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Article ; Online: Ranking of Pentagonal Neutrosophic Numbers and its Applications to solve Assignment Problem

K.Radhika / K.Arun Prakash

Neutrosophic Sets and Systems, Vol 35, Pp 464-

2020 Volume 477

Abstract: Introduction of Neutrosophic sets and Neutrosophic numbers paves a way to handle uncertainty more effectively. In this paper we propose a new approach for ranking neutrosophic number by using its magnitude. We develop an algorithm for the solution of ... ...

Abstract	Introduction of Neutrosophic sets and Neutrosophic numbers paves a way to handle uncertainty more effectively. In this paper we propose a new approach for ranking neutrosophic number by using its magnitude. We develop an algorithm for the solution of neutrosophic assignment problems involving pentagonal neutrosophic number. The proposed method is easy to understand and to apply for finding solution of neutrosophic assignment problems occurring in real life situations. To show the proposed strategy numerical models are given and the acquired results are analyzed.
Keywords	neutrosophic sets ; neutrosophic number ; pentagonal neutrosophic number ; neutrosophic assignment problem ; optimal solution ; Mathematics ; QA1-939 ; Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	University of New Mexico
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Validation of the Ayurvedic construct, Rasadhatudushti, in adults at risk of cardiovascular diseases - A mixed-method study.

Rani R K, Radhika / Shajahan, M A

Journal of Ayurveda and integrative medicine

2022 Volume 13, Issue 3, Page(s) 100627

Abstract: Background: Rasadhatudushti (RD), the deranged state of Rasadhatu, is a construct in Ayurveda mentioned as the cause of diseases affecting the circulatory channels and the heart, collectively called cardiovascular diseases (CVD). It is a morbid ... ...

Abstract	Background: Rasadhatudushti (RD), the deranged state of Rasadhatu, is a construct in Ayurveda mentioned as the cause of diseases affecting the circulatory channels and the heart, collectively called cardiovascular diseases (CVD). It is a morbid condition generic to some other disorders, hence is non-specific to CVD. It was observed that RD was present in majority of acute coronary artery disease in a cross-sectional, descriptive study in 250 patients stabilized after an acute episode. Objectives: To validate the available scale for assessing RD in the context of CVD risk. To study the prevalence of RD in participants at risk of cardiovascular diseases. Method: In the first part, validation of the scale for assessing RD, as mentioned in the texts, was done through standard steps for scale validation in the context of CVD risk. Psychometric analysis was done after administering the draft scale of 39 items in 218 participants above the age of 40 years who were not yet diagnosed with overt CVD conditions. Construct validation was done by comparing mean score of Framingham global risk score in high and low RD scores and comparing the reduction in CVD risk score assessed by Qrisk®2-2017 by life style modification and a conventional RD correction as add on. Second part was a cross sectional survey study to estimate the prevalence of RD in a specific population vulnerable to CVD. This was done in a sample of 160 sedentary government employees of Thiruvananthapuram District, Kerala, aged above 40, using the validated RD assessment scale. Result: -The final scale to assess RD, 'RAS-RCVD', with 25 symptoms was found to have concurrent validity using WHO/ISH risk prediction as the reference standard. Framingham global risk score also showed significant but low positive correlation with eight as the cut off for RD score. The reduction in mean (SD) Qrisk score was 2.53 (3.22) in the trial group receiving RD correction drug and 0.30 (3.43) in the control with statistical significance (p < 0.05). The prevalence of RD as assessed by RD score above the cut off in the second part of the study was 49.4%. The prevalence of RD was significantly high in participants with moderate to high risk for CVD (61.3%). Conclusion: - The construct RD was observed to be valid in pre-clinical states of CVD. There was a high prevalence of this morbid construct in moderate to high-risk individuals. Ayurvedic CVD prevention strategies need to target on correction of RD along with individual risk factor management.
Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Journal Article
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2022.100627
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Article ; Online: Prevalence and causes of endemic hydric fluorosis in a village in rural Karnataka, India

Arjunan Isaac / S Pruthvish / K Radhika / N S Murthy

CHRISMED Journal of Health and Research, Vol 9, Iss 1, Pp 71-

2022 Volume 75

Abstract: Background: Fluorosis is caused because of excessive fluoride intake. Karnataka is one among the states that have reported high fluoride content in the groundwater. This study aimed to determine the prevalence of and clinical manifestations suggestive of ...

Abstract	Background: Fluorosis is caused because of excessive fluoride intake. Karnataka is one among the states that have reported high fluoride content in the groundwater. This study aimed to determine the prevalence of and clinical manifestations suggestive of fluorosis, along with the causes for fluorosis among the population of Kaiwara village. Methodology: The present cross-sectional survey was performed among 3003 permanent residents of Kaiwara village. Demographic details such as age, occupation, education, economic status, and anthropometric details were recorded. Parameters such as predominant diet, genu valgum, and grades of goiter were studied and recorded to determine their association with fluorosis. Dean's index was used to detect dental fluorosis. The levels of fluoride in urine were estimated using the ELICO-LI-126 Fluoride ion analyzer. Results: The most observed age group among study subjects was 10–49 years (males: 813 and females: 1304). Age, diet, genu valgum, and grade of goiter were significantly (P < 0.001) associated with Dean's index. Of the study subjects, about 11.8% were unable to touch their toes indicating fluorosis. 2.075 mg/dl was the mean baseline fluoride level found in all the four samples from the main water tanks supplying water to the village. Out of 100 urine samples randomly taken, all had fluoride levels above the acceptable levels (>0.1 ppm). Conclusion: Hydric fluorosis is endemic among the general population of Kaiwara village in Karnataka. The main leading cause for fluorosis occurrence in this region might be due to high fluoride levels reported in the groundwater.
Keywords	age groups ; dental ; genu valgum ; goiter ; urinalysis ; Medicine ; R ; Nursing ; RT1-120
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: dsDNA-templated fluorescent copper nanoparticles for the detection of lipopolysaccharides

N. K., Radhika / Gorthi, Sai Siva

Analytical methods. 2021 Jan. 21, v. 13, no. 2

2021

Abstract: The introduction of lipopolysaccharides (LPS) or endotoxins that originate from Gram-negative bacteria into the human blood stream induces a severe immune response that can lead to septic shock, and even death. Hence, the accurate detection of LPS is of ... ...

Abstract	The introduction of lipopolysaccharides (LPS) or endotoxins that originate from Gram-negative bacteria into the human blood stream induces a severe immune response that can lead to septic shock, and even death. Hence, the accurate detection of LPS is of great importance in the medical and pharmaceutical sectors. This paper proposes a novel label-free fluorescence assay for the detection of LPS utilizing aptamers and the interference synthesis of dsDNA-templated copper nanoparticles. The assay can be performed at room temperature and does not require expensive reagents. The proposed assay has a limit of detection of 0.95 ng ml⁻¹ of LPS, and the fluorescence emission from the copper nanoparticles was found to vary linearly with the concentration of LPS over a wide range (1 to 10⁵ ng ml⁻¹) with R² = 0.9877.
Keywords	ambient temperature ; blood flow ; copper nanoparticles ; death ; detection limit ; endotoxins ; fluorescence ; humans ; immune response ; lipopolysaccharides ; oligonucleotides ; septic shock
Language	English
Dates of publication	2021-0121
Size	p. 186-191.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d0ay01906b
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: dsDNA-templated fluorescent copper nanoparticles for the detection of lipopolysaccharides.

N K, Radhika / Gorthi, Sai Siva

Analytical methods : advancing methods and applications

2020 Volume 13, Issue 2, Page(s) 186–191

Abstract	The introduction of lipopolysaccharides (LPS) or endotoxins that originate from Gram-negative bacteria into the human blood stream induces a severe immune response that can lead to septic shock, and even death. Hence, the accurate detection of LPS is of great importance in the medical and pharmaceutical sectors. This paper proposes a novel label-free fluorescence assay for the detection of LPS utilizing aptamers and the interference synthesis of dsDNA-templated copper nanoparticles. The assay can be performed at room temperature and does not require expensive reagents. The proposed assay has a limit of detection of 0.95 ng ml-1 of LPS, and the fluorescence emission from the copper nanoparticles was found to vary linearly with the concentration of LPS over a wide range (1 to 105 ng ml-1) with R2 = 0.9877.
MeSH term(s)	Copper ; DNA ; Fluorescent Dyes ; Humans ; Lipopolysaccharides ; Metal Nanoparticles
Chemical Substances	Fluorescent Dyes ; Lipopolysaccharides ; Copper (789U1901C5) ; DNA (9007-49-2)
Language	English
Publishing date	2020-12-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d0ay01906b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A rapid aptamer-based fluorescence assay for the detection of lipopolysaccharides using SYBR Green I.

N K, Radhika / Kamali R, Vishaalini / Gorthi, Sai Siva

Luminescence : the journal of biological and chemical luminescence

2021 Volume 36, Issue 7, Page(s) 1632–1637

Abstract: Lipopolysaccharides (endotoxins), found on Gram-negative bacteria, can trigger a severe immune response in humans leading to septic shock and in extreme cases, even death. Therefore, the detection and neutralization of lipopolysaccharides (LPS) is of ... ...

Abstract	Lipopolysaccharides (endotoxins), found on Gram-negative bacteria, can trigger a severe immune response in humans leading to septic shock and in extreme cases, even death. Therefore, the detection and neutralization of lipopolysaccharides (LPS) is of utmost importance in the pharmaceutical and medical industries. The United States Food and Drug Administration (US FDA) recommended detection method for LPS, the Limulus amebocyte lysate (LAL) assay, is expensive, time consuming, complex, and is prone to interference from proteases. As an alternative, this paper proposes a rapid, label-free fluorescence-based assay using LPS-specific aptamers and the SYBR Green DNA stain. The proposed method has a detection limit of 0.1 ng/ml, which is sufficient to detect the permissible levels of LPS in many pharmaceutical drugs and medical products. The fluorescence signal was found to be a linear function of the concentration of LPS in the range from 0.1 ng/ml to 10
MeSH term(s)	Benzothiazoles ; Biological Assay ; Diamines ; Endotoxins ; Humans ; Lipopolysaccharides ; Oligonucleotides ; Quinolines ; United States
Chemical Substances	Benzothiazoles ; Diamines ; Endotoxins ; Lipopolysaccharides ; Oligonucleotides ; Quinolines ; SYBR Green I (163795-75-3)
Language	English
Publishing date	2021-07-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4104
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Article ; Online: Physicochemical basis of resistance in certain green gram genotypes to pulse bruchid, Calloso bruchus chinensis (L.)

Kavitha G / Mahalakshmi MS / K. Bayyapu Reddy / Y. Pushpa Reni / K. Radhika

Environment Conservation Journal, Vol 22, Iss

2021 Volume 3

Abstract: A study was conducted to know the influence of physical and biochemical parameters on development of the pulse bruchid in green gram at RARS, Lam during 2017-18. The physical parameters of seed viz., colour, shape, surface texture, seed length and width, ...

Abstract	A study was conducted to know the influence of physical and biochemical parameters on development of the pulse bruchid in green gram at RARS, Lam during 2017-18. The physical parameters of seed viz., colour, shape, surface texture, seed length and width, seed coat hardness and 100 seed weight and biochemical parameters such as protein content, phenol content and total sugars were evaluated for twelve genotypes of greengram. The greengram genotypes with smooth texture, oblong or globose shape and light coloured seed might be less preferred by the pulse bruchid for egg laying. The data showed that genotypes having low sugar and protein contents and high phenol content were resistant to pulse bruchid. The correlation studies showed that biological parameters i.e., number of eggs, adult emergence and growth index had significant positive association with protein content, sugar content, moisture content and electrical conductivity and negative correlation phenol content, 100 seed weight and seed coat hardness. In contrast, mean development period had negative association with protein content, sugar content, electrical conductivity and moisture content and positive correlation with phenol content, 100 seed weight and seed coat hardness. Multiple linear regression studies revealed that all the physical and biochemical properties of seed together were contributing to a large and significant variation (65 to 87 %) in growth parameters of pulse bruchid.
Keywords	Bruchid ; Greengram ; Phenols ; Proteins ; Seed coat thickness ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Action for Sustainable Efficacious Development and Awareness
Document type	Article ; Online
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Article ; Online: Enhancement of the fluorescence properties of double stranded DNA templated copper nanoparticles.

N K, Radhika / Gorthi, Sai Siva

Materials science & engineering. C, Materials for biological applications

2019 Volume 98, Page(s) 1034–1042

Abstract: The weak fluorescence emission from dsDNA templated copper nanoparticles necessitates the use of high-end detectors like photomultiplier tubes for their detection. This sets limitations on their applicability to in-situ analyte detection and point-of- ... ...

Abstract	The weak fluorescence emission from dsDNA templated copper nanoparticles necessitates the use of high-end detectors like photomultiplier tubes for their detection. This sets limitations on their applicability to in-situ analyte detection and point-of-care applications which utilize comparatively low cost and less sensitive detectors. In this article, a technique to improve the fluorescence properties of copper nanoparticles templated on dsDNA is reported. The fluorescence enhancement is achieved by introducing a modification in the conventional synthesis technique by using a combination of sodium ascorbate and Taq buffer. When compared to the existing methods, the proposed method achieves 11 times higher fluorescence signal intensity from the dsDNA templated copper nanoparticles and 4 times faster attainment of maximum fluorescence signal. The effect of the ionic strength of the individual constituent components of Taq buffer on the fluorescence emission from the copper nanoparticles is also studied here. The utility of this enhancement strategy for analyte measurement is demonstrated with the example of melamine detection from milk samples. A linear relationship was observed between the fluorescence intensity from the copper nanoparticles and the concentration of melamine in the range from 0.5 ppm to 100 ppm (R
MeSH term(s)	Copper/chemistry ; DNA/chemistry ; Fluorescence ; Fluorescent Dyes/chemistry ; Limit of Detection ; Metal Nanoparticles/chemistry ; Spectrometry, Fluorescence/methods
Chemical Substances	Fluorescent Dyes ; Copper (789U1901C5) ; DNA (9007-49-2)
Language	English
Publishing date	2019-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2019.01.042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Migraine Disability, Quality of Life, and Its Predictors.

R, Pradeep / S C, Nemichandra / S, Harsha / K, Radhika

Annals of neurosciences

2020 Volume 27, Issue 1, Page(s) 18–23

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-07-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2576191-2
ISSN	0976-3260 ; 0972-7531
ISSN (online)	0976-3260
ISSN	0972-7531
DOI	10.1177/0972753120929563
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Article ; Online: A clinicopathologic study of malignant melanoma based on cytomorphology

K Radhika / A K Prayaga / C Sundaram

Indian Journal of Cancer, Vol 53, Iss 1, Pp 199-

2016 Volume 203

Abstract: Context: Melanoma accounts for 1-3% of all malignancies. It is usually diagnosed as metastasis in the draining lymph nodes, that is inguinal lymph node. Due to paucity of cytological studies on melanoma in India, the present study was undertaken. AIM: To ...

Abstract	Context: Melanoma accounts for 1-3% of all malignancies. It is usually diagnosed as metastasis in the draining lymph nodes, that is inguinal lymph node. Due to paucity of cytological studies on melanoma in India, the present study was undertaken. AIM: To study the cytomorphology of malignant melanoma and to correlate the cytological diagnosis with histopathology and clinical details. Settings and Design: Sixteen cytomorphological features were studied and analysed from the cases diagnosed as melanoma on cytology with histopathological correlation. Materials and Methods: Thirty patients diagnosed with malignant melanoma on fine-needle aspiration cytology (FNAC) were studied over a period of 10 years and compared by histopathology. Papanicolaou (Pap)- and May Grunwald Giemsa (MGG)-stained smears were studied and analysed for the cytomorphological spectrum of melanoma. Results: Among the 30 patients studied, males were 19 and females were 11 (M:F:1.7:1) with a mean age of 49.3 years. The commonest primary site was foot followed by maxilla and thigh. The most common site for metastasis was inguinal lymph node. All 30 cases had histopathological correlation. Pigmented melanophages (83%) was the predominant feature followed by presence of melanin pigment (77%) and pseudo-inclusions (73%). Condensed chromatin was observed in the majority of the patients (53%). Smooth and irregular nuclear contours were seen in combination in 37% of the cases. A combination of nuclear placement, that is eccentric and central was observed as a predominant feature (53%). Spindle cell pattern was the predominant shape. Among cytoplasmic features, melanin granules and vacuoles were equally distributed (50%). Mixed pattern, that is singly scattered plasmacytoid cell pattern and cell clusters was the predominant cell architecture. Conclusion: A spectrum of cytomorphological features in correlation with clinical details leads to greater precision in diagnosis and helps to avoid pitfalls in diagnosing melanoma.
Keywords	Cytomorphology ; fine-needle aspiration cytology ; melanoma ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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