  6. AU="Quiñonez, C"
  7. AU=Chen Nancy
  8. AU="Behl, Gautam"
  9. AU="Zhang, Honghe"
  10. AU="Rian Roelofs"
  11. AU=Kellum John A.
  12. AU="César I. A. Vela"
  13. AU="van Riel, Annick"
  14. AU="Ting Shu"
  15. AU="Doria, Margaux"
  16. AU="Heinz Flessa"
  17. AU="R.Mittleman, "
  18. AU="F.Baldaccini, "
  19. AU="Butler, W R"

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  1. Buch ; Dissertation / Habilitation: Vergleichende Untersuchungen zwischen der elektrischen Zahnbürste Rotamed und einer Handzahnbürste

    Köster, Frank

    1988  

    Umfang 70 S. : Ill., graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Tübingen, Univ., Diss., 1988
    HBZ-ID HT003357437
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    89 D 5457 bestellbar zur Ausleihe Magazin

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  2. Artikel ; Online: Prevalence of PD-L1 in Cervical Cancer Patients and the Potential for Combining an Immune Checkpoint Inhibitor With Lenvatinib.

    Bräutigam, Karen / Schmidt, Talina / Baur, Meike / Tauber, Nikolas / Kontomanolis, Emmanuel N / Hemptenmacher, Franziska / Rody, Achim / Köster, Frank

    Anticancer research

    2024  Band 44, Heft 2, Seite(n) 503–510

    Abstract: Background/aim: Cervical cancer is the fourth most common cause of cancer-related deaths in women worldwide. The potential for targeted therapy against the immune checkpoint programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) and receptor ... ...

    Abstract Background/aim: Cervical cancer is the fourth most common cause of cancer-related deaths in women worldwide. The potential for targeted therapy against the immune checkpoint programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) and receptor tyrosine kinases was examined in cervical cancer patients and cell lines.
    Materials and methods: On tissue microarrays, PD-L1 was analyzed in 123 samples of patients with cervical cancer using immunohistochemistry. In SiHa, HeLa, and CaSki cervical cancer cell lines we examined the combination of lenvatinib with a PD-1/PD-L1 inhibitor using cell viability assays, the activation of cell signaling pathway proteins using western blots and gene expression using quantitative reverse transcriptase-PCR.
    Results: Of 113 evaluable samples, 90 (79.6%) had more than 1% PD-L1 positive cells. The single treatment with the PD-1/PD-L1 inhibitor resulted in the greatest reduction in growth for CaSki and lenvatinib in HeLa cells. In contrast, the combined treatment of lenvatinib with the PD-1/PD-L1 inhibitor demonstrated a significantly stronger impeded proliferation compared to the single treatment in all three cell lines. Moreover, the combined treatment caused significantly less phosphorylation of the signaling molecules ERK and S6 in SiHa and of S6 and STAT3 in HeLa cells but not in CaSki. All treatments diminished the mRNA levels of PD-L1, Il-8, and FGFR in SiHa cells.
    Conclusion: PD1 is frequently expressed in cervical cancer samples. Combining lenvatinib with a PD-1/PD-L1 inhibitor diminished proliferation of cervical cancer cell lines. Consequently, this combination might be a promising option to treat cervical cancer. Signaling pathways involved in tumor cell growth are blocked by the combined treatment but still a model of the underlying mechanism cannot be drawn.
    Mesh-Begriff(e) Female ; Humans ; B7-H1 Antigen/metabolism ; HeLa Cells ; Immune Checkpoint Inhibitors/therapeutic use ; Phenylurea Compounds ; Prevalence ; Programmed Cell Death 1 Receptor ; Quinolines ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/genetics
    Chemische Substanzen B7-H1 Antigen ; Immune Checkpoint Inhibitors ; lenvatinib (EE083865G2) ; Phenylurea Compounds ; Programmed Cell Death 1 Receptor ; Quinolines
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16838
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1642: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel: The InflateSAR Campaign: Testing SAR Vessel Detection Systems for Refugee Rubber Inflatables

    Lanz, Peter / Marino, Armando / Brinkhoff, Thomas / Köster, Frank / Möller, Matthias

    Remote Sensing. 2021 Apr. 13, v. 13, no. 8

    2021  

    Abstract: Countless numbers of people lost their lives at Europe’s southern borders in recent years in the attempt to cross to Europe in small rubber inflatables. This work examines satellite-based approaches to build up future systems that can automatically ... ...

    Abstract Countless numbers of people lost their lives at Europe’s southern borders in recent years in the attempt to cross to Europe in small rubber inflatables. This work examines satellite-based approaches to build up future systems that can automatically detect those boats. We compare the performance of several automatic vessel detectors using real synthetic aperture radar (SAR) data from X-band and C-band sensors on TerraSAR-X and Sentinel-1. The data was collected in an experimental campaign where an empty boat lies on a lake’s surface to analyse the influence of main sensor parameters (incidence angle, polarization mode, spatial resolution) on the detectability of our inflatable. All detectors are implemented with a moving window and use local clutter statistics from the adjacent water surface. Among tested detectors are well-known intensity-based (CA-CFAR), sublook-based (sublook correlation) and polarimetric-based (PWF, PMF, PNF, entropy, symmetry and iDPolRAD) approaches. Additionally, we introduced a new version of the volume detecting iDPolRAD aimed at detecting surface anomalies and compare two approaches to combine the volume and the surface in one algorithm, producing two new highly performing detectors. The results are compared with receiver operating characteristic (ROC) curves, enabling us to compare detectors independently of threshold selection.
    Schlagwörter algorithms ; angle of incidence ; boats ; entropy ; lakes ; rubber ; satellites ; statistics ; synthetic aperture radar ; Europe
    Sprache Englisch
    Erscheinungsverlauf 2021-0413
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs13081487
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Buch ; Online ; Dissertation / Habilitation: Medikamentöser Einfluss auf die epithelial-mesenchymale Transition bei triple-negativen Brustkrebszelllinien

    Stelbrink, Johanna Susanne [Verfasser] / Köster, Frank [Akademischer Betreuer] / Bernd, Heinz-Wolfram [Akademischer Betreuer]

    2022  

    Verfasserangabe Johanna Susanne Stelbrink ; Akademische Betreuer: Frank Köster, Heinz-Wolfram Bernd
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Zentrale Hochschulbibliothek Lübeck
    Erscheinungsort Lübeck
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  5. Buch ; Online: Extraction and Analysis of Highway On-Ramp Merging Scenarios from Naturalistic Trajectory Data

    Klitzke, Lars / Gimm, Kay / Koch, Carsten / Köster, Frank

    2021  

    Abstract: Connected and Automated Vehicles (CAVs) are envisioned to transform the future industrial and private transportation sectors. However, due to the system's enormous complexity, functional verification and validation of safety aspects are essential before ... ...

    Abstract Connected and Automated Vehicles (CAVs) are envisioned to transform the future industrial and private transportation sectors. However, due to the system's enormous complexity, functional verification and validation of safety aspects are essential before the technology merges into the public domain. Therefore, in recent years, a scenario-driven approach has gained acceptance, emphasizing the requirement of a solid data basis of scenarios. The large-scale research facility Test Bed Lower Saxony (TFNDS) enables the provision of ample information for a database of scenarios on highways. For that purpose, however, the scenarios of interest must be identified and extracted from the collected Naturalistic Trajectory Data (NTD). This work addresses this problem and proposes a methodology for onramp scenario extraction, enabling scenario categorization and assessment. An Hidden Markov Model (HMM) and Dynamic Time Warping (DTW) is utilized for extraction and a decision tree with the Surrogate Measure of Safety (SMoS) Post Enroachment Time (PET) for categorization and assessment. The efficacy of the approach is shown with a dataset of NTD collected on the TFNDS.

    Comment: 7 pages
    Schlagwörter Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Computer Science - Robotics ; I.2.8 ; I.5.4 ; I.6.5
    Thema/Rubrik (Code) 006
    Erscheinungsdatum 2021-04-12
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Buch ; Online ; Dissertation / Habilitation: Die Regulation von Wachstumsarrest und Zellmigration in Zellen des duktalen Pankreasadenokarzinoms durch die kleine GTPase RAC1B

    Otterbein, Hannah [Verfasser] / Ungefroren, Hendrik [Akademischer Betreuer] / Köster, Frank [Akademischer Betreuer]

    2022  

    Verfasserangabe Hannah Otterbein ; Akademische Betreuer: Hendrik Ungefroren, Frank Köster
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Zentrale Hochschulbibliothek Lübeck
    Erscheinungsort Lübeck
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  7. Artikel: Entwicklung eines konzeptionellen Frameworks für Elektromobilitätskonzepte mit dem Fokus auf Geschäftsmodellen sowie IKT

    Osmani, Hewad / Köster, Frank / Wagner vom Berg, Benjamin

    Nachhaltige betriebliche Umweltinformationssysteme : Konferenzband zu den 9. BUIS-Tagen , p. 253-268

    2018  , Seite(n) 253–268

    Verfasserangabe Hewad Osmani, Benjamin Wagner vom Berg, Frank Köster
    Sprache Deutsch
    Verlag Springer Gabler
    Erscheinungsort Wiesbaden
    Dokumenttyp Artikel
    ISBN 3-658-20379-X ; 978-3-658-20379-5
    Datenquelle ECONomics Information System

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  8. Artikel: The InflateSAR Campaign: Evaluating SAR Identification Capabilities of Distressed Refugee Boats

    Lanz, Peter / Marino, Armando / Brinkhoff, Thomas / Köster, Frank / Möller, Matthias

    Remote Sensing. 2020 Oct. 27, v. 12, no. 21

    2020  

    Abstract: Most of the recent research in the field of marine target detection has been concentrating on ships with large metallic parts. The focus of this work is on much more challenging targets represented by small rubber inflatables. They are of importance, ... ...

    Abstract Most of the recent research in the field of marine target detection has been concentrating on ships with large metallic parts. The focus of this work is on much more challenging targets represented by small rubber inflatables. They are of importance, since in recent years they have largely been used by migrants to cross the Mediterranean Sea between Libya and Europe. The motivation of this research is to mitigate the ongoing humanitarian crisis at Europe’s southern borders. These boats, packed with up to 200 people, are in no way suitable to cross the Mediterranean Sea or any other big water body and are in distress from the moment of departure. The establishment of a satellite-based surveillance infrastructure could considerably support search and rescue missions in the Mediterranean Sea, reduce the number of such boats being missed and mitigate the ongoing death in the open ocean. In this work we describe and analyze data from the InflateSAR acquisition campaign, wherein we gathered multiple-platform SAR imagery of an original refugee inflatable. The test site for this campaign is a lake which provides background clutter that is more predictable. The analysis considered a sum of experiments, enabling investigations of a broad range of scene settings, such as the vessel’s orientation, superstructures and speed. We assess their impact on the detectability of the chosen target under different sensor parameters, such as polarimetry, resolution and incidence angle. Results show that TerraSAR-X Spotlight and Stripmap modes offer good capabilities to potentially detect those types of boats in distress. Low incidence angles and cross-polarization decrease the chance of a successful identification, whereas a fully occupied inflatable, orthogonally oriented to the line of sight, seems to be better visible than an empty one. The polarimetric analyses prove the vessel’s different polarimetric behavior in comparison with the water surface, especially when it comes to entropy. The analysis considered state-of-the-art methodologies with single polarization and dual polarization channels. Finally, different metrics are used to discuss whether and to which extent the results are applicable to other open ocean datasets. This paper does not introduce any vessel detection or classification algorithm from SAR images. Rather, its results aim at paving the way to the design and the development of a specially tailored detection algorithm for small rubber inflatables.
    Schlagwörter algorithms ; angle of incidence ; boats ; classification ; concentrating ; data analysis ; data collection ; death ; design ; detection ; distress ; entropy ; infrastructure ; lakes ; monitoring ; motivation ; paper ; people ; polarimetry ; remote sensing ; research ; rubber ; satellites ; ships ; surface water ; Europe ; Libya ; Mediterranean Sea
    Sprache Englisch
    Erscheinungsverlauf 2020-1027
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs12213516
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel: Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix.

    Bräutigam, Karen / Meier, Stefanie / Meneder, Sabina / Proppe, Louisa / Stroschein, Katharina / Polack, Stephan / Köster, Frank / Rody, Achim / Baum, Sascha

    Cancers

    2022  Band 14, Heft 13

    Abstract: Background: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections.: Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from ...

    Abstract Background: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections.
    Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from 509 patients visiting our dysplasia consultation clinic. HPV genotyping was performed using the EUROArray HPV test.
    Results: Positivity of HR HPV was found in 60.4-64.3% of anogenital and 14.6% of oral samples. HPV 16 showed the highest incidence in all investigated areas. In cervical and vaginal samples HPV 31 was detected second most, while in vulvar, anal, and oral samples HPV 53 was the second most common subtype. HPV 18 was found lower in all areas, while HPV 51, HPV 52, and HPV 73 were detected higher than expected from published data. A good concordance between cervical, vaginal and vulvar samples was examined for most of the HPV. HR HPV infection was higher in cervical cancer (CC; 91.7%) and high-grade intraepithelial squamous lesions (HSIL; 93.9%) compared to low-grade SIL (LSIL; 69.6%) and normal samples (44.8%).
    Conclusion: In addition to the well described HPV subtypes, we found others with high incidences in the investigated areas which may be evident for HSIL and CC of those areas.
    Sprache Englisch
    Erscheinungsdatum 2022-06-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14133136
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Buch ; Online ; Dissertation / Habilitation: Vergleichende Proteomanalyse zwischen Colitis Ulcerosa assoziierten und sporadischen kolorektalen Karzinomen nach Laser Capture Mikrodissektion

    Kollbeck, Sophie L. G. [Verfasser] / Habermann, Jens [Akademischer Betreuer] / Köster, Frank [Gutachter]

    Comparative proteomic analysis of Ulcerative Colitis associated and Sporadic Colorectal Cancer after Laser Capture Microdissection

    2020  

    Verfasserangabe Sophie L. G. Kollbeck ; Gutachter: Frank Köster ; Akademischer Betreuer: Jens Habermann
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Zentrale Hochschulbibliothek Lübeck
    Erscheinungsort Lübeck
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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