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  1. Book ; Online: Umweltrisikobewertung von Zytostatika

    Kümmerer, Klaus

    (Texte / Umweltbundesamt ; [20]09,6 ; UBA-FB ; 1256 ; Umweltforschungsplan des Bundesministeriums für Umwelt, Naturschutz und Reaktorsicherheit, Forschungsbericht ...)

    2009  

    Institution Deutschland / Umweltbundesamt
    Author's details von Klaus Kümmerer ... Hrsg.: Umweltbundesamt
    Series title Texte / Umweltbundesamt ; [20]09,6
    UBA-FB ; 1256
    Umweltforschungsplan des Bundesministeriums für Umwelt, Naturschutz und Reaktorsicherheit, Forschungsbericht ...
    Collection
    Subject code 610
    Language German
    Publisher Umweltbundesamt
    Publishing place Dessau-Roßlau
    Publishing country Germany
    Document type Book ; Online
    Note Zsfassung in engl. Sprache
    HBZ-ID HT017680784
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Pharmaceuticals in the environment

    Kümmerer, Klaus

    sources, fate, effects and risks ; with 77 tables

    2004  

    Author's details Klaus Kümmerer (ed.)
    Keywords Arzneimittel ; Umweltbelastung
    Subject Fertigarzneimittel ; Therapeutikum ; Medikament ; Medukamente ; Pharmakon ; Pharmaka ; Arzneistoff ; Arzneimittelwirkstoff ; Arznei ; Pharmazeutikum ; Pharmazeutika ; Pharmazeutischer Wirkstoff ; Arzneidroge ; Ökologische Belastung ; Umweltbeeinträchtigung ; Umweltproblem ; Umwelt
    Language English
    Size XXXI, 527 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014075800
    ISBN 3-540-21342-2 ; 978-3-540-21342-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    048/1157 available for loan (reading room) Freihandmagazin (U1)

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  3. Book: Bodenlos

    Kümmerer, Klaus

    zum nachhaltigen Umgang mit Böden ; mit der Erstveröffentlichung eines Vorschlages für eine internationale Bodenkonvention

    (Politische Ökologie : Sonderheft ; 10)

    1997  

    Author's details Klaus Kümmerer ... (Hrsg.)
    Series title Politische Ökologie : Sonderheft ; 10
    Politische Ökologie
    Politische Ökologie ; Sonderheft
    Collection Politische Ökologie
    Politische Ökologie ; Sonderheft
    Keywords Bodenschutz ; Nachhaltigkeit ; Bodenverschmutzung ; Bodennutzung
    Subject Nachhaltige Entwicklung ; Langfristige Entwicklung ; Sustainable Development ; Dauerhafte Entwicklung ; Zukunftsfähige Entwicklung ; Landwirtschaftliche Bodennutzung ; Landwirtschaftliche Flächennutzung ; Boden ; Kulturboden ; Bodenkontamination ; Bodenbelastung ; Schadstoffbelastung ; Bodenerhaltung
    Language German
    Size 132 S. : Ill., graph. Darst., Kt.
    Publisher Ökom
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT008008514
    ISBN 3-928244-29-9 ; 978-3-928244-29-9
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  4. Article ; Online: How data on transformation products can support the redesign of sulfonamides towards better biodegradability in the environment.

    Puhlmann, Neele / Olsson, Oliver / Kümmerer, Klaus

    The Science of the total environment

    2024  Volume 921, Page(s) 171027

    Abstract: Sulfonamide antibiotics (SUAs) released into the environment can affect environmental und human health, e.g., by accelerating the development and selection of antimicrobial resistant bacteria. Benign by Design (BbD) of SUAs is an effective risk ... ...

    Abstract Sulfonamide antibiotics (SUAs) released into the environment can affect environmental und human health, e.g., by accelerating the development and selection of antimicrobial resistant bacteria. Benign by Design (BbD) of SUAs is an effective risk prevention approach. BbD principles aim for fast and complete mineralization or at least deactivation of the SUA after release into the aquatic environment. Main objective was to test if mixtures of transformation products (TPs) generated via photolysis of SUAs can be used as an efficient way to screen for similarly effective but better biodegradable SUA alternatives. Six SUAs were photolyzed (Hg ultraviolet (UV) light), and generated UV-mixtures analysed by high performance liquid chromatography coupled to an UV and tandem mass spectrometry detector. UV-mixtures were screened for antibiotic activity (luminescence bacteria test, LBT, on luminescence and growth inhibition of Aliivibrio Fischeri) and environmental biodegradability (manometric respirometry test, MRT, OECD 301F) using untreated parent SUAs in comparison. Additionally, ready environmental biodegradability of three commercially available hydroxylated sulfanilamide derivatives was investigated. SUA-TPs contributed to acute and chronic bacterial luminescence inhibition by UV-mixtures. LBT's third endpoint, growth inhibition, was not significant for UV-mixtures. However, it cannot be excluded for tested TPs as concentrations were lower than parents' concentrations and inhibition by most parental concentrations tested was also not significant. HPLC analysis of MRT samples revealed that one third of SUA-TPs was reduced during incubation. Three of these TPs, likely OH-SIX, OH-SMX and OH-STZ, were of interest for BbD because the sulfonamide moiety is still present. However, hydroxylated sulfanilamide derivatives, tested to investigate the effect of hydroxylation on biodegradability, were not readily biodegraded. Thus, improving mineralization through hydroxylation as a general rule couldn't be confirmed, and no BbD candidate could be identified. This study fills data gaps on bioactivity and environmental biodegradability of SUAs' TP-mixtures. Findings may support new redesign approaches.
    MeSH term(s) Humans ; Sulfonamides/chemistry ; Biodegradation, Environmental ; Sulfanilamide/analysis ; Anti-Bacterial Agents/chemistry ; Photolysis ; Water Pollutants, Chemical/analysis ; Ultraviolet Rays
    Chemical Substances Sulfonamides ; Sulfanilamide (21240MF57M) ; Anti-Bacterial Agents ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-02-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Analysis of environmental biodegradability of cellulose-based pharmaceutical excipients in aqueous media.

    Bading, Mila / Olsson, Oliver / Kümmerer, Klaus

    Chemosphere

    2024  Volume 352, Page(s) 141298

    Abstract: Pharmaceutical cellulosic polymers will inevitably reach natural water systems if they are not removed after entering wastewater. Biodegradation of organic chemicals in sewage or in the aquatic environment is an important removal mechanism. In this study, ...

    Abstract Pharmaceutical cellulosic polymers will inevitably reach natural water systems if they are not removed after entering wastewater. Biodegradation of organic chemicals in sewage or in the aquatic environment is an important removal mechanism. In this study, we investigated the environmental biodegradation of 14 cellulose derivatives commonly utilized as pharmaceutical excipients using three different test systems that are based on the closed bottle test (OECD 301D) and the manometric respirometry test (OECD 301F). For the different cellulose derivatives tested, we observed varying degrees of biodegradation ranging from 0 to 20.4 % chemical oxygen demand (COD). However, none met the criteria for classification as 'readily biodegradable'. In addition, 10 out of 14 cellulose derivatives and/or their possible transformation products formed during the experiments, may exhibit possible toxic inhibitory effects on the inoculum. This includes one or several derivatives of hydroxy propyl methyl cellulose, hydroxy propyl cellulose, methyl cellulose, ethyl cellulose, and hydroxy ethyl cellulose. Based on the results obtained, we have developed a graded classification score ('traffic light system') for excipient biodegradation. This could help streamline the assessment and classification of cellulose derivatives concerning risk of persistence and potential adverse environmental effects, thereby assisting in the prioritization of more favorable compounds. In the long term, however, excipients should be designed from the very beginning to be biodegradable and mineralizable in the environment ('benign by design').
    MeSH term(s) Excipients ; Biodegradation, Environmental ; Sewage/chemistry ; Water ; Cellulose
    Chemical Substances Excipients ; Sewage ; Water (059QF0KO0R) ; Cellulose (9004-34-6)
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141298
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
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  6. Article ; Online: Biodegradation of flavonoids - Influences of structural features.

    Schnarr, Lena / Olsson, Oliver / Kümmerer, Klaus

    Chemosphere

    2024  Volume 359, Page(s) 142234

    Abstract: Flavonoids, a class of natural products with a variety of applications in nutrition, pharmacy and as biopesticides, could substitute more harmful synthetic chemicals that persist in the environment. To gain a better understanding of the biodegradability ... ...

    Abstract Flavonoids, a class of natural products with a variety of applications in nutrition, pharmacy and as biopesticides, could substitute more harmful synthetic chemicals that persist in the environment. To gain a better understanding of the biodegradability of flavonoids and the influence of structural features, firstly, the ultimate biodegradation of 19 flavonoids was investigated with the Closed Bottle Test according to the OECD guideline 301 D. Secondly, regarding the fast abiotic degradation reported for several flavonoids with severe concentration decrease within hours and its possible impacts on the processes behind the ultimate biodegradation, primary degradation of 4 selected flavonoids was compared at conditions representing biodegradation, abiotic degradation, and mixed substrates by monitoring the flavonoids' concentrations with HPLC-UV/vis. Our results showed that 17 out of the 19 tested flavonoids were readily biodegradable. Structural features like a hydroxy group at C3, the C2-C3 bond order, a methoxy group in the B ring, and the position of the B ring in regard to the chromene core did not affect biodegradation of the tested flavonoids. Only flavone without any hydroxy groups and morin with an uncommon 2',4' pattern of hydroxy groups were non-readily biodegradable. Monitoring the concentration of 4 selected flavonoids by HPLC-UV/vis revealed that biodegradation occurred faster than abiotic degradation at CBT conditions with no other carbon sources present. The presence of an alternative carbon source tends to increase lag phases and decrease biodegradation rates. At this condition, abiotic degradation contributed to the degradation of unstable flavonoids. Overall, as a first tier to assess the environmental fate, our results indicate low risks for persistence of most flavonoids. Thus, flavonoids could represent benign substitutes for persistent synthetic chemicals.
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.142234
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    In stock of ZB MED Cologne/Königswinter

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  7. Book: Abwasser aus Einrichtungen des Gesundheitswesens - Charakterisierung, Technologien, Kommunikation und Konzepte

    Pinnekamp, Johannes / Palmowski, Laurence / Kümmerer, Klaus / Schramm, Engelbert

    Abschlussbericht des durch das Bundesministerium für Bildung und Forschung geförerten Vorhabens "Innovative Konzepte und Technologien für die separate Behandlung von Abwasser aus Einrichtungen des Gesundheitswesens (Sauber+)

    (Gewässerschutz, Wasser, Abwasser ; 238)

    2015  

    Author's details herausgegeben von J. Pinnekamp, L. Palmowski, K. Kümmerer, E. Schramm
    Series title Gewässerschutz, Wasser, Abwasser ; 238
    Collection
    Language German
    Size viii, 371 Seiten, Illustrationen, Diagramme
    Publisher Gesellschaft zur Förderung der Siedlungswasserwirtschaft an der RWTH Aachen
    Publishing place Aachen
    Publishing country Germany
    Document type Book
    HBZ-ID HT018845983
    ISBN 978-3-938996-44-7 ; 3-938996-44-7
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    158/448 available for loan (reading room) Freihandmagazin (U1)

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  8. Article: Chemistry and materials science for a sustainable circular polymeric economy.

    Zuin, Vânia G / Kümmerer, Klaus

    Nature reviews. Materials

    2022  Volume 7, Issue 2, Page(s) 76–78

    Abstract: Chemistry plays a determining role in every stage of the plastic life cycle. We reflect on the challenges and limitations of plastics - their sheer abundance, chemodiversity and imperfect recoverability leading to loss of material - and on the need for ... ...

    Abstract Chemistry plays a determining role in every stage of the plastic life cycle. We reflect on the challenges and limitations of plastics - their sheer abundance, chemodiversity and imperfect recoverability leading to loss of material - and on the need for chemical and non-chemical approaches to overcome them.
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article
    ISSN 2058-8437
    ISSN 2058-8437
    DOI 10.1038/s41578-022-00415-2
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  9. Article ; Online: Environmental degradation of human metabolites of cyclophosphamide leads to toxic and non-biodegradable transformation products.

    Suk, Morten / Kümmerer, Klaus

    The Science of the total environment

    2022  Volume 857, Issue Pt 3, Page(s) 159454

    Abstract: The present study assessed the ready biodegradability of the prodrug cyclophosphamide (CPA) and its stable human metabolites in the closed bottle test (CBT). The results of the CBT showed that only the main human metabolite, carboxyphosphamide (CXP), was ...

    Abstract The present study assessed the ready biodegradability of the prodrug cyclophosphamide (CPA) and its stable human metabolites in the closed bottle test (CBT). The results of the CBT showed that only the main human metabolite, carboxyphosphamide (CXP), was biodegradable to a certain extent (23 ± 2.4 % ThOD
    MeSH term(s) Humans ; Cyclophosphamide/toxicity ; Cyclophosphamide/chemistry ; Biodegradation, Environmental ; Antineoplastic Agents
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; Antineoplastic Agents
    Language English
    Publishing date 2022-10-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.159454
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  10. Article ; Online: Repurposing chemical waste: Sustainable chemistry for circularity beyond artificial intelligence.

    Zuin, Vânia G / Kümmerer, Klaus

    Cell

    2022  Volume 185, Issue 15, Page(s) 2655–2656

    Abstract: Generating considerable amounts of industrial waste requires rethinking chemistry for circularity in a broader picture. We discuss the study by Wołos et al. (2022) showing that the critical application of artificial intelligence on chemical reactivity ... ...

    Abstract Generating considerable amounts of industrial waste requires rethinking chemistry for circularity in a broader picture. We discuss the study by Wołos et al. (2022) showing that the critical application of artificial intelligence on chemical reactivity can help us trace an unprecedented number of syntheses to novel responsible uses of waste.
    MeSH term(s) Artificial Intelligence
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.06.041
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