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  1. Article: Efficiency and Safety of Patent Ductus Arteriosus Surgical Ligation in Extremely Low Birth Weight Infants Without Chest Tube Placement.

    Kourelis, Georgios / Kanakis, Meletios / Loukas, Constantinos / Kakava, Felicia / Kyriakoulis, Konstantinos / Bobos, Dimitrios / Apostolopoulou, Sotiria / Rammos, Spyridon / Giannopoulos, Nikolaos

    Journal of pediatric intensive care

    2021  Volume 12, Issue 4, Page(s) 264–270

    Abstract: Patent ductus arteriosus (PDA) has been associated with increased morbidity and mortality in preterm infants. Surgical ligation (SL) is generally performed in symptomatic infants when medical management is contraindicated or has failed. We ... ...

    Abstract Patent ductus arteriosus (PDA) has been associated with increased morbidity and mortality in preterm infants. Surgical ligation (SL) is generally performed in symptomatic infants when medical management is contraindicated or has failed. We retrospectively reviewed our institution's experience in surgical management of PDA for extremely low birth weight (ELBW) infants without chest tube placement assessing its efficiency and safety. We evaluated 17 consecutive ELBW infants undergoing SL for symptomatic PDA (January 2012-January 2018) with subsequent follow-up for 6 months postdischarge. Patients consisted of 9 (53%) females and 8 (47%) males. Mean gestational age (GA) at birth was 27.9 ± 2.1 weeks. Median values for surgical age (SA) from birth to operation was 10 days (interquartile range [IQR]: 8-12); PDA diameter 3.4 mm (IQR: 3.2-3.5); surgical weight (SW) 750 g (IQR: 680-850); and days of mechanical ventilation (DMV) as estimated by Kaplan-Meier curve 22 days (95% confidence interval: 14.2-29.8). We observed a statistically significant negative association between DMV and GA at birth (rho = - 0.587,
    Language English
    Publishing date 2021-07-07
    Publishing country Germany
    Document type Journal Article
    ISSN 2146-4618
    ISSN 2146-4618
    DOI 10.1055/s-0041-1731786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Acute Kidney Injury Predictors and Outcomes after Cardiac Surgery in Children with Congenital Heart Disease: An Observational Cohort Study.

    Kourelis, Georgios / Kanakis, Meletios / Samanidis, George / Tzannis, Kimon / Bobos, Dimitrios / Kousi, Theofili / Apostolopoulou, Sotiria / Kakava, Felicia / Kyriakoulis, Konstantinos / Bounta, Stavroula / Rammos, Spyridon / Papagiannis, John / Giannopoulos, Nickolas / Orfanos, Stylianos E / Dimopoulos, George

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 10

    Abstract: Acute Kidney Injury (AKI) commonly complicates cardiac surgery in children with congenital heart disease (CHD). In this study we assessed incidence, risk factors, and outcomes of postoperative AKI, while testing the hypothesis that, depending on the ... ...

    Abstract Acute Kidney Injury (AKI) commonly complicates cardiac surgery in children with congenital heart disease (CHD). In this study we assessed incidence, risk factors, and outcomes of postoperative AKI, while testing the hypothesis that, depending on the underlying diagnosis, there would be significant differences in AKI incidence among different diagnostic groups. We conducted an observational cohort study of children with CHD undergoing cardiac surgery in a single tertiary center between January 2019 and August 2021 (n = 362). Kidney Disease Improving Global Outcome (KDIGO) criteria were used to determine the incidence of postoperative AKI. Diagnosis was incorporated into multivariate models using an anatomic-based CHD classification system. Overall survival was estimated using Kaplan−Meier curves. Log-rank test and adjusted Cox proportional hazard modelling were used to test for differences in survival distributions and determine AKI effect on survival function, respectively. AKI occurred in 70 (19.3%), with 21.4% in-hospital mortality for AKI group. Younger age, lower weight, longer cardiopulmonary bypass time, preoperative mechanical ventilation and diagnostic category were associated with postoperative AKI. Resolution rate was 92.7% prior to hospital discharge for survivors. AKI was associated with longer duration of mechanical ventilation, ICU and hospital length of stay. AKI patients had significantly higher probability of all-cause mortality postoperatively when compared to the non-AKI group (log-rank test, p < 0.001). Adjusted hazard ratio for AKI versus non-AKI group was 11.08 (95% CI 2.45−50.01; p = 0.002). Diagnostic category was associated with cardiac surgery-related AKI in children with CHD, a finding supporting the development of lesion specific models for risk stratification. Postoperative AKI had detrimental impact on clinical outcomes and was associated with decreased survival to hospital discharge.
    Language English
    Publishing date 2022-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12102397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ambulatory Intravenous Inotropic Support and or Levosimendan in Pediatric and Congenital Heart Failure: Safety, Survival, Improvement, or Transplantation.

    Apostolopoulou, Sotiria C / Vagenakis, George A / Tsoutsinos, Alexandros / Kakava, Felicia / Rammos, Spyridon

    Pediatric cardiology

    2018  Volume 39, Issue 7, Page(s) 1315–1322

    Abstract: End-stage heart failure (HF) frequently needs continuous inotropic support in hospital and has high morbidity and mortality in absence of heart transplantation. This study reports outcome, efficacy, and safety of continuous ambulatory inotropes (AI) and/ ... ...

    Abstract End-stage heart failure (HF) frequently needs continuous inotropic support in hospital and has high morbidity and mortality in absence of heart transplantation. This study reports outcome, efficacy, and safety of continuous ambulatory inotropes (AI) and/or periodic levosimendan (LS) infusions in pediatric HF patients. The study included 27 patients, median age 9.4 (0.1-26.1) years, with severe HF (6 myocarditis, 13 dilated cardiomyopathy, 2 restrictive cardiomyopathy, 6 repaired congenital heart disease). Dobutamine and milrinone AI were administered in 21 patients through a permanent central catheter for median duration 1.0 (0.3-3.7) years. Additionally, 14 AI patients and the remaining 6 study patients received periodic LS infusions for median duration 1.1 (0.2-4.2) years. During median follow-up 2.1 (0.3-21.3) years, 4 patients died of worsening HF after 0.8-2.1 years AI, 6 patients underwent heart transplantation with only 3 survivors, while the rest remained stable out of the hospital with complications 4 line infections treated with antibiotics and 4 catheter reinsertions due to dislodgement. Severe pulmonary hypertension was reversed with AI in 2 patients, allowing successful heart-only transplantation. Therapy with AI was discontinued after 1.4-0.4 years in 6 improved myocarditis and 3 cardiomyopathy patients without deterioration. In conclusion, prolonged AI and/or LS infusions in HF are safe and beneficial even in small infants, allowing stabilization and reasonable social and family life out of the hospital. It may provide precious time for heart transplantation or myocardial remodeling, improvement, and possible discontinuation even after long periods of support.
    MeSH term(s) Adolescent ; Adult ; Cardiotonic Agents/administration & dosage ; Cardiotonic Agents/adverse effects ; Child ; Child, Preschool ; Dobutamine/administration & dosage ; Dobutamine/adverse effects ; Female ; Follow-Up Studies ; Heart Failure/drug therapy ; Heart Failure/mortality ; Heart Transplantation/statistics & numerical data ; Humans ; Infant ; Infusions, Intravenous ; Male ; Milrinone/administration & dosage ; Milrinone/adverse effects ; Retrospective Studies ; Simendan/administration & dosage ; Simendan/adverse effects ; Survival Rate ; Treatment Outcome ; Young Adult
    Chemical Substances Cardiotonic Agents ; Simendan (349552KRHK) ; Dobutamine (3S12J47372) ; Milrinone (JU9YAX04C7)
    Language English
    Publishing date 2018-05-18
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-018-1897-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article: Efficiency and Safety of Patent Ductus Arteriosus Surgical Ligation in Extremely Low Birth Weight Infants Without Chest Tube Placement

    Kourelis, Georgios / Kanakis, Meletios / Loukas, Constantinos / Kakava, Felicia / Kyriakoulis, Konstantinos / Bobos, Dimitrios / Apostolopoulou, Sotiria / Rammos, Spyridon / Giannopoulos, Nikolaos

    Journal of Pediatric Intensive Care

    2021  Volume 12, Issue 04, Page(s) 264–270

    Abstract: Patent ductus arteriosus (PDA) has been associated with increased morbidity and mortality in preterm infants. Surgical ligation (SL) is generally performed in symptomatic infants when medical management is contraindicated or has failed. We ... ...

    Abstract Patent ductus arteriosus (PDA) has been associated with increased morbidity and mortality in preterm infants. Surgical ligation (SL) is generally performed in symptomatic infants when medical management is contraindicated or has failed. We retrospectively reviewed our institution's experience in surgical management of PDA for extremely low birth weight (ELBW) infants without chest tube placement assessing its efficiency and safety. We evaluated 17 consecutive ELBW infants undergoing SL for symptomatic PDA (January 2012–January 2018) with subsequent follow-up for 6 months postdischarge. Patients consisted of 9 (53%) females and 8 (47%) males. Mean gestational age (GA) at birth was 27.9 ± 2.1 weeks. Median values for surgical age (SA) from birth to operation was 10 days (interquartile range [IQR]: 8–12); PDA diameter 3.4 mm (IQR: 3.2–3.5); surgical weight (SW) 750 g (IQR: 680–850); and days of mechanical ventilation (DMV) as estimated by Kaplan–Meier curve 22 days (95% confidence interval: 14.2–29.8). We observed a statistically significant negative association between DMV and GA at birth (rho = − 0.587, p  = 0.017), SA (rho = − 0.629, p  = 0.009) and SW (rho = − 0.737, p  = 0.001). One patient experienced left laryngeal nerve palsy confirmed by laryngoscopy. Otherwise, there were no adverse events to include surgical-related mortality, recurrence of PDA, or need for chest tube placement during follow-up. SL of PDA in ELBW infants without chest tube placement is both efficient and safe. Universal consensus recommendations for the management of PDA in ELBW neonates are needed. Further study is required regarding the use of the less invasive option of percutaneous PDA closure in ELBW infants.
    Keywords birth, premature ; infant, extremely low birth weight ; ductus arteriosus, patent ; chest tube
    Language English
    Publishing date 2021-07-07
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2146-4626 ; 2146-4618
    ISSN (online) 2146-4626
    ISSN 2146-4618
    DOI 10.1055/s-0041-1731786
    Database Thieme publisher's database

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Severe infant botulism with cardiac arrest

    Kakava, Felicia V. / Papazoglou, Kleoniki G. / Sideri, Georgia I. / Papadatos, John H.

    Journal of Pediatric Neurology

    2007  Volume 05, Issue 02, Page(s) 175–177

    Abstract: Botulism is caused by the toxin produced by Clostridium botulinum. This toxin binds the peripheral presynaptic cholinergic membranes, preventing the release of acetylcholine and thereby producing a life-threatening, paralytic illness. We report the case ... ...

    Abstract Botulism is caused by the toxin produced by Clostridium botulinum. This toxin binds the peripheral presynaptic cholinergic membranes, preventing the release of acetylcholine and thereby producing a life-threatening, paralytic illness. We report the case of an infant with botulism who proceeded to cardiorespiratory arrest, but whose outcome was very satisfactory, in spite of the delay in diagnosis.
    Keywords Botulism ; cardiorespiratory arrest ; hypotonia
    Language English
    Publishing date 2007-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1875-9041 ; 1304-2580
    ISSN (online) 1875-9041
    ISSN 1304-2580
    DOI 10.1055/s-0035-1557369
    Database Thieme publisher's database

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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