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Article ; Online: David V procedure and hemiarch replacement in a patient with Loeys-Dietz-Syndrome and beta thalassemia minor: a case report.

Kainz, Frieda-Maria / Freystaetter, Kathrin / Podesser, Bruno K / Holzinger, Christoph

2023 Volume 18, Issue 1, Page(s) 253

Abstract: We report the case of a 36-year-old European female patient presenting with a sinus valsalva aneurysm of 47 mm with moderate aortic regurgitation. Additionally, an aneurysm of the brachiocephalic trunk and multiple aneurysms of the right internal mammary ...

Abstract	We report the case of a 36-year-old European female patient presenting with a sinus valsalva aneurysm of 47 mm with moderate aortic regurgitation. Additionally, an aneurysm of the brachiocephalic trunk and multiple aneurysms of the right internal mammary artery were identified. Previous medical history included Loeys-Dietz syndrome (LDS) Type RII due to a TGF-beta receptor mutation, and beta thalassemia minor with a baseline hemoglobin of 9,3 g/dL on admission.Reconstruction of the aortic root and hemiarch replacement was performed in circulatory arrest under moderate hypothermia. During surgery, hypothermia was required as part of the cerebral protection strategy. We aim to highlight special considerations and discuss the effects of cooling, rewarming and the use of cardiopulmonary bypass (CPB) during extensive surgery in a patient with LDS and beta thalassemia minor.
MeSH term(s)	Humans ; Female ; Adult ; Loeys-Dietz Syndrome/complications ; Loeys-Dietz Syndrome/surgery ; beta-Thalassemia/complications ; Hypothermia ; Aorta ; Aortic Valve Insufficiency
Language	English
Publishing date	2023-08-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02347-6
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Article ; Online: Transplanted stents: a case report.

Kainz, Frieda-Maria / Wallner, Stephanie / Uyanik-Uenal, Keziban / Andreas, Martin / Zuckermann, Andreas

BMC cardiovascular disorders

2020 Volume 20, Issue 1, Page(s) 312

Abstract: Background: An optimal donor work-up to exclude preexisting conditions is recommended, but urgency and technical equipment in donor centers must be considered. We report a case of two coronary stents present in the donor heart and the related long-term ... ...

Abstract	Background: An optimal donor work-up to exclude preexisting conditions is recommended, but urgency and technical equipment in donor centers must be considered. We report a case of two coronary stents present in the donor heart and the related long-term outcome. Case presentation: A 59-year-old European male patient suffering from dilated cardiomyopathy with severely reduced left ventricular function and presenting with NYHA III underwent cardiac transplantation in 2004. At the one-year follow-up, during routine cardiac catheterization, two stents were found, one in the right coronary artery and one in the circumflex artery, in the patient's transplanted heart. As no stent implantation was performed since transplantation, these were present prior to transplantation and had been transplanted without causing clinical signs. One of the stents showed in-stent restenosis, and the patient received an additional stent 7 years after transplantation. The other stent still showed a good result, and no further intervention has been required so far. The patient is currently in good clinical condition. Conclusion: This is the first case report of favorable long-term stented coronary arteries prior to transplantation. This case highlights the importance of the donor work-up and meticulous palpation of the coronary arteries during donor evaluation.
MeSH term(s)	Cardiomyopathy, Dilated/complications ; Cardiomyopathy, Dilated/diagnosis ; Cardiomyopathy, Dilated/physiopathology ; Coronary Restenosis/etiology ; Coronary Restenosis/therapy ; Donor Selection ; Heart Failure/diagnosis ; Heart Failure/etiology ; Heart Failure/physiopathology ; Heart Failure/surgery ; Heart Transplantation/adverse effects ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/instrumentation ; Stents ; Tissue Donors ; Treatment Outcome
Language	English
Publishing date	2020-06-30
Publishing country	England
Document type	Case Reports
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-020-01597-9
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Article ; Online: Electrical Stimulation of the Greater Auricular Nerve to Reduce Postoperative Atrial Fibrillation.

Andreas, Martin / Arzl, Philipp / Mitterbauer, Andreas / Ballarini, Nicolas M / Kainz, Frieda-Maria / Kocher, Alfred / Laufer, Guenther / Wolzt, Michael

Circulation. Arrhythmia and electrophysiology

2019 Volume 12, Issue 10, Page(s) e007711

Abstract: Background: Postoperative atrial fibrillation (POAF) occurs in up to 40% of patients undergoing cardiac surgery. Invasive stimulation of the vagal nerve previously demonstrated a reduced risk of POAF. Therefore, we examined the antiarrhythmic and anti- ... ...

Abstract	Background: Postoperative atrial fibrillation (POAF) occurs in up to 40% of patients undergoing cardiac surgery. Invasive stimulation of the vagal nerve previously demonstrated a reduced risk of POAF. Therefore, we examined the antiarrhythmic and anti-inflammatory effects of noninvasive low-level transcutaneous electrical stimulation (LLTS) of the greater auricular nerve in a pilot trial including patients undergoing cardiac surgery. Methods: Patients were randomized into a sham (n=20) or a treatment group (n=20) for LLTS. After cardiac surgery, electrodes were applied in the triangular fossa of the ear. Stimulation (amplitude 1 mA, frequency 1 Hz for 40 minutes, followed by a 20 minutes break) was performed for up to 2 weeks after cardiac surgery. Heart rhythm was recorded continuously using an ECG during the observation period. CRP (C-reactive protein) and IL (interleukin)-6 plasma concentrations were measured immediately after surgery as well as on day 2 and 7 postsurgery. Results: Patients receiving LLTS had a significantly reduced occurrence of POAF (4 of 20) when compared with controls (11 of 20, Conclusions: LLTS of the greater auricular nerve may be a potential therapy for POAF. We demonstrated the feasibility to conduct a randomized trial of neurostimulation as an outlay for a multisite clinical trial.
MeSH term(s)	Aged ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/prevention & control ; Cardiac Surgical Procedures/adverse effects ; Double-Blind Method ; Ear Auricle/innervation ; Electrocardiography, Ambulatory ; Female ; Follow-Up Studies ; Heart Conduction System/physiopathology ; Heart Rate/physiology ; Humans ; Male ; Pilot Projects ; Postoperative Complications/physiopathology ; Postoperative Complications/prevention & control ; Retrospective Studies ; Transcutaneous Electric Nerve Stimulation/methods ; Treatment Outcome
Language	English
Publishing date	2019-10-10
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.119.007711
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Zs.A 6667: Show issues

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Article ; Online: Response by Andreas et al to Letter Regarding Article, "Electrical Stimulation of the Greater Auricular Nerve to Reduce Postoperative Atrial Fibrillation".

Andreas, Martin / Arzl, Philipp / Mitterbauer, Andreas / Ballarini, Nicolas M / Kainz, Frieda-Maria / Kocher, Alfred / Laufer, Guenther / Wolzt, Michael

Circulation. Arrhythmia and electrophysiology

2019 Volume 12, Issue 12, Page(s) e008067

MeSH term(s)	17-alpha-Hydroxyprogesterone ; Androstane-3,17-diol ; Androstenediol ; Androstenedione ; Atrial Fibrillation ; Dehydroepiandrosterone ; Dihydrotestosterone ; Electric Stimulation ; Estradiol ; Humans ; Male ; Sexual Maturation ; Testosterone ; Varicocele
Chemical Substances	Dihydrotestosterone (08J2K08A3Y) ; Androstane-3,17-diol (25126-76-5) ; Testosterone (3XMK78S47O) ; Androstenedione (409J2J96VR) ; Dehydroepiandrosterone (459AG36T1B) ; Estradiol (4TI98Z838E) ; 17-alpha-Hydroxyprogesterone (68-96-2) ; Androstenediol (95PS51EMXY)
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.119.008067
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Article ; Online: Intravenous Heme Arginate Induces HO-1 (Heme Oxygenase-1) in the Human Heart.

Andreas, Martin / Oeser, Claudia / Kainz, Frieda-Maria / Shabanian, Shiva / Aref, Tandis / Bilban, Martin / Messner, Barbara / Heidtmann, Julian / Laufer, Guenther / Kocher, Alfred / Wolzt, Michael

Arteriosclerosis, thrombosis, and vascular biology

2018 Volume 38, Issue 11, Page(s) 2755–2762

Abstract: Objective- HO-1 (heme oxygenase-1) induction may prevent or reduce ischemia-reperfusion injury. We previously evaluated its in vivo induction after a single systemic administration of heme arginate in peripheral blood mononuclear cells. The current trial ...

Abstract	Objective- HO-1 (heme oxygenase-1) induction may prevent or reduce ischemia-reperfusion injury. We previously evaluated its in vivo induction after a single systemic administration of heme arginate in peripheral blood mononuclear cells. The current trial was designed to assess the pharmacological tissue induction of HO-1 in the human heart with heme arginate in vivo. Approach and Results- Patients planned for conventional aortic valve replacement received placebo (n=8), 1 mg/kg (n=7) or 3 mg/kg (n=9) heme arginate infused intravenously 24 hours before surgery. A biopsy of the right ventricle was performed directly before aortic cross-clamping and after cross-clamp release. In addition, the right atrial appendage was partially removed for analysis. HO-1 protein and mRNA concentrations were measured in tissue samples and in peripheral blood mononuclear cells before to and up to 72 hours after surgery. No study medication-related adverse events occurred. A strong, dose-dependent effect on myocardial HO-1 mRNA levels was observed (right ventricle: 7.9±5.0 versus 88.6±49.1 versus 203.6±148.7; P=0.002 and right atrium: 10.8±8.8 versus 229.8±173.1 versus 392.7±195.7; P=0.001). This was paralleled by a profound increase of HO-1 protein concentration in atrial tissue (8401±3889 versus 28 585±10 692 versus 29 022±8583; P<0.001). Surgery and heme arginate infusion significantly increased HO-1 mRNA concentration in peripheral blood mononuclear cells ( P<0.001). HO-1 induction led to a significant increase of postoperative carboxyhemoglobin (1.7% versus 1.4%; P=0.041). No effect on plasma HO-1 protein levels could be detected. Conclusions- Myocardial HO-1 mRNA and protein can be dose-dependently induced by heme arginate. Protective effects of this therapeutic strategy should be evaluated in upcoming clinical trials. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT02314780.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Arginine/administration & dosage ; Arginine/adverse effects ; Arginine/pharmacokinetics ; Austria ; Carboxyhemoglobin/metabolism ; Dose-Response Relationship, Drug ; Double-Blind Method ; Enzyme Induction ; Feasibility Studies ; Female ; Heme/administration & dosage ; Heme/adverse effects ; Heme/pharmacokinetics ; Heme Oxygenase-1/biosynthesis ; Heme Oxygenase-1/genetics ; Humans ; Infusions, Intravenous ; Leukocytes, Mononuclear/enzymology ; Male ; Middle Aged ; Myocardium/enzymology ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics
Chemical Substances	RNA, Messenger ; Heme (42VZT0U6YR) ; Carboxyhemoglobin (9061-29-4) ; Arginine (94ZLA3W45F) ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18) ; heme arginate (R1B526117P)
Language	English
Publishing date	2018-10-24
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.118.311832
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Article ; Online: Impact of the coronavirus disease 2019 (COVID-19) pandemic on the care of patients with acute and chronic aortic conditions.

Czerny, Martin / Gottardi, Roman / Puiu, Paul / Bernecker, Oliver Y / Citro, Rodolfo / Della Corte, Alessandro / di Marco, Luca / Fink, Martina / Gosslau, Yvonne / Haldenwang, Peter Lukas / Heijmen, Robin H / Hugas-Mallorqui, Maria / Iesu, Severino / Jacobsen, Oyvind / Jassar, Arminder S / Juraszek, Andrzej / Kolowca, Maciej / Lepidi, Sandro / Marrocco-Trischitta, Massimiliano M /

Matsuda, Hitoshi / Meisenbacher, Katrin / Micari, Antonio / Minatoya, Kenji / Park, Kay-Hyun / Peterss, Sven / Petrich, Michael / Piffaretti, Gabriele / Probst, Chris / Reutersberg, Benedikt / Rosati, Fabrizio / Schachner, Bruno / Schachner, Thomas / Sorokin, Vitali A / Szeberin, Zoltan / Szopinski, Piotr / Di Tommaso, Luigi / Trimarchi, Santi / Verhoeven, Eric L G / Vogt, Ferdinand / Voetsch, Andreas / Walter, Tim / Weiss, Gabriel / Yuan, Xun / Benedetto, Filippo / De Bellis, Antonio / D Oria, Mario / Discher, Philipp / Zierer, Andreas / Rylski, Bartosz / van den Berg, Jos C / Wyss, Thomas R / Bossone, Eduardo / Schmidli, Jürg / Nienaber, Christoph / Accarino, Giulio / Baldascino, Francesco / Böckler, Dittmar / Corazzari, Claudio / D Alessio, Ilenia / de Beaufort, Hector / De Troia, Christopher / Dumfarth, Julia / Galbiati, Denise / Gorgatti, Filippo / Hagl, Christian / Hamiko, Marwan / Huber, Florian / Hyhlik-Duerr, Alexander / Ianelli, Gabriele / Iesu, Ivana / Jung, Joon-Chui / Kainz, Frieda-Maria / Katsargyris, Athanasios / Koter, Stephan / Kusmierczyk, Mariusz / Kolsut, Piotr / Lengyel, Balazs / Lomazzi, Chiara / Muneretto, Claudio / Nava, Giovanni / Nolte, Thomas / Pacini, Davide / Pleban, Eliza / Rychla, Miriam / Sakamoto, Kazuhisa / Shijo, Takayuki / Yokawa, Koki / Siepe, Matthias / Sirch, Joachim / Strauch, Justus / Sule, Jai Ajitchandra / Tobler, Eva-Luca / Walter, Corinna / Weigang, Ernst

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2021 Volume 59, Issue 5, Page(s) 1096–1102

Abstract: Objectives: To evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on acute and elective thoracic and abdominal aortic procedures.: Methods: Forty departments shared their data on acute and elective thoracic and abdominal aortic ... ...

Abstract	Objectives: To evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on acute and elective thoracic and abdominal aortic procedures. Methods: Forty departments shared their data on acute and elective thoracic and abdominal aortic procedures between January and May 2020 and January and May 2019 in Europe, Asia and the USA. Admission rates as well as delay from onset of symptoms to referral were compared. Results: No differences in the number of acute thoracic and abdominal aortic procedures were observed between 2020 and the reference period in 2019 [incidence rates ratio (IRR): 0.96, confidence interval (CI) 0.89-1.04; P = 0.39]. Also, no difference in the time interval from acute onset of symptoms to referral was recorded (<12 h 32% vs > 12 h 68% in 2020, < 12 h 34% vs > 12 h 66% in 2019 P = 0.29). Conversely, a decline of 35% in elective procedures was seen (IRR: 0.81, CI 0.76-0.87; P < 0.001) with substantial differences between countries and the most pronounced decline in Italy (-40%, P < 0.001). Interestingly, in Switzerland, an increase in the number of elective cases was observed (+35%, P = 0.02). Conclusions: There was no change in the number of acute thoracic and abdominal aortic cases and procedures during the initial wave of the COVID-19 pandemic, whereas the case load of elective operations and procedures decreased significantly. Patients with acute aortic syndromes presented despite COVID-19 and were managed according to current guidelines. Further analysis is required to prove that deferral of elective cases had no impact on premature mortality.
MeSH term(s)	Asia ; COVID-19 ; Elective Surgical Procedures ; Europe ; Humans ; Italy ; Pandemics ; SARS-CoV-2 ; Switzerland
Language	English
Publishing date	2021-05-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezaa452
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Article ; Online: Corrigendum to 'Impact of the coronavirus disease 2019 (COVID-19) pandemic on the care of patients with acute and chronic aortic conditions'.

Czerny, Martin / Gottardi, Roman / Puiu, Paul / Bernecker, Oliver Y / Citro, Rodolfo / Corte, Alessandro Della / di Marco, Luca / Fink, Martina / Gosslau, Yvonne / Haldenwang, Peter Lukas / Heijmen, Robin H / Hugas-Mallorqui, Maria / Iesu, Severino / Jacobsen, Oyvind / Jassar, Arminder S / Juraszek, Andrzej / Kolowca, Maciej / Lepidi, Sandro / Marrocco-Trischitta, Massimiliano M /

Matsuda, Hitoshi / Meisenbacher, Katrin / Micari, Antonio / Minatoya, Kenji / Park, Kay-Hyun / Peterss, Sven / Petrich, Michael / Piffaretti, Gabriele / Probst, Chris / Reutersberg, Benedikt / Rosati, Fabrizio / Schachner, Bruno / Schachner, Thomas / Sorokin, Vitaly A / Szeberin, Zoltan / Szopinski, Piotr / Di Tommaso, Luigi / Trimarchi, Santi / Verhoeven, Eric L G / Vogt, Ferdinand / Voetsch, Andreas / Walter, Tim / Weiss, Gabriel / Yuan, Xun / Benedetto, Filippo / De Bellis, Antonio / D'Oria, Mario / Discher, Philipp / Zierer, Andreas / Rylski, Bartosz / van den Berg, Jos C / Wyss, Thomas R / Bossone, Eduardo / Schmidli, Jürg / Nienaber, Christoph / Accarino, Giulio / Baldascino, Francesco / Böckler, Dittmar / Corazzari, Claudio / D'Alessio, Ilenia / de Beaufort, Hector / De Troia, Christopher / Dumfarth, Julia / Galbiati, Denise / Gorgatti, Filippo / Hagl, Christian / Hamiko, Marwan / Huber, Florian / Hyhlik-Duerr, Alexander / Ianelli, Gabriele / Iesu, Ivana / Jung, Joon-Chui / Kainz, Frieda-Maria / Katsargyris, Athanasios / Koter, Stephan / Kusmierczyk, Mariusz / Kolsut, Piotr / Lengyel, Balazs / Lomazzi, Chiara / Muneretto, Claudio / Nava, Giovanni / Nolte, Thomas / Pacini, Davide / Pleban, Eliza / Rychla, Miriam / Sakamoto, Kazuhisa / Shijo, Takayuki / Yokawa, Koki / Siepe, Matthias / Sirch, Joachim / Strauch, Justus / Sule, Jai Ajitchandra / Tobler, Eva-Luca / Walter, Corinna / Weigang, Ernst

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2021 Volume 60, Issue 3, Page(s) 724–725

Language	English
Publishing date	2021-08-11
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezab314
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Article ; Online: David V procedure and hemiarch replacement in a patient with Loeys-Dietz-Syndrome and beta thalassemia minor: a case report.

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Article ; Online: Transplanted stents: a case report.

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Article ; Online: Electrical Stimulation of the Greater Auricular Nerve to Reduce Postoperative Atrial Fibrillation.

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Article ; Online: Response by Andreas et al to Letter Regarding Article, "Electrical Stimulation of the Greater Auricular Nerve to Reduce Postoperative Atrial Fibrillation".

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Article ; Online: Intravenous Heme Arginate Induces HO-1 (Heme Oxygenase-1) in the Human Heart.

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Article ; Online: Impact of the coronavirus disease 2019 (COVID-19) pandemic on the care of patients with acute and chronic aortic conditions.

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Article ; Online: Corrigendum to 'Impact of the coronavirus disease 2019 (COVID-19) pandemic on the care of patients with acute and chronic aortic conditions'.

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