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Article ; Online: Serum Levels of Copper and Zinc and Survival in Breast Cancer Patients.

Szwiec, Marek / Marciniak, Wojciech / Derkacz, Róża / Huzarski, Tomasz / Gronwald, Jacek / Cybulski, Cezary / Dębniak, Tadeusz / Jakubowska, Anna / Lener, Marcin R / Falco, Michał / Kładny, Józef / Baszuk, Piotr / Kotsopoulos, Joanne / Narod, Steven A / Lubiński, Jan

Nutrients

2024 Volume 16, Issue 7

Abstract: There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included ... ...

Abstract	There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included 583 patients with breast cancer diagnosed between 2008 and 2015 in the region of Szczecin, Poland. In a blood sample obtained before treatment, serum zinc and copper levels were quantified by mass spectroscopy. Each patient was assigned to one of four categories (quartiles) based on the distribution of the elements in the entire cohort. Patients were followed from diagnosis to death over a mean of 10.0 years. The 10-year overall survival was 58.3% for women in the highest and 82.1% for those in the lowest quartile of serum copper/zinc ratio (
MeSH term(s)	Humans ; Female ; Breast Neoplasms ; Copper ; Zinc ; Breast ; Mass Spectrometry
Chemical Substances	Copper (789U1901C5) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16071000
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Article: Przerzut raka odbytnicy do ośrodkowego układu nerwowego jako pierwszy objaw choroby nowotworowej.

Kładny, Józef

Wiadomosci lekarskie (Warsaw, Poland : 1960)

2006 Volume 59, Issue 5-6, Page(s) 436

Title translation	Comment to the study: Metastasis to brain from rectal cancer as the first manifestation of neoplasmatic disease.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/secondary ; Adenocarcinoma/therapy ; Anus Neoplasms/diagnosis ; Anus Neoplasms/pathology ; Anus Neoplasms/therapy ; Brain Neoplasms/diagnosis ; Brain Neoplasms/pathology ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Diagnosis, Differential ; Diagnostic Errors/prevention & control ; Female ; Humans
Language	Polish
Publishing date	2006
Publishing country	Poland
Document type	Comment ; Letter
ZDB-ID	414731-5
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
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Article ; Online: Colorectal cancer and Blastocystis sp. infection.

Sulżyc-Bielicka, Violetta / Kołodziejczyk, Lidia / Adamska, Małgorzata / Skotarczak, Bogumiła / Jaczewska, Sylwia / Safranow, Krzysztof / Bielicki, Paweł / Kładny, Józef / Bielicki, Dariusz

Parasites & vectors

2021 Volume 14, Issue 1, Page(s) 200

Abstract: Background: Blastocystis sp. is a common intestinal protozoan found worldwide. Based on gene analysis, 17 subtypes (STs, ST1-ST17) have been identified, 9 of which have been isolated from humans. Differences in clinical consequences may depend on ... ...

Abstract	Background: Blastocystis sp. is a common intestinal protozoan found worldwide. Based on gene analysis, 17 subtypes (STs, ST1-ST17) have been identified, 9 of which have been isolated from humans. Differences in clinical consequences may depend on differences among the STs. Here, we evaluated the prevalence of Blastocystis sp. in patients with colorectal cancer (CRC) compared to a control group and assessed the relationships between Blastocystis sp. infection and sex; age; and CRC grade, stage, and location. Methods: The study included 107 CRC patients (41 women and 66 men, median age 65 years); 124 subjects without colorectal cancer or a history of oncological disease comprised the control group (55 women and 69 men, median age 63). Stool samples were collected from patients before oncological treatment and examined using light microscopy (iodine-stained smear). Additionally, PCR-based identification of Blastocystis sp. was performed in 95 stool samples from CRC patients and 76 stool samples from the control group. Results: Light microscopy showed that the prevalence of Blastocystis sp. was significantly higher in CRC patients than in the control group (12.15% and 2.42%, respectively; p = 0.0041). Multivariate analysis showed that the odds of Blastocystis sp. infection were fivefold higher in the CRC group than in the control group. PCR-based molecular examinations demonstrated that the proportion of patients infected with Blastocystis sp. was significantly higher in the CRC group than in the control group (12.63% and 2.63%, respectively; p = 0.023). The predominant ST in the CRC group was ST3, detected in nine patients (75%), followed by ST1 (2 patients, 16.7%) and ST2 (1 patient, 8.3%). No association was found between Blastocystis sp. infection and age, sex, or CRC stage, grade, or location. Conclusions: The results showed that CRC was associated with an increased risk of opportunistic Blastocystis sp. infection, even before oncological treatment. To the best of our knowledge, this is the first report estimating the prevalence of Blastocystis sp. infection in CRC patients before oncological treatment in Europe.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Blastocystis/classification ; Blastocystis/genetics ; Blastocystis/isolation & purification ; Blastocystis Infections/parasitology ; Blastocystis Infections/pathology ; Case-Control Studies ; Colorectal Neoplasms/parasitology ; Colorectal Neoplasms/pathology ; DNA, Protozoan/genetics ; Feces/parasitology ; Female ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Sex Factors
Chemical Substances	DNA, Protozoan
Language	English
Publishing date	2021-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-021-04681-x
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Article ; Online: Leiomyosarcoma in adrenal gland.

Dymek, Przemysław / Kiełbowski, Kajetan / Sienkiewicz, Sandra / Błaszkowski, Tomasz / Kudrymska, Aleksandra / Halczak, Mirosław / Lubikowski, Jerzy / Kładny, Józef

Endokrynologia Polska

2021 Volume 72, Issue 6, Page(s) 674–675

Abstract: Not required for Clinical Vignette. ...

Abstract	Not required for Clinical Vignette.
MeSH term(s)	Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/surgery ; Adrenal Glands/diagnostic imaging ; Adrenalectomy ; Aged ; Diabetes Mellitus, Type 2/complications ; Humans ; Laparoscopy ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/surgery ; Male ; Pulmonary Arterial Hypertension/complications ; Smooth Muscle Tumor/diagnosis ; Smooth Muscle Tumor/surgery ; Tomography, X-Ray Computed ; Ultrasonography
Language	English
Publishing date	2021-10-14
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	419270-9
ISSN	2299-8306 ; 0423-104X
ISSN (online)	2299-8306
ISSN	0423-104X
DOI	10.5603/EP.a2021.0083
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Article ; Online: The Influence Of Obesity On Results Of AT (Doxorubicin Plus Docetaxel) Neoadjuvant Chemotherapy In Locally Advanced Breast Cancer Patients

Karpińska Agnieszka / Safranow Krzysztof / Kładny Józef / Sulżyc-Bielicka Violetta

Polish Journal of Surgery, Vol 87, Iss 5, Pp 231-

2015 Volume 237

Abstract: The achieve pathologic complete response is proven to be the most important parameter of prognosis. Thereports evaluating the impact of obesity on the obtained pathologic response to chemotherapy are unequal. ...

Abstract	The achieve pathologic complete response is proven to be the most important parameter of prognosis. Thereports evaluating the impact of obesity on the obtained pathologic response to chemotherapy are unequal.
Keywords	obesity ; neoadjuvant chemotherapy ; breast cancer ; Medicine (General) ; R5-920 ; Medicine ; R
Language	English
Publishing date	2015-05-01T00:00:00Z
Publisher	Versita
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lynch syndrome (HNPCC)

Kładny Józef / Lubiński Jan

Hereditary Cancer in Clinical Practice , Vol 6, Iss 2, Pp 99-

2008 Volume 102

Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2008-06-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Role of sonography in assessing complications after laparoscopic cholecystectomy.

Smereczyński, Andrzej / Starzyńska, Teresa / Kołaczyk, Katarzyna / Kładny, Józef

Journal of ultrasonography

2014 Volume 14, Issue 57, Page(s) 152–162

Abstract: Laparoscopic cholecystectomy, which was introduced to the arsenal of surgical procedures in the middle of the 1980s, is a common alternative for conventional cholecystectomy. Its primary advantage is less invasive character which entails shorter ... ...

Abstract	Laparoscopic cholecystectomy, which was introduced to the arsenal of surgical procedures in the middle of the 1980s, is a common alternative for conventional cholecystectomy. Its primary advantage is less invasive character which entails shorter hospitalization and faster recovery. Nevertheless, the complications of both procedures are comparable and encompass multiple organs and tissues. The paper presents ultrasound presentation of the surgical bed after laparoscopic cholecystectomy and of complications associated with this procedure. In the first week following the surgery, the presence of up to 60 ml of fluid in the removed gallbladder bed should be considered normal in certain patients. The fluid will gradually absorb. In single cases, slight amounts of fluid are detected in the peritoneal cavity, which also should not be alarming. Carbon dioxide absorbs from the peritoneal cavity within two days. Ultrasound assessment of the surgical bed after cholecystectomy is inhibited by hemostatic material left during the surgery. Its presentation may mimic an abscess. In such cases, the decisive examination is magnetic resonance imaging but not computed tomography. On the other hand, rapidly accumulating fluid around the liver is an alarming symptom, particularly when there is inadequate blood supply or when peritoneum irritation symptoms develop. Depending on the suspected cause of the patient's deteriorating condition, it is essential to perform urgent computed tomography angiography, celiac angiography or endoscopic retrograde cholangiopancreatography or magnetic resonance cholangiopancreatography. The character of the fluid collection may be determined by its ultrasound-guided puncture. This procedure allows for aspiration of fluid and placement of a drain. Moreover, transabdominal ultrasound examination after laparoscopic cholecystectomy may contribute to the identification of: dropped stones in the right hypochondriac region, residual fragment of the gallbladder with possible concretions, undiagnosed choledocholithiasis, existing cholestasis, pseudoaneurysm of the hepatic artery, portal vein thrombosis and hematoma as well as hernias of the abdominal walls. Moreover, ultrasound examination helps to identify optimal sites in the abdominal integuments, which enables collision-free access to the peritoneal cavity.
Language	English
Publishing date	2014-06-30
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2843824-3
ISSN	2084-8404
ISSN	2084-8404
DOI	10.15557/JoU.2014.0015
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Article: Tissue reactions of abdominal integuments to surgical sutures in sonography.

Smereczyński, Andrzej / Starzyńska, Teresa / Kołaczyk, Katarzyna / Kładny, Józef

Journal of ultrasonography

2014 Volume 14, Issue 56, Page(s) 21–27

Abstract: Unlabelled: Classical abdominal surgeries usually require long incisions of the abdominal integuments followed by tight closure with adequate suturing material. Nonabsorbable sutures may cause various reactions, including granuloma reactions, both ... ...

Abstract	Unlabelled: Classical abdominal surgeries usually require long incisions of the abdominal integuments followed by tight closure with adequate suturing material. Nonabsorbable sutures may cause various reactions, including granuloma reactions, both sterile and inflammatory. The aim of the study: The aim of the study was to analyze prospective ultrasound examinations of the abdominal integuments in order to detect tissue reactions to surgical sutures. Material and methods: For 10 years, ultrasound examinations of the abdominal integuments involved the assessment of surgical scars in all patients who underwent open or closed surgeries for various reasons (in total 2254 patients). Ultrasound examinations were performed only with the use of linear probes with the frequency ranging from 7 to 12 MHz. Each scar in the abdominal integuments was scanned in at least two planes. When a lesion was detected, the image was enlarged and the transducer was rotated by approximately 180° in order to capture the dimensions of the granuloma and the most characteristic image of the suture. Moreover, vascularization of the lesion was also assessed with the use of color Doppler mode set to detect the lowest flows. Results: All granulomas (19 lesions, two in one patient) created hypoechoic oval or round nodules, were relatively well-circumscribed and their size ranged from 8 × 4 mm to 40 × 14 mm. In the center of the lesion, it was possible to notice a thread that was coiled to various degrees and presented itself as a double, curved hyperechoic line. In 9 out of 19 granulomas, slight peripheral vascularization was observed. The substantial majority of the lesions (n = 15) were in contact with the fascia. In seven patients, compression with the transducer induced known local pain (n = 4) or intensified pain that had already been present (n = 3); all of these granulomas infiltrated the fascia and showed slight peripheral vascularization. Cutaneous fistulae developed in two patients with purulent reactions to the running stitch (in one patient - two fistulae). Conclusions: Suture granulomas in the abdominal integuments manifest themselves as nodular hypoechoic lesions, usually localized at the edge of the fascia - subcutaneous fat. A pathognomonic sign of this type of granulomas is the presence of a thread in their center that usually manifests itself as a chaotically shaped, double hyperechoic line. In some granulomas, particularly those with clinical presentation, slight peripheral vascularization is observed.
Language	English
Publishing date	2014-03-30
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2843824-3
ISSN	2084-8404
ISSN	2084-8404
DOI	10.15557/JoU.2014.0002
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Article: Melanoma of unknown primary origin coexisting with early-onset multifocal basal cell carcinoma.

Kiedrowicz, Magdalena / Halczak, Mirosław / Kładny, Józef / Królicki, Andrzej / Maleszka, Romuald

Postepy dermatologii i alergologii

2015 Volume 32, Issue 4, Page(s) 320–322

Language	English
Publishing date	2015-08-12
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/pdia.2014.40972
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Article: Blood Copper Levels and the Occurrence of Colorectal Cancer in Poland.

Baszuk, Piotr / Marciniak, Wojciech / Derkacz, Róża / Jakubowska, Anna / Cybulski, Cezary / Gronwald, Jacek / Dębniak, Tadeusz / Huzarski, Tomasz / Białkowska, Katarzyna / Pietrzak, Sandra / Muszyńska, Magdalena / Kładny, Józef / Narod, Steven A / Lubiński, Jan / Lener, Marcin R

Biomedicines

2021 Volume 9, Issue 11

Abstract: There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level ... ...

Abstract	There is a need for sensitive and specific biomarkers for the early detection of colorectal cancer. In this retrospective study, we assessed whether a high blood copper level was associated with the presence of colorectal cancer. The blood copper level was measured among 187 colorectal cancer patients and 187 matched controls. Cases and controls were matched for sex, smoking status (yes/no) and year of birth. Among the cases, the mean blood copper level was 1031 µg/L (range 657 µg/L to 2043 µg/L) and among the controls, the mean blood copper level was 864 µg/L (range 589 µg/L to 1433 µg/L). The odds ratio for colorectal cancer for those in the highest quartile of copper level (versus the lowest) was 12.7 (95% CI: 4.98-32.3;
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9111628
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