Article ; Online: A novel CT-based automated analysis method provides comparable results with MRI in measuring brain atrophy and white matter lesions.
2021 Volume 63, Issue 12, Page(s) 2035–2046
Abstract: Purpose: Automated analysis of neuroimaging data is commonly based on magnetic resonance imaging (MRI), but sometimes the availability is limited or a patient might have contradictions to MRI. Therefore, automated analyses of computed tomography (CT) ... ...
| Abstract | Purpose: Automated analysis of neuroimaging data is commonly based on magnetic resonance imaging (MRI), but sometimes the availability is limited or a patient might have contradictions to MRI. Therefore, automated analyses of computed tomography (CT) images would be beneficial. Methods: We developed an automated method to evaluate medial temporal lobe atrophy (MTA), global cortical atrophy (GCA), and the severity of white matter lesions (WMLs) from a CT scan and compared the results to those obtained from MRI in a cohort of 214 subjects gathered from Kuopio and Helsinki University Hospital registers from 2005 - 2016. Results: The correlation coefficients of computational measures between CT and MRI were 0.9 (MTA), 0.82 (GCA), and 0.86 (Fazekas). CT-based measures were identical to MRI-based measures in 60% (MTA), 62% (GCA) and 60% (Fazekas) of cases when the measures were rounded to the nearest full grade variable. However, the difference in measures was 1 or less in 97-98% of cases. Similar results were obtained for cortical atrophy ratings, especially in the frontal and temporal lobes, when assessing the brain lobes separately. Bland-Altman plots and weighted kappa values demonstrated high agreement regarding measures based on CT and MRI. Conclusions: MTA, GCA, and Fazekas grades can also be assessed reliably from a CT scan with our method. Even though the measures obtained with the different imaging modalities were not identical in a relatively extensive cohort, the differences were minor. This expands the possibility of using this automated analysis method when MRI is inaccessible or contraindicated. |
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| MeSH term(s) | Alzheimer Disease/pathology ; Atrophy/diagnostic imaging ; Atrophy/pathology ; Brain/diagnostic imaging ; Brain/pathology ; Humans ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed ; White Matter/diagnostic imaging ; White Matter/pathology |
| Language | English |
| Publishing date | 2021-08-14 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 123305-1 |
| ISSN | 1432-1920 ; 0028-3940 |
| ISSN (online) | 1432-1920 |
| ISSN | 0028-3940 |
| DOI | 10.1007/s00234-021-02761-4 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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