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  1. Book ; Online ; Thesis: Prospektive Untersuchung tumorassoziierter und immunonkologisch relevanter miRNA im Verlauf der Strahlentherapie von Patienten mit nicht-kleinzelligem Bronchialkarzinom (NSCLC)

    Kadler, Frauke [Verfasser] / Schütte, Wolfgang [Gutachter] / Rödel, Franz [Gutachter]

    2023  

    Author's details Frauke Kadler ; Gutachter: Wolfgang Schütte, Franz Rödel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek Sachsen-Anhalt
    Publishing place Halle (Saale)
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients.

    Bache, Matthias / Kadler, Frauke / Struck, Olivia / Medenwald, Daniel / Ostheimer, Christian / Güttler, Antje / Keßler, Jacqueline / Kappler, Matthias / Riemann, Anne / Thews, Oliver / Seliger, Barbara / Vordermark, Dirk

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore, biological markers are urgently needed, which allow the assessment of prognosis, or prediction of the ... ...

    Abstract Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore, biological markers are urgently needed, which allow the assessment of prognosis, or prediction of the success of therapy or resistance in this disease. Circulating microRNAs (miRs) have potential as biomarkers for the prognosis and prediction of response to therapy in cancer patients. Based on recent evidence that circulating miR-16, miR-29a, miR-144 and miR-150 can be regulated by ionizing radiation, the concentration of these four miRs was assessed in the plasma of NSCLC patients at different time points of radiotherapy by digital droplet PCR (ddPCR). Furthermore, their impact on patients' prognosis was evaluated. The mean plasma levels of miR-16, miR-29a, miR-144 and miR-150 significantly differed intra- and inter-individually, and during therapy in NSCLC patients, but showed a strong positive correlation. The individual plasma levels of miR-16, miR-29a and miR-144 had prognostic value in NSCLC patients during or at the end of radiotherapy in Cox's regression models. NSCLC patients with low levels of these three miRs at the end of radiotherapy had the worst prognosis. However, miR-150 plasma levels and treatment-dependent changes were not predictive. In conclusion, circulating miR-16, miR-29a and miR-144, but not miR-150, have a prognostic value in NSCLC patients undergoing radiotherapy.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Lung Neoplasms/genetics ; Lung Neoplasms/radiotherapy ; MicroRNAs/genetics ; Radiation Oncology ; Circulating MicroRNA/genetics
    Chemical Substances MicroRNAs ; Circulating MicroRNA ; MIRN144 microRNA, human ; MIRN150 microRNA, human ; MIRN16 microRNA, human
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correlation between circulating miR-16, miR-29a, miR-144 and miR-150, and the radiotherapy response and survival of non-small-cell lung cancer patients

    Bache, Matthias / Kadler, Frauke / Struck, Olivia / Medenwald, Daniel / Ostheimer, Christian / Güttler, Antje / Keßler, Jacqueline / Kappler, Matthias / Riemann, Anne / Thews, Oliver / Seliger, Barbara / Vordermark, Dirk

    2023  

    Abstract: Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore, biological markers are urgently needed, which allow the assessment of prognosis, or prediction of the ... ...

    Abstract Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore, biological markers are urgently needed, which allow the assessment of prognosis, or prediction of the success of therapy or resistance in this disease. Circulating microRNAs (miRs) have potential as biomarkers for the prognosis and prediction of response to therapy in cancer patients. Based on recent evidence that circulating miR-16, miR-29a, miR-144 and miR-150 can be regulated by ionizing radiation, the concentration of these four miRs was assessed in the plasma of NSCLC patients at different time points of radiotherapy by digital droplet PCR (ddPCR). Furthermore, their impact on patients’ prognosis was evaluated. The mean plasma levels of miR-16, miR-29a, miR-144 and miR-150 significantly differed intra- and inter-individually, and during therapy in NSCLC patients, but showed a strong positive correlation. The individual plasma levels of miR-16, miR-29a and miR-144 had prognostic value in NSCLC patients during or at the end of radiotherapy in Cox’s regression models. NSCLC patients with low levels of these three miRs at the end of radiotherapy had the worst prognosis. However, miR-150 plasma levels and treatment-dependent changes were not predictive. In conclusion, circulating miR-16, miR-29a and miR-144, but not miR-150, have a prognostic value in NSCLC patients undergoing radiotherapy.

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    Keywords Non-small-cell lung cancer ; Circulating microRNA ; Radiotherapy ; Prognosis ; Digital droplet PCR
    Subject code 610
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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