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  1. Article: Characterization of microglia/macrophage phenotypes in the spinal cord following intervertebral disc herniation.

    Kühl, Bianca / Beyerbach, Martin / Baumgärtner, Wolfgang / Gerhauser, Ingo

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 942967

    Abstract: Dogs frequently suffer from traumatic spinal cord injury (SCI). Most cases of SCI have a favorable prognosis but 40-50% of dogs with paraplegia and absence of nociception do not regain ambulatory abilities, eventually leading to euthanasia. Microglia and ...

    Abstract Dogs frequently suffer from traumatic spinal cord injury (SCI). Most cases of SCI have a favorable prognosis but 40-50% of dogs with paraplegia and absence of nociception do not regain ambulatory abilities, eventually leading to euthanasia. Microglia and infiltrating macrophages play a crucial role in inflammatory process after SCI. However, little is known about microglia/macrophage phenotypes representing a potential target for future therapeutic strategies. In the present study, the microglia/macrophage phenotype was characterized by immunohistochemistry in the morphologically unaltered canine spinal cord (10 control dogs) and during acute and subacute SCI (1-4 and 5-10 days post injury, 9 and 8 dogs, respectively) using antibodies directed against IBA1, MAC387, MHC-II, lysozyme, EGR2, myeloperoxidase, CD18, CD204 and lectin from
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.942967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ependymoma in a dwarf goat.

    Kühl, Bianca / Peters, Martin / Gies, Nicole / Wohlsein, Peter

    Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere

    2020  Volume 48, Issue 1, Page(s) 45–49

    Abstract: Ependymomas are relatively rare neuroglial tumours that derive from ependymal cells, lining the ventricles of the brain and the central canal of the spinal cord. They occur particularly in dogs, while reports in goats are extremely scarce. A 15-year-old ... ...

    Title translation Ependymom bei einer Zwergziege.
    Abstract Ependymomas are relatively rare neuroglial tumours that derive from ependymal cells, lining the ventricles of the brain and the central canal of the spinal cord. They occur particularly in dogs, while reports in goats are extremely scarce. A 15-year-old female dwarf goat was found in lateral recumbency, developed opisthotonus and was killed humanely. Necropsy revealed a well-demarcated, non-encapsulated mass in the diencephalon at the level of the interthalamic adhesion. Histologically, the neoplasm showed highly cellular sheets of tumour cells with occasional perivascular pseudorosettes and true rosettes. Immunohistochemistry revealed an extensive and perivascularly accentuated expression of S100 protein and glial fibrillary acidic protein, while vimentin expression was observed to a minor extent. Tumour cells were negative for cytokeratin and CNPase. Ultrastructurally, intercellular junctions were present, but cilia and blepharoblasts were lacking. The presented findings are consistent with a cellular subtype of an ependymoma. Ependymomas should be regarded as a rare cause of central nervous signs in goats.
    MeSH term(s) Animals ; Autopsy/veterinary ; Brain Neoplasms/pathology ; Brain Neoplasms/ultrastructure ; Brain Neoplasms/veterinary ; Diencephalon/pathology ; Diencephalon/ultrastructure ; Ependymoma/pathology ; Ependymoma/ultrastructure ; Ependymoma/veterinary ; Euthanasia, Animal ; Female ; Goat Diseases/pathology ; Goats ; Immunohistochemistry/veterinary ; Microscopy, Electron, Transmission/veterinary
    Language English
    Publishing date 2020-02-14
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2178387-1
    ISSN 2567-5834 ; 1434-1220
    ISSN (online) 2567-5834
    ISSN 1434-1220
    DOI 10.1055/a-1067-3925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ependymoma in a dwarf goat

    Kühl, Bianca / Peters, Martin / Gies, Nicole / Wohlsein, Peter

    Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere

    2020  Volume 48, Issue 01, Page(s) 45–49

    Abstract: Ependymomas are relatively rare neuroglial tumours that derive from ependymal cells, lining the ventricles of the brain and the central canal of the spinal cord. They occur particularly in dogs, while reports in goats are extremely ... ...

    Abstract Ependymomas are relatively rare neuroglial tumours that derive from ependymal cells, lining the ventricles of the brain and the central canal of the spinal cord. They occur particularly in dogs, while reports in goats are extremely scarce. A 15-year-old female dwarf goat was found in lateral recumbency, developed opisthotonus and was killed humanely. Necropsy revealed a well-demarcated, non-encapsulated mass in the diencephalon at the level of the interthalamic adhesion. Histologically, the neoplasm showed highly cellular sheets of tumour cells with occasional perivascular pseudorosettes and true rosettes. Immunohistochemistry revealed an extensive and perivascularly accentuated expression of S100 protein and glial fibrillary acidic protein, while vimentin expression was observed to a minor extent. Tumour cells were negative for cytokeratin and CNPase. Ultrastructurally, intercellular junctions were present, but cilia and blepharoblasts were lacking. The presented findings are consistent with a cellular subtype of an ependymoma. Ependymomas should be regarded as a rare cause of central nervous signs in goats.
    Keywords Goat ; brain ; tumour ; immunohistochemistry ; electron microscopy ; Ziege ; Gehirn ; Tumor ; Immunhistochemie ; Elektronenmikroskopie
    Language English
    Publishing date 2020-02-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2178387-1
    ISSN 2567-5834 ; 1434-1220
    ISSN (online) 2567-5834
    ISSN 1434-1220
    DOI 10.1055/a-1067-3925
    Database Thieme publisher's database

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  4. Book ; Online ; Thesis: Phenotypic characterization of canine microglia/macrophages within the injured spinal cord following intervertebral disc degeneration

    Kühl, Bianca [Verfasser] / Gerhauser, Ingo [Akademischer Betreuer] / Gerhauser, Ingo [Gutachter] / Volk, Holger [Gutachter]

    2022  

    Author's details Bianca Kühl ; Gutachter: Ingo Gerhauser, Holger Volk ; Betreuer: Ingo Gerhauser
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language English
    Publisher Stiftung Tierärztliche Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  5. Article ; Online: Highly pathogenic avian influenza A virus (HPAIV) H5N1 infection in two European grey seals (

    Mirolo, Monica / Pohlmann, Anne / Ahrens, Ann Kathrin / Kühl, Bianca / Rubio-Garcìa, Ana / Kramer, Katharina / Meinfelder, Ulrike / Rosenberger, Tanja / Morito, Hannah Leah / Beer, Martin / Ludlow, Martin / Wohlsein, Peter / Baumgärtner, Wolfgang / Harder, Timm / Osterhaus, Albert

    Emerging microbes & infections

    2023  Volume 12, Issue 2, Page(s) e2257810

    Abstract: ... ...

    Abstract ABSTRACT
    MeSH term(s) Animals ; Encephalitis ; Influenza A Virus, H5N1 Subtype/genetics ; Orthomyxoviridae Infections ; Retrospective Studies ; Seals, Earless
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2257810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neurotropic Highly Pathogenic Avian Influenza A(H5N1) Virus in Red Foxes, Northern Germany.

    Baechlein, Christine / Kleinschmidt, Sven / Hartmann, Dorothee / Kammeyer, Patricia / Wöhlke, Anne / Warmann, Tobias / Herms, Louise / Kühl, Bianca / Beineke, Andreas / Wohlsein, Peter / Harder, Timm / Runge, Martin

    Emerging infectious diseases

    2023  Volume 29, Issue 12, Page(s) 2509–2512

    Abstract: In a 1-year survey of wild terrestrial predators in northern Germany, we found that 5 of 110 foxes were infected with contemporary avian influenza A(H5N1) viruses, forming a temporal cluster during January‒March 2023. Encephalitis and strong cerebral ... ...

    Abstract In a 1-year survey of wild terrestrial predators in northern Germany, we found that 5 of 110 foxes were infected with contemporary avian influenza A(H5N1) viruses, forming a temporal cluster during January‒March 2023. Encephalitis and strong cerebral virus replication but only sporadic mammalian-adaptive viral polymerase basic 2 protein E627K mutations were seen.
    MeSH term(s) Animals ; Humans ; Influenza in Birds/epidemiology ; Influenza A Virus, H5N1 Subtype/genetics ; Foxes ; Viral Proteins/genetics ; Germany/epidemiology
    Chemical Substances Viral Proteins
    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2912.230938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Conference proceedings: Die Genfer Initiative - ein Tor zum Frieden im Nahen Osten?

    Kühl, Bianca

    internationale Konferenz, Berlin, 15. Januar 2004 ; [Dokumentation]

    2004  

    Institution Friedrich-Ebert-Stiftung / Referat Naher, Mittlerer Osten und Nordafrika
    Event/congress Internationale Konferenz (2004.01.15, Berlin)
    Author's details [Hrsg.: Friedrich-Ebert-Stiftung, Abteilung Internationale Entwicklungszusammenarbeit, Referat Naher/Mittlerer Osten und Nordafrika. Red.: Bianca Kühl; Elisabeth Schumann-Braune]
    Language German
    Size 96 S., Ill., Kt., 21 cm
    Publisher Friedrich-Ebert-Stiftung, Referat Naher/Mittlerer Osten und Nordafrika
    Publishing place Berlin
    Document type Book ; Conference proceedings
    ISBN 389892274X ; 9783898922746
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article: Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury.

    Spitzbarth, Ingo / Moore, Sarah A / Stein, Veronika M / Levine, Jonathan M / Kühl, Bianca / Gerhauser, Ingo / Baumgärtner, Wolfgang

    Frontiers in veterinary science

    2020  Volume 7, Page(s) 595796

    Abstract: Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed ... ...

    Abstract Spinal cord injury (SCI) in dogs is commonly attributed to intervertebral disc extrusion (IVDE). Over the last years substantial progress was made in the elucidation of factors contributing to the pathogenesis of this common canine disease. A detailed understanding of the underlying histopathological and molecular alterations in the lesioned spinal cord represents a prerequisite to translate knowledge on the time course of secondary injury processes into the clinical setting. This review summarizes the current state of knowledge of the underlying pathology of canine IVDE-related SCI. Pathological alterations in the spinal cord of dogs affected by IVDE-related SCI include early and persisting axonal damage and glial responses, dominated by phagocytic microglia/macrophages. These processes are paralleled by a pro-inflammatory microenvironment with dysregulation of cytokines and matrix metalloproteinases within the spinal cord. These data mirror findings from a clinical and therapeutic perspective and can be used to identify biomarkers that are able to more precisely predict the clinical outcome. The pathogenesis of progressive myelomalacia, a devastating complication of SCI in dogs, is not understood in detail so far; however, a fulminant and exaggerating secondary injury response with massive reactive oxygen species formation seems to be involved in this unique neuropathological entity. There are substantial gaps in the knowledge of pathological changes in IVDE with respect to more advanced and chronic lesions and the potential involvement of demyelination. Moreover, the role of microglia/macrophage polarization in IVDE-related SCI still remains to be investigated. A close collaboration of clinical neurologists and veterinary pathologists will help to facilitate an integrative approach to a more detailed understanding of the molecular pathogenesis of canine IVDE and thus to identify therapeutic targets.
    Language English
    Publishing date 2020-10-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.595796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neurotropic highly pathogenic avian influenza A(H5N1) virus in red foxes, northern Germany

    Baechlein, Christine / Kleinschmidt, Sven / Hartmann, Dorothee / Kammeyer, Patricia / Wöhlke, Anne / Warmann, Tobias / Herms, Louise / Kühl, Bianca / Beineke, Andreas / Wohlsein, Peter / Harder, Timm C. / Runge, Martin

    2023  

    Abstract: In a 1-year survey of wild terrestrial predators in northern Germany, we found that 5 of 110 foxes were infected with contemporary avian influenza A(H5N1) viruses, forming a temporal cluster during January‒March 2023. Encephalitis and strong cerebral ... ...

    Abstract In a 1-year survey of wild terrestrial predators in northern Germany, we found that 5 of 110 foxes were infected with contemporary avian influenza A(H5N1) viruses, forming a temporal cluster during January‒March 2023. Encephalitis and strong cerebral virus replication but only sporadic mammalian-adaptive viral polymerase basic 2 protein E627K mutations were seen.
    Keywords Text ; article ; ddc:630
    Language English
    Publishing date 2023-10-31
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Swinepox Virus Strains Isolated from Domestic Pigs and Wild Boar in Germany Display Altered Coding Capacity in the Terminal Genome Region Encoding for Species-Specific Genes

    Kaiser, Franziska K. / Wiedemann, Anastasia / Kühl, Bianca / Menke, Laura / Beineke, Andreas / Baumgärtner, Wolfgang / Wohlsein, Peter / Rigbers, Kerstin / Becher, Paul / Peters, Martin / Osterhaus, Albert D. M. E. / Ludlow, Martin

    Viruses. 2021 Oct. 09, v. 13, no. 10

    2021  

    Abstract: Swinepox virus (SWPV) is a globally distributed swine pathogen that causes sporadic cases of an acute poxvirus infection in domesticated pigs, characterized by the development of a pathognomonic proliferative dermatitis and secondary ulcerations. More ... ...

    Abstract Swinepox virus (SWPV) is a globally distributed swine pathogen that causes sporadic cases of an acute poxvirus infection in domesticated pigs, characterized by the development of a pathognomonic proliferative dermatitis and secondary ulcerations. More severe disease with higher levels of morbidity and mortality is observed in congenitally SWPV-infected neonatal piglets. In this study, we investigated the evolutionary origins of SWPV strains isolated from domestic pigs and wild boar. Analysis of whole genome sequences of SWPV showed that at least two different virus strains are currently circulating in Germany. These were more closely related to a previously characterized North American SWPV strain than to a more recent Indian SWPV strain and showed a variation in the SWPV-specific genome region. A single nucleotide deletion in the wild boar (wb) SWPV strain leads to the fusion of the SPV019 and SPV020 open reading frames (ORFs) and encodes a new hypothetical 113 aa protein (SPVwb020-019). In addition, the domestic pig (dp) SWPV genome contained a novel ORF downstream of SPVdp020, which encodes a new hypothetical 71aa protein (SPVdp020a). In summary, we show that SWPV strains with altered coding capacity in the SWPV specific genome region are circulating in domestic pig and wild boar populations in Germany.
    Keywords Swinepox virus ; dermatitis ; disease severity ; morbidity ; mortality ; pathogens ; sequence analysis ; sequence deletion ; viruses ; wild boars ; Germany
    Language English
    Dates of publication 2021-1009
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13102038
    Database NAL-Catalogue (AGRICOLA)

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