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  1. Article ; Online: Deep learning approach to unmask hidden salt effects in the era of artificial intelligence.

    Manolis, Athanasios J / Kallistratos, Manolis S

    European heart journal

    2023  Volume 44, Issue 42, Page(s) 4458–4460

    MeSH term(s) Humans ; Artificial Intelligence ; Acetaminophen ; Deep Learning ; Blood Pressure ; Sodium ; Cardiovascular Diseases
    Chemical Substances Acetaminophen (362O9ITL9D) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad673
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  2. Article ; Online: Recent published hypertension guidelines: A critical approach.

    Manolis, Athanasios J / Kallistratos, Manolis S

    European journal of internal medicine

    2019  Volume 63, Page(s) 1–2

    MeSH term(s) Europe ; Humans ; Hypertension/diagnosis ; Hypertension/therapy ; Practice Guidelines as Topic ; Societies, Medical ; United States
    Language English
    Publishing date 2019-04-27
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2019.04.005
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  3. Article ; Online: Treating hypertension with beta blockers: the European Sleep Apnea Database.

    Manolis, Athanasios J / Poulimenos, Leonidas E / Kallistratos, Manolis S

    Journal of hypertension

    2020  Volume 39, Issue 2, Page(s) 231–233

    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Humans ; Hypertension/drug therapy ; Sleep Apnea Syndromes
    Chemical Substances Adrenergic beta-Antagonists
    Language English
    Publishing date 2020-12-17
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 614: Show issues

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  4. Article ; Online: Beta blockers, calcium channel blockers, and long-acting nitrates for patients with stable angina and low blood pressure levels: should this recommendation be reconsidered?

    Kallistratos, Manolis S / Poulimenos, Leonidas E / Manolis, Athanasios J

    European heart journal

    2019  Volume 41, Issue 3, Page(s) 479

    MeSH term(s) Adrenergic beta-Antagonists ; Angina, Stable ; Calcium Channel Blockers ; Humans ; Hypotension ; Nitrates ; Syndrome
    Chemical Substances Adrenergic beta-Antagonists ; Calcium Channel Blockers ; Nitrates
    Language English
    Publishing date 2019-12-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz900
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  5. Article: Angina and hypertension.

    Manolis, Athanasios J / Kallistratos, Manolis S / Poulimenos, Leonidas E

    European heart journal supplements : journal of the European Society of Cardiology

    2019  Volume 21, Issue Suppl C, Page(s) C15–C16

    Language English
    Publishing date 2019-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartj/suz041
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  6. Article ; Online: Hypertension and aortic stenosis: no strangers, not anymore!

    Manolis, Athanasios J / Kallistratos, Manolis S / Poulimenos, Leonidas E

    Journal of hypertension

    2019  Volume 37, Issue 11, Page(s) 2156–2158

    MeSH term(s) Aortic Valve Stenosis ; Humans ; Hypertension
    Language English
    Publishing date 2019-09-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002226
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  7. Article ; Online: Recent advances in understanding and managing resistant/refractory hypertension.

    Doumas, Michael / Imprialos, Konstantinos P / Kallistratos, Manolis S / Manolis, Athanasios J

    F1000Research

    2020  Volume 9

    Abstract: The management of resistant hypertension presents several challenges in everyday clinical practice. During the past few years, several studies have been performed to identify efficient and safe pharmacological and non-pharmacological options for the ... ...

    Abstract The management of resistant hypertension presents several challenges in everyday clinical practice. During the past few years, several studies have been performed to identify efficient and safe pharmacological and non-pharmacological options for the management of such patients. The Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2) trial demonstrated significant benefits with the use of spinorolactone as a fourth-line drug for the treatment of resistant hypertension over doxazosin and bisoprolol. In addition, recent data support that spironolactone may demonstrate superiority over central acting drugs in such patients, as well. Based on the European guidelines, spironolactone is recommended as the fourth-line drug option, followed by amiloride, other diuretics, doxazosin, bisoprolol or clonidine.  Among several device-based approaches, renal sympathetic denervation had fallen into hibernation after the disappointing results of the Renal Denervation in Patients With Uncontrolled Hypertension (SYMPLICITY HTN) 3 trial. However, the technique re-emerged at the epicenter of the clinical and research interest after the favorable results of three sham-controlled studies, which facilitated novel catheters and techniques to perform the denervation. Significant results of iliac anastomosis on blood pressure levels have also been demonstrated. Nevertheless, the technique-related adverse events resulted in withdrawal of this interventional approach. Last, the sympatholytic properties of the carotid baroreceptor activation therapy were associated with significant blood pressure reductions in patients with resistant hypertension, which need to be verified in larger controlled trials. Currently device-based approaches are recommended only in the setting of clinical trials until more safety and efficacy data become available.
    MeSH term(s) Antihypertensive Agents/therapeutic use ; Bisoprolol/therapeutic use ; Catheters ; Clinical Trials as Topic ; Clonidine/therapeutic use ; Denervation ; Doxazosin/therapeutic use ; Humans ; Hypertension/therapy ; Kidney ; Spironolactone/therapeutic use
    Chemical Substances Antihypertensive Agents ; Spironolactone (27O7W4T232) ; Clonidine (MN3L5RMN02) ; Doxazosin (NW1291F1W8) ; Bisoprolol (Y41JS2NL6U)
    Language English
    Publishing date 2020-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.21669.1
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  8. Article ; Online: Effectiveness and Adherence to Treatment with Perindopril/Indapamide/Amlodipine Single-Pill Combination in a Greek Population with Hypertension.

    Tsioufis, Kostas / Douma, Stella / Kallistratos, Manolis S / Manolis, Athanasios J

    Clinical drug investigation

    2019  Volume 39, Issue 4, Page(s) 385–393

    Abstract: Background: Despite the overwhelming evidence and the established benefits of antihypertensive treatment, adherence to treatment remains low.: Objective: To assess the adherence to treatment with a perindopril/indapamide/amlodipine single-pill ... ...

    Abstract Background: Despite the overwhelming evidence and the established benefits of antihypertensive treatment, adherence to treatment remains low.
    Objective: To assess the adherence to treatment with a perindopril/indapamide/amlodipine single-pill combination (SPC), its effectiveness on blood pressure (BP) reduction, as well as the safety and tolerability of this SPC over a 4-month treatment period.
    Methods: This multicenter, non-interventional study prospectively included 2285 hypertensive patients on perindopril/indapamide/amlodipine SPC. The data were recorded at baseline, 1 month, and 4 months.
    Results: Of the 2285 hypertensive patients included in the study, 50.5% were at "high/very high risk". Mean systolic (SBP)/diastolic (DBP) decreased from 162.3 ± 13.3/93.1 ± 9.3 mmHg at baseline to 129.7 ± 8.3/78.6 ± 7.1 mmHg at 4 months (p < 0.001). Patients with higher baseline BP levels showed greater BP reduction. Patients with hypertension stages 1, 2, and 3 showed mean SBP/DBP reductions of 21.5/10.4 mmHg, 34.2/14.7 mmHg, and 51.2/22.5 mmHg, respectively, at study end (p < 0.001). Only 26 patients (1.1%) prematurely discontinued treatment (0.58% due to an adverse reaction or event).
    Conclusions: Perindopril/indapamide/amlodipine SPC decreased BP levels rapidly and significantly. The degree of BP reduction was associated with the severity of hypertension and/or with total cardiovascular risk at baseline. Simplifying the drug regimen by using this SPC improved adherence and showed excellent tolerability.
    MeSH term(s) Adult ; Aged ; Amlodipine/administration & dosage ; Antihypertensive Agents/administration & dosage ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Drug Combinations ; Female ; Greece/epidemiology ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Indapamide/administration & dosage ; Male ; Medication Adherence ; Middle Aged ; Perindopril/administration & dosage ; Prospective Studies
    Chemical Substances Antihypertensive Agents ; Drug Combinations ; Amlodipine (1J444QC288) ; Indapamide (F089I0511L) ; Perindopril (Y5GMK36KGY)
    Language English
    Publishing date 2019-02-21
    Publishing country New Zealand
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-019-00761-0
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    Zs.A 2807: Show issues Location:
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  9. Article ; Online: Adverse Effects of Mineralocorticoid Receptor Antagonist Administration.

    Kallistratos, Manolis S / Pittaras, Andreas / Theodoulidis, Iakovos / Grassos, Charris / Poulimenos, Leonidas E / Manolis, Athanasios J

    Current pharmaceutical design

    2019  Volume 24, Issue 46, Page(s) 5537–5541

    Abstract: Background: Mineralocorticoid receptor antagonists consist of a class of drugs with pleiotropic beneficial effects in several cardiovascular diseases. However, physicians frequently overlook their use due to the adverse effects of such agents.: ... ...

    Abstract Background: Mineralocorticoid receptor antagonists consist of a class of drugs with pleiotropic beneficial effects in several cardiovascular diseases. However, physicians frequently overlook their use due to the adverse effects of such agents.
    Objectives: To determine the adverse effects of mineralocorticoid receptor antagonists and to suggest clinically meaningful options. We present data on the two most administered agents of this class: spironolactone and eplerenone.
    Method: We conducted an in-depth review of the existing international literature to draft a mini review about the mineralocorticoid receptor antagonists-related side effects.
    Result: Mineralocorticoid receptor antagonists are associated with increased risk of hyperkalemia and acute deterioration of renal function. Of note, these adverse effects are dose-dependent, more common during the initial period of treatment, and are usually reversed after the withdrawal of therapy. Sex-related adverse events are noted mainly in spironolactone while switching to eplerenone could attenuate those.
    Conclusion: Mineralocorticoid receptor antagonists therapy is significantly limited due to their side effects. The development of novel non-steroidal mineralocorticoid receptor antagonists could substantially widen the use of such agents.
    MeSH term(s) Breast Feeding ; Female ; Gynecomastia/chemically induced ; Humans ; Hyperkalemia/chemically induced ; Kidney Diseases/chemically induced ; Mineralocorticoid Receptor Antagonists/adverse effects ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Pregnancy
    Chemical Substances Mineralocorticoid Receptor Antagonists
    Language English
    Publishing date 2019-02-23
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612825666190222144359
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    Zs.A 4714: Show issues Location:
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  10. Article ; Online: Skeletal muscle alterations and exercise intolerance in heart failure with preserved ejection fraction patients: ultrasonography assessment of diaphragm and quadriceps.

    Andriopoulou, Maria / Dimaki, Niki / Kallistratos, Manolis S / Chamodraka, Eftihia / Jahaj, Edison / Vassiliou, Alice G / Giokas, Georgios / Kotanidou, Anastasia / Manolis, Athanasios J / Piepoli, Massimo F / Filippatos, Gerasimos

    European journal of heart failure

    2022  Volume 24, Issue 4, Page(s) 729–731

    MeSH term(s) Diaphragm/diagnostic imaging ; Diaphragm/metabolism ; Exercise Tolerance/physiology ; Heart Failure/diagnostic imaging ; Heart Failure/metabolism ; Humans ; Muscle, Skeletal/metabolism ; Oxygen Consumption/physiology ; Stroke Volume/physiology ; Ultrasonography
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Letter
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2462
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