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  1. Article ; Online: Analysis of epidemic characteristics of forty-two COVID-19 cluster outbreaks in Hangzhou

    SUN Zhou / CHEN Junfang / LIU Muwen / KAO Qingjun / KONG Qingxin

    Shanghai yufang yixue, Vol 34, Iss 3, Pp 265-

    2022  Volume 267

    Abstract: ObjectiveTo determine the epidemic characteristics of forty-two coronavirus disease 2019 （COVID-19） cluster outbreaks in Hangzhou city and provide scientific evidence for further prevention and control measures.MethodsData of the COVID-19 cluster ... ...

    Abstract ObjectiveTo determine the epidemic characteristics of forty-two coronavirus disease 2019 （COVID-19） cluster outbreaks in Hangzhou city and provide scientific evidence for further prevention and control measures.MethodsData of the COVID-19 cluster outbreaks in Hangzhou were obtained from the National Public Health Emergency Management Information System. Epidemic characteristics were summarized by reviewing the epidemiological investigation reports.ResultsA total of forty-two COVID-19 cluster outbreaks were documented in Hangzhou in 2020， including 130 confirmed cases and 7 cases with asymptomatic infection. The majority occurred from January to February， 2020. Moreover， 92.86% （39/42） of the cluster outbreaks were familial transmission. The proportion of the cluster outbreaks involving 2 cases accounted for 54.7% （23/42）. In the secondary cases， family members accounted for 84.15% （69/82）.ConclusionThe COVID-19 cluster outbreaks in Hangzhou mainly occur in families， and the majority of the secondary cases is family members.
    Keywords covid-19 ; cluster outbreak ; epidemiology ; investigation ; Medicine ; R
    Language Chinese
    Publishing date 2022-03-01T00:00:00Z
    Publisher Shanghai Preventive Medicine Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China.

    Zhao, Gang / Xie, Lu / Wu, Yan / Wang, Bing / Teng, Weilin / Sun, Zhou / Kao, Qingjun / Liu, Wei / Pi, Xionge / Ma, Haiyan

    Frontiers in microbiology

    2023  Volume 14, Page(s) 989303

    Abstract: Introduction: Owing to urbanization, living habits have changed widely, leading to alterations in the intestinal microbiota of urban residents. However, there are few studies on the characteristics of intestinal microbiota of adolescents living in ... ...

    Abstract Introduction: Owing to urbanization, living habits have changed widely, leading to alterations in the intestinal microbiota of urban residents. However, there are few studies on the characteristics of intestinal microbiota of adolescents living in different urbanized areas in China.
    Methods: A total of 302 fecal samples collected from adolescent students in eastern China were examined. 16S rRNA high-throughput sequencing was used to identify the fecal microbiota. These data were combined with questionnaire survey results to investigate the effect of urbanization on the intestinal microbiota of adolescents in eastern China. Moreover, the role of lifestyle habits in this relationship was also evaluated.
    Results: The results revealed significant differences in the structure of the intestinal microbiota among adolescents living in regions with different levels of urbanization. Adolescents living in urban regions had a significantly higher proportion of
    Discussion: Our research has preliminarily demonstrated that there were differences in the composition of Gut microbiome in stool samples of adolescents living in different urbanized areas, and provide a scientific basis for the maintenance of a healthy intentional microbota in adolescences.
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.989303
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  3. Article: [Analysis of epidemiologic and etiology of hepatitis E in Hangzhou, 2004-2011].

    Kao, Qingjun / Sun, Zhou / Xie, Li / Pu, Xiaoying / Yang, Xuhui / Huang, Renjie

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2014  Volume 48, Issue 9, Page(s) 766–770

    Abstract: Objective: To comprehend the epidemiologic of hepatitis E and genetic characteristics of hepatitis E virus (HEV) in Hangzhou from 2004 to 2011.: Methods: Using China information system for disease control and prevention, the incidence of hepatitis E ... ...

    Abstract Objective: To comprehend the epidemiologic of hepatitis E and genetic characteristics of hepatitis E virus (HEV) in Hangzhou from 2004 to 2011.
    Methods: Using China information system for disease control and prevention, the incidence of hepatitis E from 2004 to 2011 in Hangzhou city, and the basic information of patients were collected. In 2011, 65 hepatitis E laboratory confirmed cases were selected by random number table sampling method from the hospitals designated infectious diseases in Hangzhou city, and acquisition of the 60 blood specimens and stool specimens of 18 copies. One city and two surrounding counties were selected by cluster random sampling method in the context of Hangzhou city, and the pig slaughters and farmers were selected as the sampling point, and acquisition of pig gallbladder specimens of 52 copies, and 30 stool samples of scatter-feed pigs, 15 stool specimens of scatter-feed rabbits. HEV was tested in samples, gene extraction and analysis of gene sequence were conducted which were compared with gene bank HEV gene sequence, and a phylogenetic tree was formed. The epidemic characteristics of hepatitis E of Hangzhou city from 2004 to 2011 were described. The difference of incidence of hepatitis E was analyzed between years and sexes in Hangzhou city.
    Results: There were reported a total of 3 490 cases of hepatitis E in Hangzhou from 2004 to 2011, and 3 cases of death; The average annual incidence rate was 5.79/100 000 (3 490/60 276 338). There was the overall upward trend in incidence between different years (χ² = 52.38, P < 0.01) , which the highest was 8.10/100 000 (705/8 700 373) in 2011, and the lowest incidence rate was 4.19/100 000 in 2005. The incidence of males (8.12/100 000 (2 474/30 450 990) ) was significantly higher than that of the females (3.46/100 000 (1 016/29 384 491) ) (χ² = 558.45, P < 0.05). 78 specimens of blood and stool were collected, including 16 positive samples, with positive rate 21%. There were a total of 97 specimens of pig gallbladder, pig manure and rabbit stool, including 2 positive rabbit stool samples, with positive rate of 2%. HEV genes isolated from Hangzhou were mainly type IV, with homology of 91.8% to 100%; compared with human type IV strains, the homology of nucleotide was 84.6%-96.7%; compared with type IV strain of pig genome sequence alignment, homology was 82.6%-95.2%.
    Conclusion: Hepatitis E's incidence showed an increasing trend year by year in Hangzhou. HEV of type IV was dominant, and HEV strains in the human and swine were highly homologous.
    MeSH term(s) Adolescent ; Animals ; China/epidemiology ; Disease Vectors ; Feces ; Female ; Hepatitis E/epidemiology ; Hepatitis E/etiology ; Hepatitis E virus ; Humans ; Incidence ; Male ; Rabbits/blood ; Rabbits/microbiology ; Rural Population/statistics & numerical data ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; Sex Factors ; Swine/blood ; Swine/microbiology ; Urban Population/statistics & numerical data
    Language Chinese
    Publishing date 2014-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Retrospective study of risk factors for mortality in human avian influenza A(H7N9) cases in Zhejiang Province, China, March 2013 to June 2014.

    Cheng, Qing-Lin / Ding, Hua / Sun, Zhou / Kao, Qing-Jun / Yang, Xu-Hui / Huang, Ren-Jie / Wen, Yuan-Yuan / Wang, Jing / Xie, Li

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2015  Volume 39, Page(s) 95–101

    Abstract: Background: The influenza A(H7N9) virus causes a serious disease that threatens human health. Fatalities associated with human infections caused by this virus are of great public health concern; however, the possible risk factors are not yet fully known. ...

    Abstract Background: The influenza A(H7N9) virus causes a serious disease that threatens human health. Fatalities associated with human infections caused by this virus are of great public health concern; however, the possible risk factors are not yet fully known.
    Methods: A stratified sampling method, incorporating household income levels and a random number table method, was used to select laboratory-confirmed A(H7N9) cases for this study. Eighty-five patients were selected randomly from 139 laboratory-confirmed A(H7N9) cases occurring in Zhejiang Province between March 1, 2013 and June 30, 2014. Data were collected using a standard method. To test the statistical significance among discrete variables, univariate analyses were used to compare two groups. The Kaplan-Meier product-limit method was used to analyze the patient survival fraction. The Cox proportional hazards regression model was used to analyze all variables with p ≤ 0.05 in the univariate analysis. Lastly, a stepwise procedure was used to construct a final model with a significance level of p > 0.10 for removal and p<0.05 for re-entry.
    Results: A total of 85 patients with H7N9 virus infection were identified. Among these, 30 (35.29%) died. In the univariate analysis, the following factors were associated with a high risk of influenza A(H7N9) case fatality: age ≥ 60 years (p=0.008), low education level (p=0.030), chronic diseases (p=0.029), poor hand hygiene (p=0.010), time from illness onset to the first medical visit (p=0.029) and to intensive care unit admission (p=0.008), an incubation period of ≤ 5 days (p=0.039), a peak C-reactive protein ≥ 120 mg/l (p=0.012), increased initial neutrophil count (p=0.020), decreased initial lymphocyte count (p=0.021), and initial infection of both lungs (p=0.003). Multivariate analysis confirmed that the independent predictors of H7N9 virus infection mortality in Zhejiang, China were hand hygiene (hazard ratio (HR) 5.163, 95% confidence interval (CI) 1.164-22.661), age (HR 1.042, 95% CI 1.007-1.076), and peak CRP (HR 1.009, 95% CI 1.002-1.016).
    Conclusions: Improvements in immunity, early case identification and treatment, and personal protection measures are key to addressing the high human avian influenza A(H7N9) case fatality rate.
    MeSH term(s) Adult ; Aged ; Animals ; China/epidemiology ; Female ; Hand Hygiene ; Humans ; Influenza A Virus, H7N9 Subtype ; Influenza, Human/mortality ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2015-10
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2015.09.008
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  5. Article ; Online: Epidemiologic characterization of 30 confirmed cases of human infection with avian influenza A(H7N9) virus in Hangzhou, China.

    Ding, Hua / Xie, Li / Sun, Zhou / Kao, Qing-Jun / Huang, Ren-Jie / Yang, Xu-Hui / Huang, Chun-ping / Wen, Yuan-Yuan / Pan, Jing-Cao / Pu, Xiao-Ying / Jin, Tao / Zhou, Xiao-Hong / Zheng, Lin / Li, Jian / Wang, Feng-Juan

    BMC infectious diseases

    2014  Volume 14, Page(s) 175

    Abstract: Background: We examined the clinical and epidemiological characteristics of 30 cases of human infection with avian influenza A(H7N9) virus in Hangzhou and investigated their external environments to provide evidence for contact tracing and disease ... ...

    Abstract Background: We examined the clinical and epidemiological characteristics of 30 cases of human infection with avian influenza A(H7N9) virus in Hangzhou and investigated their external environments to provide evidence for contact tracing and disease prevention and control.
    Methods: The cases confirmed from April 1 through May 1, 2013 were studied. Field epidemiologic surveys were conducted to collect the clinical and epidemiologic data. Case-related and environmental specimens were collected for etiologic detection.
    Results: Thirty cases of human infection with avian influenza A(H7N9) virus were confirmed in Hangzhou from April 1 through May 1, 2013, including one pregnant woman and three deaths. The median age of the patients was 62 years (range: 38-86 years). Twenty-three of the patients were men (76.67%). The median duration between disease onset and occurrence of respiratory failure and confirmed diagnosis was 5 and 6 days, respectively. Maximum medical observation of 666 close contacts of the patients revealed no irregularity. Of 314 external environmental specimens, the overall positive detection rate of H7N9 nucleic acid was 28.98%. Eight districts of Hangzhou city had positive detections in the external environments, the highest rate being in Yuhang District (78.13%). Statistical analysis of the specimen collection locations indicates a significant difference between the case-linked locations and the non-case locations (χ2 = 16.563, p < 0.05) in terms of H7N9 viral nucleic acid detection rate. No epidemiologic link has been found among the 30 cases.
    Conclusions: Most of the infected were retired individuals aged 60 years or older. Men made the majority. The cases are sporadic at present, with no evidence of human-to-human transmission. Exposures to poultry and live poultry markets may be important sources of infection.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Environmental Microbiology ; Female ; Humans ; Influenza A Virus, H7N9 Subtype/isolation & purification ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Male ; Middle Aged ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/virology
    Language English
    Publishing date 2014-03-31
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/1471-2334-14-175
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  6. Article: [Distributive characteristics and sources of exposure of human infections with avian influenza A (HN7N9) virus in Hangzhou, Zhejiang province].

    Xie, Li / Ding, Hua / Sun, Zhou / Kao, Qing-jun / Huang, Ren-jie / Wen, Yuan-yuan / Yang, Xu-hui / Huang, Chun-ping / Yu, Xin-fen / Li, Jun / Pu, Xiao-ying / Pan, Jin-cao / Jin, Tao / Zhou, Xiao-hong / Zheng, Lin / Li, Jian / Wang, Fen-juan

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

    2013  Volume 34, Issue 9, Page(s) 944–945

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Female ; Humans ; Influenza A Virus, H7N9 Subtype ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Male ; Middle Aged
    Language Chinese
    Publishing date 2013-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 645026-x
    ISSN 0254-6450
    ISSN 0254-6450
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