Article ; Online: Impact of the extent of resection of neuroendocrine tumor liver metastases on survival: A systematic review and meta-analysis.
Annals of hepato-biliary-pancreatic surgery
2021 Volume 26, Issue 1, Page(s) 31–39
Abstract: In patients with neuroendocrine tumors with liver metastases (NETLMs), complete resection of both the primary and liver metastases is a potentially curative option. When complete resection is not possible, debulking of the tumour burden has been proposed ...
Abstract | In patients with neuroendocrine tumors with liver metastases (NETLMs), complete resection of both the primary and liver metastases is a potentially curative option. When complete resection is not possible, debulking of the tumour burden has been proposed to prolong survival. The objective of this systematic review was to evaluate the effect of curative surgery (R0-R1) and debulking surgery (R2) on overall survival (OS) in NETLMs. For the subgroup of R2 resections, outcomes were compared by the degree of hepatic debulking (≥ 90% or ≥ 70%). A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines using PubMed, Medline, CINAHL, Cochrane, and Embase databases. Hazard ratios (HRs) were estimated for each study and pooled using a random-effects inverse-variance meta-analysis model. Of 538 articles retrieved, 11 studies (1,729 patients) reported comparisons between curative and debulking surgeries. After pooling these studies, OS was found to be significantly shorter in debulking resections, with an HR of 3.49 (95% confidence interval, 2.70-4.51; |
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Language | English |
Publishing date | 2021-12-10 |
Publishing country | Korea (South) |
Document type | Journal Article ; Review |
ZDB-ID | 3012179-6 |
ISSN | 2508-5859 ; 2508-5778 |
ISSN (online) | 2508-5859 |
ISSN | 2508-5778 |
DOI | 10.14701/ahbps.21-101 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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