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  1. Article ; Online: Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action.

    Macegoniuk, Katarzyna / Tabor, Wojciech / Mazzei, Luca / Cianci, Michele / Giurg, Mirosław / Olech, Kamila / Burda-Grabowska, Małgorzata / Kaleta, Rafał / Grabowiecka, Agnieszka / Mucha, Artur / Ciurli, Stefano / Berlicki, Łukasz

    Journal of medicinal chemistry

    2023  Volume 66, Issue 3, Page(s) 2054–2063

    Abstract: Screening of 25 analogs of Ebselen, diversified at the N-aromatic residue, led to the identification of the most potent inhibitors ... ...

    Abstract Screening of 25 analogs of Ebselen, diversified at the N-aromatic residue, led to the identification of the most potent inhibitors of
    MeSH term(s) Urease ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Bacteria/metabolism ; Isoindoles/pharmacology ; Azoles/pharmacology
    Chemical Substances Urease (EC 3.5.1.5) ; ebselen (40X2P7DPGH) ; Enzyme Inhibitors ; Isoindoles ; Azoles
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.2c01799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

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  2. Article ; Online: Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL

    Zmudzinski, Mikolaj / Rut, Wioletta / Olech, Kamila / Granda, Jarosław / Giurg, Mirosław / Burda-Grabowska, Małgorzata / Kaleta, Rafał / Zgarbova, Michala / Kasprzyk, Renata / Zhang, Linlin / Sun, Xinyuanyuan / Lv, Zongyang / Nayak, Digant / Kesik-Brodacka, Malgorzata / Olsen, Shaun K / Weber, Jan / Hilgenfeld, Rolf / Jemielity, Jacek / Drag, Marcin

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9161

    Abstract: Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease ( ... ...

    Abstract Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (M
    MeSH term(s) Humans ; SARS-CoV-2/metabolism ; COVID-19 ; Methyltransferases ; Peptide Hydrolases ; Antiviral Agents/pharmacology ; Antiviral Agents/metabolism ; Cysteine Endopeptidases/metabolism ; Protease Inhibitors/pharmacology ; Molecular Docking Simulation
    Chemical Substances ebselen (40X2P7DPGH) ; Methyltransferases (EC 2.1.1.-) ; Peptide Hydrolases (EC 3.4.-) ; Antiviral Agents ; Cysteine Endopeptidases (EC 3.4.22.-) ; Protease Inhibitors
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35907-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reaction of bis[(2-chlorocarbonyl)phenyl] Diselenide with Phenols, Aminophenols, and Other Amines towards Diphenyl Diselenides with Antimicrobial and Antiviral Properties.

    Giurg, Mirosław / Gołąb, Anna / Suchodolski, Jakub / Kaleta, Rafał / Krasowska, Anna / Piasecki, Egbert / Piętka-Ottlik, Magdalena

    Molecules (Basel, Switzerland)

    2017  Volume 22, Issue 6

    Abstract: A reaction of bis[(2-chlorocarbonyl)phenyl] diselenide with various mono and bisnucleophiles such as aminophenols, phenols, and amines have been studied as a convenient general route to a series of new antimicrobial and antiviral diphenyl diselenides. ... ...

    Abstract A reaction of bis[(2-chlorocarbonyl)phenyl] diselenide with various mono and bisnucleophiles such as aminophenols, phenols, and amines have been studied as a convenient general route to a series of new antimicrobial and antiviral diphenyl diselenides. The compounds, particularly bis[2-(hydroxyphenylcarbamoyl)]phenyl diselenides and reference benzisoselenazol-3(2
    MeSH term(s) Amines/chemical synthesis ; Amines/chemistry ; Aminophenols/chemical synthesis ; Aminophenols/chemistry ; Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Benzene Derivatives/chemical synthesis ; Benzene Derivatives/chemistry ; Benzene Derivatives/pharmacology ; Candida/drug effects ; Candida/pathogenicity ; Escherichia coli/drug effects ; Escherichia coli/pathogenicity ; Herpesvirus 1, Human/drug effects ; Herpesvirus 1, Human/pathogenicity ; Humans ; Microbial Sensitivity Tests ; Organoselenium Compounds/chemical synthesis ; Organoselenium Compounds/chemistry ; Organoselenium Compounds/pharmacology ; Phenols/chemical synthesis ; Phenols/chemistry
    Chemical Substances Amines ; Aminophenols ; Anti-Infective Agents ; Antifungal Agents ; Antioxidants ; Antiviral Agents ; Benzene Derivatives ; Organoselenium Compounds ; Phenols ; diphenyldiselenide (1666-13-3)
    Language English
    Publishing date 2017-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules22060974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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