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  1. AU="Kalima, Pota"
  2. AU="Charisi, Martha"
  3. AU="Carrie L. Byington"
  4. AU="Weakland, Leo F"
  5. AU="Johannes Müller"
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  1. Article ; Online: National case series of group A streptococcus pleural empyema in children: clinical and microbiological features.

    Holdstock, Victoria / Twynam-Perkins, Jonathan / Bradnock, Timothy / Dickson, Elizabeth M / Harvey-Wood, Kathleen / Kalima, Pota / King, Jill / Olver, William J / Osman, Mustafa / Sabharwal, Atul / Smith, Andrew / Unger, Stefan / Pollock, Louisa / Langley, Ross / Davies, Philip / Williams, Thomas C

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 2, Page(s) 154–156

    MeSH term(s) Child ; Humans ; Empyema, Pleural/microbiology ; Streptococcus pneumoniae ; Streptococcus pyogenes
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00008-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A case of cutaneous toxigenic

    Othieno, Richard / Mark, Kate / Etherson, Michelle / Foster, Geoffrey / Murray, Steven / Kalima, Pota / Fry, Norman K / Cameron, Claire / Strachan, Jenni

    Access microbiology

    2019  Volume 1, Issue 7, Page(s) e000025

    Abstract: Introduction: Corynebacterium ulcerans: Case presentation: A 60-year-old female presented with a slow-healing finger-burn wound. A skin swab cultured : Conclusion: This was a rare case of cutaneous diphtheria secondary ... ...

    Abstract Introduction: Corynebacterium ulcerans
    Case presentation: A 60-year-old female presented with a slow-healing finger-burn wound. A skin swab cultured
    Conclusion: This was a rare case of cutaneous diphtheria secondary to
    Language English
    Publishing date 2019-05-30
    Publishing country England
    Document type Case Reports
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluating the Safety of Performing Flexible Cystoscopy When Urinalysis Suggests Presence of "Infection": Results of a Prospective Clinical Study in 2350 patients.

    Trail, Matthew / Cullen, Julia / Fulton, Emma / Clayton, Faye / McGregor, Ewan / McWilliam, Faye / Dick, Lachlan / Kalima, Pota / Donat, Roland / Mariappan, Paramananthan

    European urology open science

    2021  Volume 31, Page(s) 28–36

    Abstract: Background: There is significant underutilisation of allocated health service resources when a scheduled flexible cystoscopy (FC) is cancelled because a pre-cystoscopy urinalysis (PCU) suggests "infection", despite patients being asymptomatic for ... ...

    Abstract Background: There is significant underutilisation of allocated health service resources when a scheduled flexible cystoscopy (FC) is cancelled because a pre-cystoscopy urinalysis (PCU) suggests "infection", despite patients being asymptomatic for urinary tract infection (UTI).
    Objective: To evaluate the risk of UTI or urinary sepsis when FC is performed in asymptomatic patients with a PCU positive for leucocyte esterase and/or nitrites.
    Design setting and participants: A prospective cohort study was conducted in a high-volume UK centre recruiting all patients undergoing outpatient FC.
    Intervention: A protocol was developed to guide response to PCU performed prior to FC, which was performed regardless of the result, unless patients were symptomatic for UTI. All patients completed a questionnaire to identify risk factors and were followed up via a telephone survey and a review of electronic clinical records.
    Outcome measurements and statistical analysis: Post-FC UTI was defined as hospital admission with UTI/urinary sepsis or if patients were symptomatic for UTI with receipt of antibiotics or with positive urine culture and sensitivity. An analysis of the association was performed.
    Results and limitations: An initial pilot study confirmed the safety and feasibility of our protocol. Of 1996 patients, 136 (6.8%) developed a UTI by our definition, with 51 (2.6%) having a culture-proven infection. The risk was higher in patients with a positive PCU (odds ratio [OR] 1.61, 95% confidence interval [CI] = 1.07-2.40,
    Conclusions: We observed a clinically low and acceptable risk of UTI, with no incidence of sepsis, when FC was performed in asymptomatic patients with a PCU suggesting "infection". Routine cancellation of these patients is unnecessary and may worsen the burden on health service resources.
    Patient summary: We evaluated the safety of performing flexible cystoscopy when the urine dipstick on the day suggested presence of an "infection" but the patient had no symptoms of urinary tract infection (UTI). Our study in over 2000 patients demonstrated a low incidence of UTI, and none of these patients developed sepsis. We therefore recommend that flexible cystoscopy should not be cancelled automatically on the basis of the dipstick result alone, as it might delay a time-sensitive crucial diagnosis.
    Language English
    Publishing date 2021-07-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2021.06.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Should a near-patient test be part of the management of pharyngitis in the pediatric emergency department?

    Enright, Kevin / Kalima, Pota / Taheri, Sepideh

    Pediatric emergency care

    2011  Volume 27, Issue 12, Page(s) 1148–1150

    Abstract: Objective: The study's objective was to evaluate the efficacy of a rapid streptococcal test as a single diagnostic agent in the diagnosis of streptococcal pharyngitis in patients presenting to a pediatric emergency department.: Methods: We performed ... ...

    Abstract Objective: The study's objective was to evaluate the efficacy of a rapid streptococcal test as a single diagnostic agent in the diagnosis of streptococcal pharyngitis in patients presenting to a pediatric emergency department.
    Methods: We performed a rapid streptococcal test as part of the diagnostic workup for patients presenting with clinical findings consistent with streptococcal pharyngitis. In addition to undergoing the study intervention, each patient had a standard throat swab sent to the laboratory for formal culture. A questionnaire detailing the clinical features was to be completed in each case.
    Results: Two hundred ten near-patient tests were performed. Complete laboratory results were available in 177 cases (77%). Clinical data were available for analysis in 94 patients (53%). In our patient population, the near-patient test had a high specificity (98.6%) but a low sensitivity (71%). The clinical presentation of confirmed group A β-hemolytic streptococcal pharyngitis is very variable.
    Conclusions: The QuickVue In-Line Strep A test for streptococcal pharyngitis is unreliable in our patient population. Clinical findings are unhelpful in confirming the diagnosis. Formal laboratory culture is the criterion standard for identifying the organism, but the results are not clinically significant in every case. Acute pharyngitis presenting to the pediatric emergency department can be managed in accordance with the recommendations in the Scottish Intercollegiate Guideline Network guideline.
    MeSH term(s) Adolescent ; Anti-Bacterial Agents/therapeutic use ; Antigens, Bacterial/analysis ; Child ; Child, Preschool ; Early Diagnosis ; Emergency Service, Hospital ; Female ; Humans ; Immunoassay/methods ; Infant ; Male ; Pediatrics ; Pharyngitis/immunology ; Pharyngitis/microbiology ; Reagent Kits, Diagnostic ; Reproducibility of Results ; Sensitivity and Specificity ; Streptococcal Infections/diagnosis ; Streptococcal Infections/drug therapy ; Streptococcal Infections/immunology ; Streptococcus agalactiae/immunology ; Streptococcus agalactiae/isolation & purification ; Surveys and Questionnaires
    Chemical Substances Anti-Bacterial Agents ; Antigens, Bacterial ; Reagent Kits, Diagnostic
    Language English
    Publishing date 2011-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0b013e31823aff44
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Secrets of the Hospital Underbelly: Patterns of Abundance of Antimicrobial Resistance Genes in Hospital Wastewater Vary by Specific Antimicrobial and Bacterial Family.

    Perry, Meghan R / Lepper, Hannah C / McNally, Luke / Wee, Bryan A / Munk, Patrick / Warr, Amanda / Moore, Barbara / Kalima, Pota / Philip, Carol / de Roda Husman, Ana Maria / Aarestrup, Frank M / Woolhouse, Mark E J / van Bunnik, Bram A D

    Frontiers in microbiology

    2021  Volume 12, Page(s) 703560

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.703560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Microbiological characteristics of acute osteoarticular infections in children.

    Russell, Clark D / Ramaesh, Rishi / Kalima, Pota / Murray, Alastair / Gaston, Mark S

    Journal of medical microbiology

    2015  Volume 64, Issue Pt 4, Page(s) 446–453

    Abstract: This study aimed to describe the microbiological characteristics of acute septic arthritis (SA) and osteomyelitis (OM) in children. Cases of children (0-15 years) with SA/OM were identified through a retrospective search of hospital discharge codes over ... ...

    Abstract This study aimed to describe the microbiological characteristics of acute septic arthritis (SA) and osteomyelitis (OM) in children. Cases of children (0-15 years) with SA/OM were identified through a retrospective search of hospital discharge codes over a six-year period. In addition, a systematic literature search and meta-analysis of studies reporting culture results of children with SA/OM was performed. In our retrospective chart review, we identified 65 cases of OM and 46 cases of SA. The most frequently cultured organisms in both conditions were Gram-positive cocci, primarily Staphylococcus aureus. On admission, most patients had a normal white blood cell count (WCC) but elevated C-reactive protein (CRP) and/or erythrocyte sedimentation rate (ESR). Bacteraemia was associated with a longer mean length of hospitalization for both infections. Considering our results and the meta-analysis, we found low rates of culture-positivity in cases of clinically confirmed infection. In SA, articular fluid was culture-positive in 42.49% [95% confidence interval (CI) 28.39-57.23]. In OM, intra-operative samples were culture-positive in 52.65% (95% CI 30.54-74.22). Bacteraemia was detected in 23.91% (95% CI 8.40-44.24) of children with SA and 21.48% (95% CI 10.89-34.47) with OM. Despite appropriate sampling, a positive microbiological diagnosis is often lacking in paediatric acute osteoarticular infection using standard culture-based methods. This highlights the need for validation and use of more sensitive diagnostic methods, such as PCR.
    MeSH term(s) Adolescent ; Arthritis, Infectious/complications ; Arthritis, Infectious/epidemiology ; Arthritis, Infectious/microbiology ; Arthritis, Infectious/pathology ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Bacteremia/pathology ; Bacteria/classification ; Bacteria/isolation & purification ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; Bacterial Infections/pathology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Osteomyelitis/complications ; Osteomyelitis/epidemiology ; Osteomyelitis/microbiology ; Osteomyelitis/pathology ; Retrospective Studies
    Language English
    Publishing date 2015-01-16
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.000026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Does mixing acute medical admissions with burn patients increase infective complications from paediatric thermal injuries?

    Shaban, Fadlo / Stewart, Ken / Kalima, Pota

    JRSM short reports

    2010  Volume 1, Issue 1, Page(s) 1

    Abstract: In the winter of 2005-2006, the management at our children's hospital elected to admit 'overspill' acute medical admissions to the ward used for plastic surgery and burns for logistical reasons. This study was conducted to assess the effects of that ... ...

    Abstract In the winter of 2005-2006, the management at our children's hospital elected to admit 'overspill' acute medical admissions to the ward used for plastic surgery and burns for logistical reasons. This study was conducted to assess the effects of that change on the incidence of infective complications in thermally-injured patients. Seventy-three patients were studied, 23 in the sample winter and 50 in the two preceding control winters. The data gathered included days on IV fluids and antibiotics, transfer to the Paediatric Intensive Care Unit (PICU), microbiology and a 'septic signs score' - based on pyrexia, irritability, diarrhoea/vomiting, wound colonization, bacteraemia. The outcomes studied were: the maximum 'septic signs score'; patients with a score ≥3; wound colonization; PICU admission; days on antibiotics and IV fluids. A statistically significant increase in patients with septic episodes was demonstrated by an increase in the mean septic signs score (0.66-1.48, P = 0.044) and the number of patients with a score ≥3 (4-22%, P = 0.017). Other analysed variables did not reach statistical significance although the raw data suggested a trend. It was concluded that there is an association between mixing acute medical admissions with thermally-injured patients and an increase in the incidence of infective complications in the latter group.
    Language English
    Publishing date 2010-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2563002-7
    ISSN 2042-5333 ; 2042-5333
    ISSN (online) 2042-5333
    ISSN 2042-5333
    DOI 10.1258/shorts.2009.090026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical outcomes and macrolide resistance in Mycoplasma pneumoniae infection in Scotland, UK.

    Ferguson, Graeme D / Gadsby, Naomi J / Henderson, Sarah S / Hardie, Alison / Kalima, Pota / Morris, Andrew Conway / Hill, Adam T / Cunningham, Steve / Templeton, Kate E

    Journal of medical microbiology

    2013  Volume 62, Issue Pt 12, Page(s) 1876–1882

    Abstract: Mycoplasma pneumoniae has a cyclical, epidemic pattern of infection and the most recent epidemic occurred in Europe in 2011. Macrolides are recommended for the treatment of M. pneumoniae respiratory tract infection, but macrolide resistance has been ... ...

    Abstract Mycoplasma pneumoniae has a cyclical, epidemic pattern of infection and the most recent epidemic occurred in Europe in 2011. Macrolides are recommended for the treatment of M. pneumoniae respiratory tract infection, but macrolide resistance has been reported at low levels in Europe. The aim of the study was to examine the clinical impact of the recent M. pneumoniae epidemic in a hospital setting in Scotland and to determine whether macrolide-resistant strains are present. Data were analysed retrospectively for 307 patients with M. pneumoniae respiratory infection diagnosed in 2010 and 2011 in Edinburgh, UK. Genotypic macrolide resistance testing was also carried out in 32 patients in whom resistance was considered most likely, based on their clinical picture. We found that 175 patients (59 %) were admitted to hospital, 20 (7 %) were admitted to critical care and 97 (38 %) required oxygen. All 48 adult patients (100 %) were admitted to hospital, compared with 127 children (51 %). Adults were also more likely to require oxygen [odds ratio (OR) 4.964, P<0.001, 95 % confidence interval (CI) 2.129-11.803] and to be admitted to critical care (OR 4.909, P = 0.001, 95 % CI 1.735-13.829), compared with children. Macrolide resistance conferred by the 23S rRNA gene mutation was found in samples from 6 out of 32 patients (19 %) in the subset tested. The results suggest that the recent M. pneumoniae epidemic was associated with a significant burden of hospital admission locally. The study also describes the first case series of macrolide-resistant M. pneumoniae in the UK, indicating that macrolide resistance surveillance is warranted in preparation for the next epidemic.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; DNA, Bacterial/genetics ; Drug Resistance, Bacterial ; Female ; Genotype ; Humans ; Infant ; Infant, Newborn ; Macrolides/therapeutic use ; Male ; Middle Aged ; Mycoplasma Infections/drug therapy ; Mycoplasma Infections/epidemiology ; Mycoplasma Infections/microbiology ; Mycoplasma pneumoniae/drug effects ; Mycoplasma pneumoniae/genetics ; Pneumonia, Mycoplasma/drug therapy ; Pneumonia, Mycoplasma/epidemiology ; Pneumonia, Mycoplasma/microbiology ; RNA, Ribosomal, 23S/genetics ; Retrospective Studies ; Scotland/epidemiology ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; DNA, Bacterial ; Macrolides ; RNA, Ribosomal, 23S
    Keywords covid19
    Language English
    Publishing date 2013-09-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.066191-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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