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  1. Article ; Online: Matrix metalloproteinase-9: A magic drug target in neuropsychiatry?

    Kaczmarek, Krzysztof T / Protokowicz, Karolina / Kaczmarek, Leszek

    Journal of neurochemistry

    2023  

    Abstract: Neuropsychiatric conditions represent a major medical and societal challenge. The etiology of these conditions is very complex and combines genetic and environmental factors. The latter, for example, excessive maternal or early postnatal inflammation, as ...

    Abstract Neuropsychiatric conditions represent a major medical and societal challenge. The etiology of these conditions is very complex and combines genetic and environmental factors. The latter, for example, excessive maternal or early postnatal inflammation, as well as various forms of psychotrauma, often act as triggers leading to mental illness after a prolonged latent period (sometimes years). Matrix metalloproteinase-9 (MMP-9) is an extracellularly and extrasynaptic operating protease that is markedly activated in response to the aforementioned environmental insults. MMP-9 has also been shown to play a pivotal role in the plasticity of excitatory synapses, which, in its aberrant form, has repeatedly been implicated in the etiology of mental illness. In this conceptual review, we evaluate the experimental and clinical evidence supporting the claim that MMP-9 is uniquely positioned to be considered a drug target for ameliorating the adverse effects of environmental insults on the development of a variety of neuropsychiatric conditions, such as schizophrenia, bipolar disorder, major depression, autism spectrum disorders, addiction, and epilepsy. We also identify specific challenges and bottlenecks hampering the translation of knowledge on MMP-9 into new clinical treatments for the conditions above and suggest ways to overcome these barriers.
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.15976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of Modifications on the Immunosuppressive Properties of Cyclolinopeptide A and Its Analogs in Animal Experimental Models.

    Zimecki, Michał / Kaczmarek, Krzysztof

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 9

    Abstract: The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds, and its linear precursor on their biological activities and mechanisms of action, are reviewed. The modifications included ... ...

    Abstract The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds, and its linear precursor on their biological activities and mechanisms of action, are reviewed. The modifications included truncation of the peptide chain, replacement of amino acid residues with proteinogenic or non-proteinogenic ones, modifications of peptide bond, and others. The studies revealed changes in the immunosuppressive potency of these analogs investigated in a number of in vitro and in vivo experimental models, predominantly in rodents, as well as differences in their postulated mechanism of action. The modified peptides were compared with cyclosporine A and parent CLA. Some of the synthesized and investigated peptides show potential therapeutic usefulness.
    MeSH term(s) Amino Acid Sequence/genetics ; Animals ; Bedding and Linens ; Immunosuppressive Agents/chemistry ; Immunosuppressive Agents/pharmacology ; Models, Animal ; Peptides/chemistry ; Peptides/genetics ; Peptides/pharmacology ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/genetics ; Peptides, Cyclic/pharmacology ; Seeds/chemistry ; Structure-Activity Relationship
    Chemical Substances Immunosuppressive Agents ; Peptides ; Peptides, Cyclic ; cyclolinopeptide A
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26092538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Wearable cardioverter-defibrillator in daily clinical practice: A single-centre experience.

    Wojtaszczyk, Adam / Kaczmarek, Krzysztof / Urbanek, Irmina / Cygankiewicz, Iwona / Wranicz, Jerzy Krzysztof

    Kardiologia polska

    2024  Volume 82, Issue 4, Page(s) 434–437

    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Wearable Electronic Devices ; Aged ; Defibrillators ; Adult ; Defibrillators, Implantable
    Language English
    Publishing date 2024-02-20
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/v.phj.99309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Implementation of sugar-sweetened beverages tax and its perception among public health stakeholders. A study from Poland.

    Brukało, Katarzyna / Kaczmarek, Krzysztof / Kowalski, Oskar / Romaniuk, Piotr

    Frontiers in nutrition

    2022  Volume 9, Page(s) 957256

    Abstract: Background: One of tools to tackle growing problem of overweight and obesity are the taxation mechanisms applied to sugar-sweetened beverages, which are expected to influence the common eating behaviors, but also they have impact on the market and ... ...

    Abstract Background: One of tools to tackle growing problem of overweight and obesity are the taxation mechanisms applied to sugar-sweetened beverages, which are expected to influence the common eating behaviors, but also they have impact on the market and public finances. The solution is therefore highly entangled in the complex of social and intersectoral interests generating a number of opportunities and threats affecting its feasibility.
    Aims: The study aims to depict the views of Polish stakeholders on the implementation of the sugar tax in Poland, particularly the perception of success determinants, barriers, as well as views on the features of the implemented solutions and possible alternatives.
    Methods: We used semi-structured interviews with 18 individuals representing key public health stakeholders in Poland. The interview consisted of four parts, where first concentrated on the advantages and disadvantages of the SSB tax, the second part explored stakeholder involvement and stances, third concerned the feasibility of the project, and in the fourth part respondents were asked for suggestions for decision-makers regarding the content of the project and its implementation process. To reconstruct position of 4 main political parties we applied desk research. We used MAXQDA v2020 to analyse the collected data.
    Results: Stakeholders tend to expressed conflicting views on the effectiveness, relevance and socio-economic impact of the SSB tax. All of them agreed that the tax may appear severe for the poorest groups, children and adolescents, while disagreeing about the economic impact of the levy. The allocation of additional tax revenues was raising doubts, with stakeholders believing that the fiscal aim is the basic reason for implementing the tax, while these resources should be primarily dedicated to health promotion intervention and prevention of diet-related diseases. On the other hand, the political debate on the tax was highly superficial with strong populism arising of the presented positions.
    Conclusions: There is a need to conduct a thorough public debate and improvements in terms of public communication to increase social awareness, sealing and refining the implemented solutions. Close cooperation with market players and non-governmental organizations is highly recommended.
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.957256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The use of evaluation methods for the overall assessment of health policy: potential and limitations.

    Kaczmarek, Krzysztof / Romaniuk, Piotr

    Cost effectiveness and resource allocation : C/E

    2020  Volume 18, Page(s) 43

    Abstract: Background: The implementation of public policies requires special attention from public authorities to ensure their transparency, effectiveness and efficiency. For this reason, efforts to evaluate the abovementioned politics gained attention and ... ...

    Abstract Background: The implementation of public policies requires special attention from public authorities to ensure their transparency, effectiveness and efficiency. For this reason, efforts to evaluate the abovementioned politics gained attention and importance. Similar processes, by their very nature, are also noticeable in the area of health policy, however, the nature of the solutions used raises questions about the extent to which they allow to capture the assessed phenomenon in a holistic way. The current approach to the problem of evaluating health policy shows a tendency to break down this phenomenon into components including policies, programs or projects. The purpose of this publication was to assess the main methodological approaches used in evaluation studies in terms of their usefulness and limitations in conducting overall assessment of health policy.
    Main body: The publication divides evaluation methods based on three main criteria identified in the literature-time, purpose and scope of evaluation. Methodological approaches to evaluation activities detailed on this basis are discussed from the point of view of their characteristics, usefulness and limitations in the creation of comprehensive health policy assessments. The growing awareness of the need for a different approach to evaluation, which was confirmed by the course of the discourse on evaluation in public health, was also pointed out.
    Conclusion: Given the complexity of the matter making up the health policy, attempts aimed at its overall assessment should be based on an approach integrating many approaches, while ensuring coordination of evaluation activities that should be subject to common assumptions.
    Language English
    Publishing date 2020-10-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2119372-1
    ISSN 1478-7547
    ISSN 1478-7547
    DOI 10.1186/s12962-020-00238-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Antiviral Activity of a Cyclic Pro-Pro-

    Zaczyńska, Ewa / Kaczmarek, Krzysztof / Zabrocki, Janusz / Artym, Jolanta / Zimecki, Michał

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 11

    Abstract: The core of Cyclolinopeptide A (CLA, cyclo(LIILVPPFF)), responsible for its high immunosuppressive activity, contains a Pro-Pro-Phe-Phe sequence. A newly synthesized cyclic tetrapeptide, cyclo(Pro-Pro- ...

    Abstract The core of Cyclolinopeptide A (CLA, cyclo(LIILVPPFF)), responsible for its high immunosuppressive activity, contains a Pro-Pro-Phe-Phe sequence. A newly synthesized cyclic tetrapeptide, cyclo(Pro-Pro-
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Dipeptides ; Herpesvirus 1, Human ; Immunosuppressive Agents/pharmacology ; Mice ; Peptides ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/pharmacology
    Chemical Substances Antiviral Agents ; Dipeptides ; Immunosuppressive Agents ; Peptides ; Peptides, Cyclic ; prolyl-proline
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27113552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: On the Neutrosophic, Pythagorean and Some Other Novel Fuzzy Sets Theories Used in Decision Making: Invitation to Discuss.

    Sevastjanov, Pavel / Dymova, Ludmila / Kaczmarek, Krzysztof

    Entropy (Basel, Switzerland)

    2021  Volume 23, Issue 11

    Abstract: In this short paper, a critical analysis of the Neutrosophic, Pythagorean and some other novel fuzzy sets theories foundations is provided, taking into account that they actively used for the solution of the decision-making problems. The shortcomings of ... ...

    Abstract In this short paper, a critical analysis of the Neutrosophic, Pythagorean and some other novel fuzzy sets theories foundations is provided, taking into account that they actively used for the solution of the decision-making problems. The shortcomings of these theories are exposed. It is stated that the independence hypothesis, which is a cornerstone of the Neutrosophic sets theory, is not in line with common sense and therefore leads to the paradoxical results in the asymptotic limits of this theory. It is shown that the Pythagorean sets theory possesses questionable foundations, the sense of which cannot be explained reasonably. Moreover, this theory does not completely solve the declared problem. Similarly, important methodological problems of other analyzed theories are revealed. To solve the interior problems of the Atanassov's intuitionistic fuzzy sets and to improve upon them, this being the reason most of the criticized novel sets theories were developed, an alternative approach based on extension of the intuitionistic fuzzy sets in the framework of the Dempster-Shafer theory is proposed. No propositions concerned with the improvement of the Cubic sets theory and Single-Valued Neutrosophic Offset theory were made, as their applicability was shown to be very dubious. In order to stimulate discussion, many statements are deliberately formulated in a hardline form.
    Language English
    Publishing date 2021-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e23111485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Fuzzy Multiple Criteria Decision Making Approach with a Complete User Friendly Computer Implementation.

    Dymova, Ludmila / Kaczmarek, Krzysztof / Sevastjanov, Pavel / Kulawik, Joanna

    Entropy (Basel, Switzerland)

    2021  Volume 23, Issue 2

    Abstract: The paper presents the generalization of the almost forty years of experience in the field of setting and solving the multiple criteria decision-making (MCDM) problems in various branches of a human activity under different types of uncertainties that ... ...

    Abstract The paper presents the generalization of the almost forty years of experience in the field of setting and solving the multiple criteria decision-making (MCDM) problems in various branches of a human activity under different types of uncertainties that inevitably accompany such problems. Based only on the pragmatic intentions, the authors avoid the detailed descriptions of the known methods for the decision-making, while instead focusing on the most frequently used mathematical tools and methodologies in the decision-making practice. Therefore, the paper may be classified as a special kind of illustrative review of the mathematical tools that are focused on applications and are the most used in the solutions of MCDM problems. As an illustrative example, a complete user-friendly computer implementation of such tools and methodology is presented with application to the simple "buying a cat" problem, which, however, possesses all the attributes of the hierarchical fuzzy MCDM task.
    Language English
    Publishing date 2021-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e23020203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Shoulder girdle function in patients with a subcutaneous implantable cardioverter-defibrillator.

    Zatorska-Berner, Monika / Berner, Rafał / Janicki, Maksymilian / Strzelecki, Aleksander / Cygankiewicz, Iwona / Wranicz, Jerzy Krzysztof / Kaczmarek, Krzysztof

    Kardiologia polska

    2024  Volume 82, Issue 3, Page(s) 318–320

    MeSH term(s) Humans ; Defibrillators, Implantable/adverse effects ; Shoulder ; Electric Countershock ; Pacemaker, Artificial
    Language English
    Publishing date 2024-01-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/v.kp.98552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Real world experience with cryoballoon ablation for the treatment of atrial fibrillation in Poland: 24-month outcomes from the Cryo Global Registry.

    Kaczmarek, Krzysztof / Kuniewicz, Marcin / Romanek, Janusz / van Bragt, Kelly A / Obidigbo, Valentine / Kaplon, Rachelle E / Ptaszyński, Paweł

    Kardiologia polska

    2024  

    Language English
    Publishing date 2024-05-07
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/v.phj.100380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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