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Article ; Online: Using Pericholedochal Varix Inflow for Complete Portal Vein Thrombosis in Living Donor Liver Transplantation: A Case Report.

Tırnova, İsmail / Karataş, Cihan / Mecit, Nesimi / Kanmaz, Turan / Kalayoğlu, Münci

2022 Volume 54, Issue 6, Page(s) 1654–1656

Abstract: One of the crucial steps of liver transplantation is to provide the portal inflow. Portal vein thrombosis is the most challenging factor to achieve. Using a pericholedochal varix for portal inflow in a patient with complete portal vein thrombosis in ... ...

Abstract	One of the crucial steps of liver transplantation is to provide the portal inflow. Portal vein thrombosis is the most challenging factor to achieve. Using a pericholedochal varix for portal inflow in a patient with complete portal vein thrombosis in living donor liver transplantation (LDLT) is a rare technique. We present our experience of a LDLT with PVT.
MeSH term(s)	Humans ; Liver Diseases/complications ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Living Donors ; Portal Vein/diagnostic imaging ; Portal Vein/surgery ; Varicose Veins/complications ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/etiology ; Venous Thrombosis/surgery
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2022.05.006
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Article ; Online: Cardiac Intervention Before Liver Transplantation.

Imam, Ashraf / Karatas, Cihan / Mecit, Nesimi / Kalayoglu, Munci / Kanmaz, Turan

Transplantation proceedings

2021 Volume 53, Issue 5, Page(s) 1622–1625

Abstract: Background: Cardiovascular complication is one of the leading causes of mortality after liver transplantation (LT). Thus, a thorough cardiac evaluation is a must before proceeding to a liver transplant surgery. Percutaneous coronary intervention (PCI) ... ...

Abstract	Background: Cardiovascular complication is one of the leading causes of mortality after liver transplantation (LT). Thus, a thorough cardiac evaluation is a must before proceeding to a liver transplant surgery. Percutaneous coronary intervention (PCI) with stent and to a lesser extent coronary artery bypass grafting (CABG) are both valuable treatment options for patients with coronary artery disease. Methods: A retrospective, single-center study that included patients who underwent cardiac intervention and subsequent LT for end-stage liver disease. All patients who had PCI or CABG were included in the study. Results: Twenty-nine adult patients out of 51 had a cardiac intervention before liver transplantation. Twenty-four patients had a diagnostic PCI, 3 patients had therapeutic PCI with stent, and 2 had failed PCI and proceeded to CABG before liver transplant. The mean age of the patients was 60.5 years. There were 24 men. All patients had cirrhosis. The 2 CABG cases were done during the same admission with a 13- and 18-day interval between the CABG and the transplantation. Both cases were live-related liver transplantation. No mortality was reported. Conclusion: In case of PCI failure, CABG may be a valuable and safe treatment option for cirrhotic patients as a preparation for liver transplantation. Live donor liver transplantation may be a good back-up for those patients in case they develop hepatic decompensation.
MeSH term(s)	Aged ; Coronary Artery Bypass ; Coronary Artery Disease/surgery ; Female ; Humans ; Liver Transplantation/adverse effects ; Living Donors ; Male ; Middle Aged ; Percutaneous Coronary Intervention ; Retrospective Studies
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2021.03.012
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Article: Complications and outcomes of 890 living liver donor hepatectomies at a single center: risks of saving loved one's life.

Yankol, Yücel / Mecit, Nesimi / Kanmaz, Turan / Kalayoğlu, Münci / Acarlı, Koray

Turkish journal of surgery

2020 Volume 36, Issue 2, Page(s) 192–201

Abstract: Objectives: Living liver donor surgery is a major surgical procedure applied to healthy people with mortality and morbidity risks and does not provide any direct therapeutic advantage to the donor. We retrospectively analyzed the postoperative ... ...

Abstract	Objectives: Living liver donor surgery is a major surgical procedure applied to healthy people with mortality and morbidity risks and does not provide any direct therapeutic advantage to the donor. We retrospectively analyzed the postoperative complication of our living liver donors to figure out the risks of donation. Material and methods: Between November, 2006 and December, 2018, a total of 939 living liver donor hepatectomies were performed with no mortality to the living-related donors. Eight hundred and ninety donors with a minimum 1-year follow-up were analyzed retrospectively. Results: Of the 890 donors, 519 (58.3%) were males and 371 (41.7%) were females. Mean age was 35 years (18-64) and mean body mass index was 25.7 kg/m Conclusion: All donor candidates should be well-informed not only on the details of early and late complications of living liver donation, also possible outcomes of the recipient. In addition to detailed physical evaluation, preoperative psychosocial evaluation is also mandatory. Comprehensive donor evaluation, surgical experience, surgical technique, close postoperative follow-up and establishing a good dialog with the donor allows better outcomes.
Language	English
Publishing date	2020-06-08
Publishing country	Turkey
Document type	Journal Article
ISSN	2564-6850
ISSN	2564-6850
DOI	10.5578/turkjsurg.4548
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Article ; Online: Starting a liver transplant program in Turkey; Akdeniz University model.

Kalayoğlu, Münci

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2008 Volume 19, Issue 1, Page(s) 1

MeSH term(s)	Hospitals, University/organization & administration ; Humans ; Liver Transplantation ; Models, Organizational ; Tissue and Organ Procurement/organization & administration ; Turkey
Language	English
Publishing date	2008-03
Publishing country	Turkey
Document type	Editorial
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
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Zs.A 4524: Show issues

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Article: Extreme living donation: A single center simultaneous and sequential living liver-kidney donor experience with long-term outcomes under literature review.

Yankol, Yücel / Karataş, Cihan / Kanmaz, Turan / Koçak, Burak / Kalayoğlu, Münci / Acarlı, Koray

Turkish journal of surgery

2021 Volume 37, Issue 3, Page(s) 207–214

Abstract: Objectives: Living liver and kidney donor surgeries are major surgical procedures applied to healthy people with mortality and morbidity risks not providing any direct therapeutic advantage to the donor. In this study, we aimed to share our simultaneous ...

Abstract	Objectives: Living liver and kidney donor surgeries are major surgical procedures applied to healthy people with mortality and morbidity risks not providing any direct therapeutic advantage to the donor. In this study, we aimed to share our simultaneous and sequential living liver-kidney donor experience under literature review in this worldwide rare practice. Material and methods: Between January 2007 and February 2018, a total of 1109 living donor nephrectomies and 867 living liver donor hepatectomies were performed with no mortality to living-related donors. Eight donors who were simultaneous or sequential living liver-kidney donors in this time period were retrospectively reviewed and presented with their minimum 2- year follow-up. Results: Of the 8 donors, 3 of them were simultaneous and 5 of them were sequential liver-kidney donation. All of them were close relatives. Mean age was 39 (26-61) years and mean BMI was 25.7 (17.7-40). In 3 donors, right lobe, in 4 donors, left lateral sector, and in 1 donor, left lobe hepatectomy were performed. Median hospital stay was 9 (7-13) days. Two donors experienced early and late postoperative complications (Grade 3b and Grade 1). No mortality and no other long-term complication occurred. Conclusion: Expansion of the donor pool by utilizing grafts from living donors is a globally-accepted proposition since it provides safety and successful outcomes. Simultaneous or sequential liver and kidney donation from the same donor seems to be a reasonable option for combined liver-kidney transplant recipients in special circumstances with acceptable outcomes.
Language	English
Publishing date	2021-09-28
Publishing country	Turkey
Document type	Journal Article
ISSN	2564-6850
ISSN	2564-6850
DOI	10.47717/turkjsurg.2021.5387
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Article ; Online: [No title information]

Yankol, Yücel / Hoş, Gültekin / Kanmaz, Turan / Mecit, Nesimi / Çakaloğlu, Yılmaz / Kalayoğlu, Münci / Acarlı, Koray Sadık

Turkish journal of medical sciences

2021 Volume 51, Issue 5, Page(s) 2383–2395

Abstract: Background/aim: With the increased experience in living donor liver transplantation (LDLT), it has been adopted for the treatment of hepatocellular carcinoma (HCC), with emerging discussions of criteria beyond tumor size and number. In contrast to ... ...

Abstract	Background/aim: With the increased experience in living donor liver transplantation (LDLT), it has been adopted for the treatment of hepatocellular carcinoma (HCC), with emerging discussions of criteria beyond tumor size and number. In contrast to deceased donor liver transplantation (DDLT), recipient selection for LDLT is not limited by organ allocation systems. We discuss herein the assessment, criteria, and experience with liver transplantation (LT) in HCC cases at a high-volume LDLT center. Material and methods: Between August 2006 and December 2017, 191 adult LT HCC recipients with at least one-year follow-up were retrospectively analyzed. Results: In 191 patients, one-, three- and five-year survival rates were 87.2%, 81.6%, and 76.2%, respectively, including early postoperative mortality. In 174 patients with long-term follow-up, one-, three- and five-year disease-free survival rates were 91.6%, 87.7%, and 84.4%, respectively. When multivariate analysis was utilized, tumor differentiation was the only factor which statistically affected survival (p = 0.025). Conclusion: LDLT allows us to push the limits forward and the question “Are the criteria always right?” is always on the table. We can conclude that, with the advantage of LDLT, every HCC patient deserves a case-by-case basis discussion for LT under scientific literature support. In borderline cases, tumor biopsy might help determine the decision for LT.
MeSH term(s)	Adolescent ; Adult ; Aged ; Carcinoma, Hepatocellular/surgery ; Female ; Humans ; Liver Neoplasms/surgery ; Liver Transplantation ; Living Donors ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-10-21
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2101-51
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Article ; Online: Liver Transplant and Improvements in Cholesterol Biosynthesis Defects: A Case Report of Smith-Lemli-Opitz Syndrome.

Ertugrul, Gokhan / Yankol, Yucel / Mecit, Nesimi / Kirimlioglu, Hale / Kanmaz, Turan / Acarli, Koray / Kalayoglu, Munci

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2019 Volume 20, Issue 1, Page(s) 104–107

Abstract: Smith-Lemli-Opitz syndrome is an autosomal recessive metabolic disease characterized by mental retardation and multiple congenital anomalies. The main pathology is the lack of the enzyme 3β-hydroxysterol Δ7-reductase, which is the last enzymatic step in ... ...

Abstract	Smith-Lemli-Opitz syndrome is an autosomal recessive metabolic disease characterized by mental retardation and multiple congenital anomalies. The main pathology is the lack of the enzyme 3β-hydroxysterol Δ7-reductase, which is the last enzymatic step in cholesterol synthesis, ending with a low cholesterol level. Cholesterol is vitally important in cell membranes and myelination of the nervous system. The cholesterol level affects many systems of the body, especially the nervous system. The cause of liver involvement in Smith-Lemli-Opitz syndrome is unclear, and many hypotheses have been suggested. Here, we present the early results of a patient with Smith-Lemli-Opitz syndrome who underwent living-donor liver transplant due to cirrhosis. As a result of liver transplant, normal cholesterol levels were shown, as well as improvements in the patient's neurodevelopment and behavior. Early liver transplant may be considered for patients with a defect of cholesterol biosynthesis, even in the absence of cirrhosis, and may be a future treatment option to prevent risks of neurologic deterioration.
MeSH term(s)	Cholesterol ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/surgery ; Liver Transplantation/adverse effects ; Living Donors ; Oxidoreductases Acting on CH-CH Group Donors ; Smith-Lemli-Opitz Syndrome/diagnosis ; Smith-Lemli-Opitz Syndrome/surgery ; Treatment Outcome
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-)
Language	English
Publishing date	2019-01-21
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2018.0131
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Article ; Online: Argininosuccinic Aciduria-A Rare Indication for Liver Transplant: Report of Two Cases.

Yankol, Yucel / Mecit, Nesimi / Kanmaz, Turan / Acarli, Koray / Kalayoglu, Munci

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2017 Volume 15, Issue 5, Page(s) 581–584

Abstract: Argininosuccinic aciduria is a urea cycle disorder caused by an argininosuccinate lyase enzyme deficiency that ends with nitrogen accumulation as ammonia. Argininosuccinic aciduria patients are at risk for long-term complications including poor ... ...

Abstract	Argininosuccinic aciduria is a urea cycle disorder caused by an argininosuccinate lyase enzyme deficiency that ends with nitrogen accumulation as ammonia. Argininosuccinic aciduria patients are at risk for long-term complications including poor neurocognitive outcome, hepatic disease, and systemic hypertension despite strict pharmacologic and dietary therapy. As the liver is the principle site of activity of the urea cycle, it is logical that a liver transplant should be an option, with careful patient selection, even in the absence of cirrhosis. We present 2 pediatric argininosuccinic aciduria patients who underwent a living-donor liver transplant from their mothers. After the liver transplant, the general well-being of the patients and their quality of life improved significantly. Liver transplant should be an option for argininosuccinic aciduria patients to prevent further neurologic deterioration and improve the patient's quality of life.
Language	English
Publishing date	2017-10
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2015.0078
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Article ; Online: Oligosymptomatic Kidney Transplant Patients With COVID-19: Do They Pose a Risk to Other Recipients?

Kocak, Burak / Arpali, Emre / Akyollu, Basak / Yelken, Berna / Tekin, Suda / Kanbay, Mehmet / Turkmen, Aydin / Kalayoglu, Munci

Transplantation proceedings

2020 Volume 52, Issue 9, Page(s) 2663–2666

Abstract: The clinical course of viral infections in patients under immunosuppression can be atypical and/or fatal if not diagnosed and treated appropriately. The coronavirus disease 2019 (COVID-19) may also have an atypical presentation. Contrary to the general ... ...

Abstract	The clinical course of viral infections in patients under immunosuppression can be atypical and/or fatal if not diagnosed and treated appropriately. The coronavirus disease 2019 (COVID-19) may also have an atypical presentation. Contrary to the general opinion, transplant patients may be asymptomatic or oligosymptomatic, which could be a risk factor for underdiagnosis and the dissemination of this viral disease. This study presents the clinical features of 2 oligosymptomatic kidney transplant patients diagnosed with COVID-19. We suggest that new screening algorithms for COVID-19 should be reconsidered for the transplant patient population.
MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/immunology ; Female ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Middle Aged ; Pandemics ; Pneumonia, Viral/immunology ; Risk Factors ; SARS-CoV-2 ; Transplant Recipients
Chemical Substances	Immunosuppressive Agents
Keywords	covid19
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2020.05.028
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Book ; Online: Oligosymptomatic kidney transplant patients with COVID-19

Arpalı, Emre / Akyollu, Başak / Koçak, Burak / Yelken, Berna / Kalayoğlu, Münci / Türkmen, Aydın / Koruk, Süda Tekin / Kanbay, Mehmet (ORCID 0000-0002-1297-0675 & YÖK ID 110580)

Transplantation Proceedings

do they pose a risk to other recipients?

2020

Abstract	The clinical course of viral infections in patients under immunosuppression can be atypical and/or fatal if not diagnosed and treated appropriately. The coronavirus disease 2019 (COVID-19) may also have an atypical presentation. Contrary to the general opinion, transplant patients may be asymptomatic or oligosymptomatic, which could be a risk factor for underdiagnosis and the dissemination of this viral disease. This study presents the clinical features of 2 oligosymptomatic kidney transplant patients diagnosed with COVID-19. We suggest that new screening algorithms for COVID-19 should be reconsidered for the transplant patient population.
Keywords	Medicine ; Middle East respiratory syndrome coronavirus ; Coronavirus infections ; covid19
Language	English
Publisher	Elsevier
Publishing country	tr
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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