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  1. Article ; Online: Should post-operative stereotactic radiosurgery be the standard of care in Craniopharyngioma patients?

    Gupta, Saurabh / Agrawal, Deepak / Kedia, Shweta / Kale, Shashank Sharad

    World neurosurgery: X

    2024  Volume 22, Page(s) 100327

    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Journal Article
    ISSN 2590-1397
    ISSN (online) 2590-1397
    DOI 10.1016/j.wnsx.2024.100327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction of pediatric cervical kyphosis: our experience and systematic-literature review.

    Kumarasamy, Sivaraman / Sawarkar, Dattaraj Parmanand / Singh, Pankaj Kumar / Kumar, Rajinder / Chandra, Poodipedi Sarat / Kale, Shashank Sharad

    Spine deformity

    2024  Volume 12, Issue 3, Page(s) 603–620

    Abstract: Background: Pediatric cervical kyphosis is a distinct entity with diverse etiology (congenital, syndromic, traumatic, metabolic or neoplastic). Surgical correction in pediatric population is challenging due to their growing spine and low blood volume.!## ...

    Abstract Background: Pediatric cervical kyphosis is a distinct entity with diverse etiology (congenital, syndromic, traumatic, metabolic or neoplastic). Surgical correction in pediatric population is challenging due to their growing spine and low blood volume.
    Purpose: To analyse their presentation, surgical techniques and outcome of pediatric cervical kyphosis and systematically review the pertinent literature.
    Design: Retrospective study.
    Patient sample: 16 patients aged ≤ 18 years who underwent correction for cervical kyphosis between 2009 and 2021.
    Outcome measures: Nurick's grading, mJOA score and Global cobb's angle.
    Methods: Clinical parameters (Nurick grading and mJOA score) were noted from database on admission and on follow-up at 6 months. Radiological parameters of assessment included Global Cobb's angle. The C2-C7 Cobb angle was the angle of C2 vertebra lower end plate and C7 vertebra lower end plate. For C1-2 kyphosis, anterior border of C1 and anterior border of C2 angle was taken. Radiographic parameters were studied on CT and radiographs of cervical spine to assess for stability, the degree of deformity correction and fusion status at 6 months follow-up.
    Results: 16 patients with mean age of 14.2 ± 3 years (9 syndromic, 4 post-traumatic, 2 metabolic and 1 post-laminectomy). All underwent surgical correction, 6 underwent Antero-posterior spinal fusion, 6 underwent Posterior spinal fusion and 4 underwent Anterior spinal fusion. There was significant clinical improvement postoperatively with-Nurick grade (pre vs. post: 2.8 vs. 1.8, p = 0.004), mJOA score (pre vs. post: 11.3 vs. 14, p = 0.003). There was significant deformity correction of Cobb's angle from 40.7 ± 26.5° to 14.9 ± 10° (p = 0.001). Early complications included intraoperative hemodynamic instability (3) and wound complication (1). Mean follow-up was 76.9 ± 59.3 months.
    Conclusion: Pediatric cervical kyphosis is a debilitating condition which are managed surgically. Approach has to be individualized to the pathology and good results can be achieved. Patients should be screened for syndromic association and followed-up regularly.
    MeSH term(s) Humans ; Kyphosis/surgery ; Kyphosis/diagnostic imaging ; Kyphosis/etiology ; Cervical Vertebrae/surgery ; Cervical Vertebrae/diagnostic imaging ; Adolescent ; Spinal Fusion/methods ; Child ; Retrospective Studies ; Male ; Female ; Treatment Outcome
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2717704-X
    ISSN 2212-1358 ; 2212-134X ; 2212-1358
    ISSN (online) 2212-1358 ; 2212-134X
    ISSN 2212-1358
    DOI 10.1007/s43390-023-00809-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gamma Knife Stereotactic Radiosurgery for Giant Intracranial Tumors - A Series of 70 Patients.

    Verma, Satish Kumar / Agrawal, Deepak / Santhoor, Hemanth Amardeep / Singh, Manmohan / Kale, Shashank Sharad

    Neurology India

    2023  Volume 71, Issue Supplement, Page(s) S123–S132

    Abstract: Background and objective: Surgery remains the primary option in large intracranial tumors, but significant number of patients may not be amenable for surgery. We explored the role of stereotactic radiosurgery as an alternative to external beam radiation ...

    Abstract Background and objective: Surgery remains the primary option in large intracranial tumors, but significant number of patients may not be amenable for surgery. We explored the role of stereotactic radiosurgery as an alternative to external beam radiation therapy (EBRT) in such patients. Our study objective was to assess the clinicoradiological outcomes of large intracranial tumors (volume ≥20 cm
    Materials and methods: This was a single-center, retrospective study conducted from January 2012 to December 2019. Patients with intracranial tumor volume ≥20 cm
    Results: Seventy patients who had a pre-GKRS tumor volume ≥20 cm
    Conclusion: The present series defines "large intracranial lesions" for GKRS and demonstrates excellent radiological and clinical outcomes in these patients. GKRS may be considered as the primary option in such large intracranial lesions in which surgery carries significant risk based on patient-related factors.
    MeSH term(s) Humans ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Radiosurgery/adverse effects ; Follow-Up Studies ; Retrospective Studies ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/surgery ; Brain Neoplasms/etiology ; Treatment Outcome
    Language English
    Publishing date 2023-03-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.373627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Posterior reversible encephalopathy syndrome following cervical spine surgery: insights from an interesting case.

    Phalak, Manoj / Ganeshkumar, Akshay / Sharma, Ravi / Kale, Shashank Sharad

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2022  Volume 39, Issue 4, Page(s) 1089–1092

    Abstract: A 14-month child presenting with complaints of spastic paraplegia was diagnosed with C6-D1 intramedullary cyst. A cysto-subarachnoid shunt was performed; the patient was clinically stable in the immediate post-operative period. On post-operative day 2, ... ...

    Abstract A 14-month child presenting with complaints of spastic paraplegia was diagnosed with C6-D1 intramedullary cyst. A cysto-subarachnoid shunt was performed; the patient was clinically stable in the immediate post-operative period. On post-operative day 2, the patient developed multiple episodes of generalized tonic-clonic seizures (GTCS) with altered sensorium, NCCT head revealed bilateral diffuse parieto-occipital hypodensities. MRI brain showed on T2WI and FLAIR, diffuse hyperintensities in bilateral parieto-occipital region suggestive of posterior reversible encephalopathy syndrome (PRES). The patient never experienced hypertensive episodes and was treated with anti-epileptics. The patient's symptoms improved and repeat MRI after 10 weeks revealed normal signal intensity in bilateral parieto-occipital areas. PRES after spinal surgeries is very rare and more so in pediatric cases, CSF hypotension may contribute to PRES in such cases.
    MeSH term(s) Humans ; Child ; Posterior Leukoencephalopathy Syndrome/diagnostic imaging ; Posterior Leukoencephalopathy Syndrome/etiology ; Seizures ; Magnetic Resonance Imaging ; Neuroimaging ; Cervical Vertebrae
    Language English
    Publishing date 2022-12-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-022-05726-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Non-chordomatous clival bony tumors: A rare experience and systematic literature review.

    Kumarasamy, Sivaraman / Kumar, Amandeep / Singh, Pankaj Kumar / Suri, Ashish / Chandra, Poodipedi Sarat / Kale, Shashank Sharad

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Volume 40, Issue 4, Page(s) 1065–1077

    Abstract: Background: Non-chordomatous bony tumors of the clivus are extremely rare. Site, extent, and aggressiveness of tumor limits the extent of resection. It poses challenge to the neurosurgeons due to the complexity of anatomy. There is paucity of literature ...

    Abstract Background: Non-chordomatous bony tumors of the clivus are extremely rare. Site, extent, and aggressiveness of tumor limits the extent of resection. It poses challenge to the neurosurgeons due to the complexity of anatomy. There is paucity of literature exclusively on non-chordomatous bone tumors of the clivus in young adults.
    Objectives: To analyze the clinical presentation, imaging findings, surgical approach, complications, and outcome of primary clival bony tumors in young adults.
    Methods: We retrospectively reviewed children and young adults with primary clival bony tumors excluding chordoma who underwent surgical resection between years 2010 and 2023 in our center. We analyzed the demographic details, imaging findings, operative variables, perioperative complications, length of stay, complications, and outcome at latest follow-up.
    Results: The mean age was 17.5 ± 1.73 years (range 16 to 19 years). Headache was the presenting complaint in all four patients (100%). The mean duration of symptom was 7.25 ± 3.2 months (range 5 to 12 months). The tumor was localized in clivus in all four patients (100%). The mean length of stay in hospital was 30.5 ± 13.48 days (range 11 to 40 days). All patients underwent surgical treatment. Surgical approaches used were anterior approach in four patients (100%). Gross total excision was performed in one patient (25%), sub-total excision was performed in two patients (50%), and tumor decompression was performed in one patient (25%). Of these, three were designated as having benign tumors and one had a malignant tumor. There was no perioperative mortality. There was one mortality (25%) on 2 months follow-up due to tumor progression. Three patients (75%) had improved symptomatically at latest follow-up. Two patients (50%) received adjuvant chemoradiotherapy. The mean follow-up was 38 ± 39.29 months (range 2 to 72 months).
    Conclusion: Non-chordomatous bony tumors of the clivus are rare and often underestimated. Surgery is the treatment of choice. Tumor consistency and adhesion to critical neurovascular structures precludes gross total resection. Various approaches are in the armamentarium. Approach to be decided based on the expertise of the neurosurgeon to achieve safe maximal resection. Multidisciplinary approach is mandatory for streamlined management. Adjuvant therapy is decided based on the residual tumor following surgery.
    MeSH term(s) Young Adult ; Child ; Humans ; Adolescent ; Adult ; Follow-Up Studies ; Retrospective Studies ; Chordoma/surgery ; Bone Neoplasms/pathology ; Cranial Fossa, Posterior/surgery ; Skull Base Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-12-05
    Publishing country Germany
    Document type Systematic Review ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-06237-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cervical kyphosis correction in Marfan syndrome: our experience and literature review.

    Kumarasamy, Sivaraman / Sawarkar, Dattaraj P / Singh, Pankaj Kumar / Kumar, Rajinder / Chandra, Poodipedi Sarat / Kale, Shashank Sharad

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Volume 40, Issue 2, Page(s) 495–502

    Abstract: Background: Spinal deformities are common in Marfan syndrome (MFS). They usually involve the thoraco-lumbar spine but rarely involves the cervical spine. Kyphosis is the common spine deformity of the cervical spine and mandates surgical correction as ... ...

    Abstract Background: Spinal deformities are common in Marfan syndrome (MFS). They usually involve the thoraco-lumbar spine but rarely involves the cervical spine. Kyphosis is the common spine deformity of the cervical spine and mandates surgical correction as they are at risk of neurological deterioration since they are refractory to conservative management. Few studies of surgical correction of spine deformity included cervical deformity.
    Objectives: To analyze the challenges faced during surgery, clinical and radiological outcome, and complications following surgical correction for cervical kyphosis in Marfan syndrome.
    Methods: We identified that 5 patients with a diagnosis of MFS with cervical kyphosis who underwent fusion surgery between the years 2010 and 2022 were reviewed, retrospectively. We analyzed the demographic details, radiological parameters, operative variables (blood loss and nuances), perioperative complications, length of stay, clinical and radiological outcome, and complications following fusion surgery for cervical kyphosis in MFS.
    Results: The mean age of patients was 16.6 ± 4.72 years (range, 12-23 years). The average kyphotic vertebra involved is 3 ± 0.7 bodies (range 2-4) with 2 patients with thoracic deformity. All patients underwent surgical deformity correction. All patients improved clinically with Nurick grade (pre vs. post: 3.4 vs. 2.2) and mJOA (pre vs. post: 8.2 vs. 12.6). There was significant deformity correction from 37.48° to 9.1°. Mean blood loss encountered was 900 ± 173.2 ml. Perioperative complications: wound complication with CSF leak (1). Late complications: ventilator dependence (1) and junctional kyphosis (1). Mean length of hospital stay was 103 ± 178.9 days. All patients were doing symptomatically better after mean follow-up of 58 ± 28.32 months. One patient is bedridden and hospitalized.
    Conclusion: Cervical kyphosis is a rare spine deformity in patients with MFS, and they usually present with neurological deterioration mandating surgical correction. Multidisciplinary approach (pediatrics, genetics and cardiology) is required for systematic evaluation of these patients. They should be evaluated with necessary imaging to rule out associated spinal deformity (atlanto-axial subluxation, scoliosis, and intraspinal pathology like ductal ectasia). Our results suggest better surgical outcome in terms of low operative complications with neurologic improvement in MFS patients. These patients require regular follow-up to identify late complications (instrument failure, non-union, and pseudarthrosis).
    MeSH term(s) Humans ; Child ; Adolescent ; Young Adult ; Adult ; Marfan Syndrome/complications ; Marfan Syndrome/surgery ; Retrospective Studies ; Treatment Outcome ; Kyphosis/diagnostic imaging ; Kyphosis/etiology ; Kyphosis/surgery ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Spinal Fusion/methods
    Language English
    Publishing date 2023-07-01
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-06046-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Extra-skeletal intracranial mesenchymal chondrosarcoma: systematic-literature review.

    Kumarasamy, Sivaraman / Garg, Kanwaljeet / Garg, Ajay / Sharma, M C / Singh, Manmohanjit / Chandra, Poodipedi Sarat / Kale, Shashank Sharad

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2024  

    Abstract: Background: Intracranial mesenchymal chondrosarcoma (IMC) is a rare malignant tumor in pediatric population. IMC can present as extra- or intra-axial lesion in pediatric patients, though the former is commoner causing raised intracranial pressure (ICP). ...

    Abstract Background: Intracranial mesenchymal chondrosarcoma (IMC) is a rare malignant tumor in pediatric population. IMC can present as extra- or intra-axial lesion in pediatric patients, though the former is commoner causing raised intracranial pressure (ICP). Radiological diagnosis is a challenge in these cases, as is it difficult to differentiate these from other extra-axial neoplasms due to the wide differential diagnosis in pediatric population. We aim to systematically review the literature and present a rare case of extraskeletal intracranial mesenchymal chondrosarcoma treated with safe maximal resection.
    Methods: A systematic review of literature was conducted in accordance with PRISMA guidelines. PubMed and Scopus databases were queried using the search terms, "primary intracranial chondrosarcoma", "extraskeletal mesenchymal chondrosarcoma", "mesenchymal chondrosarcoma" and "pediatric". Presentation, surgical management and outcome of a 15-year-old male with an extraskeletal IMC are also described.
    Results: The search yielded 25 articles which met the inclusion criteria. These published records consisted of 33 IMC cases with mean age at presentation of 9.81 ± 5.2 years (range 2 months to 18 years). Frontal region was the commonest locations (11, 33.3%). Most common presentation was headache (14, 42.4%). All patients underwent surgical intervention: gross total resection (20, 60.6%), subtotal resection (9, 27.3%) and no extent mentioned (4, 12.1%). No adjuvant therapy was received in 15 patients (45.5%). On latest follow-up, 11 patients (33.3%) are on remission, 5 patients (15.2%) are symptom free, 3 patients (9.1%) had recurrence, 2 patients (6.1%) had metastasis and 9 patients (27.3%) expired.
    Conclusion: IMC is a rare entity in pediatric population with imaging findings which are non-characteristic leading to its diagnostic challenge. It can masquerade as other extra-axial intracranial neoplasm (meningioma or hemangiopericytoma). Combination of clinico-radiological and pathological examination can help in accurate diagnosis.  Safe Maximal resection followed by radiotherapy is the preferred treatment strategy.
    Language English
    Publishing date 2024-05-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-024-06452-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Investigation of optimal planning strategy in gamma knife perfexion for vestibular schwannoma tumor using hybrid plan technique.

    Agarwal, Priyanka / Natanasabapathi, Gopishankar / Bisht, Raj Kishor / Malhotra, Rajeev Kumar / Kale, Shashank Sharad

    Biomedical physics & engineering express

    2022  Volume 8, Issue 6

    Abstract: Purpose. ...

    Abstract Purpose.
    MeSH term(s) Humans ; Radiosurgery/methods ; Neuroma, Acoustic/diagnostic imaging ; Neuroma, Acoustic/surgery ; Radiotherapy Dosage ; Algorithms ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article
    ISSN 2057-1976
    ISSN (online) 2057-1976
    DOI 10.1088/2057-1976/ac9abb
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Surgical challenges and functional outcomes in dystrophic cervical kyphosis in Neurofibromatosis -1: an institutional experience.

    Murlidharan, Shrijith / Singh, Pankaj Kumar / Chandra, P Sarat / Agarwal, Deepak / Kale, Shashank Sharad

    Spine deformity

    2022  Volume 10, Issue 3, Page(s) 697–707

    Abstract: Objective: Dystrophic cervical kyphosis secondary to neurofibromatosis 1 (NF1) is rarely reported. The primary objective is to highlight the clinical presentation and surgical outcomes based on clinical and biomechanical parameters. The secondary ... ...

    Abstract Objective: Dystrophic cervical kyphosis secondary to neurofibromatosis 1 (NF1) is rarely reported. The primary objective is to highlight the clinical presentation and surgical outcomes based on clinical and biomechanical parameters. The secondary objective is to highlight the early and late complications of these surgeries.
    Methods: The hospital records of six patients operated between 2008 and 2018 were retrospectively reviewed with a minimum follow-up of 24 months. Besides demographics information, radiological findings and operative details, the outcome measures reported were neurological (MJOA score, Nurick scale), pain (VAS score) and operative complications.
    Results: The mean age of patients was 15.1 years (8-32 years). The average kyphotic vertebra involved-3.6 bodies (range 2-5 bodies) with four patients showing intraspinal anomaly-neurofibromas, dural ectasia. Clinically, patients improved postoperatively with-VAS (pre vs. post-: 6.6 vs. 2.6, p - < 0.05), MJOA score (pre vs. post: 10.3 vs. 13.3, p - < 0.05), Nurick grade (pre vs. post: 3.5 vs. 2.1, p - < 0.05). There was significant deformity correction from 66.8° to 20.7° (p value < 0.031), mean T1 Slope (pre vs. post - 1.8 ± 20.4 to 0.6 ± 12.8, p value - < 0.43). Mean blood loss encountered was 1800 ± 434.6 cc; however, patients with paraspinal neurofibromas reported greater blood loss. Late complications included pseudoarthrosis (1), C5 palsy (1) and junctional kyphosis (1). Vertebral dysplasia and erosions continued in all patients post-operatively.
    Conclusions: Antero-posterior approach provides circumferential decompression and better sagittal balance correction. Cervical spine must be screened in all NF-1 patients and followed up regularly to assess for dystrophic changes.
    MeSH term(s) Adolescent ; Adult ; Cervical Vertebrae ; Child ; Humans ; Kyphosis/diagnostic imaging ; Kyphosis/etiology ; Kyphosis/surgery ; Neurofibromatosis 1/complications ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2717704-X
    ISSN 2212-1358 ; 2212-134X ; 2212-1358
    ISSN (online) 2212-1358 ; 2212-134X
    ISSN 2212-1358
    DOI 10.1007/s43390-021-00465-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Metabolic imaging in recurrent gliomas: comparative performance of 18F-FDOPA, 18F-fluorocholine and 18F-FDG PET/CT.

    Sharma, Anshul / Garg, Ajay / Singh, Manmohan / Sharma, Mehar Chand / Gupta, Subhash / Kunhiparambath, Haresh / Tripathi, Madhavi / Kale, Shashank Sharad / Bal, Chandrasekhar

    Nuclear medicine communications

    2023  Volume 45, Issue 2, Page(s) 139–147

    Abstract: Purpose: The aim of this study was to directly evaluate glucose, amino-acid and membrane metabolism in tumor cells for diagnosis and prognostication of recurrent gliomas.: Methods: Fifty-five patients (median age = 36 years; 33 men) with ... ...

    Abstract Purpose: The aim of this study was to directly evaluate glucose, amino-acid and membrane metabolism in tumor cells for diagnosis and prognostication of recurrent gliomas.
    Methods: Fifty-five patients (median age = 36 years; 33 men) with histologically proven gliomas and suspected recurrence were prospectively recruited and underwent 18F-FDG (Fluorodeoxyglucose), 18F-FDOPA (fluorodopa) and 18F-Fluorocholine-PET/CT. Images were evaluated by two physicians visually and quantitatively [lesion-SUVmax, tumor (T) to gray-matter (G) and metabolically-active tumor volumes (MTV)]. After median follow-up of 51.5 months, recurrence was diagnosed in 49 patients. Thirty-one patients died with a median survival of 14 months.
    Results: Diagnostic-accuracies for 18F-FDOPA, 18F-Fluorocholine,18F-FDG and contrast-enhanced-MRI were 92.7% (95% CI 82.7-97.1), 81.8% (69.7-89.8), 45.5% (33.0-58.5) and 44.7% (30.2-60.3), respectively. Among the 20 lesions, missed by MRI; 18F-FDOPA, 18F-Fluorocholine and 18F-FDG were able to detect 19, 14 and 4 lesions. Corresponding area-under-the-curves (T/G ratios) were 0.817 (0.615-1.000), 0.850 (0.736-0.963) and 0.814 (0.658-0.969), when differentiating recurrence from treatment-induced changes. In univariate-survival-analysis, 18F-FDOPA-T/G, visually detectable recurrence in 18F-FDG, 18F-FDOPA-MTV, cell-lineage and treatment-type were significant parameters. In Multivariate-Cox-regression analysis, 18F-FDOPA-MTV [HR = 1.009 (1.001-1.017); P  = 0.024 (~0.9% increase in hazard for every mL increase of MTV)] and cell-lineage [3.578 (1.447-8.846); P  = 0.006] remained significant. 18F-FDOPA-MTV cutoff <29.59 mL predicted survival higher than 2 years. At cutoff ≥29.59 mL, HR at 2 years was 2.759 (1.310-5.810).
    Conclusion: 18F-FDOPA-PET/CT can diagnose recurrence with high accuracy and MTV predicts survival. 18F-Fluorocholine is a good alternative. Higher 18F-FDG uptake is an adverse prognostic indicator.
    MeSH term(s) Male ; Humans ; Adult ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Neoplasm Recurrence, Local/diagnostic imaging ; Glioma/diagnostic imaging ; Prognosis ; Retrospective Studies ; Radiopharmaceuticals ; Tumor Burden
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; fluorodopa F 18 (2C598205QX) ; fluorocholine (6029HGL0QP) ; fluoromethylcholine ; Radiopharmaceuticals
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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