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Article ; Online: A generalized model for monitor units determination in ocular proton therapy using machine learning: A proof-of-concept study.

Fleury, Emmanuelle / Herault, Joël / Spruijt, Kees / Kouwenberg, Jasper / Angellier, Gaëlle / Hofverberg, Petter / Horwacik, Tomasz / Kajdrowicz, Tomasz / Pignol, Jean-Philippe / Hoogeman, Mischa / Trnková, Petra

Physics in medicine and biology

2024 Volume 69, Issue 4

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Humans ; Proton Therapy/methods ; Radiotherapy Planning, Computer-Assisted/methods ; Machine Learning ; Protons ; Radiotherapy Dosage ; Eye Neoplasms/radiotherapy ; Melanoma
Chemical Substances	Protons
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ad1d68
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Article ; Online: 3D Dosimetry Based on LiMgPO

Sądel, Michał / Gajewski, Jan / Sowa, Urszula / Swakoń, Jan / Kajdrowicz, Tomasz / Bilski, Paweł / Kłosowski, Mariusz / Pędracka, Anna / Horwacik, Tomasz

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 18

Abstract: A direct verification of the three-dimensional (3D) proton clinical treatment plan prepared for tumor in the eyeball, using the Eclipse Ocular Proton Planning system (by Varian Medical Systems), has been presented. To achieve this, a prototype of the ... ...

Abstract	A direct verification of the three-dimensional (3D) proton clinical treatment plan prepared for tumor in the eyeball, using the Eclipse Ocular Proton Planning system (by Varian Medical Systems), has been presented. To achieve this, a prototype of the innovative two-dimensional (2D) circular silicone foils, made of a polymer with the embedded optically stimulated luminescence (OSL) material in powder form (LiMgPO
MeSH term(s)	Humans ; Luminescence ; Neoplasms ; Phantoms, Imaging ; Protons ; Radiometry ; Radiotherapy Dosage ; Silicones
Chemical Substances	Protons ; Silicones
Language	English
Publishing date	2021-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21186015
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Article ; Online: Characterization of the HollandPTC proton therapy beamline dedicated to uveal melanoma treatment and an interinstitutional comparison.

Fleury, Emmanuelle / Trnková, Petra / Spruijt, Kees / Herault, Joël / Lebbink, Franciska / Heufelder, Jens / Hrbacek, Jan / Horwacik, Tomasz / Kajdrowicz, Tomasz / Denker, Andrea / Gerard, Anaïs / Hofverberg, Petter / Mamalui, Maria / Slopsema, Roelf / Pignol, Jean-Philippe / Hoogeman, Mischa

Medical physics

2021 Volume 48, Issue 8, Page(s) 4506–4522

Abstract: Purpose: Eye-dedicated proton therapy (PT) facilities are used to treat malignant intraocular lesions, especially uveal melanoma (UM). The first commercial ocular PT beamline from Varian was installed in the Netherlands. In this work, the conceptual ... ...

Abstract	Purpose: Eye-dedicated proton therapy (PT) facilities are used to treat malignant intraocular lesions, especially uveal melanoma (UM). The first commercial ocular PT beamline from Varian was installed in the Netherlands. In this work, the conceptual design of the new eyeline is presented. In addition, a comprehensive comparison against five PT centers with dedicated ocular beamlines is performed, and the clinical impact of the identified differences is analyzed. Material/methods: The HollandPTC eyeline was characterized. Four centers in Europe and one in the United States joined the study. All centers use a cyclotron for proton beam generation and an eye-dedicated nozzle. Differences among the chosen ocular beamlines were in the design of the nozzle, nominal energy, and energy spectrum. The following parameters were collected for all centers: technical characteristics and a set of distal, proximal, and lateral region measurements. The measurements were performed with detectors available in-house at each institution. The institutions followed the International Atomic Energy Agency (IAEA) Technical Report Series (TRS)-398 Code of Practice for absolute dose measurement, and the IAEA TRS-398 Code of Practice, its modified version or International Commission on Radiation Units and Measurements Report No. 78 for spread-out Bragg peak normalization. Energy spreads of the pristine Bragg peaks were obtained with Monte Carlo simulations using Geant4. Seven tumor-specific case scenarios were simulated to evaluate the clinical impact among centers: small, medium, and large UM, located either anteriorly, at the equator, or posteriorly within the eye. Differences in the depth dose distributions were calculated. Results: A pristine Bragg peak of HollandPTC eyeline corresponded to the constant energy of 75 MeV (maximal range 3.97 g/cm Conclusions: HollandPTC eyeline specifications are in accordance with five other ocular PT beamlines. Similar clinical concepts can be applied to expect the same high local tumor control. Dosimetrical properties among the six institutions induce most likely differences in ocular radiation-related toxicities. This interinstitutional comparison could support further research on ocular post-PT complications. Finally, the findings reported in this study could be used to define dosimetrical guidelines for ocular PT to unify the concepts among institutions.
MeSH term(s)	Humans ; Melanoma ; Monte Carlo Method ; Proton Therapy ; Radiotherapy Dosage ; Uveal Neoplasms/radiotherapy
Language	English
Publishing date	2021-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.15024
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Article ; Online: Experimental assessment of inter-centre variation in stopping-power and range prediction in particle therapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2021 Volume 163, Page(s) 7–13

Abstract: Purpose: Experimental assessment of inter-centre variation and absolute accuracy of stopping-power-ratio (SPR) prediction within 17 particle therapy centres of the European Particle Therapy Network.: Material and methods: A head and body phantom with ...

Abstract	Purpose: Experimental assessment of inter-centre variation and absolute accuracy of stopping-power-ratio (SPR) prediction within 17 particle therapy centres of the European Particle Therapy Network. Material and methods: A head and body phantom with seventeen tissue-equivalent materials were scanned consecutively at the participating centres using their individual clinical CT scan protocol and translated into SPR with their in-house CT-number-to-SPR conversion. Inter-centre variation and absolute accuracy in SPR prediction were quantified for three tissue groups: lung, soft tissues and bones. The integral effect on range prediction for typical clinical beams traversing different tissues was determined for representative beam paths for the treatment of primary brain tumours as well as lung and prostate cancer. Results: An inter-centre variation in SPR prediction (2σ) of 8.7%, 6.3% and 1.5% relative to water was determined for bone, lung and soft-tissue surrogates in the head setup, respectively. Slightly smaller variations were observed in the body phantom (6.2%, 3.1%, 1.3%). This translated into inter-centre variation of integral range prediction (2σ) of 2.9%, 2.6% and 1.3% for typical beam paths of prostate-, lung- and primary brain-tumour treatments, respectively. The absolute error in range exceeded 2% in every fourth participating centre. The consideration of beam hardening and the execution of an independent HLUT validation had a positive effect, on average. Conclusion: The large inter-centre variations in SPR and range prediction justify the currently clinically used margins accounting for range uncertainty, which are of the same magnitude as the inter-centre variation. This study underlines the necessity of higher standardisation in CT-number-to-SPR conversion.
MeSH term(s)	Humans ; Male ; Phantoms, Imaging ; Proton Therapy ; Radiotherapy Planning, Computer-Assisted ; Tomography, X-Ray Computed ; Uncertainty
Language	English
Publishing date	2021-07-27
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2021.07.019
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Article ; Online: Profile of European proton and carbon ion therapy centers assessed by the EORTC facility questionnaire

Weber, D.C. / Abrunhosa Branquinho, A. / Bolsi, A. / Kacperek, A. / Dendale, R. / Geismar, D. / Bachtiary, B. / Hall, A. / Heufelder, J. / Herfarth, K. / Debus, J. / Amichetti, M. / Krause, M. / Orecchia, R. / Vondracek, V. / Thariat, J. / Kajdrowicz, T. / Nilsson, K. / Grau, C.

2017

Abstract: Background We performed a survey using the modified EORTC Facility questionnaire pFQ to evaluate the human, technical and organizational resources of particle centers in Europe. Material and methods The modified pFQ consisted of 235 questions distributed ...

Abstract	Background We performed a survey using the modified EORTC Facility questionnaire pFQ to evaluate the human, technical and organizational resources of particle centers in Europe. Material and methods The modified pFQ consisted of 235 questions distributed in 11 sections accessible on line on an EORTC server. Fifteen centers from 8 countries completed the pFQ between May 2015 and December 2015. Results The average number of patients treated per year and per particle center was 221 range, 40 557 . The majority 66.7 of centers had pencil beam or raster scanning capability. Four 27 centers were dedicated to eye treatment only. An increase in the patients health professional FTE ratio was observed for eye tumor only centers when compared to other centers. All centers treated routinely chordomas chondrosarcomas, brain tumors and sarcomas but rarely breast cancer. The majority of centers treated pediatric cases with particles. Only a minority of the queried institutions treated non static targets. Conclusions As the number of particle centers coming online will increase, the experience with this treatment modality will rise in Europe. Children can currently be treated in these facilities in a majority of cases. The majority of these centers provide state of the art particle beam therapy. 2017 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 124 2017 185 189
Keywords	Accelerator research and development
Subject code	616
Language	Undetermined
Publishing date	2017-01-01
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Profile of European proton and carbon ion therapy centers assessed by the EORTC facility questionnaire.

Weber, Damien C / Abrunhosa-Branquinho, André / Bolsi, Alessandra / Kacperek, Andrzej / Dendale, Rémi / Geismar, Dirk / Bachtiary, Barbara / Hall, Annika / Heufelder, Jens / Herfarth, Klaus / Debus, Jürgen / Amichetti, Maurizio / Krause, Mechthild / Orecchia, Roberto / Vondracek, Vladimir / Thariat, Juliette / Kajdrowicz, Tomasz / Nilsson, Kristina / Grau, Cai

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2017 Volume 124, Issue 2, Page(s) 185–189

Abstract: Background: We performed a survey using the modified EORTC Facility questionnaire (pFQ) to evaluate the human, technical and organizational resources of particle centers in Europe.: Material and methods: The modified pFQ consisted of 235 questions ... ...

Abstract	Background: We performed a survey using the modified EORTC Facility questionnaire (pFQ) to evaluate the human, technical and organizational resources of particle centers in Europe. Material and methods: The modified pFQ consisted of 235 questions distributed in 11 sections accessible on line on an EORTC server. Fifteen centers from 8 countries completed the pFQ between May 2015 and December 2015. Results: The average number of patients treated per year and per particle center was 221 (range, 40-557). The majority (66.7%) of centers had pencil beam or raster scanning capability. Four (27%) centers were dedicated to eye treatment only. An increase in the patients-health professional FTE ratio was observed for eye tumor only centers when compared to other centers. All centers treated routinely chordomas/chondrosarcomas, brain tumors and sarcomas but rarely breast cancer. The majority of centers treated pediatric cases with particles. Only a minority of the queried institutions treated non-static targets. Conclusions: As the number of particle centers coming online will increase, the experience with this treatment modality will rise in Europe. Children can currently be treated in these facilities in a majority of cases. The majority of these centers provide state of the art particle beam therapy.
Language	English
Publishing date	2017-08
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2017.07.012
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Conference proceedings: New Eyeball Phantom for Verification of Patient Positioning and Eye Fixation at the IFJ PAN eye proton facility

Kajdrowicz, T. / Czopyk, L. / Cywicka-Jakiel, T. / Dulny, B. / Horwacik, T. / Olko, P. / Ptaszkiewicz, M. / Swakon, J.

2009 , Page(s) 09ptcog101

Event/congress	Meeting of the Particle Therapy Co-Operative Group; PTCOG 48; Heidelberg; Particle Therapy Co-Operative Group; 2009
Keywords	Medizin, Gesundheit
Publishing date	2009-09-24
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/09ptcog101
Database	German Medical Science

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Article: Two-dimensional dosimetry of radiotherapeutical proton beams using thermoluminescence foils.

Czopyk, L / Klosowski, M / Olko, P / Swakon, J / Waligorski, M P R / Kajdrowicz, T / Cuttone, G / Cirrone, G A P / Di Rosa, F

Radiation protection dosimetry

2007 Volume 126, Issue 1-4, Page(s) 185–189

Abstract: In modern radiation therapy such as intensity modulated radiation therapy or proton therapy, one is able to cover the target volume with improved dose conformation and to spare surrounding tissue with help of modern measurement techniques. Novel ... ...

Abstract	In modern radiation therapy such as intensity modulated radiation therapy or proton therapy, one is able to cover the target volume with improved dose conformation and to spare surrounding tissue with help of modern measurement techniques. Novel thermoluminescence dosimetry (TLD) foils, developed from the hot-pressed mixture of LiF:Mg,Cu,P (MCP TL) powder and ethylene-tetrafluoroethylene (ETFE) copolymer, have been applied for 2-D dosimetry of radiotherapeutical proton beams at INFN Catania and IFJ Krakow. A TLD reader with 70 mm heating plate and CCD camera was used to read the 2-D emission pattern of irradiated foils. The absorbed dose profiles were evaluated, taking into account correction factors specific for TLD such as dose and energy response. TLD foils were applied for measuring of dose distributions within an eye phantom and compared with predictions obtained from the MCNPX code and Eclipse Ocular Proton Planning (Varian Medical Systems) clinical radiotherapy planning system. We demonstrate the possibility of measuring 2-D dose distributions with point resolution of about 0.5 x 0.5 mm(2).
MeSH term(s)	Equipment Design ; Equipment Failure Analysis ; Metals/radiation effects ; Neutrons ; Protons/therapeutic use ; Radiation Dosage ; Radiometry/instrumentation ; Radiometry/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Thermoluminescent Dosimetry/instrumentation ; Thermoluminescent Dosimetry/methods
Chemical Substances	Metals ; Protons
Language	English
Publishing date	2007
Publishing country	England
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncm039
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Article ; Online: Harmonization of proton treatment planning for head and neck cancer using pencil beam scanning: first report of the IPACS collaboration group.

Stock, Markus / Gora, Joanna / Perpar, Ana / Georg, Petra / Lehde, Alexander / Kragl, Gabriele / Hug, Eugen / Vondracek, Vladimir / Kubes, Jiri / Poulova, Zuzana / Algranati, Carlo / Cianchetti, Marco / Schwarz, Marco / Amichetti, Maurizio / Kajdrowicz, Tomasz / Kopeć, Renata / Mierzwińska, Gabriela / Olko, Paweł / Skowrońska, Katarzyna /

Sowa, Urszula / Góra, Eleonora / Kisielewicz, Kamil / Sas-Korczyńska, Beata / Skóra, Tomasz / Bäck, Anna / Gustafsson, Magnus / Sooaru, Maret / Witt Nyström, Petra / Nyman, Jan / Björk Eriksson, Thomas

Acta oncologica (Stockholm, Sweden)

2019 Volume 58, Issue 12, Page(s) 1720–1730

Abstract: Background and purpose: ...

Abstract	Background and purpose:
MeSH term(s)	Brain Stem/radiation effects ; Cochlea/radiation effects ; Europe ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/radiotherapy ; Humans ; International Cooperation ; Larynx/radiation effects ; Nose Neoplasms/diagnostic imaging ; Nose Neoplasms/radiotherapy ; Optic Nerve/radiation effects ; Organs at Risk/radiation effects ; Paranasal Sinus Neoplasms/diagnostic imaging ; Paranasal Sinus Neoplasms/radiotherapy ; Parotid Gland/radiation effects ; Photons/therapeutic use ; Proton Therapy/methods ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; Tomography, X-Ray Computed ; Tumor Burden
Language	English
Publishing date	2019-08-08
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2019.1648858
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