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Article ; Online: Malignant prediction of incidental findings using ring-type dedicated breast positron emission tomography.

Sasada, Shinsuke / Masumoto, Norio / Emi, Akiko / Kadoya, Takayuki / Okada, Morihito

2022 Volume 12, Issue 1, Page(s) 1144

Abstract: The classification according to uptake patterns and metabolic parameters on ring-type dedicated breast positron emission tomography (dbPET) is useful for detecting breast cancer. This study investigated the performance of dbPET for incidental findings ... ...

Abstract	The classification according to uptake patterns and metabolic parameters on ring-type dedicated breast positron emission tomography (dbPET) is useful for detecting breast cancer. This study investigated the performance of dbPET for incidental findings that were not detected by mammography and ultrasonography. In 1,076 patients with breast cancer who underwent dbPET, 276 findings were incidentally diagnosed before treatment. Each finding was categorized as focus (uptake size ≤ 5 mm), mass (> 5 mm), or non-mass (multiple uptake) according to uptake patterns. Non-mass uptakes were additionally classified based on their distributions as-linear, focal, segmental, regional, or diffuse. Thirty-two findings (11.6%) were malignant and 244 (88.4%) were benign. Visually, 227 (82.3%) findings were foci, 7 (2.5%) were masses, and 42 (15.2%) were non-masses. Malignant rates of focus, mass, and non-mass were 9.7%, 28.6%, and 19.0%, respectively. In the non-mass findings, 23 were regional and diffuse distributions, and presented as benign lesions. Focus uptake with low lesion-to-background ratio (LBR) and no hereditary risk were relatively low (2.7%) in breast cancer. In multivariate analysis, LBR and hereditary risk were significantly associated with breast cancer (p = 0.006 and p = 0.013, respectively). Uptake patterns, LBR, and hereditary risk are useful for predicting breast cancer risk in incidental dbPET findings.
MeSH term(s)	Breast/diagnostic imaging ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/pathology ; Feasibility Studies ; Female ; Fluorodeoxyglucose F18/administration & dosage ; Humans ; Incidental Findings ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/administration & dosage ; Risk Assessment/methods
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05166-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Monitoring of Programmed Cell Death Ligand-1 Blockade Using FDG PET/CT for Microsatellite Instability-High Metastatic Breast Cancer.

Kawamata, Ayumi / Sasada, Shinsuke / Emi, Akiko / Masumoto, Norio / Kadoya, Takayuki

Clinical nuclear medicine

2021 Volume 47, Issue 3, Page(s) e252–e253

Abstract: Abstract: Microsatellite instability-high/mismatch repair deficiency is one of biomarkers predicting the response to pembrolizumab, an immune checkpoint inhibitor for metastatic solid tumors. A 44-year-old woman with stage IIIC right breast cancer was ... ...

Abstract	Abstract: Microsatellite instability-high/mismatch repair deficiency is one of biomarkers predicting the response to pembrolizumab, an immune checkpoint inhibitor for metastatic solid tumors. A 44-year-old woman with stage IIIC right breast cancer was treated with mastectomy and axillary node dissection after primary systemic chemotherapy followed by radiation, chemotherapy, and hormonal therapy. Eighteen months after surgery, recurrent diseases were revealed and refractory to multiple treatments. The recurrent site biopsy showed microsatellite instability-high, and programmed cell death ligand-1 inhibitor pembrolizumab was administrated. FDG PET/CT showed complete metabolic response over 12 months and is useful to monitor the response of active immunotherapy.
MeSH term(s)	Adult ; Apoptosis ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Female ; Fluorodeoxyglucose F18 ; Humans ; Immunotherapy ; Ligands ; Mastectomy ; Microsatellite Instability ; Neoplasm Recurrence, Local ; Positron Emission Tomography Computed Tomography
Chemical Substances	Ligands ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-09-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003950
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Zs.A 1276: Show issues

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Article ; Online: Four Patterns of Abnormal Ring-Like Uptakes on Dedicated Breast PET.

Sasada, Shinsuke / Kai, Azusa / Kimura, Yuri / Masumoto, Norio / Kadoya, Takayuki

Clinical nuclear medicine

2021 Volume 47, Issue 2, Page(s) e192–e193

Abstract: Abstract: The high resolution of dedicated breast PET (dbPET) enables the visualization of small breast cancers and a heterogeneity of breast tumors. Some tumors present with a ring-like appearance, the central uptake defect possibly reflecting ... ...

Abstract	Abstract: The high resolution of dedicated breast PET (dbPET) enables the visualization of small breast cancers and a heterogeneity of breast tumors. Some tumors present with a ring-like appearance, the central uptake defect possibly reflecting intratumoral fibrosis and necrosis, associated with high-grade malignancy, and a triple-negative subtype. However, a ring-like finding is not only found in high-grade breast cancers. We describe 4 representative patterns of ring-like uptakes on dbPET: high-grade invasive cancer, intracystic tumor, extended noninvasive carcinoma, and change after vacuum-assisted breast biopsy. Ring-like uptakes on dbPET should be evaluated in association with clinical information.
MeSH term(s)	Breast ; Breast Neoplasms ; Female ; Fluorodeoxyglucose F18 ; Humans ; Positron-Emission Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003877
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Zs.A 1276: Show issues

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Article ; Online: Effect of Secondary Prophylactic G-CSF on the Occurrence of Febrile Neutropenia in Breast Cancer.

Suzuki, Kanako / Sasada, Shinsuke / Kimura, Yuri / Emi, Akiko / Kadoya, Takayuki / Okada, Morihito

Anticancer research

2022 Volume 42, Issue 12, Page(s) 5945–5949

Abstract: Background/aim: Docetaxel and cyclophosphamide (TC) combination therapy is widely used as adjuvant chemotherapy for early-stage breast cancer and is associated with a high incidence of febrile neutropenia (FN). Granulocyte colony-stimulating factor (G- ... ...

Abstract	Background/aim: Docetaxel and cyclophosphamide (TC) combination therapy is widely used as adjuvant chemotherapy for early-stage breast cancer and is associated with a high incidence of febrile neutropenia (FN). Granulocyte colony-stimulating factor (G-CSF) is recommended in the primary prevention of febrile neutropenia (FN). This study aimed to evaluate the FN-suppressing effect of G-CSF in patients with breast cancer receiving TC. Patients and methods: We performed 272 treatment cycles after FN onset in 106 patients with breast cancer receiving TC. We retrospectively evaluated the effect of G-CSF as secondary prophylaxis. The frequency of FN was calculated based on the treatment cycles to adjust for differences in the number of cycles per case and FN occurrence. Results: FN occurred in 58 cycles (21.3%). The incidence of FN with and without secondary prophylactic G-CSF was 10.1% and 25.9%, respectively (p=0.003). Multivariate analysis showed secondary prophylactic G-CSF administration to be an independent predictor of FN incidence [odds ratio (OR)=0.33, 95% confidence interval (CI)=0.14-0.74, p=0.007]. Conclusion: Secondary prophylaxis with G-CSF is recommended for patients with breast cancer undergoing TC chemotherapy to reduce the incidence of FN.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Retrospective Studies ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Chemotherapy, Adjuvant/adverse effects ; Febrile Neutropenia/chemically induced ; Febrile Neutropenia/epidemiology ; Febrile Neutropenia/prevention & control
Chemical Substances	Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2022-12-01
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16104
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Zs.A 1642: Show issues

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Article ; Online: Dual-phase FDG PET/CT for predicting prognosis in operable breast cancer.

Ikejiri, Haruka / Sasada, Shinsuke / Emi, Akiko / Masumoto, Norio / Kadoya, Takayuki / Okada, Morihito

Breast (Edinburgh, Scotland)

2022 Volume 65, Page(s) 98–103

Abstract: Purpose: We aimed to investigate the role of dual-phase FDG PET/CT in predicting the prognosis of patients with operable breast cancer.: Methods: We retrospectively reviewed the data of 998 patients who underwent radical treatment for breast cancer. ... ...

Abstract	Purpose: We aimed to investigate the role of dual-phase FDG PET/CT in predicting the prognosis of patients with operable breast cancer. Methods: We retrospectively reviewed the data of 998 patients who underwent radical treatment for breast cancer. Before treatment, PET/CT scans were performed 1 and 2 h after FDG administration. The maximum standardized uptake value (SUVmax) at both time points (SUVmax1 and SUVmax2) in the primary tumor and the retention index (RI) were calculated. PET recurrence risk (PET-RR) was determined based on the SUVmax1 and RI, and disease-free survival (DFS) and overall survival (OS) were evaluated according to the metabolic parameters. Propensity score matching was performed to adjust for biological characteristics. Results: The cut-off values for SUVmax1 and RI were 3 and 5%, respectively. The 5-year DFS was 94.9% and 86.1% (P < 0.001), and the 5-year OS was 97.6% and 92.7% (P < 0.001) in the low and high PET-RR groups, respectively. In multivariate analysis, high T status, nodal metastasis, the triple-negative subtype, and high PET-RR were independent factors of poor DFS. Propensity score matching revealed similar findings (5-year DFS 91.8% vs. 88.6%, P = 0.041 and 5-year OS 97.1% vs. 94.2%, P = 0.240, respectively). Conclusion: The combined parameters of SUVmax1 and RI on dual-phase FDG PET/CT were useful for predicting prognosis of patients with breast cancer. Patients with a high SUVmax1 and a negative time course of FDG uptake had a favorable prognosis.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/metabolism ; Breast Neoplasms/surgery ; Female ; Fluorodeoxyglucose F18/metabolism ; Humans ; Neoplasm Recurrence, Local/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Prognosis ; Radiopharmaceuticals ; Retrospective Studies
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-07-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2022.07.008
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Zs.A 3620: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 588: Show issues

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Article: [A Case of Breast Metastasis from Renal Cell Carcinoma].

Kawamata, Ayumi / Emi, Akiko / Fujimoto, Mutsumi / Kai, Azusa / Suzuki, Eri / Kobayashi, Yoshie / Sasada, Shinsuke / Masumoto, Norio / Kadoya, Takayuki / Okada, Morihito

Gan to kagaku ryoho. Cancer & chemotherapy

2023 Volume 49, Issue 13, Page(s) 1891–1892

Abstract: The patient was a woman in her 90s. Right radical nephrectomy for right renal cell carcinoma had been performed 2 years and 6 months ago. Since then, there had been no recurrence. However, computed tomography during postoperative follow- up period showed ...

Abstract	The patient was a woman in her 90s. Right radical nephrectomy for right renal cell carcinoma had been performed 2 years and 6 months ago. Since then, there had been no recurrence. However, computed tomography during postoperative follow- up period showed a 3 cm mass in the right breast, and the patient was referred to our department. Breast ultrasonography indicated a well-circumscribed, oval, and almost smooth-surfaced tumor, 27 mm in size, located in the D region of the right breast. Results of a core needle biopsy showed metastatic renal cell carcinoma and clear cell carcinoma. Preoperative examination confirmed intramammary metastases of renal cell carcinoma. Given that the patient did not experience systemic metastases, partial mastectomy of the right breast was performed. Metastatic renal cell carcinoma is associated with poor prognosis. Generally, standard treatment in this disease is chemotherapy. However, surgical resection is selected with the aim of improving the prognosis and achieving radical cure of patients with this complication if these patients are in an oligometastatic state and complete resection of metastatic lesions is feasible, as in the present case. To achieve radical cure, the patient underwent partial mastectomy under local anesthesia, which is a relatively minimally invasive surgery.
MeSH term(s)	Humans ; Female ; Carcinoma, Renal Cell/surgery ; Carcinoma, Renal Cell/secondary ; Breast Neoplasms/pathology ; Kidney Neoplasms/pathology ; Mastectomy/methods ; Nephrectomy ; Melanoma, Cutaneous Malignant
Language	Japanese
Publishing date	2023-02-02
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Zs.B 2573: Show issues

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Article ; Online: Cross-Correlation of Confocal Images for Excised Breast Tissues of Total Mastectomy.

Song, Hang / Sasada, Shinsuke / Kadoya, Takayuki / Arihiro, Koji / Okada, Morihito / Xiao, Xia / Ishikawa, Tomomi / O'Loughlin, Declan / Takada, Jun-Ichi / Kikkawa, Takamaro

IEEE transactions on bio-medical engineering

2024 Volume 71, Issue 5, Page(s) 1705–1716

Abstract: Object: The purpose of this study is to develop an image artifact removal method for radar-based microwave breast imaging and demonstrates the detectability on excised breast tissues of total mastectomy.: Methods: A cross-correlation method was ... ...

Abstract	Object: The purpose of this study is to develop an image artifact removal method for radar-based microwave breast imaging and demonstrates the detectability on excised breast tissues of total mastectomy. Methods: A cross-correlation method was proposed and measurements were conducted. A hand-held radar-based breast cancer detector was utilized to measure a breast at different orientations. Images were generated by multiplying the confocal image data from two scans after cross-correlation. The optimum reconstruction permittivity values were extracted by the local maxima of the confocal image intensity as a function of reconstruction permittivity. Results: With the proposed cross-correlation method, the contrast of the imaging result was enhanced and the clutters were removed. The proposed method was applied to 50 cases of excised breast tissues and the detection sensitivity of 72% was achieved. With the limited number of samples, the dependency of detection sensitivity on the breast size, breast density, and tumor size were examined. Conclusion and significance: The detection sensitivity was strongly influenced by the breast density. The sensitivity was high for fatty breasts, whereas the sensitivity was low for heterogeneously dense breasts. In addition, it was observed that the sensitivity was high for extremely dense breast. This is the first detailed report on the excised breast tissues.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Mastectomy/methods ; Breast/diagnostic imaging ; Breast/surgery ; Microwave Imaging ; Microscopy, Confocal/methods ; Middle Aged ; Sensitivity and Specificity ; Adult ; Artifacts ; Algorithms ; Aged
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/TBME.2023.3348480
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Zs.A 425: Show issues

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Article ; Online: Clinical effect of the pathological axillary assessment method in breast cancer without clinical nodal metastasis.

Sasada, Shinsuke / Masumoto, Norio / Emi, Akiko / Kadoya, Takayuki / Arihiro, Koji / Okada, Morihito

Breast cancer (Tokyo, Japan)

2021 Volume 28, Issue 5, Page(s) 1016–1022

Abstract: Background: This study aimed to assess the clinical effect of the pathological axillary assessment method in breast cancer without clinical lymph node metastasis.: Methods: Data of patients with clinically node-negative breast cancer were ... ...

Abstract	Background: This study aimed to assess the clinical effect of the pathological axillary assessment method in breast cancer without clinical lymph node metastasis. Methods: Data of patients with clinically node-negative breast cancer were retrospectively reviewed. The study period was divided into early (January 2000-July 2007) and late (August 2007-December 2014) periods based on the pathological assessment method used (single-sectional and detailed multi-sectional lymph node processing). In the late period, lymph nodes were evaluated at six levels including immunohistochemistry on each 1.5-2 mm interval section. The axillary diagnostic accuracy and role of chemotherapy were assessed. Results: In 1698 patients, 27 isolated tumor cells (ITCs), 39 micrometastases, and 205 macrometastases were noted. The sensitivity for pathological N0 diagnosis was dependent on clinical T stage, Tis (97.8%), T1 (83.0%), T2 (74.2%), T3 (54.5%), and T4 (63.6%). ITCs and micrometastases were detected only in the late period, and 84.7% and 91.6% of cases in the early and late period, respectively, did not have macrometastases. The 5-year disease-free interval (DFI) rates were 95.2% in node-negative cases, 98.4% in ITCs/micrometastases, and 91.4% in macrometastases (P < 0.001). In multivariate analysis, the predictor for DFI was estrogen receptor negativity (P = 0.013). Chemotherapy did not improve DFI in patients with node-positive breast cancer. Conclusions: The detailed multi-sectional pathological assessment of axillary lymph nodes detected ITCs and micrometastases. Implementation of chemotherapy should not be based on the minimal nodal metastasis and this type of serially nodal sectioned processing had little clinical significance.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Axilla/pathology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Disease-Free Survival ; Female ; Humans ; Lymphatic Metastasis/diagnosis ; Lymphatic Metastasis/pathology ; Middle Aged ; Neoplasm Micrometastasis/diagnosis ; Neoplasm Micrometastasis/pathology ; Neoplasm Staging ; Progression-Free Survival ; Retrospective Studies ; Sentinel Lymph Node Biopsy/methods
Language	English
Publishing date	2021-03-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-021-01236-x
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Zs.A 5536: Show issues

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Article ; Online: Breast cancer detection by dedicated breast positron emission tomography according to the World Health Organization classification of breast tumors.

Sasada, Shinsuke / Kimura, Yuri / Masumoto, Norio / Emi, Akiko / Kadoya, Takayuki / Arihiro, Koji / Okada, Morihito

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2021 Volume 47, Issue 7, Page(s) 1588–1592

Abstract: Objective: Considering the difficulty in detecting primary breast cancers using whole-body positron emission tomography (WBPET) owing to its limited spatial resolution, we aimed to evaluate the detectability of breast cancer by ring-type dedicated ... ...

Abstract	Objective: Considering the difficulty in detecting primary breast cancers using whole-body positron emission tomography (WBPET) owing to its limited spatial resolution, we aimed to evaluate the detectability of breast cancer by ring-type dedicated breast PET (DbPET) on the World Health Organization (WHO) histological classification in comparison with WBPET. Methods: A total of 938 patients with breast cancer underwent WBPET and ring-type DbPET, and 1021 lesions were histologically assessed based on the WHO classification of tumors of the breast. The findings of WBPET and DbPET were retrospectively evaluated and compared. Results: The size-related sensitivity of DbPET was superior to that of WBPET for subcentimetric tumors (81.9% vs. 52.4%, P < 0.001). The histological distribution was as follows: 11 lobular carcinoma in situ, 158 ductal carcinoma in situ, 738 infiltrating duct carcinoma not otherwise specified (NOS), 12 lobular carcinoma NOS, 40 mucinous adenocarcinoma, 13 tubular carcinoma, 36 invasive breast carcinoma others, and 13 papillary neoplasms. WBPET had low sensitivity for lobular carcinoma in situ, ductal carcinoma in situ, lobular carcinoma NOS, mucinous adenocarcinoma, and tubular carcinoma. DbPET showed improved sensitivity for all the above except lobular and tubular carcinoma. The maximum standardized uptake values (SUVmax) of DbPET were significantly higher than those of WBPET for histological types, excluding lobular carcinoma in situ. The SUVmax of papillary neoplasms was high regardless of low-grade histology and Ki-67 labeling index. Conclusions: DBPET was found to have high sensitivity and SUVmax values for all histologic types that showed low sensitivity of detection on WBPET, except lobular carcinoma in situ.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/classification ; Breast Neoplasms/diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Humans ; Middle Aged ; Neoplasm Staging ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Retrospective Studies ; Sensitivity and Specificity ; Whole Body Imaging ; World Health Organization
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2021.02.026
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 549: Show issues

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Article ; Online: Performance of dedicated breast positron emission tomography in the detection of small and low-grade breast cancer.

Sueoka, Satoshi / Sasada, Shinsuke / Masumoto, Norio / Emi, Akiko / Kadoya, Takayuki / Okada, Morihito

Breast cancer research and treatment

2021 Volume 187, Issue 1, Page(s) 125–133

Abstract: Purpose: This study compares the sensitivity of dedicated breast positron emission tomography (DbPET) and whole body positron emission tomography (WBPET) in detecting invasive breast cancer based on tumor size and biology. Further, we explored the ... ...

Abstract	Purpose: This study compares the sensitivity of dedicated breast positron emission tomography (DbPET) and whole body positron emission tomography (WBPET) in detecting invasive breast cancer based on tumor size and biology. Further, we explored the relationship between maximum standardized uptake value (SUVmax) of DbPET and biological features of the tumor. Methods: A total of 639 invasive breast cancer lesions subjected to both DbPET and WBPET before surgery, between January 2016 and May 2019, were included in the study. The sensitivity of DbPET and WBPET in detection and the biology of the tumor according to the clinicopathological features were retrospectively evaluated. Results: The overall sensitivity of DbPET was higher than that of WBPET (91.4% vs. 80.3%, p < 0.001). Subcentimetric tumors were significant (80.9% vs. 54.3%, p < 0.001). Regardless of the nuclear grade, DbPET could detect more lesions than WBPET. The SUVmax was positively correlated with tumor size (R = 0.395, p < 0.001) and the nuclear grade (p < 0.001). Luminal A-like breast cancer had significantly lower SUVmax values than the other subtypes (p < 0.001). Conclusions: DbPET is superior to WBPET in the detection of subcentimetric, low-grade breast cancers. Further, by using SUVmax, DbPET can distinguish luminal A-like breast cancer from the other subtypes.
MeSH term(s)	Breast ; Breast Neoplasms/diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Humans ; Positron-Emission Tomography ; Radiopharmaceuticals ; Retrospective Studies
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-01-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-020-06088-1
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Zs.A 1655: Show issues

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