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Article ; Online: Oncolytic viral therapy for gliomas: Advances in the mechanisms and approaches to delivery.

Romanishin, A / Vasilev, A / Khasanshin, E / Evtekhov, A / Pusynin, E / Rubina, K / Kakotkin, V / Agapov, M / Semina, E

2024 Volume 593, Page(s) 110033

Abstract: Glioma is a diverse category of tumors originating from glial cells encompasses various subtypes, based on the specific type of glial cells involved. The most aggressive is glioblastoma multiforme (GBM), which stands as the predominant primary malignant ... ...

Abstract	Glioma is a diverse category of tumors originating from glial cells encompasses various subtypes, based on the specific type of glial cells involved. The most aggressive is glioblastoma multiforme (GBM), which stands as the predominant primary malignant tumor within the central nervous system in adults. Despite the application of treatment strategy, the median survival rate for GBM patients still hovers around 15 months. Oncolytic viruses (OVs) are artificially engineered viruses designed to selectively target and induce apoptosis in cancer cells. While clinical trials have demonstrated encouraging results with intratumoral OV injections for some cancers, applying this approach to GBM presents unique challenges. Here we elaborate on current trends in oncolytic viral therapy and their delivery methods. We delve into the various methods of delivering OVs for therapy, exploring their respective advantages and disadvantages and discussing how selecting the optimal delivery method can enhance the efficacy of this innovative treatment approach.
MeSH term(s)	Adult ; Humans ; Oncolytic Virotherapy/methods ; Glioma/therapy ; Oncolytic Viruses/genetics ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Apoptosis
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2024.110033
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Article: Bolevoi sindrom i kachestvo zhizni posle laparoskopicheskoi transabdominal'noi preperitoneal'noi gernioplastiki s raznymi sposobami fiksatsii bryushiny. Rezul'taty dosrochno zavershennogo randomizirovannogo klinicheskogo issledovaniya.

Agapov, M A / Kakotkin, V V / Gallyamov, E A / Kubyshkin, V A

Khirurgiia

2022 , Issue 9, Page(s) 14–20

Abstract: Objective: To compare and statistically evaluate the severity of pain syndrome and quality of life depending on the method of fixation of the parietal peritoneum during laparoscopic hernia repair (suture fixation or the use of tack fixation).: Methods! ...

Title translation	Pain and quality of life after laparoscopic transabdominal preperitoneal hernioplasty with different ways of fixing the peritoneum. Results of early completion randomized clinical trial.
Abstract	Objective: To compare and statistically evaluate the severity of pain syndrome and quality of life depending on the method of fixation of the parietal peritoneum during laparoscopic hernia repair (suture fixation or the use of tack fixation). Methods: A randomized clinical trial was conducted from May to June 2021 at the Lomonosov Moscow State University Medical Center. It was planned to observe patients for a year. In the first group, the fixation of the parietal peritoneum was performed using suture fixation, in the second group, the peritoneal flap was fixed using a fixation device. In the course of statistical data processing, it was planned to study the dependence of the duration of the operation, the severity of the pain syndrome in the early postoperative period, the frequency of complications, the quality of life of patients in the postoperative period on the chosen method of the fixation of the parietal peritoneum. Results: At the initial stage of the study, 8 patients with inguinal hernias were selected in the first group during randomization, and 6 patients were selected in the second group. Each patient of the second group in the early postoperative period had a more pronounced local pain, protective muscle tension in the projection of fixation of the parietal peritoneum with tacks, which was accompanied by negative psychoemotional reactions, an increase in the dose of analgesic drugs. Due to the revealed features of the early postoperative period in patients of second group, it was considered unethical and inappropriate to continue the study within the protocol. Conclusion: The results obtained do not allow us to draw statistically supported conclusions. The solution of the problem of the peritoneal flap fixation method is possible in two ways: abandoning stapler fixation in favor of suture or conducting additional clinical studies with an analysis of the impact of the choice of peritoneal fixation technique not only on acute and chronic postoperative pain, but on quality of life in the early and delayed postoperative periods.
MeSH term(s)	Herniorrhaphy/methods ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Peritoneum/surgery ; Quality of Life ; Surgical Mesh/adverse effects ; Treatment Outcome
Language	Russian
Publishing date	2022-06-01
Publishing country	Russia (Federation)
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
DOI	10.17116/hirurgia202209114
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Article: Shared genetic architecture of COVID-19 and Alzheimer's disease.

Matveeva, Natalia / Kiselev, Ivan / Baulina, Natalia / Semina, Ekaterina / Kakotkin, Viktor / Agapov, Mikhail / Kulakova, Olga / Favorova, Olga

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1287322

Abstract: The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the сoronavirus disease 2019 (COVID-19) have become a global health threat. At the height of the pandemic, major efforts were focused on reducing COVID-19-associated morbidity ... ...

Abstract	The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the сoronavirus disease 2019 (COVID-19) have become a global health threat. At the height of the pandemic, major efforts were focused on reducing COVID-19-associated morbidity and mortality. Now is the time to study the long-term effects of the pandemic, particularly cognitive impairment associated with long COVID. In recent years much attention has been paid to the possible relationship between COVID-19 and Alzheimer's disease, which is considered a main cause of age-related cognitive impairment. Genetic predisposition was shown for both COVID-19 and Alzheimer's disease. However, the analysis of the similarity of the genetic architecture of these diseases is usually limited to indicating a positive genetic correlation between them. In this review, we have described intrinsic linkages between COVID-19 and Alzheimer's disease, pointed out shared susceptibility genes that were previously identified in genome-wide association studies of both COVID-19 and Alzheimer's disease, and highlighted a panel of SNPs that includes candidate genetic risk markers of the long COVID-associated cognitive impairment.
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1287322
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Article: Ventral'nye gryzhi i ékstratselliuliarnyĭ matriks soedinitel'noĭ tkani.

Kubyshkin, V A / Agapov, M A / Davlyatov, M R / Kakotkin, V V

Khirurgiia

2020 , Issue 2, Page(s) 62–67

Abstract: Ventral hernia is still one of the most common reason for scheduled and emergency surgery. The review is designed to reveal relationships between metabolism in extracellular matrix of connective tissue and pathogenesis of ventral hernias. These data will ...

Title translation	Ventral hernias and extracellular matrix of connective tissue.
Abstract	Ventral hernia is still one of the most common reason for scheduled and emergency surgery. The review is designed to reveal relationships between metabolism in extracellular matrix of connective tissue and pathogenesis of ventral hernias. These data will be valuable to develop a personalized approach to the treatment of these patients.
MeSH term(s)	Connective Tissue/metabolism ; Extracellular Matrix/metabolism ; Hernia, Ventral ; Humans ; Surgical Mesh
Language	Russian
Publishing date	2020-03-09
Publishing country	Russia (Federation)
Document type	Journal Article ; Review
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
DOI	10.17116/hirurgia202002162
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Article: Sravnenie bezopasnosti i effektivnosti primeneniya metodiki ruchnogo intrakorporal'nogo ezofagoenteroanastomoza i apparatnogo ezofagoenteroanastomoza s ispol'zovaniem lineinykh sshivayushchikh apparatov posle laparoskopicheskoi gastrektomii po povodu raka zheludka.

Gallyamov, E A / Agapov, M A / Donchenko, K A / Gallyamov, E E / Kakotkin, V V

Khirurgiia

2020 , Issue 4, Page(s) 11–17

Abstract: Objective: To compare laparoscopic manual esophagoenterostomy and esophagoenterostomy with mechanical stapling anastomotic devices after laparoscopic gastrectomy for stomach cancer.: Material and methods: There were 34 patients who underwent ... ...

Title translation	Comparison of efficiency and safety of laparoscopic manual esophagoenterostomy and esophagoenterostomy with mechanical anastomotic devices after laparoscopic gastrectomy for stomach cancer.
Abstract	Objective: To compare laparoscopic manual esophagoenterostomy and esophagoenterostomy with mechanical stapling anastomotic devices after laparoscopic gastrectomy for stomach cancer. Material and methods: There were 34 patients who underwent laparoscopic gastrectomy for stomach in 2015-2018. Roux-en-Y esophagoenterostomy was used to reconstruct the gastrointestinal tract. Manual anastomoses were performed in 18 patients (group 1), stapled anastomoses (endogia 45 mm, covidien, mansfield, ma, usa) - in 16 patients (group 2). There was no randomization. Surgery duration, length of icu-stay, terms of enteral nutrition initiation, postoperative complications, hospital-stay were analyzed. Results: Mean duration of surgery in the first group was 217 (184-302) min, in the second group - 201 (162-311) min. Duration of surgery in the first group was 1.08-fold higher than in the second group (95% CI 1.03-1.13, Conclusion: Laparoscopic manual esophagoenterostomy proposed by our surgical team does not have disadvantages in comparison with stapling anastomotic devices and these methods may be alternative to each other.
MeSH term(s)	Anastomosis, Roux-en-Y/instrumentation ; Anastomosis, Roux-en-Y/methods ; Esophagus/surgery ; Gastrectomy/methods ; Humans ; Jejunum/surgery ; Laparoscopy ; Stomach Neoplasms/surgery ; Surgical Stapling ; Treatment Outcome
Keywords	covid19
Language	Russian
Publishing date	2020-04-29
Publishing country	Russia (Federation)
Document type	Comparative Study ; Journal Article
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
DOI	10.17116/hirurgia202004111
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Article: Rezul'taty razlichnykh metodik fiksatsii setchatogo proteza pri laparoskopicheskoi gernioplastiki (TAPP).

Gallyamov, E A / Agapov, M A / Busyrev, Yu B / Kakotkin, V V / Kubyshkin, V A / Donchenko, K A / Gadlevskiy, G S / Wu, Z

Khirurgiia

2021 , Issue 1, Page(s) 34–41

Abstract: Objective: To compare early and long-term results of various mesh prosthesis fixation methods in laparoscopic inguinal hernia repair.: Material and methods: It is a prospective clinical non-randomized trial. The study included 212 patients. ... ...

Title translation	Outcomes of various techniques of mesh prosthesis fixation in laparoscopic hernia repair.
Abstract	Objective: To compare early and long-term results of various mesh prosthesis fixation methods in laparoscopic inguinal hernia repair. Material and methods: It is a prospective clinical non-randomized trial. The study included 212 patients. Conventional stapler fixation (112 patients), self-gripping mesh implants (48 patients) and Results: Early postoperative morbidity, activation of patients and hospital-stay were similar in all groups. Pain syndrome within 6 postoperative hours in the first group exceeded the same parameter in the second group by 1.23 times (95% CI 1.15-1.31, Conclusion: There were no significant between-group differences. However, we found the correlation of postoperative pain syndrome with mesh implant fixation technique.
MeSH term(s)	Cyanoacrylates/administration & dosage ; Cyanoacrylates/adverse effects ; Hernia, Inguinal/surgery ; Herniorrhaphy/adverse effects ; Humans ; Laparoscopy ; Pain, Postoperative/etiology ; Prospective Studies ; Prosthesis Implantation/adverse effects ; Prosthesis Implantation/methods ; Surgical Mesh/adverse effects ; Suture Techniques/adverse effects ; Sutureless Surgical Procedures/adverse effects ; Sutureless Surgical Procedures/methods ; Time Factors ; Tissue Adhesives/administration & dosage ; Tissue Adhesives/adverse effects ; Treatment Outcome
Chemical Substances	Cyanoacrylates ; Tissue Adhesives
Language	Russian
Publishing date	2021-01-05
Publishing country	Russia (Federation)
Document type	Clinical Trial ; Comparative Study ; Journal Article
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
DOI	10.17116/hirurgia202101134
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Article: Issledovanie assotsiatsii adenokartsinom zheludka s malymi virusnymi RNK virusa Epshteina—Barr.

Danilova, N V / Mikhailov, I A / Kalinin, D V / Oleynikova, N A / Chayka, A V / Khomyakov, V M / Kakotkin, V V / Yudin, M Yu / Vychuzhanin, D V / Andreeva, Yu Yu / Malkov, P G

Arkhiv patologii

2022 Volume 84, Issue 2, Page(s) 5–12

Abstract: Objective: Assessment of the incidence of EBV-associated gastric adenocarcinomas in a sample of Russian patients, as well as clarification of the clinical and morphological characteristics and median survival of patients with EBV-associated gastric ... ...

Title translation	Study of gastric adenocarcinomas association with the Epstein-Barr virus-encoded small RNAs.
Abstract	Objective: Assessment of the incidence of EBV-associated gastric adenocarcinomas in a sample of Russian patients, as well as clarification of the clinical and morphological characteristics and median survival of patients with EBV-associated gastric cancer. Material and methods: We used samples of surgical material from 282 patients with a verified diagnosis of gastric cancer. Each sample was stained by in situ hybridization using primers for the Epstein-Barr virus-encoded small RNAs (EBER). The results obtained were compared with the main clinical and morphological characteristics of gastric cancer. Results: The detection rate of EBV-associated gastric adenocarcinoma in our sample was 9.57%. EBER-positive tumors much more often ( Conclusion: Separately taken EBER-status is not a significant independent prognostic factor and can be considered only in conjunction with the «classical» clinical and morphological characteristics, primarily with the stage of the tumor process, since it is they that determine the prognostic properties of the tumor.
MeSH term(s)	Adenocarcinoma/pathology ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/genetics ; Herpesvirus 4, Human/genetics ; Humans ; In Situ Hybridization ; Stomach Neoplasms/complications
Language	Russian
Publishing date	2022-04-09
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol2022840215
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Article: Ekspressiya PD-L1 v EBV-assotsiirovannom rake zheludka.

Danilova, N V / Sotnikova, T N / Kalinin, D V / Oleynikova, N A / Chayka, A V / Khomyakov, V M / Kakotkin, V V / Vychuzhanin, D V / Andreeva, Yu Yu / Malkov, P G

Arkhiv patologii

2022 Volume 84, Issue 4, Page(s) 5–12

Abstract: Objective: Assessment of the incidence of PD-L1 expression in EBV-associated gastric adenocarcinomas, as well as clarification of the clinical and morphological characteristics and median survival of patients with PD-L1-positive EBV-associated gastric ... ...

Title translation	PD-L1 expression in EBV-associated gastric carcinomas.
Abstract	Objective: Assessment of the incidence of PD-L1 expression in EBV-associated gastric adenocarcinomas, as well as clarification of the clinical and morphological characteristics and median survival of patients with PD-L1-positive EBV-associated gastric cancer. Material and methods: Samples of surgical material from 127 patients with stomach cancer were studied. Each sample was stained by Results: The detection rate of PD-L1 SP263 and PD-L1 SP142 in EBV-associated gastric adenocarcinoma in our sample was 100% and 76.9% respectively, thus, PD-L1 expression (SP263, SP142) is significantly more frequently detected in EBV-associated gastric carcinomas. It was found that patients with positive expression of PD-L1 in EBV-associated gastric carcinomas are younger (mean age 56.3 years for SP263 and 55.6 years for SP142), belonging to male gender. In addition, this group is dominated by proximal localization of tumors, ulcerative form of growth, tubular histological type, intermediate subtype according to P. Lauren. These characteristics do not depend on the antibody clone: positive expression of SP142 and SP 263 was detected in the same patients with a few exceptions. The overall median survival of patients with positive PD-L1 status SP263 in EBV-associated gastric carcinomas was 35 months, for patients with positive PD-L1 status SP142 - 25 months. Median survival of SP142 PD-L1 positive patients is higher than overall median survival of PD-L1 negative patients in EBV-associated gastric carcinomas. It was found that PD-L1 status in EBV-associated gastric cancer is not a significant prognostic factor. Conclusion: A single PD-L1 status does not significantly affect the prognosis in patients with gastric cancer, including those in the group of EBV-associated carcinomas, and can only be considered in conjunction with 'classic' clinical and morphological characteristics, primarily with the stage of the tumor process, since they determine the prognostic properties of the tumor.
MeSH term(s)	Adenocarcinoma/complications ; Adenocarcinoma/genetics ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/genetics ; Herpesvirus 4, Human/genetics ; Humans ; Male ; Middle Aged ; Stomach Neoplasms/complications ; Stomach Neoplasms/genetics
Chemical Substances	B7-H1 Antigen
Language	Russian
Publishing date	2022-03-08
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol2022840415
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Article: Persistentsiya antigenov virusa Epshteina—Barr pri rake zheludka: kharakteristika vospalitel'nykh kletochnykh reaktsii v opukholi.

Danilova, N V / Mikhailov, I A / Oleynikova, N A / Malkov, P G / Chayka, A V / Khomyakov, V M / Kakotkin, V V / Yudin, M Yu

Arkhiv patologii

2020 Volume 83, Issue 1, Page(s) 18–24

Abstract: The aim of the study: Is to establish the relationship between the persistence of viral antigens of the Epstein-Barr virus (EBV) and the cellular composition of the immune microenvironment of tumor tissue and the mucous membrane of peritumoral area in ... ...

Title translation	Persistence of Epstein-Barr virus antigens in gastric cancer: characteristic of inflammatory cellular reactions in tumor.
Abstract	The aim of the study: Is to establish the relationship between the persistence of viral antigens of the Epstein-Barr virus (EBV) and the cellular composition of the immune microenvironment of tumor tissue and the mucous membrane of peritumoral area in gastric cancer. Material and methods: We used samples of surgical material from 55 patients with a verified diagnosis of gastric cancer. The expression of CD4, CD8, CD68, CD1a and LMP-1 was assessed. The results were assessed by the morphometric method. We selected three fields of view (magnification x200) in tumor tissue and in peritumoral areas separately and counted an absolute number of cells with positive staining with further calculation of the average number of cells and the median. Results: LMP-1-negative tumors with LMP-1 expression in epithelium of peritumoral area were characterized by the highest density of CD4+ lymphocyte infiltration in the central part of the tumor; the highest density of CD8+ lymphocyte infiltration in the mucous membrane of peritumoral area ( Conclusion: High density of infiltration of glandular epithelium of peritumoral area with the expression of LMP-1 by CD4+ and CD8+ lymphocytes is most likely associated with the activation of the cellular immune response and may be one of the signs of the persistence of viral antigens. It was shown for the first time that the phenomenon of persistence of the LMP-1 viral antigen is characterized by a trend towards negative predictive value for patients with gastric cancer.
MeSH term(s)	Antigens, Viral ; Epstein-Barr Virus Nuclear Antigens ; Herpesvirus 4, Human/genetics ; Humans ; Stomach Neoplasms ; Tumor Microenvironment ; Viral Matrix Proteins
Chemical Substances	Antigens, Viral ; Epstein-Barr Virus Nuclear Antigens ; Viral Matrix Proteins
Language	Russian
Publishing date	2020-12-18
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol20218301118
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Article: Sravnitel'naia otsenka minimal'no invazivnykh metodik lecheniia infitsirovannogo pankreonekroza.

Gallyamov, E A / Agapov, M A / Busyrev, Yu B / Gallyamov, E E / Kakotkin, V V / Allakhverdieva, A R

Khirurgiia

2020 , Issue 3, Page(s) 22–28

Abstract: Aim: the assessment of the role of minimally invasive interventional procedures in the treatment of patients with infected pancreatic necrosis and their safety, as well as comparison of the results of the most common modern minimally invasive techniques ...

Title translation	Comparison of minimal invasive technologies for treatment of infected pancreatic necrosis.
Abstract	Aim: the assessment of the role of minimally invasive interventional procedures in the treatment of patients with infected pancreatic necrosis and their safety, as well as comparison of the results of the most common modern minimally invasive techniques among themselves. Methods: The results of treatment of 310 patients are presented with infected destructive pancreatitis from 2013 to 2018 on the basis of the city clinical hospital named after I.V. Davydovsky. The patients were divided into three groups: in the first one (n=170) patients underwent puncture followed by drainage of necrotic foci under ultrasound and CT control, in the second (n=98) patients underwent sanation of foci completely by laparoscopic access, in the third (n=42) a series of retroperitoneoscopy was used for the same purpose. Results: In 114 (67.1%) cases, patients from the first group did not require further surgical intervention. The results of percutaneous drainage were successful. The average length of hospital stay in the first group was 27 days, in the second and third groups - 31 days (the ratio in the 2nd and 3rd groups was 1.03 (95% CI 0.97-1.08; p<0.05)). In the course of treatment, complications were identified in 35 (35.7%) patients in the 2nd and 17 (40.4%) patients in the 3rd group (ratio 0.88 (95% CI 0.82-0.94)). There were 22 (7.1%) deaths. The causes of death were: 1 (0.3%) of the patient had arrosive bleeding, 2 (0.7%) had duodenal fistulas, 19 (6.1%) multiple organ failure against the background of widespread retroperitoneal phlegmon. Conclusion: The efficacy of treatment of infected pancreatic necrosis depends on the possibility of full drainage of the necrotic focus, regardless of approach. Minimally invasive techniques can reduce intraoperative trauma by reducing the wound surface, which contribute to develop systemic inflammatory response syndrome.
MeSH term(s)	Debridement/methods ; Drainage/methods ; Humans ; Laparoscopy ; Minimally Invasive Surgical Procedures/methods ; Necrosis/surgery ; Necrosis/therapy ; Pancreatitis, Acute Necrotizing/diagnostic imaging ; Pancreatitis, Acute Necrotizing/surgery ; Pancreatitis, Acute Necrotizing/therapy ; Retroperitoneal Space/surgery ; Surgery, Computer-Assisted ; Treatment Outcome
Language	Russian
Publishing date	2020-04-21
Publishing country	Russia (Federation)
Document type	Comparative Study ; Journal Article
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
DOI	10.17116/hirurgia202003122
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