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  1. Article ; Online: Familial autoimmunity in pediatric patients with type 1 diabetes (T1D) and its associations with the severity of clinical presentation at diabetes diagnosis and with coexisting autoimmunity.

    Kossiva, Lydia / Korona, Anastasia / Kafassi, Nikolitsa / Karanasios, Spyridon / Karavanaki, Kyriaki

    Hormones (Athens, Greece)

    2022  Volume 21, Issue 2, Page(s) 277–285

    Abstract: Purpose: The aim was to evaluate the impact of familial autoimmunity on the age and severity of type 1 diabetes (T1D) presentation and on the coexistence of other autoimmune diseases.: Methods: We retrospectively evaluated the medical records of 121 ... ...

    Abstract Purpose: The aim was to evaluate the impact of familial autoimmunity on the age and severity of type 1 diabetes (T1D) presentation and on the coexistence of other autoimmune diseases.
    Methods: We retrospectively evaluated the medical records of 121 children/adolescents (male: 63) followed in our Diabetic Clinic from 2002 to 2016.
    Results: Seventy-six patients (62.8%) had at least one relative with an autoimmune disease, Hashimoto's thyroiditis (49.5%) and T1D (22.3%) being the commonest. Children with familial autoimmunity were younger at T1D diagnosis (mean age ± SD) (6.766 ± 3.75). Median fasting c-peptide levels at presentation were not related to familial autoimmunity. Patients with familial autoimmunity more often exhibited GADA autoantibody positivity at diagnosis. The larger the number of the patient's relatives diagnosed with an autoimmune disease, the higher were the patient's GADA levels (Spearman's rho test = 0.19, p = 0.049). Children with a first-degree relative with autoimmunity had a coexisting autoimmune disorder at a significantly higher percentage (p = 0.016). Family history of autoimmunity was negatively associated with the presence of diabetic ketoacidosis (DKA) (p = 0.024). Patients with a relative with T1D less frequently exhibited DKA at diagnosis (12.8 vs. 87.2%, p = 0.003). The presence of DKA was associated with younger age (p = 0.05) and lower c-peptide levels (p = 0.033).
    Conclusions: Familial autoimmunity was present in 62.8% of children with T1D, autoimmune thyroiditis and T1D being the two most frequent familial autoimmune diseases. Familial autoimmunity reduced the risk of DKA at diagnosis, but these patients were younger and had higher levels of pancreatic autoantibodies and a greater risk of developing additional autoimmune diseases.
    MeSH term(s) Autoantibodies ; Autoimmune Diseases/diagnosis ; Autoimmunity ; C-Peptide ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetic Ketoacidosis/complications ; Diabetic Ketoacidosis/diagnosis ; Female ; Hashimoto Disease ; Humans ; Male ; Retrospective Studies
    Chemical Substances Autoantibodies ; C-Peptide
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2075912-5
    ISSN 2520-8721 ; 1109-3099
    ISSN (online) 2520-8721
    ISSN 1109-3099
    DOI 10.1007/s42000-022-00358-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5613: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Predictors of associated and multiple autoimmunity in children and adolescents with type 1 diabetes mellitus.

    Kakleas, Konstantinos / Kossyva, Lydia / Korona, Anastasia / Kafassi, Nikolitsa / Karanasios, Spyridon / Karavanaki, Kyriaki

    Annals of pediatric endocrinology & metabolism

    2021  Volume 27, Issue 3, Page(s) 192–200

    Abstract: Purpose: Type 1 diabetes mellitus (T1DM) is an autoimmune condition characterised by the presence of antipancreatic antibodies. The autoimmune process is also directed against other organs, most frequently against the thyroid gland, intestinal mucosa, ... ...

    Abstract Purpose: Type 1 diabetes mellitus (T1DM) is an autoimmune condition characterised by the presence of antipancreatic antibodies. The autoimmune process is also directed against other organs, most frequently against the thyroid gland, intestinal mucosa, and gastric parietal cells.
    Methods: Our investigation included 121 children with T1DM with a mean age±standard deviation of 11.99±4.63 years (range, 2.0-20.0 years). We explored the frequency of associated autoimmunity; the presence of predictive factors such as current age, sex, and severity at diabetes diagnosis; T1DM duration; and family history of autoimmunity.
    Results: Associated autoimmunity was present in 28.9% of T1DM patients. Children with associated autoimmunity were older at diabetes diagnosis (p=0.009) and had a longer diabetes duration compared to children without associated autoimmunity (p=0.044). Adolescents aged 12-20 years had a statistically significant higher chance of developing thyroid autoimmunity compared to children aged 1-5 years (p=0.019). Multiple autoimmunity (MA), T1DM, and 2 or more autoimmune diseases were present in 5.8% of the study population. All children with MA presented with ketoacidosis at diabetes diagnosis and had a higher percentage of familial autoimmunity (p=0.042). The familial autoimmunity of these patients most frequently affected ≥3 relatives (p=0.026) and was more frequently diagnosed before 5 years of age (p=not significant).
    Conclusion: Associated autoimmunity was present in almost one-third of T1DM patients. Significant associations with associated autoimmunity were longer diabetes duration, female sex, older age at diabetes diagnosis, and glutamic acid decarboxylase positivity. Predictors of MA were age <5 years at T1DM diagnosis, the presence of diabetic ketoacidosis at diagnosis, and a significant family history of autoimmunity.
    Language English
    Publishing date 2021-11-15
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2800460-7
    ISSN 2287-1292 ; 2287-1012
    ISSN (online) 2287-1292
    ISSN 2287-1012
    DOI 10.6065/apem.2142168.084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2).

    Louraki, Maria / Katsalouli, Marina / Kanaka-Gantenbein, Christina / Kafassi, Nikolitsa / Critselis, Eleni / Kallinikou, Dimitra / Tsentidis, Charalampos / Karavanaki, Kyriaki

    Diabetes research and clinical practice

    2016  Volume 117, Page(s) 82–90

    Abstract: Aim: To evaluate the prevalence of early somatic neuropathy in children and adolescents with Type 1 diabetes mellitus (Type 1 DM) and its association with the presence of glutamic acid decarboxylase and islet antigen-2 autoantibodies (GADA and IA-2A).!## ...

    Abstract Aim: To evaluate the prevalence of early somatic neuropathy in children and adolescents with Type 1 diabetes mellitus (Type 1 DM) and its association with the presence of glutamic acid decarboxylase and islet antigen-2 autoantibodies (GADA and IA-2A).
    Methods: A cross-sectional study was conducted in a hospital-based cohort of pediatric Type 1 DM patients (n=85, mean(±SD) age: 13.5±3.4years, mean(±SD) disease duration 5.5±3.4years). Peripheral neuropathy was assessed with nerve conduction studies (NCS). GADA and IA-2A titers were measured with radioligand assays.
    Results: Among the study population, 34.1% had at least one abnormal electrophysiological parameter, although predominantly asymptomatic. The highest rates of abnormality were detected in sensory peroneal nerve (25.9%) followed by sural nerve (15.3%). Affected patients were not different in terms of age, diabetes duration or glycaemic control. Among the participants, 62.4% had positive GADA, 58.8% positive IA-2A and 42.4% double antibody positivity. Abnormal NCS correlated neither with GADA nor with IA-2A levels or positivity. However lower sensory nerve action potential in the peroneal nerve, indicative of early axonal dysfunction, was observed in patients with GADA or IA-2A positivity. Absence of both antibodies was associated with better action potentials in all the examined nerves of the lower limbs.
    Conclusions: Impaired indices of subclinical peripheral primarily sensory neuropathy were present among one third of Type 1 DM children and adolescents, with no impact of diabetes duration or glycaemic control. GADA and IA-2A seem to be involved in the development of axonal degeneration, in a pathway which remains to be identified.
    MeSH term(s) Adolescent ; Autoantibodies/blood ; Autoantibodies/immunology ; Blood Glucose/analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/physiopathology ; Female ; Glutamate Decarboxylase/immunology ; Greece/epidemiology ; Humans ; Male ; Peripheral Nervous System Diseases/epidemiology ; Peripheral Nervous System Diseases/immunology ; Prevalence ; Receptor-Like Protein Tyrosine Phosphatases, Class 8/immunology
    Chemical Substances Autoantibodies ; Blood Glucose ; ICA512 autoantibody ; PTPRN protein, human (EC 3.1.3.48) ; Receptor-Like Protein Tyrosine Phosphatases, Class 8 (EC 3.1.3.48) ; Glutamate Decarboxylase (EC 4.1.1.15)
    Language English
    Publishing date 2016-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2016.04.044
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
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  4. Article ; Online: Accreditation of flow cytometry in Europe.

    Sack, Ulrich / Barnett, David / Demirel, Gulderen Yanikkaya / Fossat, Chantal / Fricke, Stephan / Kafassi, Nikolitsa / Nebe, Thomas / Psarra, Katherina / Steinmann, Jörg / Lambert, Claude

    Cytometry. Part B, Clinical cytometry

    2013  Volume 84, Issue 3, Page(s) 135–142

    Abstract: ISO 15189 has been introduced to enable any clinical laboratory, irrespective of geographic location, to be accredited against internationally recognized standards and therefore facilitate direct international comparison of laboratories. Together with ... ...

    Abstract ISO 15189 has been introduced to enable any clinical laboratory, irrespective of geographic location, to be accredited against internationally recognized standards and therefore facilitate direct international comparison of laboratories. Together with increasing use of ISO 15189 for standardization and competition purposes, often triggered by demands of patients and clinicians, clinical flow cytometry laboratories are becoming increasingly challenged to introduce compliant quality management systems. Whilst in most countries, ISO 15189 accreditation is not yet compulsory, there is increasing evidence to suggest that the implementation of this standard is growing. As a result, the European Society of Clinical Cell Analysis (ESCCA) has analysed the impact of accreditation in clinical flow cytometry laboratories. It found, through a discussion forum, that staff qualification, adaptation of multicolour antibody panels, and implementation of a comprehensive quality system (including quality assessment) have been identified as major challenges.
    MeSH term(s) Accreditation ; Europe ; Flow Cytometry/standards ; Humans ; Laboratories, Hospital/standards ; Quality Control
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099657-3
    ISSN 1552-4957 ; 1552-4949 ; 0196-4763
    ISSN (online) 1552-4957
    ISSN 1552-4949 ; 0196-4763
    DOI 10.1002/cyto.b.21079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1688: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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