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Article ; Online: Inflammatory myofibroblastic tumor of the spermatic cord: two cases and review of the literature.

Aydemir, Huseyin / Budak, Salih / Kahyaoglu, Zeynep / Kumsar, Sukru

2020 Volume 40, Issue 1, Page(s) 66–71

Abstract: Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biological potential. Few cases of spermatic cord IMT have been reported in the literature. Inflammatory myofibroblastic tumor is a consequence of the proliferation of fibroblasts and ...

Abstract	Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biological potential. Few cases of spermatic cord IMT have been reported in the literature. Inflammatory myofibroblastic tumor is a consequence of the proliferation of fibroblasts and inflammatory cells. Despite its benign nature, the tumor often clinically mimics intrascrotal malignancy and usually remains undiagnosed preoperatively. The diagnosis of spermatic IMT is difficult preoperatively due to the non-specific findings. Therefore, if testicular tumors cannot be precisely excluded, radical orchiectomy should be performed for the diagnosis and treatment. However, it mainly occurs in children and young adults; spermatic IMT may also be seen among elderly men. Here, we report two cases of inflammatory myofibroblastic tumor involving the spermatic cord. SIMILAR CASES PUBLISHED: There are seven cases entitled "inflammatory myofibroblastic tumor of spermatic cord" in the literature. In our study we present two cases that had a spermatic cord IMT. Furthermore, one of these cases was 82 years of age and is the oldest patient presented in the literature.
MeSH term(s)	Aged, 80 and over ; Genital Neoplasms, Male/pathology ; Humans ; Male ; Middle Aged ; Neoplasms, Muscle Tissue/pathology ; Spermatic Cord/pathology
Language	English
Publishing date	2020-02-06
Publishing country	Saudi Arabia
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	639014-6
ISSN	0975-4466 ; 0256-4947
ISSN (online)	0975-4466
ISSN	0256-4947
DOI	10.5144/0256-4947.2020.66
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Article: An Atherosclerosis Indicator Hyaluronic Acid: Can Plasma Hyaluronic Acid Be Useful in Diagnosing Alzheimer's Disease?

Ceylan, Serdar / Guner, Merve / Okyar-Bas, Arzu / Kahyaoglu, Zeynep / Koc, Neriman S / Koksal, Gamze N / Kiran, Yasin / Sagir, Aykut / Balci, Cafer / Halil, Meltem G / Cankurtaran, Mustafa / Yildirim, Tolga / Lay, Incilay / Dogu, Burcu B

Clinical laboratory

2024 Volume 70, Issue 3

Abstract: Background: The aim is to compare the plasma levels of hyaluronic acid (HA) which is closely related to inflam-mation and vascular changes and arterial stiffness (AS) related values in patients with Alzheimer's disease (AD), amnestic type mild cognitive ...

Abstract	Background: The aim is to compare the plasma levels of hyaluronic acid (HA) which is closely related to inflam-mation and vascular changes and arterial stiffness (AS) related values in patients with Alzheimer's disease (AD), amnestic type mild cognitive impairment (aMCI), and normal cognitive functions (NCF). Methods: Ninety participants were categorized into three groups, patients with AD, MCI, and NCF. Arterial stiffness measurement in the nephrology outpatient clinic, and storage and analysis of plasma samples in the biochemistry laboratory. Results: Of the 90 patients, 32 had NCF, 32 had aMCI, and 26 had AD. Between groups, there was no difference in HA, pulse wave velocity, and augmentation index. The HA level had no statistically significant correlation with any of the other variables. Conclusions: Plasma HA levels will not be useful in the diagnosis of AD. More comprehensive studies with larger number of patients are needed.
MeSH term(s)	Humans ; Alzheimer Disease/diagnosis ; Hyaluronic Acid ; Pulse Wave Analysis ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Atherosclerosis/diagnosis
Chemical Substances	Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230734
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Article: The effect of social frailty on mental health and quality of life in older people: a cross-sectional study.

Odaci Comertoglu, Ezgi / Ozturk, Yelda / Hafizoglu, Merve / Kahyaoglu, Zeynep / Cavusoglu, Cagatay / Balci, Cafer / Dogu, Burcu Balam / Halil, Meltem / Erden Aki, Ozlem / Cankurtaran, Mustafa

European geriatric medicine

2024 Volume 15, Issue 2, Page(s) 453–461

Abstract: Purpose: This study aims to evaluate anxiety, depression, loneliness, death anxiety, and quality of life and investigate their relationship with social frailty in the geriatric population. Additionally, it aimed to identify social frailty predictors.: ...

Abstract	Purpose: This study aims to evaluate anxiety, depression, loneliness, death anxiety, and quality of life and investigate their relationship with social frailty in the geriatric population. Additionally, it aimed to identify social frailty predictors. Methods: The study included 136 participants admitted to the geriatric outpatient clinic. The 15-item Geriatric Depression Scale (GDS-15), the Multidimensional Scale of Perceived Social Support (MSPSS), the Cumulative Illness Rating Scale for Geriatrics (CIRS-G), the Templer Death Anxiety Scale (T-DAS), the Loneliness Scale for the Elderly (LSE), the Quality of Life Scale (CASP-19), the Generalized Anxiety Disorder-7 Test (GAD-7), the Tilburg Frailty Indicator (TFI), the FRAIL Scale, and the Clinical Frailty Scale (CFS) were performed. The TFI was used to collect data about social frailty. Results: There were 61.8% females, and the median age (min-max) was 72.2 (65.3-90.3) years. The prevalence rate of social frailty was 26.7%. The rates of depression, loneliness, anxiety, death anxiety, the burden of chronic disease, and frailty were higher in the social frailty group. Furthermore, logistic regression analysis revealed a strong relationship between social frailty status and widowhood (odds ratio (OR) 6.86; 95% confidence interval (95% CI), 2.42-19.37; p < 0.001), moderate to severe anxiety symptoms (OR 4.37; 95% CI 1.08-17.68; p = 0.038), and a TFI-physical frailty score (OR 1.40; 95% CI 1.12-1.73; p = 0.002). Conclusion: In older adults, the social dimension of frailty is associated with quality of life and psychological state. Physical frailty and sociodemographic characteristics may affect the development of social frailty.
MeSH term(s)	Female ; Humans ; Aged ; Aged, 80 and over ; Male ; Frailty/epidemiology ; Frailty/diagnosis ; Cross-Sectional Studies ; Quality of Life ; Frail Elderly ; Mental Health ; Geriatric Assessment/methods
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2556794-9
ISSN	1878-7657 ; 1878-7649
ISSN (online)	1878-7657
ISSN	1878-7649
DOI	10.1007/s41999-024-00931-0
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Article ; Online: Phase-angle is associated with frailty in community-dwelling older adults

Güner, Merve / Ceylan, Serdar / Baş, Arzu Okyar / Kahyaoğlu, Zeynep / Çöteli, Süheyla / Koca, Meltem / Öztürk, Yelda / Deniz, Olgun / Doğu, Burcu Balam / Halil, Meltem Gülhan / Cankurtaran, Mustafa / Balcı, Cafer

Nutrition. 2023 July 06, p.112157-

2023 , Page(s) 112157–

Abstract: Frailty is a geriatric syndrome associated with adverse outcomes. Malnutrition and sarcopenia are other conditions intertwined with frailty. Phase angle (PA), used as a method in evaluating the nutritional status and sarcopenia, shows the cell membrane ... ...

Abstract	Frailty is a geriatric syndrome associated with adverse outcomes. Malnutrition and sarcopenia are other conditions intertwined with frailty. Phase angle (PA), used as a method in evaluating the nutritional status and sarcopenia, shows the cell membrane integrity and is closely relevant to clinical outcomes and mortality in many chronic conditions. This study aimed to evaluate the relationship between PA and frailty in community-dwelling older adults. A total of 299 older adults admitted to a geriatric outpatient clinic were included. Comprehensive geriatric assessment was performed on all participants. Frailty was evaluated via the Clinical Frailty Scale (CFS), ≥4 levels were accepted as living with frailty. All participants underwent Bioimpedance analysis (BIA) and PA was recorded for each participant. The prevalence of frailty was 53.1% among participants. The median PA was lower in patients living with frailty than in robust ones (5.10 [4.55-7.80] and 5.90 [3.90-6.90], respectively, and p= 0.014). In multivariable regression analysis, it was shown that PA was also associated with frailty in both sexes (OR: 0.920 and p=0.034 for males, OR: 0.81 and p=0.005 for females, respectively) independent of age, handgrip strength, and nutritional status, body mass index, living alone and the burden of morbidities. PA calculated by BIA was significantly associated with frailty. Further research with large samples is needed to determine whether PA demonstrates potential utility as a biomarker for frailty.
Keywords	bioelectrical impedance ; biomarkers ; body mass index ; cell membranes ; hand strength ; malnutrition ; mortality ; nutritional status ; regression analysis ; sarcopenia ; Frailty ; phase angle ; bioelectrical impedance analysis ; older adult
Language	English
Dates of publication	2023-0706
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2023.112157
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Article ; Online: Changes in Place of Death of Older Adults during the COVID-19 Pandemic: A Retrospective Study from an Aging Country.

Ceylan, Serdar / Guner Oytun, Merve / Okyar Bas, Arzu / Kahyaoglu, Zeynep / Ayaz, Caglayan Merve / Balci, Cafer / Dogu, Burcu Balam / Cankurtaran, Mustafa / Halil, Meltem Gulhan

Omega

2023 , Page(s) 302228231154361

Abstract: In the COVID-19 pandemic, due to the difficulties in patients' applications to health centres, changes have occurred in the places of death of older adults. It is aimed to investigate the change in the places of death of older adults in Turkey, which is ... ...

Abstract	In the COVID-19 pandemic, due to the difficulties in patients' applications to health centres, changes have occurred in the places of death of older adults. It is aimed to investigate the change in the places of death of older adults in Turkey, which is one of the countries most affected by the pandemic. Patients admitted to the geriatric outpatient clinic of a university hospital from 01.01.2013 to 29.02.2020 were included. Place and date of death were recorded as hospital or out-of-hospital death. According to results, while the median age of those who died during the pandemic was higher than before (
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	207363-8
ISSN	1541-3764 ; 0030-2228
ISSN (online)	1541-3764
ISSN	0030-2228
DOI	10.1177/00302228231154361
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Article: Relationships of Fall Risk With Frailty, Sarcopenia, and Balance Disturbances in Mild-to-Moderate Alzheimer's Disease.

Güner Oytun, Merve / Topuz, Semra / Baş, Arzu Okyar / Çöteli, Süheyla / Kahyaoğlu, Zeynep / Boğa, İlker / Ceylan, Serdar / Doğu, Burcu Balam / Cankurtaran, Mustafa / Halil, Meltem

Journal of clinical neurology (Seoul, Korea)

2023 Volume 19, Issue 3, Page(s) 251–259

Abstract: Background and purpose: Cognitive impairment is one of the main risk factors for falls, and hence it commonly coexists with balance issues. Frailty and sarcopenia are intertwined and prevalent in dementia, and are closely related to falls. We aimed to ... ...

Abstract	Background and purpose: Cognitive impairment is one of the main risk factors for falls, and hence it commonly coexists with balance issues. Frailty and sarcopenia are intertwined and prevalent in dementia, and are closely related to falls. We aimed to determine the relationships of the fall risk with balance disturbances, sarcopenia, and frailty in mild-to-moderate Alzheimer's disease (AD). Methods: The study enrolled 56 patients with probable AD. A comprehensive geriatric assessment was performed, and muscle strength and mass, performance status, gait, and balance were evaluated. All parameters were compared between fallers and nonfallers with AD. Results: Fallers comprised 53.6% of the study population. The demographic features and AD stages did not differ between fallers and nonfallers. Fallers were more frail than nonfallers ( Conclusions: We found that falls were not influenced by AD stage. Both physical and cumulative frailty were strongly associated with falls in patients with mild-to-moderate AD.
Language	English
Publishing date	2023-01-02
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2500489-X
ISSN	2005-5013 ; 1738-6586
ISSN (online)	2005-5013
ISSN	1738-6586
DOI	10.3988/jcn.2022.0219
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Article ; Online: Dysphagia is closely related to frailty in mild-to-moderate Alzheimer's disease.

Güner, Merve / Baş, Arzu Okyar / Ceylan, Serdar / Kahyaoğlu, Zeynep / Çöteli, Süheyla / Ünsal, Pelin / Çavuşoğlu, Çağatay / Özsürekci, Cemile / Doğu, Burcu Balam / Cankurtaran, Mustafa / Halil, Meltem Gülhan

BMC geriatrics

2023 Volume 23, Issue 1, Page(s) 304

Abstract: Introduction: Physical phenotype and the cumulative deficit model are two well-known concepts of frailty. One of the main components of frailty is loss of muscle mass and function, which may also include swallowing muscles, therefore is a risk factor ... ...

Abstract	Introduction: Physical phenotype and the cumulative deficit model are two well-known concepts of frailty. One of the main components of frailty is loss of muscle mass and function, which may also include swallowing muscles, therefore is a risk factor for dysphagia. Since dysphagia is seen starting from the early stages of Alzheimer's Disease (AD), in this study we aimed to reveal the relationship between frailty and dysphagia and dysphagia-related quality of life through Swallow Quality of Life (SwalQoL) tool in patients with AD and compare them with cognitively intact older adults. Methods: Comprehensive geriatric assessment, dysphagia evaluation by Eating-Assessment Tool (EAT-10) and SwalQoL questionnaire, and frailty assessment via FRAIL and Clinical Frailty Scale (CFS) were performed on all 101 participants of the study. Thirty-five patients were cognitively intact, 36 patients were diagnosed with mild AD, and 30 patients were diagnosed with moderate AD. Results: Sex distribution was similar between the groups, however, there was a statistically significant age difference. The prevalence of frailty increased according to both frailty indexes as the cognitive status deteriorated. All parameters of SwalQoL except fear and sleep parameters deteriorated as cognitive status impaired. In quantile regression of the total score of the SwalQoL questionnaire and multivariable logistic regression of EAT-10, frailty, as defined by CFS and FRAIL, was associated with dysphagia and poor quality of life regardless of age, presence of dementia, as well as nutritional status. Conclusion: Swallowing difficulties in AD negatively affects the quality of life, and it is closely related to frailty in mild-to-moderate AD.
MeSH term(s)	Humans ; Aged ; Frailty/diagnosis ; Frailty/epidemiology ; Frailty/complications ; Alzheimer Disease/complications ; Alzheimer Disease/diagnosis ; Alzheimer Disease/epidemiology ; Deglutition Disorders/diagnosis ; Deglutition Disorders/epidemiology ; Frail Elderly/psychology ; Quality of Life ; Geriatric Assessment
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-023-04020-y
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Article: Which comorbidity index is more appropriate for geriatric patients from the frailty perspective?

Hafızoğlu, Merve / Odacı Cömertoğlu, Ezgi / Öztürk, Yelda / Kahyaoğlu, Zeynep / Çavuşoglu, Çağatay / Balcı, Cafer / Halil, Meltem Gülhan / Erden Aki, Özlem / Cankurtaran, Mustafa / Doğu, Burcu Balam

European geriatric medicine

2023 Volume 15, Issue 1, Page(s) 115–125

Abstract: Objectives: This study examined the relationship between comorbidity indices and physical, psychologic and social frailty and 1-year mortality.: Methods: A cross-sectional analysis was conducted with 136 community-dwelling older adults. The ... ...

Abstract	Objectives: This study examined the relationship between comorbidity indices and physical, psychologic and social frailty and 1-year mortality. Methods: A cross-sectional analysis was conducted with 136 community-dwelling older adults. The relationship of 4 comorbidity indices (CIRS-G, ACCI, GIC, ICED) with 3 different frailty scales (FRAIL, CFS, TFI) was examined. Results: The participants' median age was 72 years (65-90); 62% of the participants were female. Overall, 15.4% of the participants were living with frailty according to the FRAIL scale, 27.9% of them according to the CFS, 58.8% of them according to the TFI, 47.7% of them living with psychological frailty, and 28.6% of them living with social frailty. There were significant and moderate correlations between CIRS-G and FRAIL, CFS and TFI total scores, TFI-Psychological scores and TFI-Social scores (respectively; p < 0.001, r = 0.530; p < 0.001, r = 0.471; p < 0.001, r = 0.535; p < 0.001, r = 0.402; p = 0.016 r = 0.206). AUC for CIRS-G was calculated as 0.716 among comorbidity indices in predicting the presence of frailty according to the FRAIL scale (p = 0.002, 95%CI [0.60-0.82]), 0.765 according to the CFS (p < 0.001, 95%CI [0.66-0.86]), 0.746 according to the TFI (p < 0.001, 95%CI [0.66-0.82]). Conclusion: The CIRS-G index was found to be superior to other indices in predicting the presence of frailty of comorbidity indices, and only GIC scores showed significant results in predicting mortality. However, it would not be the right approach to recommend a single comorbidity index when evaluating older adults.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Frailty/diagnosis ; Frailty/epidemiology ; Frail Elderly ; Cross-Sectional Studies ; Geriatric Assessment/methods ; Comorbidity
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2556794-9
ISSN	1878-7657 ; 1878-7649
ISSN (online)	1878-7657
ISSN	1878-7649
DOI	10.1007/s41999-023-00851-5
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Article: The role of ultrasonographically measured rectus femoris muscle on falls in community-dwelling older adults: a single-center study.

Güner, Merve / Boğa, İlker / Topuz, Semra / Okyar Baş, Arzu / Ceylan, Serdar / Çöteli, Süheyla / Kahyaoğlu, Zeynep / Balcı, Cafer / Doğu, Burcu Balam / Cankurtaran, Mustafa / Halil, Meltem

European geriatric medicine

2023 Volume 14, Issue 5, Page(s) 1065–1073

Abstract: Background: There are many risk factors for falls and sarcopenia has emerged as an important risk factor. Measuring muscle mass is a useful method to determine sarcopenia. Our aim was to determine the difference in muscle mass between older adults with ( ...

Abstract	Background: There are many risk factors for falls and sarcopenia has emerged as an important risk factor. Measuring muscle mass is a useful method to determine sarcopenia. Our aim was to determine the difference in muscle mass between older adults with (fallers) and without history of falls (non-fallers) using ultrasonography (US). Methods: Two hundred ten geriatric patients were enrolled. Fall was defined as an event declared by the person who fell. Sarcopenia was defined by EWGSOP2 criteria. Muscle mass was assessed by muscle ultrasonography of five different muscles. Results: The mean age of the whole study group was 74.1 ± 6.3 years and 58.1% (n = 122) of the total study population was female. Among the participants, 69 patients (31.3%) had a fall history. The sarcopenia ratio was 23.2% in the fallers, and it was 13.7% in the non-fallers, the difference was statistically insignificant (p > 0.05), the measurement of rectus femoris muscle (RF) thickness and cross-sectional area (RFCSA) were significantly smaller among the fallers than non-fallers (p < 0.05). The ROC analysis revealed that RF and RFCSA could determine the history of falls [for RF area under curve (AUC): 0.606, 95% confidence interval (CI) 0.526-0.686, p = 0.010 and for RFCSA AUC: 0.621, 95% CI 0.538-0.704, p = 0.004]. RFCSA was statistically relevant with a history of falls, regardless of age, sex, multimorbidity, incontinence, nutritional status, and frailty status. Conclusion: Decreased RF and RFCSA determined by muscle US is a potentially modifiable risk factor for falls in older adults. Muscle US may be used for determining the risk of falls in older adults.
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2556794-9
ISSN	1878-7657 ; 1878-7649
ISSN (online)	1878-7657
ISSN	1878-7649
DOI	10.1007/s41999-023-00823-9
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Article ; Online: Phase angle is associated with frailty in community-dwelling older adults.

Güner, Merve / Ceylan, Serdar / Okyar Baş, Arzu / Kahyaoğlu, Zeynep / Çöteli, Süheyla / Koca, Meltem / Öztürk, Yelda / Deniz, Olgun / Doğu, Burcu Balam / Halil, Meltem Gülhan / Cankurtaran, Mustafa / Balcı, Cafer

Nutrition (Burbank, Los Angeles County, Calif.)

2023 Volume 116, Page(s) 112157

Abstract: Objectives: Frailty is a geriatric syndrome associated with adverse outcomes. Malnutrition and sarcopenia are conditions intertwined with frailty. Phase angle (PhA), used to evaluate nutritional status and sarcopenia, shows the cell membrane integrity ... ...

Abstract	Objectives: Frailty is a geriatric syndrome associated with adverse outcomes. Malnutrition and sarcopenia are conditions intertwined with frailty. Phase angle (PhA), used to evaluate nutritional status and sarcopenia, shows the cell membrane integrity and is closely related to clinical outcomes and mortality in many chronic conditions. The aim of this study was to evaluate the relationship between PhA and frailty in community-dwelling older adults. Methods: The study included 299 older adults admitted to a geriatric outpatient clinic. A comprehensive geriatric assessment was performed on all participants. Frailty was evaluated via the Clinical Frailty Scale, ≥4 levels were accepted as living with frailty. All participants underwent bioelectrical impedance analysis, and PhA was recorded for each participant. Results: The prevalence of frailty among the participants was 53%. The median PhA was lower in patients living with frailty than in those who were robust (5.10 [4.55-7.80] and 5.90 [3.90-6.90] degrees, respectively, and P = 0.014). Multivariable regression analysis showed that PhA was also associated with frailty in both sexes (odds ratio [OR], 0.920; P = 0.034 for men; OR, 0.81; P = 0.005 for women, respectively) independent of age, handgrip strength, nutritional status, body mass index, living alone, and burden of morbidities. Conclusion: PhA calculated with bioelectrical impedance analysis was significantly associated with frailty. Further research with large samples is needed to determine whether PhA demonstrates potential utility as a biomarker for frailty.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Sarcopenia/epidemiology ; Frailty/epidemiology ; Hand Strength ; Independent Living ; Nutritional Status
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2023.112157
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