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  1. AU="Kaae Andersen, Klaus"
  2. AU="de Mey, Jo" AU="de Mey, Jo"
  3. AU="Rudy, Gabriella"
  4. AU="Bonvalet, Catherine"
  5. AU="Jogie-Brahim, Sherryline"
  6. AU="Almoguera, Berta"
  7. AU="Tran, Diep"
  8. AU="Ahmad, Kafeel"
  9. AU=Gor?kov Lev P.
  10. AU="Scott, Carol E"
  11. AU="Siewiera, Jacek"
  12. AU="Clutterbuck, Elizabeth A"
  13. AU="Shin, Dong Jin"
  14. AU="Talapuhan, Wulan"
  15. AU=Wang Cheng AU=Wang Cheng
  16. AU="Bélanger, Richard E"
  17. AU="Bárcena-Flores, Luis"
  18. AU="Bhargava, Tanvi"
  19. AU="Markus Hafner"
  20. AU="Simon, Jessica E"
  21. AU="Watson, Erin"
  22. AU=Cox Fionnuala
  23. AU="Rana, Dev Yash"
  24. AU="Negreira Caamaño, Martín"
  25. AU="Johan C. Karremans"
  26. AU="Elmutaz Shaikho Elhaj Mohammed"
  27. AU="Amjad, Muhammad"
  28. AU="Rolf D Kortmann"
  29. AU="Jelena Stanojević"
  30. AU="Rafael Sáez-Jiménez"
  31. AU="Carlile, Catherine R"
  32. AU="Husain, Waleed"
  33. AU="Casanelia, S"
  34. AU="Ireland, D. G."
  35. AU=Sargon Peter J.

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  1. Artikel ; Online: Improved overall survival for Stage III NSCLC patients treated with curative-intended therapy from 2010 to 2018-a cohort study in Denmark.

    Meldgaard, Peter / Kristensen, Michael / Conte, Simona / Kaae Andersen, Klaus / Jovanovic, Aleksander / Meldgaard, Ebbe

    Acta oncologica (Stockholm, Sweden)

    2023  Band 62, Heft 12, Seite(n) 1672–1679

    Abstract: Background: Despite advances in treatment strategies and improved clinical outcomes, an unmet need remains for NSCLC patients. With an increased real-world knowledge of NSCLC, clinicians could offer patients optimal tailored treatment and disease ... ...

    Abstract Background: Despite advances in treatment strategies and improved clinical outcomes, an unmet need remains for NSCLC patients. With an increased real-world knowledge of NSCLC, clinicians could offer patients optimal tailored treatment and disease management. In this retrospective cohort study, we describe patient characteristics, treatment patterns and modality, and survival in NSCLC patients diagnosed and treated at Aarhus University Hospital, Denmark.
    Methods: Data on Stage III NSCLC patients aged ≥18 years diagnosed 2010-2018 were obtained from a regional cancer database and linked to national registries for information on socioeconomic and vital status. Patients were stratified by planned treatment intention at diagnosis (curative/palliative). Treatment patterns and overall survival (OS) were estimated using time-to-event methods.
    Results: Broad patient and diseases characteristics and multiple treatment options demonstrated the heterogeneity of this patient cohort. Of 851 Stage III NSCLC patients, 599 (70%) and 252 (30%) were offered curative- and palliative-intended treatment, respectively, upon evaluation by a multidisciplinary team (MDT). The most frequent treatment modalities were CRT (
    Conclusion: Stage III NSCLC is a heterogeneous disease as regards patient and clinical characteristics, multiple treatment options, and outcomes. Age, disease staging, performance status, and comorbidity, as well as MDT evaluation and matching treatment intent, are important determinants of curative-intended treatment. Notably, an NSCLC diagnosis in the more contemporary study period was statistically significantly associated with better OS.
    Mesh-Begriff(e) Humans ; Adolescent ; Adult ; Lung Neoplasms ; Cohort Studies ; Retrospective Studies ; Neoplasm Staging ; Carcinoma, Non-Small-Cell Lung ; Denmark/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2023-09-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2023.2254474
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Does HPV status influence survival after vulvar cancer?

    Rasmussen, Christina Louise / Sand, Freja Laerke / Hoffmann Frederiksen, Marie / Kaae Andersen, Klaus / Kjaer, Susanne K

    International journal of cancer

    2017  Band 142, Heft 6, Seite(n) 1158–1165

    Abstract: High-risk human papillomavirus (HPV) infection is essential in the carcinogenesis of a substantial part of anogenital and oropharyngeal cancers and has additionally been shown to be a possible predictive marker for survival, especially in oropharyngeal ... ...

    Abstract High-risk human papillomavirus (HPV) infection is essential in the carcinogenesis of a substantial part of anogenital and oropharyngeal cancers and has additionally been shown to be a possible predictive marker for survival, especially in oropharyngeal cancer. Studies examining the influence of HPV status on survival after vulvar cancer have been conflicting and limited by small study populations. Therefore, the aim of this review and meta-analysis was to examine whether HPV status influences survival after vulvar cancer, which, to our knowledge, has not been done before. We conducted a systematic search of PubMed, Cochrane Library and Embase to identify studies examining survival after histologically verified and HPV tested vulvar cancer. A total of 18 studies were eligible for inclusion. Study-specific and pooled HRs of the 5-year OS and DFS were calculated using a fixed effects model. The I
    Mesh-Begriff(e) Cancer Survivors/statistics & numerical data ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/virology ; DNA, Viral/isolation & purification ; Disease-Free Survival ; Female ; Humans ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/mortality ; Papillomavirus Infections/virology ; Vulvar Neoplasms/mortality ; Vulvar Neoplasms/virology
    Chemische Substanzen DNA, Viral
    Sprache Englisch
    Erscheinungsdatum 2017-11-16
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Meta-Analysis ; Review
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.31139
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.

    Puustinen, Pietri / Keldsbo, Anne / Corcelle-Termeau, Elisabeth / Ngoei, Kevin / Sønder, Stine L / Farkas, Thomas / Kaae Andersen, Klaus / Oakhill, Jon S / Jäättelä, Marja

    Autophagy

    2020  Band 16, Heft 10, Seite(n) 1871–1888

    Abstract: Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma ... ...

    Abstract Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breast carcinoma cells and identified the catalytic subunit of DNA-dependent protein kinase PRKDC/DNA-PKcs as a positive regulator of basal and DNA damage-induced autophagy. Analysis of autophagy-regulating signaling cascades placed PRKDC upstream of the AMP-dependent protein kinase (AMPK) complex and ULK1 kinase. In normal culture conditions, PRKDC interacted with the AMPK complex and phosphorylated its nucleotide-sensing γ1 subunit PRKAG1/AMPKγ1 at Ser192 and Thr284, both events being significantly reduced upon the activation of the AMPK complex. Alanine substitutions of PRKDC phosphorylation sites in PRKAG1 reduced AMPK complex activation without affecting its nucleotide sensing capacity. Instead, the disturbance of PRKDC-mediated phosphorylation of PRKAG1 inhibited the lysosomal localization of the AMPK complex and its starvation-induced association with STK11 (serine/threonine kinase 11). Taken together, our data suggest that PRKDC-mediated phosphorylation of PRKAG1 primes AMPK complex to the lysosomal activation by STK11 in cancer cells thereby linking DNA damage response to autophagy and cellular metabolism.
    Mesh-Begriff(e) AMP-Activated Protein Kinases/metabolism ; Autophagy ; Binding Sites ; Cell Line, Tumor ; Cytosol/metabolism ; DNA Damage ; DNA-Activated Protein Kinase/metabolism ; Gene Expression Regulation, Enzymologic ; Humans ; Lysosomes/enzymology ; Lysosomes/metabolism ; MCF-7 Cells ; Phagocytosis ; Phosphorylation ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Small Interfering/metabolism ; Signal Transduction/genetics
    Chemische Substanzen RNA, Small Interfering ; STK11 protein, human (EC 2.7.1.-) ; DNA-Activated Protein Kinase (EC 2.7.11.1) ; PRKAG1 protein, human (EC 2.7.11.1) ; PRKDC protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Sprache Englisch
    Erscheinungsdatum 2020-01-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2019.1710430
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Progressive strength training to prevent LYmphoedema in the first year after breast CAncer - the LYCA feasibility study.

    Ammitzbøll, Gunn / Lanng, Charlotte / Kroman, Niels / Zerahn, Bo / Hyldegaard, Ole / Kaae Andersen, Klaus / Johansen, Christoffer / Dalton, Susanne Oksbjerg

    Acta oncologica (Stockholm, Sweden)

    2017  Band 56, Heft 2, Seite(n) 360–366

    Abstract: Background: Lymphoedema is a common late effect after breast cancer (BC) that has no effective cure once chronic. Accumulating evidence supports progressive strength training (PRT) as a safe exercise modality in relation to the onset and exacerbation of ...

    Abstract Background: Lymphoedema is a common late effect after breast cancer (BC) that has no effective cure once chronic. Accumulating evidence supports progressive strength training (PRT) as a safe exercise modality in relation to the onset and exacerbation of lymphoedema. In the 'preventive intervention against LYmphoedema after breast CAncer' (LYCA) feasibility study we examined the feasibility of a program of PRT in the first year after BC to inform a planned randomised controlled trial (RCT).
    Material and methods: LYCA was a one-group prospective pilot trial inviting women operated with axillary lymph node dissection for unilateral primary BC. Participants exercised three times a week for 50 weeks (20 weeks supervised followed by 30 weeks home-based exercise). The program ensured slow individualised progression during the exercise program. The primary outcome was feasibility measured by eligibility and recruitment rates, as well as questionnaire-assessed satisfaction and adherence to exercise. Furthermore, we assessed arm interlimb volume difference by water displacement, muscle strength by dynamic and isometric muscle testing and range of movement in the shoulder by goniometry.
    Results: In August 2015, eight of 11 eligible patients accepted participation. Two of them dropped out early due to other health issues. The remaining six participants had high exercise adherence through the supervised period, but only three maintained this through the home exercise period. Program satisfaction was high and no serious adverse events from testing or exercising were reported. One participant presented with lymphoedema at 50-week follow-up. Muscle strength markedly increased with supervised exercise, but was not fully maintained through the home exercise period. Range of shoulder movement was not negatively affected by the program.
    Conclusion: Recruitment, testing, and exercise in LYCA was safe and feasible. At the 50-week follow-up, there was one case of lymphoedema. The LYCA program will be further tested in a full-scale RCT.
    Mesh-Begriff(e) Aged ; Body Composition ; Breast Cancer Lymphedema/prevention & control ; Breast Neoplasms/physiopathology ; Breast Neoplasms/surgery ; Feasibility Studies ; Female ; Humans ; Middle Aged ; Muscle Strength ; Pilot Projects ; Prospective Studies ; Resistance Training
    Sprache Englisch
    Erscheinungsdatum 2017-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2016.1268266
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Educational level and first-time PSA testing in general practice.

    Lerhmann-Lerche, Caroline Sophie / Larsen, Signe Benzon / Andersen, Ingelise / Thygesen, Lau Caspar / Kaae Andersen, Klaus / Duun-Henriksen, Anne Katrine / Johansen, Christoffer / Røder, Martin Andreas / Brasso, Klaus / Dalton, Susanne Oksbjerg

    Scandinavian journal of urology

    2019  Band 53, Heft 5, Seite(n) 275–281

    Abstract: Introduction: ...

    Abstract Introduction:
    Mesh-Begriff(e) Aged ; Cohort Studies ; Educational Status ; General Practice ; Humans ; Male ; Middle Aged ; Patient Acceptance of Health Care/statistics & numerical data ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnosis ; Socioeconomic Factors
    Chemische Substanzen Prostate-Specific Antigen (EC 3.4.21.77)
    Sprache Englisch
    Erscheinungsdatum 2019-10-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2701936-6
    ISSN 2168-1813 ; 2168-1805
    ISSN (online) 2168-1813
    ISSN 2168-1805
    DOI 10.1080/21681805.2019.1681503
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Evaluation of a digital method to assess evening meal intake in a free-living adult population

    Dahl Lassen, Anne / Poulsen, Sanne / Ernst, Lotte / Kaae Andersen, Klaus / Biltoft-Jensen, Anja / Tetens, Inge

    Food & nutrition research. 2010 Jan. 1, v. 54, no. 1

    2010  

    Abstract: Background: In recent years new applications of technologies, including digital images, to capture dietary behaviour in real time have been explored. Objectives: To validate a digital method for estimating evening meal intake in a free-living adult ... ...

    Abstract Background: In recent years new applications of technologies, including digital images, to capture dietary behaviour in real time have been explored. Objectives: To validate a digital method for estimating evening meal intake in a free-living adult population, and to examine the feasibility of the method for recording evening meal intake over a prolonged period of time. Design: The digital method was compared against weighed records of 19 participants’ usual evening meals for five consecutive days. Two trained image analysts independently estimated the weight of individual foods within the meals into major food categories, and the nutrient content was calculated. A second study included interviews with 28 participants recording their evening meals on weekdays for three consecutive weeks to get their perspective on the feasibility of the method. Results: High correlation coefficients between the digital method and weighed records were found for all measured food categories and nutrients. Comparable means and acceptable limits of agreement (mean difference +/− 2 SD) were found with regard to macronutrient distribution (e.g. fat content −5 to 6 E%), energy density (−75 to 91 kJ/100 g), and energy-adjusted foods (e.g. fruit and vegetable content −241 to 236 g/10 MJ). The majority of the participants expressed satisfaction with the method and were willing to record their evening meals for 1 month or more using the digital method. Conclusion: The digital method is valid and feasible for evening meal estimation in real-time where a prolonged recording period of participants’ meals is needed.
    Schlagwörter adults ; digital images ; energy density ; foods ; fruits ; interviews ; lipid content ; nutrient content ; nutrients ; nutritional behavior ; vegetables
    Sprache Englisch
    Erscheinungsverlauf 2010-0101
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 2418338-6
    ISSN 1654-661X ; 1654-6628
    ISSN (online) 1654-661X
    ISSN 1654-6628
    DOI 10.3402/fnr.v54i0.5311
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Evaluation of a digital method to assess evening meal intake in a free-living adult population.

    Dahl Lassen, Anne / Poulsen, Sanne / Ernst, Lotte / Kaae Andersen, Klaus / Biltoft-Jensen, Anja / Tetens, Inge

    Food & nutrition research

    2010  Band 54

    Abstract: Background: In recent years new applications of technologies, including digital images, to capture dietary behaviour in real time have been explored.: Objectives: To validate a digital method for estimating evening meal intake in a free-living adult ... ...

    Abstract Background: In recent years new applications of technologies, including digital images, to capture dietary behaviour in real time have been explored.
    Objectives: To validate a digital method for estimating evening meal intake in a free-living adult population, and to examine the feasibility of the method for recording evening meal intake over a prolonged period of time.
    Design: The digital method was compared against weighed records of 19 participants' usual evening meals for five consecutive days. Two trained image analysts independently estimated the weight of individual foods within the meals into major food categories, and the nutrient content was calculated. A second study included interviews with 28 participants recording their evening meals on weekdays for three consecutive weeks to get their perspective on the feasibility of the method.
    Results: High correlation coefficients between the digital method and weighed records were found for all measured food categories and nutrients. Comparable means and acceptable limits of agreement (mean difference +/- 2 SD) were found with regard to macronutrient distribution (e.g. fat content -5 to 6 E%), energy density (-75 to 91 kJ/100 g), and energy-adjusted foods (e.g. fruit and vegetable content -241 to 236 g/10 MJ). The majority of the participants expressed satisfaction with the method and were willing to record their evening meals for 1 month or more using the digital method.
    Conclusion: The digital method is valid and feasible for evening meal estimation in real-time where a prolonged recording period of participants' meals is needed.
    Sprache Englisch
    Erscheinungsdatum 2010-11-12
    Erscheinungsland Sweden
    Dokumenttyp Journal Article
    ZDB-ID 2418338-6
    ISSN 1654-661X ; 1654-661X
    ISSN (online) 1654-661X
    ISSN 1654-661X
    DOI 10.3402/fnr.v54i0.5311
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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