Artikel ; Online: The Effect of Intermittent Preventive Treatment of Malaria During Pregnancy and Placental Malaria on Infant Risk of Malaria.
The Journal of infectious diseases
2021 Band 225, Heft 2, Seite(n) 248–256
Abstract: Background: Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) provides greater protection from placental malaria than sulfadoxine-pyrimethamine (SP). Some studies suggest placental malaria ... ...
| Abstract | Background: Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) provides greater protection from placental malaria than sulfadoxine-pyrimethamine (SP). Some studies suggest placental malaria alters risk of malaria infection in infants, but few have quantified the effect of IPTp on infant susceptibility to malaria. Methods: Infants born to women enrolled in a randomized clinical trial comparing IPTp-SP and IPTp-DP in Malawi were followed from birth to 24 months to assess effect of IPTp and placental malaria on time to first malaria episode and Plasmodium falciparum incidence. Results: In total, 192 infants born to mothers randomized to IPTp-SP and 195 randomized to IPTp-DP were enrolled. Infants in IPTp exposure groups did not differ significantly regarding incidence of clinical malaria (incidence rate ratio [IRR], 1.03; 95% confidence interval [CI], .58-1.86) or incidence of infection (IRR, 1.18; 95% CI, .92-1.55). Placental malaria exposure was not associated with incidence of clinical malaria (IRR, 1.03; 95% CI, .66-1.59) or infection (IRR, 1.15; 95% CI, .88-1.50). Infant sex, season of birth, and maternal gravidity did not confound results. Conclusions: We did not find evidence that IPTp regimen or placental malaria exposure influenced risk of malaria during infancy in this population. Clinical Trials Registration. NCT03009526. |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mesh-Begriff(e) | Adult ; Antimalarials/therapeutic use ; Artemisinins/therapeutic use ; Drug Combinations ; Female ; Humans ; Infant ; Malaria/drug therapy ; Malaria/epidemiology ; Malaria/prevention & control ; Malawi/epidemiology ; Parasitemia/prevention & control ; Piperazines/therapeutic use ; Placenta/parasitology ; Pregnancy ; Pregnancy Complications, Parasitic/drug therapy ; Pregnancy Complications, Parasitic/epidemiology ; Pregnancy Complications, Parasitic/prevention & control ; Pyrimethamine/therapeutic use ; Quinolines/therapeutic use ; Sulfadoxine/therapeutic use ; Treatment Outcome | ||||||||||
| Chemische Substanzen | Antimalarials ; Artemisinins ; Drug Combinations ; Piperazines ; Quinolines ; fanasil, pyrimethamine drug combination (37338-39-9) ; artenimol (6A9O50735X) ; Sulfadoxine (88463U4SM5) ; piperaquine (A0HV2Q956Y) ; Pyrimethamine (Z3614QOX8W) | ||||||||||
| Sprache | Englisch | ||||||||||
| Erscheinungsdatum | 2021-07-03 | ||||||||||
| Erscheinungsland | United States | ||||||||||
| Dokumenttyp | Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural | ||||||||||
| ZDB-ID | 3019-3 | ||||||||||
| ISSN | 1537-6613 ; 0022-1899 | ||||||||||
| ISSN (online) | 1537-6613 | ||||||||||
| ISSN | 0022-1899 | ||||||||||
| DOI | 10.1093/infdis/jiab351 | ||||||||||
| Signatur |
|
||||||||||
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
| Uh II Zs.50: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 445: Hefte anzeigen |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.