LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 63

Search options

  1. Article: Two Healthy Elderly Females with Contemporaneous Subchondral Insufficiency Fractures of Bilateral Femoral Heads: A Case Report.

    Shibuta, Yutaro / Kaku, Nobuhiro / Hosoyama, Tsuguaki / Tsumura, Hiroshi

    Journal of orthopaedic case reports

    2024  Volume 14, Issue 2, Page(s) 70–75

    Abstract: Introduction: Unilateral subchondral insufficiency fractures (SIF) of the femoral head have been reported in many cases; however, bilateral cases occurring simultaneously are very rare.: Case report: We report two cases of relatively active elderly ... ...

    Abstract Introduction: Unilateral subchondral insufficiency fractures (SIF) of the femoral head have been reported in many cases; however, bilateral cases occurring simultaneously are very rare.
    Case report: We report two cases of relatively active elderly females (aged 73 and 67 years), in which bilateral hip pain appeared simultaneously without any specific triggers. There were no notable lifestyle or medication histories. Imaging and histopathology of the bone excised surgically supported the diagnosis. In Case 1, there was a decrease in bone mineral density and poor congruency between the femoral head and acetabulum. In Case 2, the posterior tilt of the pelvis with aging decreased coverage of the femoral head, and the poor congruency between the femoral head and acetabulum was thought to have contributed to uneven distribution and increased stress in the loading zone.
    Conclusion: We encountered two unusual cases with contemporaneous bilateral SIF in the elderly. In recent years, the number of highly active elderly people has increased with the increase in healthy life expectancy. The combined effect of factors such as bone fragility, posterior pelvic tilt, and high activity level likely caused bilateral SIFs, and we should be careful as we expect to see an increase in such cases in the future.
    Language English
    Publishing date 2024-02-27
    Publishing country India
    Document type Case Reports
    ZDB-ID 2658169-3
    ISSN 2250-0685
    ISSN 2250-0685
    DOI 10.13107/jocr.2024.v14.i02.4222
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: COVID-19 with Suspected Secondary Pyogenic Arthritis of the Hip: A Case Report and Literature Review.

    Horii, Ai / Kaku, Nobuhiro / Hosoyama, Tsuguaki / Shibuta, Yutaro

    Journal of orthopaedic case reports

    2024  Volume 14, Issue 4, Page(s) 120–124

    Abstract: Introduction: COVID-19 may be associated with orthopedic symptoms, including myalgia and joint pain. There are reports of reactive arthritis and acute arthritis diagnosed after COVID-19; however, COVID-19-associated pyogenic arthritis has not been ... ...

    Abstract Introduction: COVID-19 may be associated with orthopedic symptoms, including myalgia and joint pain. There are reports of reactive arthritis and acute arthritis diagnosed after COVID-19; however, COVID-19-associated pyogenic arthritis has not been reported.
    Case report: We treated a young woman with secondary pyogenic hip arthritis that started after COVID-19. The patient was a 23-year-old woman who developed acute pain in the right hip 9 days after being diagnosed with COVID-19. Blood cultures revealed methicillin-sensitive Staphylococcus aureus and contrast-enhanced computed tomography revealed joint effusion in the right hip. Although the joint fluid culture results were negative, we suspected pyogenic arthritis of the hip joint and performed curettage and continuous irrigation of the right hip joint. Intraoperative histopathological examination of the synovial membrane revealed numerous neutrophils with segmental nuclei, consistent with a diagnosis of pyogenic arthritis.
    Conclusion: To the best of our knowledge, this is the first report of probable secondary pyogenic hip arthritis in a patient with COVID-19.
    Language English
    Publishing date 2024-04-26
    Publishing country India
    Document type Case Reports
    ZDB-ID 2658169-3
    ISSN 2250-0685
    ISSN 2250-0685
    DOI 10.13107/jocr.2024.v14.i04.4382
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Femoral Bowing Increases Early Postoperative Stress around the Femoral Stem in Humans: A Finite Element Analysis.

    Kaku, Nobuhiro / Hosoyama, Tsuguaki / Shibuta, Yutaro / Tsumura, Hiroshi

    Clinics in orthopedic surgery

    2023  Volume 15, Issue 5, Page(s) 725–733

    Abstract: Background: This study aimed to clarify the characteristics of stress distribution caused by the placement of tapered wedge stems in bowed femurs compared with that in normal femurs and the effect of varus stem placement.: Methods: Models with normal ...

    Abstract Background: This study aimed to clarify the characteristics of stress distribution caused by the placement of tapered wedge stems in bowed femurs compared with that in normal femurs and the effect of varus stem placement.
    Methods: Models with normal and enhanced bowing were created from the right-side computed tomography data of a 17-year-old woman with the least bowing among 40 participants who underwent anterior cruciate ligament reconstruction or operative treatment for trauma in our hospital between January 2017 and May 2018. Finite element analysis was performed, assuming the tapered wedge stem was placed in the neutral and varus positions.
    Results: Varus stem placement on a femur with normal bowing showed a deviation and increase of von Mises stresses in the medial femur. Stem placement on a bowed femur, even when placed in the neutral position, increased stress across the periprosthetic bone. When the stem was placed in the varus position, von Mises stress across the periprosthetic bone increased. Zone 7, with strong bowing, demonstrated 3.6-fold increased stress compared with normal femurs. The maximum tensile principal stress was greatest in zone 6 and increased in zones 3 and 4.
    Conclusions: Surgeons should assess femoral bowing preoperatively and pay particular attention to intraoperative stem alignment for femurs with high bowing.
    MeSH term(s) Female ; Humans ; Adolescent ; Finite Element Analysis ; Femur/diagnostic imaging ; Femur/surgery ; Arthroplasty, Replacement, Knee/methods ; Tomography, X-Ray Computed ; Thigh/surgery
    Language English
    Publishing date 2023-08-09
    Publishing country Korea (South)
    Document type Case Reports ; Journal Article
    ZDB-ID 2502788-8
    ISSN 2005-4408 ; 2005-291X
    ISSN (online) 2005-4408
    ISSN 2005-291X
    DOI 10.4055/cios22392
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Exploring the extension quantities of a medial collateral ligament pie-crusting model using a finite element method.

    Matsuda, Shogo / Hirakawa, Masashi / Nagashima, Yu / Akase, Hiroya / Kaku, Nobuhiro / Tsumura, Hiroshi

    Computer methods in biomechanics and biomedical engineering

    2024  , Page(s) 1–8

    Abstract: Medial collateral ligament (MCL) pie-crusting can balance the soft tissue during total knee arthroplasty but requires more studies with the finite element method (FEM). We have developed three models of MCL pie-crusting utilizing FEM, treating the MCL in ...

    Abstract Medial collateral ligament (MCL) pie-crusting can balance the soft tissue during total knee arthroplasty but requires more studies with the finite element method (FEM). We have developed three models of MCL pie-crusting utilizing FEM, treating the MCL in the following ways: (1) as a singular elastic body with both ends attached to the bone (model A), (2) as 19 bundled elastic bodies, each attached to both ends of the bone (model B), and (3) as 19 bundled elastic bodies with an adhesive component in the gap, attached to both ends of the bone (model C). The pie-crusting model was created by adding a cut around the center of each model. The left side of the model was fixed and forces of 80 and 120 N in the positive direction of the
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2071764-7
    ISSN 1476-8259 ; 1025-5842
    ISSN (online) 1476-8259
    ISSN 1025-5842
    DOI 10.1080/10255842.2024.2310725
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Optimal Intermittent Administration Interval of Abaloparatide for Bone Morphogenetic Protein-Induced Bone Formation in a Rat Spinal Fusion Model.

    Abe, Tetsutaro / Miyazaki, Masashi / Sako, Noriaki / Kanezaki, Shozo / Tsubouchi, Yuta / Kaku, Nobuhiro

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Both bone morphogenetic protein 2 (BMP-2) and abaloparatide are used to promote bone formation. However, there is no consensus about their optimal administration. We investigated the optimal administration theory for the pairing of BMP-2 and ... ...

    Abstract Both bone morphogenetic protein 2 (BMP-2) and abaloparatide are used to promote bone formation. However, there is no consensus about their optimal administration. We investigated the optimal administration theory for the pairing of BMP-2 and abaloparatide in a rat spinal fusion model. Group I was only implanted in carriers and saline. Carriers with 3 µg of recombinant human BMP-2 (rhBMP-2) were implanted in other groups. Abaloparatide injections were administered three times a week for group III (for a total amount of 120 µg/kg in a week) and six times a week for group IV (for a total amount of 120 µg/kg in a week) after surgery. They were euthanized 8 weeks after the surgery, and we explanted their spines at that time. We assessed them using manual palpation tests, radiography, high-resolution micro-computed tomography (micro-CT), and histological analysis. We also analyzed serum bone metabolism markers. The fusion rate in Groups III and IV was higher than in Group I, referring to the manual palpation tests. Groups III and IV recorded greater radiographic scores than those in Groups I and II, too. Micro-CT analysis showed that Tbs. Sp in Groups III and IV was significantly lower than in Group I. Tb. N in Group IV was significantly higher than in Group I. Serum marker analysis showed that bone formation markers were higher in Groups III and IV than in Group I. On the other hand, bone resorption markers were lower in Group IV than in Group I. A histological analysis showed enhanced trabecular bone osteogenesis in Group IV. Frequent administration of abaloparatide may be suitable for the thickening of trabecular bone structure and the enhancement of osteogenesis in a rat spinal fusion model using BMP-2 in insufficient doses.
    MeSH term(s) Humans ; Animals ; Rats ; Osteogenesis ; Spinal Fusion ; X-Ray Microtomography ; Bone Morphogenetic Proteins ; Parathyroid Hormone-Related Protein
    Chemical Substances abaloparatide (AVK0I6HY2U) ; Bone Morphogenetic Proteins ; Parathyroid Hormone-Related Protein
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073655
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Asymmetric Implant Design for Posterolateral Overhang of the Femoral Component in Total Knee Arthroplasty: A Retrospective Computed Tomography-Based Study.

    Hirakawa, Masashi / Miyazaki, Masashi / Nagashima, Yu / Akase, Hiroya / Matsuda, Shogo / Kaku, Nobuhiro

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56862

    Abstract: Introduction During total knee arthroplasty (TKA), also referred to as total knee replacement (TKR), patients may experience pain in the posterolateral knee. One possible cause is the impingement between the popliteus tendon and the femoral components. ... ...

    Abstract Introduction During total knee arthroplasty (TKA), also referred to as total knee replacement (TKR), patients may experience pain in the posterolateral knee. One possible cause is the impingement between the popliteus tendon and the femoral components. The purpose of this study was to analyze the posterolateral overhang of the femoral component using 3D template software. Methods Preoperative CT scan images of 50 knees (11 males and 39 females) with osteoarthritis of grade 2 or lower according to the Kellgren-Lawrence classification were analyzed. The mean age of the subjects was 73.8±7.6 years (range 52-84 years). The Athena (Soft Cube Co., Ltd., Osaka, Japan) knee 3D image-matching software was used for the analysis. The positions of the two femoral components (symmetrical and asymmetrical) were simulated. In the coronal plane, the component overhang was measured between the resected lateral part of the posterior femur and its corresponding component size, and the two designs were compared in three zones (proximal, central, and distal). Results In the simulated femoral component, the asymmetric design had a significantly lower component overhang than the symmetric design in the proximal zone of the lateral posterior condyle (0.2±1.9 mm vs. 3.5±1.6 mm, p<0.01). In the proximal zone, significant overhang (>3 mm) was observed in 30 knees (60.0%) with the symmetric design, but only three knees (6.0%) had asymmetric designs (p<0.01). Conclusions The posterolateral overhang of the lateral posterior condyle occurs when a symmetrical prosthesis is used. The use of an asymmetric implant with a small, rounded proximal portion of the lateral posterior condyle improves this overhang and is expected to decrease problems such as impingement of the popliteus tendon and improve patient satisfaction.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56862
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Influence of femoral bowing on stress distribution of the proximal femur: a three-dimensional finite element analysis.

    Kaku, Nobuhiro / Hosoyama, Tsuguaki / Shibuta, Yutaro / Kimura, Makoto / Tsumura, Hiroshi

    Journal of orthopaedic surgery and research

    2023  Volume 18, Issue 1, Page(s) 82

    Abstract: Background: Whether femoral bowing or its direction has a mechanical effect on the proximal femur is unclear. This study aimed to define the changes in stress distribution in the proximal femur associated with femoral bowing using finite element ... ...

    Abstract Background: Whether femoral bowing or its direction has a mechanical effect on the proximal femur is unclear. This study aimed to define the changes in stress distribution in the proximal femur associated with femoral bowing using finite element analysis.
    Methods: We created four femoral models: original, entire lateral bowing, entire anterior bowing, and the middle of both (50% anterolateral bowing) from computed tomography data of women with standard bowing. Each model's stress distribution was compared by two-layering the stress distribution under loading conditions during walking. We also evaluated displacement vectors.
    Results: In all directions of femoral bowing, the stress increased in the femoral neck and the femoral trochanter in the 50% anterolateral bowing. The direction of deformation of the vector for the femoral head increased anteroinferiorly in the 50% anterolateral bowing.
    Conclusions: This study showed that the stress distribution at the proximal femur shifted laterally. The high-stress area increased at the femoral neck or trochanter due to increasing femoral bowing. Femoral bowing also increases the anteroinferior vector in the femoral head. This study provides valuable insights into the mechanism of proximal femoral fractures in older adults.
    MeSH term(s) Female ; Humans ; Aged ; Finite Element Analysis ; Femur/diagnostic imaging ; Lower Extremity ; Femur Head ; Femur Neck/diagnostic imaging ; Genu Varum
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-023-03559-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Relationship between perceived and structural leg length discrepancies of patients with hip osteoarthritis dysplasia.

    Hosoyama, Tsuguaki / Kaku, Nobuhiro / Tagomori, Hiroaki / Shibuta, Yutaro / Tsumura, Hiroshi

    Orthopaedics & traumatology, surgery & research : OTSR

    2023  Volume 109, Issue 4, Page(s) 103570

    Abstract: Background: Only few studies have been conducted on leg length discrepancy (LLD) in patients with hip osteoarthritis (OA). This study aimed to examine the relationship between perceived LLD (pLLD) and structural LLD (sLLD) in patients with advanced OA ... ...

    Abstract Background: Only few studies have been conducted on leg length discrepancy (LLD) in patients with hip osteoarthritis (OA). This study aimed to examine the relationship between perceived LLD (pLLD) and structural LLD (sLLD) in patients with advanced OA and to determine the factors influencing both LLDs. This retrospective study aimed to answer the following questions: (1) are older adults less likely to perceive LLD than younger adults? (2) is there a relationship between pLLD and sLLD? and (3) is pLLD associated with patient satisfaction?
    Hypothesis: We hypothesized that older adults are less likely to perceive LLD than younger adults.
    Patients and methods: We recruited 125 patients (102 women and 23 men) with hip OA associated with developmental dysplasia of the hip defined as grade 3 or higher according to the Tönnis classification and excluding contralateral grade 2 or higher. The mean age of the patients was 65.2±11.2 (36-85) years. Before surgery, 2-mm and 5-mm thick plates were placed on the floor on the plantar surface of the short leg to measure pLLD. Preoperative computed tomography (CT) was performed and sLLDs were measured using the 3D planning software ZedHip. The following associated factors were evaluated: age, height, weight, body mass index (BMI), adduction and abduction range of motion (ROM) of the affected hip joint, Crowe classification, standing pelvic inclination in the coronal plane, Cobb angle and Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ).
    Results: The absolute difference between pLLD and sLLD was modestly positively correlated with age (R=0.206; p<0.05) indicating older patients were less prone to perceive LLD. A strong positive correlation was found between pLLD (4.8±7.3mm; range: -37 to 28mm) and sLLD (6.4±7.0mm; range: -29.9 to 23.7mm) (R=0.714, p<0.05). The greater the pLLD, the smaller the hip abduction ROM (24.8±11.6°; range: 0 to 45°) tended to be, while the greater the sLLD, the smaller the hip abduction and adduction ROM (10.3±5.7°; range: 0 to 25°) tended to be (R= -0.259 and R= -0.297, respectively; p<0.05) The clinical significance of this finding is that pLLD may be improved if hip ROM training is performed before surgery. pLLD was significantly smaller in the group without pelvic inclination (8.0±14.1mm; range: -37 to 22mm) than in the group with pelvic inclination to the affected side (6.9±7.5mm; range: -12 to 28mm) and in the group with no inclination to the affected side (7.3±7.6mm; range: -8 to 25mm) (p<0.05) The clinical significance of this finding is that improving pelvic inclination with hip ROM training or muscle stretching may also reduce pLLD. No significant differences were noted between pLLD and JHEQ total scores or subgroups.
    Discussion: Older patients had less pLLD. Preoperative pLLD was strongly correlated with sLLD but not with patient satisfaction. These results may be useful for conservative treatment of OA, preoperative planning and intraoperative leg length correction.
    Level of evidence: IV; case control study.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Middle Aged ; Osteoarthritis, Hip/diagnostic imaging ; Osteoarthritis, Hip/surgery ; Retrospective Studies ; Case-Control Studies ; Leg/surgery ; Arthroplasty, Replacement, Hip/methods ; Hip Dislocation, Congenital/surgery ; Hip Dislocation/surgery ; Leg Length Inequality/diagnostic imaging ; Leg Length Inequality/etiology ; Leg Length Inequality/surgery
    Language English
    Publishing date 2023-02-05
    Publishing country France
    Document type Journal Article
    ISSN 1877-0568
    ISSN (online) 1877-0568
    DOI 10.1016/j.otsr.2023.103570
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Generalized Tonic-clonic Seizure Caused by Tranexamic Acid Administration in Spinal Surgery: A Case Report and Literature Review.

    Kawagishi, Masahiro / Kaku, Nobuhiro / Shin, Shuta / Tsumura, Hiroshi

    Journal of orthopaedic case reports

    2022  Volume 12, Issue 6, Page(s) 5–9

    Abstract: Introduction: Tranexamic acid, an antifibrinolytic solvent, has been widely used for perioperative hemostasis in orthopedic surgery. However, to the best of our knowledge, there have been no reports in the literature of seizures caused by tranexamic ... ...

    Abstract Introduction: Tranexamic acid, an antifibrinolytic solvent, has been widely used for perioperative hemostasis in orthopedic surgery. However, to the best of our knowledge, there have been no reports in the literature of seizures caused by tranexamic acid administration for orthopedic surgery. This report presents a case of generalized tonic-clonic seizure caused by tranexamic acid administration immediately after lumbar interbody fusion surgery for lumbar spinal canal stenosis.
    Case report: A 66-year-old Japanese woman scheduled for lumbar interbody fusion surgery was administered an intravenous pre-operative dose (1000 mg) of tranexamic acid and 2000 mg immediately after the surgery. Generalized convulsive seizures occurred on awakening from anesthesia. Although the seizures disappeared after deepening the anesthesia, they recurred on awakening, and extubation could not be performed. A computed tomography scan was immediately performed, revealing an intracranial lesion, but there were no other obvious abnormal findings. The patient was then managed in the intensive care unit, and several convulsions occurred on the 2nd post-operative day. The convulsions disappeared on the 3rd post-operative day, and the patient has had no sequelae to date.
    Conclusion: This original case report will be of interest to orthopedic surgeons, anesthesiologists, neurologists, and pharmacologists. The information presented may also have a broader impact in the field of medicine for other types of surgeons. The details provided in the report will advance knowledge in the area of orthopedic surgery, neurology, pharmacology, and anesthesiology. Orthopedic surgeons should be aware that one of the major complications of tranexamic acid administration is seizure liability.
    Language English
    Publishing date 2022-12-08
    Publishing country India
    Document type Case Reports
    ZDB-ID 2658169-3
    ISSN 2250-0685
    ISSN 2250-0685
    DOI 10.13107/jocr.2022.v12.i06.2842
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Survival rates of different bearing surfaces with the same model of stem in total hip arthroplasty: predictive factors for revision surgery.

    Ikeda, Shinichi / Kaku, Nobuhiro / Hosoyama, Tsuguaki / Tsumura, Hiroshi

    Archives of orthopaedic and trauma surgery

    2022  Volume 143, Issue 7, Page(s) 4501–4510

    Abstract: Introduction: Few studies have examined the survival rates of total hip arthroplasty (THA) with the same femoral stem, and the predictive factors leading to the revision of stemmed metal-on-metal (MoM) THA remain unknown. We determined the long-term ... ...

    Abstract Introduction: Few studies have examined the survival rates of total hip arthroplasty (THA) with the same femoral stem, and the predictive factors leading to the revision of stemmed metal-on-metal (MoM) THA remain unknown. We determined the long-term survival rate of stemmed MoM THA compared with that of metal-on-polyethylene (MoP) bearing THA, the effect of head size and cup placement angle on revision rate, and predictors of revision.
    Materials and methods: A total of 130 hips in 110 patients who underwent primary THA by the same surgeon were included. M2a-RingLoc with a metal-on-polyethylene bearing (group P, 53 hips), M2a-Taper with MoM bearing (group T, 44 hips), and M2a-Magnum with MoM bearing (group M, 33 hips) were used. The mean age at surgery was 63.1 ± 9.5 years, and the mean postoperative follow-up duration was 133.7 ± 39.1 months. Whole blood metal ion concentrations were measured preoperatively and postoperatively, and magnetic resonance imaging was performed to identify aseptic local tissue reactions (ALTRs). Kaplan-Meier survivorship analysis and multiple logistic regression analysis were performed.
    Results: The THA survival rate up to the maximum postoperative follow-up period was 96.2% at 173 months, 46.6% at 179 months, and 47.8% at 145 months in groups P, T, and M, respectively, with revision as the endpoint. The stemmed MoM THA recorded a very low survival rate (p < 0.001). The ALTR rates were 70.5% and 63.6% in groups T and M, respectively. The risk factor for revision was the use of MoM bearing, and there was no difference in the results based on the head size in group M. Cobalt levels continued to increase postoperatively, although they were not accurate predictors of revision.
    Conclusions: Stemmed MoM THA has a very low survival rate and should be used with caution. It is important to monitor the patient's symptoms and perform appropriate imaging to ensure timely revision.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Hip/methods ; Hip Prosthesis ; Survival Rate ; Reoperation/methods ; Risk Factors ; Metals ; Polyethylene ; Metal-on-Metal Joint Prostheses ; Prosthesis Design ; Prosthesis Failure
    Chemical Substances Metals ; Polyethylene (9002-88-4)
    Language English
    Publishing date 2022-11-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-022-04706-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top