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  1. Article ; Online: Crosstalk between muscle and bone.

    Kaji, Hiroshi

    Journal of bone and mineral metabolism

    2023  

    Abstract: Clinical studies revealed a relationship between osteoporosis and sarcopenia. Based on this background, crosstalk between muscle and bone has emerged as a novel research field in the past decade. Among the interactions that occur between muscle and bone, ...

    Abstract Clinical studies revealed a relationship between osteoporosis and sarcopenia. Based on this background, crosstalk between muscle and bone has emerged as a novel research field in the past decade. Among the interactions that occur between muscle and bone, humoral factors, such as osteokines and myokines, affect distant muscles and bones, respectively. Recent studies proposed several important myokines that have an impact on bone, such as myostatin and irisin. Signaling by these myokines has potential as a target for drug development and biomarkers for exercise. Mechanical stress, endocrine disorders, and chronic kidney disease partly affect bone through various myokines in crosstalk between muscle and bone. Moreover, the involvement of extracellular vesicles from bone or muscle as communication tools in the interactions between muscle and bone was recently proposed. Further clinical studies are needed to clarify the significance of myokine regulation under physiological and pathophysiological states in humans.
    Language English
    Publishing date 2023-12-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1295123-7
    ISSN 1435-5604 ; 0914-8779
    ISSN (online) 1435-5604
    ISSN 0914-8779
    DOI 10.1007/s00774-023-01472-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4894: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Recollection of How We Came Across the Protein Modification with Amino Acids by Aminoacyl tRNA-Protein Transferase.

    Kaji, Hideko / Kaji, Akira

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2620, Page(s) 15–20

    Abstract: Protein arginylation has been discovered in 1963 as a soluble activity in cell extracts that mediates the addition of amino acids to proteins. This discovery was nearly accidental, but due to the persistence of the research team, it has been followed ... ...

    Abstract Protein arginylation has been discovered in 1963 as a soluble activity in cell extracts that mediates the addition of amino acids to proteins. This discovery was nearly accidental, but due to the persistence of the research team, it has been followed through and led to the emergence of a new field of research. This chapter describes the original discovery of arginylation and the first methods used to demonstrate the existence of this important biological process.
    MeSH term(s) Amino Acids/metabolism ; Arginine/chemistry ; Proteins/metabolism ; Protein Processing, Post-Translational ; RNA, Transfer/metabolism
    Chemical Substances Amino Acids ; Arginine (94ZLA3W45F) ; Proteins ; RNA, Transfer (9014-25-9)
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2942-0_2
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  3. Article ; Online: Correlated Measurement of Endogenous ATE1 Activity on Native Acceptor Proteins in Tissues and Cultured Cells to Detect Cellular Aging.

    Kaji, Hideko / Kaji, Akira

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2620, Page(s) 41–50

    Abstract: Following our early discovery of arginylation in 1963, we have performed several studies to correlate its activity with essential biological processes. We employed cell- and tissue-based assays to detect both the level of acceptor proteins and the level ... ...

    Abstract Following our early discovery of arginylation in 1963, we have performed several studies to correlate its activity with essential biological processes. We employed cell- and tissue-based assays to detect both the level of acceptor proteins and the level of ATE1 activity under different conditions. Remarkably, in these assays, we found a close correlation between arginylation and aging, a discovery that we believe has longer-term implications in uncovering the importance of ATE1 in normal biology and disease therapies. Here, we describe the original methods we used to measure ATE1 activity in tissues and correlate it with key biological events.
    MeSH term(s) Protein Processing, Post-Translational ; Aminoacyltransferases/genetics ; Cells, Cultured ; Cellular Senescence ; Arginine/metabolism
    Chemical Substances Aminoacyltransferases (EC 2.3.2.-) ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2942-0_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Thermal Effect on Heat Shock Protein 70 Family to Prevent Atherosclerotic Cardiovascular Disease.

    Nagai, Masayo / Kaji, Hidesuke

    Biomolecules

    2023  Volume 13, Issue 5

    Abstract: Heat shock protein 70 (HSP70) is a chaperone protein induced by various stresses on cells and is involved in various disease mechanisms. In recent years, the expression of HSP70 in skeletal muscle has attracted attention for its use as a prevention of ... ...

    Abstract Heat shock protein 70 (HSP70) is a chaperone protein induced by various stresses on cells and is involved in various disease mechanisms. In recent years, the expression of HSP70 in skeletal muscle has attracted attention for its use as a prevention of atherosclerotic cardiovascular disease (ASCVD) and as a disease marker. We have previously reported the effect of thermal stimulation targeted to skeletal muscles and skeletal muscle-derived cells. In this article, we reported review articles including our research results. HSP70 contributes to the improvement of insulin resistance as well as chronic inflammation which are underlying pathologies of type 2 diabetes, obesity, and atherosclerosis. Thus, induction of HSP70 expression by external stimulation such as heat and exercise may be useful for ASCVD prevention. It may be possible to induce HSP70 by thermal stimulus in those who have difficulty in exercise because of obesity or locomotive syndrome. It requires further investigation to determine whether monitoring serum HSP70 concentration is useful for ASCVD prevention.
    MeSH term(s) Humans ; HSP70 Heat-Shock Proteins/metabolism ; Diabetes Mellitus, Type 2/prevention & control ; Diabetes Mellitus, Type 2/metabolism ; Cardiovascular Diseases/metabolism ; Muscle, Skeletal/metabolism ; Obesity/prevention & control ; Obesity/metabolism
    Chemical Substances HSP70 Heat-Shock Proteins
    Language English
    Publishing date 2023-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13050867
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  5. Article ; Online: Torsion Angle Analysis of a Thermally Activated Delayed Fluorescence Emitter in an Amorphous State Using Dynamic Nuclear Polarization Enhanced Solid-State NMR.

    Suzuki, Katsuaki / Kaji, Hironori

    Journal of the American Chemical Society

    2023  Volume 145, Issue 30, Page(s) 16324–16329

    Abstract: The torsion angle between donor and acceptor segments of a thermally activated delayed fluorescence (TADF) molecule is one of the most critical factors in determining the performance of TADF-based organic light-emitting diodes (OLEDs) because the torsion ...

    Abstract The torsion angle between donor and acceptor segments of a thermally activated delayed fluorescence (TADF) molecule is one of the most critical factors in determining the performance of TADF-based organic light-emitting diodes (OLEDs) because the torsion angle affects not only the energy gap between the singlet and triplet but also the oscillator strength and spin-orbit coupling. However, the torsion angle is difficult to analyze, because organic molecules are in an amorphous state in OLEDs. Here, we determined the torsion angle of a highly efficient TADF emitter, DACT-II, in an amorphous state by dynamic nuclear polarization enhanced solid-state NMR measurements. From the experimentally obtained chemical shift principal values of
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c05204
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  6. Article: [Body weight and bone/calcium metabolism. Muscle, myokines and bone/calcium metabolism.]

    Kaji, Hiroshi

    Clinical calcium

    2018  Volume 28, Issue 7, Page(s) 919–926

    Abstract: The interactions between skeletal muscle and bone have been noted, and muscle influences bone metabolism by secreting myokines. Myostatin is known as a myostatic factor through an inhibition of Smad2/3 signaling in muscle. It is involved in the ... ...

    Abstract The interactions between skeletal muscle and bone have been noted, and muscle influences bone metabolism by secreting myokines. Myostatin is known as a myostatic factor through an inhibition of Smad2/3 signaling in muscle. It is involved in the pathophysiology of rheumatoid arthritis via a stimulation of bone resorption. Follistatin might be involved in the regulation of muscle and bone by gravity change through an attenuation of myostatin action. Irisin with energy metabolism improvement actions is related to the effects of mechanical stress or exercise on muscle and bone. The research of myokines might lead to the improvement of clinical practice of sarcopenia and osteoporosis.
    MeSH term(s) Body Weight ; Bone and Bones ; Calcium ; Humans ; Muscle, Skeletal ; Sarcopenia
    Chemical Substances Calcium (SY7Q814VUP)
    Language Japanese
    Publishing date 2018-06-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1807919926
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6536: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Comprehensive understanding of multiple resonance thermally activated delayed fluorescence through quantum chemistry calculations.

    Shizu, Katsuyuki / Kaji, Hironori

    Communications chemistry

    2022  Volume 5, Issue 1, Page(s) 53

    Abstract: Molecules that exhibit multiple resonance (MR) type thermally activated delayed fluorescence (TADF) are highly efficient electroluminescent materials with narrow emission spectra. Despite their importance in various applications, the emission mechanism ... ...

    Abstract Molecules that exhibit multiple resonance (MR) type thermally activated delayed fluorescence (TADF) are highly efficient electroluminescent materials with narrow emission spectra. Despite their importance in various applications, the emission mechanism is still controversial. Here, a comprehensive understanding of the mechanism for a representative MR-TADF molecule (5,9-diphenyl-5,9-diaza-13b-boranaphtho[3,2,1-de]anthracene, DABNA-1) is presented. Using the equation-of-motion coupled-cluster singles and doubles method and Fermi's golden rule, we quantitatively reproduced all rate constants relevant to the emission mechanism; prompt and delayed fluorescence, internal conversion (IC), intersystem crossing, and reverse intersystem crossing (RISC). In addition, the photoluminescence quantum yield and its prompt and delayed contributions were quantified by calculating the population kinetics of excited states and the transient photoluminescence decay curve. The calculations also revealed that TADF occurred via a stepwise process of 1) thermally activated IC from the electronically excited lowest triplet state T
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-022-00668-6
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  8. Article ; Online: Enhanced precision of circadian rhythm by output system.

    Kaji, Hotaka / Mori, Fumito / Ito, Hiroshi

    Journal of theoretical biology

    2023  Volume 574, Page(s) 111621

    Abstract: Circadian rhythms are biological rhythms with a period of approximately 24 h that persist even under constant conditions without daily environmental cues. The molecular circadian clock machinery generates physiological rhythms, which can be transmitted ... ...

    Abstract Circadian rhythms are biological rhythms with a period of approximately 24 h that persist even under constant conditions without daily environmental cues. The molecular circadian clock machinery generates physiological rhythms, which can be transmitted into the downstream output system. Owing to the stochastic nature of the biochemical reactions and the extracellular environment, the oscillation period of circadian rhythms exhibited by individual organisms or cells is not constant on a daily basis with variations as high as 10%, as reflected by the coefficient of variation. Although the fluctuations in the circadian rhythm are measured through a reporter system such as bioluminescence or fluorescence, which is an example of output systems, experimentally confirming whether the fluctuations found in the reporter system are the same as those in the circadian clock is challenging. This study investigated a coupled system of a circadian clock and its output system numerically and analytically, and then compared the fluctuations in the oscillation period of the two systems. We found that the amount of fluctuations in the output system is smaller than that in the circadian clock, assuming the degradation rate of the molecules responsible for the output system is a typical value for protein degradation. The results indicate that the output system can improve the accuracy of the circadian rhythm without the need for any denoising processes.
    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2972-5
    ISSN 1095-8541 ; 0022-5193
    ISSN (online) 1095-8541
    ISSN 0022-5193
    DOI 10.1016/j.jtbi.2023.111621
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 923: Show issues Location:
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  9. Article ; Online: A novel function for eukaryotic elongation factor 3: Inhibition of stop codon readthrough in yeast.

    Kobayashi, Soushi / Kaji, Akira / Kaji, Hideko

    Archives of biochemistry and biophysics

    2023  Volume 740, Page(s) 109580

    Abstract: Eukaryotic elongation factor 3 (eEF3) is one of the essential yeast ribosome-associated ATP-binding cassette type F (ABCF) ATPases. Previously, we found that eEF3 stimulates release of mRNA from puromycin-treated polysomes. In this study, we used a cell- ... ...

    Abstract Eukaryotic elongation factor 3 (eEF3) is one of the essential yeast ribosome-associated ATP-binding cassette type F (ABCF) ATPases. Previously, we found that eEF3 stimulates release of mRNA from puromycin-treated polysomes. In this study, we used a cell-free cricket paralysis virus (CrPV) internal ribosome entry site (IRES)-mediated firefly luciferase bicistronic mRNA translation system with yeast S30 extract. When eEF3 was partially removed from the crude extract, the product from the downstream ORF was increased by the readthrough of a UAA stop codon in the upstream ORF. eEF3 enhanced the release of luciferase from the polysome by eukaryotic release factor (eRF)1 and eRF3. These results suggest that eEF3 is a factor that assists eRFs in performing normal protein synthesis termination in yeast.
    MeSH term(s) Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Codon, Terminator/metabolism ; Peptide Elongation Factors/genetics ; Peptide Elongation Factors/metabolism ; Protein Biosynthesis ; Ribosomes/metabolism
    Chemical Substances Codon, Terminator ; Peptide Elongation Factors
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2023.109580
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    Uc I Zs.237: Show issues Location:
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  10. Article ; Online: Theoretical Determination of Rate Constants from Excited States: Application to Benzophenone.

    Shizu, Katsuyuki / Kaji, Hironori

    The journal of physical chemistry. A

    2021  Volume 125, Issue 40, Page(s) 9000–9010

    Abstract: A cost-effective method of theoretically predicting electronic-transition rate constants from the excited states of molecules is reported. This method is based on density functional theory calculations of electronic states and quantitative rate constant ... ...

    Abstract A cost-effective method of theoretically predicting electronic-transition rate constants from the excited states of molecules is reported. This method is based on density functional theory calculations of electronic states and quantitative rate constant determination with the Fermi golden rule. The method is applied to the theoretical determination of the excited-state decay mechanism of photoexcited benzophenone, a representative molecule in photochemistry and biochemistry. Calculated rate constants for benzophenone are quantitatively consistent with experimental ones, which validates the reliability of our rate constant calculation. The calculated population kinetics indicate that S
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.1c06165
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