Article ; Online: Performance Optimization of a Microfluidic Virus Detection Cartridge: A Numerical and Experimental Study.
Journal of biomechanical engineering
2023 Volume 145, Issue 10
Abstract: Detection and imaging of viruses in a complex solution is particularly significant for virology and requires a comprehensive understanding of biosensors. While lab-on-a-chip systems are used in virus detection as biosensors, analysis and optimization of ... ...
Abstract | Detection and imaging of viruses in a complex solution is particularly significant for virology and requires a comprehensive understanding of biosensors. While lab-on-a-chip systems are used in virus detection as biosensors, analysis and optimization of these systems are especially challenging due to the size of the system to be used in the certain application. The system of interest for virus detection is required to be cost efficient and is also needed to be able to easily operable with a simple setup. Moreover, the detailed analysis of these microfluidic systems should be made with precision in order to predict the capabilities and the efficiency of the system accurately. This paper reports on the use of a common commercial computational fluid dynamics (cfd) software for the analysis of a microfluidic lab-on-a-chip virus detection cartridge. This study evaluates the problems commonly encountered during microfluidic applications of cfd softwares particularly in the area of reaction modeling of the antigen-antibody interaction. cfd analysis is later validated and combined with experiments to optimize the amount of dilute solution used in the tests. Thereafter, the geometry of the microchannel is also optimized and optimal test conditions are set for a cost efficient and effective virus detection kit using light microscopy. |
---|---|
MeSH term(s) | Microfluidics ; Biosensing Techniques ; Microfluidic Analytical Techniques/methods ; Lab-On-A-Chip Devices |
Language | English |
Publishing date | 2023-06-29 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 243094-0 |
ISSN | 1528-8951 ; 0148-0731 |
ISSN (online) | 1528-8951 |
ISSN | 0148-0731 |
DOI | 10.1115/1.4062850 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.B 2672: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.