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  1. Article ; Online: The efficacy of negative-pressure wound therapy for head and neck wounds: A systematic review and update.

    Onderková, Anna / Butler, Peter E M / Kalavrezos, Nicholas

    Head & neck

    2023  Volume 45, Issue 12, Page(s) 3168–3179

    Abstract: Despite the established benefits of negative-pressure wound therapy (NPWT) in various wound healing contexts, its application in head and neck surgical cases remains under-explored. This study aimed to systematically review its effectiveness, safety, and ...

    Abstract Despite the established benefits of negative-pressure wound therapy (NPWT) in various wound healing contexts, its application in head and neck surgical cases remains under-explored. This study aimed to systematically review its effectiveness, safety, and comparative efficacy. Thirty-one studies from a systematic literature search were identified and analyzed for wound healing response, overall success rate, improvements compared to conventional wound care, and variation in pressure settings, treatment lengths, and dressing change frequency. NPWT showed enhanced outcomes across diverse head and neck wounds, particularly complex post-reconstructive wounds and severe infections. Despite the predominantly case report/series evidence and lack of standardized NPWT protocols, its benefits over conventional care were clear. NPWT emerges as a promising approach for head and neck wound management, potentially improving patient outcomes and reducing complications. More randomized controlled trials are needed to solidify the evidence and standardize NPWT application protocols.
    MeSH term(s) Humans ; Device Removal ; Negative-Pressure Wound Therapy/methods ; Plastic Surgery Procedures ; Surgical Wound Infection ; Wound Healing
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1493: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Does Combined Access Mandibulotomy, Rim Mandibulectomy and Neck Dissection Compound the Late Effects of Radiotherapy?

    Tatsis, Dimitris / Kowa, Xin-Ying / Sinha, Deepti / Kalavrezos, Nicholas

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 6, Page(s) e5081

    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7091: Show issues Location:
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  3. Article ; Online: Contemporary management of advanced midface malignancy in the age of Instagram - a parallel surgical and patient's perspective.

    Fullerton, Hannah / Dawood, Andrew / Kalavrezos, Nicholas / Sinha, Deepti

    British dental journal

    2021  Volume 231, Issue 4, Page(s) 233–238

    Abstract: The internet and social media give our patients extraordinary access to information; in these unprecedented times of the COVID-19 pandemic, where so much of life takes place online, patients and professionals alike look to the internet more and more for ... ...

    Abstract The internet and social media give our patients extraordinary access to information; in these unprecedented times of the COVID-19 pandemic, where so much of life takes place online, patients and professionals alike look to the internet more and more for information and (self-)diagnosis. This article details the treatment journey for a patient with a high-grade chondroblastic osteosarcoma of the right maxilla, paranasal area and zygoma, from misdiagnosis through to resection and full rehabilitation with free flap surgery and implant reconstruction. Uniquely, the article details the patient's treatment, in parallel with her own perception of the treatment, as shared on social media.
    MeSH term(s) COVID-19 ; Female ; Humans ; Maxilla ; Neoplasms ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-021-3320-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 447: Show issues

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  4. Article ; Online: Vascularized free fibula flap oral rehabilitation using tissue engineered mucosa: Report of 3 cases.

    Vassiliou, Leandros V / Sinha, Deepti / Dawood, Andrew / Kalavrezos, Nicholas

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2022  Volume 50, Issue 6, Page(s) 485–492

    Abstract: The aim of this report is to introduce the use of the dermal substitute Integra® in the context of free fibula flap prelamination for mandibular reconstruction. Three cases of mandibular reconstruction with prefabricated and Integra-prelaminated ... ...

    Abstract The aim of this report is to introduce the use of the dermal substitute Integra® in the context of free fibula flap prelamination for mandibular reconstruction. Three cases of mandibular reconstruction with prefabricated and Integra-prelaminated vascularized fibula flaps are reported in this article. The patients reported in this case series presented with the following tumours: an extensive cemento-ossyfying fibroma, a multicystic ameloblastoma and an extensive calcifying epithelial odontogenic tumour. Virtual three-dimensional (3D) planning and 3D-printed cutting guides were used for the mandibulectomies, the flap harvest and the positioning of the implants. The dermal substitute Integra was used for prelamination instead of skin grafts. Treatment of all 3 patients was performed in two stages; the first consisted of the fibula prefabrication (dental implant insertion) and prelamination, and the second consisted of tumor resection and reconstruction with the vascularized implant-bearing fibula flap. Integra was shown to be able to generate complete mucosa-like tissue over the fibula flaps and in the peri-implant areas. The patients have been followed up for 1, 3 and 7 years, respectively, with satisfactory prosthetic, functional and aesthetic results. None of the patients developed peri-implant disease. It was observed that prelamination with the dermal substitute Integra leads to development of mucosal lining with clinical features similar to oral mucosa. In this report of three cases, use of Integra as part of the prelamination and prefabrication process, instead of skin grafts, appears able to clinically generate mucosal lining with avoidance of skin grafts.
    MeSH term(s) Bone Transplantation/methods ; Dental Implants ; Esthetics, Dental ; Fibula/transplantation ; Free Tissue Flaps/transplantation ; Humans ; Mandibular Reconstruction/methods ; Mouth Mucosa ; Reconstructive Surgical Procedures/methods
    Chemical Substances Dental Implants
    Language English
    Publishing date 2022-05-28
    Publishing country Scotland
    Document type Case Reports
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2022.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 882: Show issues Location:
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  5. Article ; Online: Correlation between oral and oropharyngeal resection subsites and impact of reconstruction on speech and swallowing function in head and neck cancer patients: A systematic review.

    Awad, Laura / Langridge, Benjamin J / Noy, Dani / Govender, Roganie / Sinha, Deepti / Butler, Peter Em / Kalavrezos, Nicholas

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2024  

    Abstract: This review aims to provide a correlation between oral and oropharyngeal subsites and type of reconstruction used in the management of head and neck cancer patients. A literature search of PubMed, Embase and Web of Science was conducted. All study types ... ...

    Abstract This review aims to provide a correlation between oral and oropharyngeal subsites and type of reconstruction used in the management of head and neck cancer patients. A literature search of PubMed, Embase and Web of Science was conducted. All study types describing long-term speech and swallow outcomes of adults following head and neck oncological reconstruction, which used a subsite classification, were included. Risk of bias was assessed using the Robbins-1 tool. A total of 2270 patients were found in 26 studies. The number of subsites/studies ranged from 2 to 18. Subsites were predominantly divided on an anatomical basis. Other classifications included functionally grouped subsites. Seven articles considered combinations, unilateral and bilateral defects. Base of tongue, FOM, and defects crossing the midline are negatively correlated with post-operative speech and swallow. Lateral distributions were associated with superior outcomes. The University of Washington Quality of Life Questionnaire (UW-QOL) was the most prevalent tool for speech and swallow assessment. Other factors that significantly affect speech and swallow outcomes include adjuvant therapy, size, type of reconstruction (free flap compared to pedicled or local). The role of neoadjuvant therapy remains unknown. A consistent and formalised approach including risk stratification for multiple contributing factors would be useful in clinical pre- and post-operative management.
    Language English
    Publishing date 2024-01-18
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2024.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Mouth Cancer for Clinicians. Part 8: Referral.

    Kalavrezos, Nicholas / Scully, Crispian

    Dental update

    2016  Volume 43, Issue 2, Page(s) 176–8, 181–2, 184–5

    Abstract: A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the ... ...

    Abstract A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the latest information and advances now employed in practice, in a form comprehensible to healthcare workers, patients and their carers. This series offers the primary care dental team in particular, an overview of the aetiopathogenesis, prevention, diagnosis and multidisciplinary care of mouth cancer, the functional and psychosocial implications, and minimization of the impact on the quality of life of patient and family. Clinical Relevance: This article offers the dental team an overview of referral procedures; oral diagnosis is not always simple and a second opinion can be valuable to all concerned in cases of doubt.
    MeSH term(s) Ambulatory Care ; Ambulatory Care Facilities ; Consumer Health Information ; Diagnosis, Differential ; Early Detection of Cancer ; Humans ; Mouth Neoplasms/diagnosis ; Patient Care Team ; Patient Education as Topic ; Practice Guidelines as Topic ; Primary Health Care ; Referral and Consultation ; State Dentistry ; United Kingdom
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 423728-6
    ISSN 0305-5000
    ISSN 0305-5000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2245: Show issues Location:
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    Zs.MO 362: Show issues

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  7. Article: Mouth Cancer for Clinicians Part 7: Cancer Diagnosis and Pre-treatment Preparation.

    Kalavrezos, Nicholas / Scully, Crispian

    Dental update

    2016  Volume 43, Issue 1, Page(s) 50–4, 57–60, 63–5

    Abstract: Unlabelled: A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most ... ...

    Abstract Unlabelled: A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the latest information and advances now employed in practice, in a form comprehensible to healthcare workers, patients and their carers. This series offers the primary care dental team in particular, an overview of the aetiopathogenesis, prevention, diagnosis and multidisciplinary care of mouth cancer, the functional and psychosocial implications, and minimization of the impact on the quality of life of patient and family.
    Clinical relevance: This article offers the dental team an overview of diagnosis, diagnostic and pre-treatment procedures.
    MeSH term(s) Biopsy/methods ; Diagnostic Imaging/methods ; Early Detection of Cancer ; Humans ; Mouth Neoplasms/diagnosis ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Physical Examination ; Precancerous Conditions/diagnosis
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 423728-6
    ISSN 0305-5000
    ISSN 0305-5000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2245: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 362: Show issues

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  8. Article: Mouth Cancer for Clinicians Part 10: Cancer Treatment (Surgery).

    Kalavrezos, Nicholas / Scully, Crispian

    Dental update

    2016  Volume 43, Issue 4, Page(s) 375–8, 381–2, 385–7

    Abstract: A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the ... ...

    Abstract A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the latest information and advances now employed in practice, in a form comprehensible to healthcare workers, patients and their carers. This series offers the primary care dental team in particular, an overview of the aetiopathogenesis, prevention, diagnosis and multidisciplinary care of mouth cancer, the functional and psychosocial implications, and minimization of the impact on the quality of life of patient and family. Clinical relevance: This article offers the dental team an overview of surgery for the treatment of mouth cancer.
    Language English
    Publishing date 2016-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 423728-6
    ISSN 0305-5000
    ISSN 0305-5000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2245: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 362: Show issues

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  9. Article: Mouth Cancer for Clinicians Part 12: Cancer Treatment (Chemotherapy and Targeted Therapy).

    Kalavrezos, Nicholas / Scully, Crispian

    Dental update

    2016  Volume 43, Issue 6, Page(s) 567–9, 571–2, 574

    Abstract: A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the ... ...

    Abstract A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the latest information and advances now employed in practice, in a form comprehensible to healthcare workers, patients and their carers. This series offers the primary care dental team in particular, an overview of the aetiopathogenesis, prevention, diagnosis and multidisciplinary care of mouth cancer, the functional and psychosocial implications, and minimization of the impact on the quality of life of patient and family. Clinical relevance: This article offers the dental team a brief overview of chemotherapy and targeted therapy.
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 423728-6
    ISSN 0305-5000
    ISSN 0305-5000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2245: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 362: Show issues

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  10. Article: Mouth Cancer for Clinicians Part 13: Life After Mouth Cancer Treatment.

    Kalavrezos, Nicholas / Scully, Crispian

    Dental update

    2016  Volume 43, Issue 7, Page(s) 672–4, 677–8, 681–2, 684–6

    Abstract: A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the ... ...

    Abstract A MEDLINE search early in 2015 revealed more than 250,000 papers on head and neck cancer; over 100,000 on oral cancer; and over 60,000 on mouth cancer. Not all publications contain robust evidence. We endeavour to encapsulate the most important of the latest information and advances now employed in practice, in a form comprehensible to healthcare workers, patients and their carers. This series offers the primary care dental team, in particular, an overview of the aetiopathogenesis, prevention, diagnosis and multidisciplinary care of mouth cancer, the functional and psychosocial implications, and minimization of the impact on the quality of life of patient and family. Clinical relevance: This article offers the dental team an overview of prognostication, quality of life and oral and dental healthcare.
    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 423728-6
    ISSN 0305-5000
    ISSN 0305-5000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2245: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 362: Show issues

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