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  1. Article ; Online: Utilizing the amide proton transfer technique to characterize diffuse gliomas based on the WHO 2021 classification of CNS tumors.

    Filimonova, Elena / Pashkov, Anton / Borisov, Norayr / Kalinovsky, Anton / Rzaev, Jamil

    The neuroradiology journal

    2024  , Page(s) 19714009241242658

    Abstract: Purpose: Diffuse gliomas present a significant challenge for healthcare systems globally. While brain MRI plays a vital role in diagnosis, prognosis, and treatment monitoring, accurately characterizing gliomas using conventional MRI techniques alone is ... ...

    Abstract Purpose: Diffuse gliomas present a significant challenge for healthcare systems globally. While brain MRI plays a vital role in diagnosis, prognosis, and treatment monitoring, accurately characterizing gliomas using conventional MRI techniques alone is challenging. In this study, we explored the potential of utilizing the amide proton transfer (APT) technique to predict tumor grade and type based on the WHO 2021 Classification of CNS Tumors.
    Methods: Forty-two adult patients with histopathologically confirmed brain gliomas were included in the study. They underwent 3T MRI imaging, which involved APT sequence. Multinomial and binary logistic regression models were employed to classify patients into clinically relevant groups based on MRI findings and demographic variables.
    Results: We found that the best model for tumor grade classification included patient age along with APT values. The highest sensitivity (88%) was observed for Grade 4 tumors, while Grade 3 tumors showed the highest specificity (79%). For tumor type classification, our model incorporated four predictors: APT values, patient's age, necrosis, and the presence of hemorrhage. The glioblastoma group had the highest sensitivity and specificity (87%), whereas balanced accuracy was the lowest for astrocytomas (0.73).
    Conclusion: The APT technique shows great potential for noninvasive evaluation of diffuse gliomas. The changes in the classification of gliomas as per the WHO 2021 version of the CNS Tumor Classification did not affect its usefulness in predicting tumor grade or type.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/19714009241242658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2823: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Masseter-to-Facial Cranial Nerve Anastomosis: A Report of 30 Cases.

    Zotov, Alexander V / Rzaev, Jamil A / Chernov, Sergey V / Dmitriev, Alexander B / Kalinovsky, Anton V / Spallone, Aldo

    Operative neurosurgery (Hagerstown, Md.)

    2020  Volume 19, Issue 5, Page(s) 502–509

    Abstract: Background: Facial nerve paralysis (FP) is a possible complication of cerebellopontine angle tumor surgery. Several donor nerves have been used in the past for facial reanimation. We report the results of 30 cases of masseter-to-facial anastomosis.: ... ...

    Abstract Background: Facial nerve paralysis (FP) is a possible complication of cerebellopontine angle tumor surgery. Several donor nerves have been used in the past for facial reanimation. We report the results of 30 cases of masseter-to-facial anastomosis.
    Objective: To prospectively evaluate the efficacy of V to VII anastomosis after FP.
    Methods: In a prospective study, we included 30 consecutive patients with FP (20 women and 10 men) whose mean age was 48.8 yr (32-76 yr). In almost all cases, FP developed after cerebellopontine angle tumor surgery (29 patients), whereas in one case, FP occurred after skull base trauma. Pre- and postoperative evaluation of facial nerve function was performed using the House-Brackmann (HB) scale and the Sokolovsky scale, as well as by electromyography. Follow-up ranged from 11 to 51 mo and averaged 22 mo.
    Results: All patients achieved functional recovery of the facial nerve from VI to either III or IV HB degree. Patients with short time FP showed significantly better postoperative recovery.
    Conclusion: The results of the V to VII anastomosis demonstrate a significant improvement of facial nerve function and virtually no complications.
    MeSH term(s) Adult ; Aged ; Anastomosis, Surgical ; Facial Nerve/surgery ; Facial Paralysis/etiology ; Facial Paralysis/surgery ; Female ; Humans ; Hypoglossal Nerve ; Male ; Middle Aged ; Prospective Studies
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1093/ons/opaa140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424 -ON-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Conference proceedings: Early Postoperative Results of Microsurgery of Anterior Clinoidal Meningiomas - Russian (Siberian) Experience

    Chernov, Sergey / Kalinovsky, Anton / Dmitriev, Alexander / Kasymov, Agadadash / Zotov, Alexander / Gormolysova, Ekaterina / Uzhakova, Elena

    Journal of Neurological Surgery Part B: Skull Base

    2016  

    Abstract: Objective: To assess the radicality and neurological deficit in the early postoperative period after microsurgery of anterior clinoid process meningiomas. Materials and Methods: From 2013 to present 29 patients with anterior clinoidal meningiomas were ... ...

    Event/congress Presentation Abstracts, Fairmont Scottsdale Princess Scottsdale, Arizona, 2016
    Abstract Objective: To assess the radicality and neurological deficit in the early postoperative period after microsurgery of anterior clinoid process meningiomas. Materials and Methods: From 2013 to present 29 patients with anterior clinoidal meningiomas were operated on. There were 23 (79%) females and 6 (21%) males. The average age was 52.44 years (from 35 to 72). Based on All-Mefty classification - type A tumor (up to 2 cm) were observed in 4 cases (13.8%), type B (2–4 cm) - 8 (27.6%) and type C (more than 4 cm) - in 17 cases (58.6%). The tumor involved: in 5 patients the internal carotid, middle, anterior cerebral artery, in 4 - the internal carotid, anterior cerebral, and anterior communicating artery, in 3 -internal carotid and middle cerebral artery, in 5 - the cavernous sinus; in 8 - tumor dislocated the internal carotid artery and 4 patients had subtentorial growth. Thus, in 16 cases (55.2%) the major cerebral arteries were involved in a tumor stroma. Headache, dizziness, memory loss and other cerebral symptoms were reported in all 29 patients, vision lost, diplopia were presented in 12 (41.4%) cases, seizures - in 5 patients (17.2%). Results: Pterional approach was used in 8 patients (27.6%), 21 patients (72.4%) were operated on via the lateral supraorbital approach. The Gross Total Removal (Simpson II) were achieved in 23 cases (79.3%), subtotal removal (Simpson IV) - in 6 patients (21.7%) due to dens stroma. Histology showed benign tumor (Grade I) in all cases. From all the16 patients with the involvement of the main arteries in the tumor parenchima good extention of resection (Simpson II) was achieved in 11 patients (68.8%) because of the soft density of the tumor and good arachnoid plane between the tumor and involved vessels. In 13 patients (44.8%) the cerebral symptoms were completely regressed, in 2 patients (16.7%) the visual acuity was improved, in 8 patients (27.6%) symptoms remained unchanched. 4 patients (13.8%) had the III nerve palsy associated with the spread of the tumor in the cavernous sinus, in 1 case (3.4%) - severe hemiparesis and motor aphasia due to intraoperative injury of the left middle cerebral artery. The mortality rate was 3.4% (1 patient) associated with spasm of the internal carotid artery, its main branches and perforators resulted in ischemia of hemisphere, upper brain stem and the hypothalamic region due to hard density with no good dissection plane between the arteries and the tumor. Conclusions: Microsurgery of anterior clinoidal meningiomas is challenging because of the location of the tumor, involvement of the main arteries, close connection with the optic nerve and chiasm, large and giant size and the presence of hyperostosis. From our experience, the degree of radicality depends on the density of the tumor: in the cases of soft meningiomas it is possible to achieve the gross total removal and good functional outcome. When the tumor is hard, the attempts of radical removal can cause trauma to the main arteries and ischemia with a high mortality rate or a significant decrease of the patients life quality
    Language English
    Publishing date 2016-03-03
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0036-1579854
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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