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Article: Assessment of Risk Factors for Acute Kidney Injury with Machine Learning Tools in Children Undergoing Hematopoietic Stem Cell Transplantation.

Musiał, Kinga / Stojanowski, Jakub / Augustynowicz, Monika / Miśkiewicz-Migoń, Izabella / Kałwak, Krzysztof / Ussowicz, Marek

Journal of clinical medicine

2024 Volume 13, Issue 8

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13082266
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Priapism at Diagnosis of Pediatric Chronic Myeloid Leukemia: Data Derived from a Large Cohort of Children and Teenagers and a Narrative Review on Priapism Management.

Suttorp, Meinolf / Sembill, Stephanie / Kalwak, Krzysztof / Metzler, Markus / Millot, Frederic

Journal of clinical medicine

2023 Volume 12, Issue 14

Abstract: Pediatric chronic myeloid leukemia (CML) is a very rare malignancy (age-related incidence 0.1/100,000) typically presenting with leucocyte counts >100,000/µL. However, clinical signs of leukostasis are observed at diagnosis in only approximately 10% of ... ...

Abstract	Pediatric chronic myeloid leukemia (CML) is a very rare malignancy (age-related incidence 0.1/100,000) typically presenting with leucocyte counts >100,000/µL. However, clinical signs of leukostasis are observed at diagnosis in only approximately 10% of all cases and among these, priapism is infrequent. Here, we analyze data from pediatric CML registries on the occurrence of priapism heralding diagnosis of CML in 16/491 (3.2%) boys (median age 13.5 years, range 4-18) with pediatric CML. In the cohort investigated, duration of priapism resulting in a diagnosis of CML was not reported in 5 patients, and in the remaining 11 patients, occurred as stuttering priapism over 3 months (
Language	English
Publishing date	2023-07-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12144776
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Article: Antifungal Drug-Drug Interactions with Commonly Used Pharmaceutics in European Pediatric Patients with Acute Lymphoblastic Leukemia.

Sienkiewicz-Oleszkiewicz, Beata / Salamonowicz-Bodzioch, Małgorzata / Słonka, Justyna / Kałwak, Krzysztof

Journal of clinical medicine

2023 Volume 12, Issue 14

Abstract: Leukemia is one of the leading childhood malignancies, with acute lymphoblastic leukemia (ALL) being the most common type. Invasive fungal disease is a concerning problem also at pediatric hemato-oncology units. Available guidelines underline the need ... ...

Abstract	Leukemia is one of the leading childhood malignancies, with acute lymphoblastic leukemia (ALL) being the most common type. Invasive fungal disease is a concerning problem also at pediatric hemato-oncology units. Available guidelines underline the need for antifungal prophylaxis and give recommendations for proper treatment in various clinical scenarios. Nonetheless, antifungal agents are often involved in drug-drug interaction (DDI) occurrence. The prediction of those interactions in the pediatric population is complicated because of the physiological differences in adults, and the lack of pharmacological data. In this review, we discuss the potential DDIs between antifungal agents and commonly used pharmaceutics in pediatric hemato-oncology settings, with special emphasis on the use of liposomal amphotericin B and ALL treatment. We obtained information from Micromedex
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12144637
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Article ; Online: KIM-1, IL-18, and NGAL, in the Machine Learning Prediction of Kidney Injury among Children Undergoing Hematopoietic Stem Cell Transplantation-A Pilot Study.

Musiał, Kinga / Stojanowski, Jakub / Miśkiewicz-Bujna, Justyna / Kałwak, Krzysztof / Ussowicz, Marek

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: Children undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are prone to developing acute kidney injury (AKI). Markers of kidney damage: kidney injury molecule (KIM)-1, interleukin (IL)-18, and neutrophil gelatinase-associated lipocalin ...

Abstract	Children undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are prone to developing acute kidney injury (AKI). Markers of kidney damage: kidney injury molecule (KIM)-1, interleukin (IL)-18, and neutrophil gelatinase-associated lipocalin (NGAL) may ease early diagnosis of AKI. The aim of this study was to assess serum concentrations of KIM-1, IL-18, and NGAL in children undergoing HSCT in relation to classical markers of kidney function (creatinine, cystatin C, estimated glomerular filtration rate (eGFR)) and to analyze their usefulness as predictors of kidney damage with the use of artificial intelligence tools. Serum concentrations of KIM-1, IL-18, NGAL, and cystatin C were assessed by ELISA in 27 children undergoing HSCT before transplantation and up to 4 weeks after the procedure. The data was used to build a Random Forest Classifier (RFC) model of renal injury prediction. The RFC model established on the basis of 3 input variables, KIM-1, IL-18, and NGAL concentrations in the serum of children before HSCT, was able to effectively assess the rate of patients with hyperfiltration, a surrogate marker of kidney injury 4 weeks after the procedure. With the use of the RFC model, serum KIM-1, IL-18, and NGAL may serve as markers of incipient renal dysfunction in children after HSCT.
MeSH term(s)	Child ; Humans ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Artificial Intelligence ; Biomarkers ; Cystatin C ; Hematopoietic Stem Cell Transplantation/adverse effects ; Interleukin-18 ; Kidney ; Lipocalin-2 ; Machine Learning ; Pilot Projects
Chemical Substances	Biomarkers ; Cystatin C ; Interleukin-18 ; Lipocalin-2 ; IL18 protein, human ; LCN2 protein, human ; HAVCR1 protein, human
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Physical Activity Level and Quality of Life of Children Treated for Malignancy, Depending on Their Place of Residence: Poland vs. the Czech Republic: An Observational Study.

Kowaluk, Aleksandra / Siewierska, Katarzyna / Choniawkova, Marie / Sedlacek, Petr / Kałwak, Krzysztof / Malicka, Iwona

Cancers

2023 Volume 15, Issue 19

Abstract: This study aimed to assess the level of physical activity (PA) and quality of life of cancer-treated children, depending on their place of residence (Poland vs. the Czech Republic, where incidence and mortality rates of childhood malignancies are similar) ...

Abstract	This study aimed to assess the level of physical activity (PA) and quality of life of cancer-treated children, depending on their place of residence (Poland vs. the Czech Republic, where incidence and mortality rates of childhood malignancies are similar). A total of 68 school-age children (7-18 years) undergoing oncological treatment were included in this study. This study used the quality of life questionnaire (KIDSCREEN-10) and the HBSC questionnaire. This study showed statistically significant differences in the level of PA between Polish and Czech children. In Poland, 93.75% of children exhibited no weekly physical effort at the level of moderate to vigorous PA. In the Czech Republic, 69.44% of children engaged in PA lasting at least 60 min per day, or at least 1 day weekly. Physically active children engaging in more frequent effort, at least 60 min daily, reported higher physical performance (rho = 0.41), higher energy levels (rho = 0.41), and less mood disturbance (rho = -0.31). Children with good relationships with parents were more likely to engage in submaximal PA and spend less time on stationary games. Our study showed that an appropriate level of PA improves well-being and quality of life. It is crucial to promote attractive PA programs tailored for cancer-treated children.
Language	English
Publishing date	2023-09-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15194695
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Article: The impact of NKG2A and NKG2D receptors and HLA-E and MICA ligands polymorphisms on post-transplant complications after paediatric allogeneic HSCT: a single-centre experience.

Siemaszko, Jagoda / Ussowicz, Marek / Rybka, Blanka / Ryczan-Krawczyk, Renata / Kałwak, Krzysztof / Bogunia-Kubik, Katarzyna

Frontiers in genetics

2023 Volume 14, Page(s) 1186123

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1186123
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Article: The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Kidney Function in Children-A Single Center Experience.

Musiał, Kinga / Kałwak, Krzysztof / Zwolińska, Danuta

Journal of clinical medicine

2021 Volume 10, Issue 5

Abstract: Background: Knowledge about the impact of allogeneic hematopoietic stem cell transplantation (alloHSCT) on renal function in children is still limited.: Objectives: The aim of the study was to evaluate kidney function in children undergoing alloHSCT, ...

Abstract	Background: Knowledge about the impact of allogeneic hematopoietic stem cell transplantation (alloHSCT) on renal function in children is still limited. Objectives: The aim of the study was to evaluate kidney function in children undergoing alloHSCT, with special focus on differences between patients transplanted due to oncological and non-oncological indications. Materials and methods: The data of 135 children undergoing alloHSCT were analyzed retrospectively. The serum creatinine and estimated glomerular filtration rate (eGFR) values were estimated before transplantation at 24 h; 1, 2, 3, 4 and 8 weeks; and 3 and 6 months after alloHSCT. Then, acute kidney injury (AKI) incidence was assessed. Results: Oncological children presented with higher eGFR values and more frequent hyperfiltration rates than non-oncological children before alloHSCT and until the 4th week after transplantation. The eGFR levels rose significantly after alloHSCT, returned to pre-transplant records after 2-3 weeks, and decreased gradually until the 6th month. AKI incidence was comparable in oncological and non-oncological patients. Conclusions: Children undergoing alloHSCT due to oncological and non-oncological reasons demonstrate the same risk of AKI, but oncological patients may be more prone to sustained renal injury. Serum creatinine and eGFR seem to be insufficient tools to assess kidney function in the early post-alloHSCT period, when hyperfiltration prevails, yet they reveal significant differences in long-term observation.
Language	English
Publishing date	2021-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10051113
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Article: The incidence of acute kidney injury in children undergoing allogenic hematopoietic stem cell transplantation: A pilot study.

Augustynowicz, Monika / Kałwak, Krzysztof / Zwolińska, Danuta / Musiał, Kinga

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2021 Volume 30, Issue 1, Page(s) 87–92

Abstract: Background: Acute kidney injury (AKI) is a common feature in adults undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). However, accurate assessment of AKI incidence in the pediatric population still seems a challenge.: ... ...

Abstract	Background: Acute kidney injury (AKI) is a common feature in adults undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). However, accurate assessment of AKI incidence in the pediatric population still seems a challenge. Objectives: To evaluate the incidence of AKI according to the pRIFLE criteria in children undergoing alloHSCT, with special focus on differences between patients transplanted due to oncological and non-oncological indications. Material and methods: A retrospective analysis of data, concerning 135 children undergoing alloHSCT due to oncological (89 patients) or other (46 patients) reasons, was performed. The values of estimated glomerular filtration rate (eGFR) were measured before alloHSCT, 24 h after, 1, 2, 3, 4, 8 weeks, 3 and 6 months after alloHSCT, and the AKI incidence was analyzed. Results: Acute kidney injury was diagnosed in 54% of all patients. The Risk stage (R) was noticed at least once in 46% of oncological and 37% of non-oncological children. The Injury stage (I) concerned 12% of oncological and 6% of non-oncological patients undergoing alloHSCT. The incidence of AKI in both groups was comparable. The mean eGFR values in oncological children were higher than those in the non-oncological patients even before transplantation and until the 4th week after alloHSCT. The eGFR increased significantly in all patients 24 h after alloHSCT and returned to pre-transplantation records after 2-3 weeks. Then, oncological patients demonstrated a gradual decrement of eGFR. Six months after transplantation, eGFR values in oncological children were significantly lower compared to pre-transplantation records, whereas in non-oncological children, these values were comparable. Conclusions: Although the type of indication for alloHSCT has no impact on the AKI incidence, children undergoing alloHSCT due to oncological reasons are at greater risk of renal impairment 6 months after transplantation than non-oncological patients.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Child ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Incidence ; Pilot Projects ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2021-02-02
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/130355
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Zastosowanie immunoglobulin dozylnych w onkohematologii dzieciecej i transplantacjach komórek hematopoetycznych u dzieci.

Kałwak, Krzysztof

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2011 Volume 30, Issue 180, Page(s) 405–408

Abstract: Intravenous immunoglobulins (IVIG) remain an important part of both causative and supportive therapy in pediatric oncohematology and after hematopoietic cell transplantation. The article presents actual recommendations on the use of IVIG based on ... ...

Title translation	The use of IVIG in pediatric oncohematology and hematopoietic stem cell transplantation.
Abstract	Intravenous immunoglobulins (IVIG) remain an important part of both causative and supportive therapy in pediatric oncohematology and after hematopoietic cell transplantation. The article presents actual recommendations on the use of IVIG based on personal experience and on UK guidelines published in 2008. IVIG substitution remains an important part of therapy in children with delayed immune reconstitution after hematopoietic stem cell transplantation (post transplants from alternative donors and in the course of acute and chronic Graft versus Host Disease). IVIG play a significant role in the immunomodulation of children with autoimmune disorders, i.e. primary immune thrombocytopenia.
MeSH term(s)	Autoimmune Diseases/drug therapy ; Autoimmune Diseases/therapy ; Child ; Graft vs Host Disease/drug therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunomodulation/immunology ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Transplantation, Homologous
Chemical Substances	Immunoglobulins, Intravenous
Language	Polish
Publishing date	2011-06
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 mRNA Vaccine Tolerance and Immunogenicity in Hematopoietic Stem Cell Transplantation Recipients Aged 5-11 Years Old-Non-Randomized Clinical Trial.

Matkowska-Kocjan, Agnieszka / Owoc-Lempach, Joanna / Ludwikowska, Kamila / Szenborn, Filip / Moskwa, Natalia / Kurek, Katarzyna / Kałwak, Krzysztof / Szenborn, Leszek / Ussowicz, Marek

Vaccines

2023 Volume 11, Issue 1

Abstract: The SARS-CoV-2 pandemic had a devastating impact on the world’s population in the years 2020−2022. The rapid development of vaccines enabled a reduction in the mortality and morbidity of COVID-19, but there are limited data about their effects on ... ...

Abstract	The SARS-CoV-2 pandemic had a devastating impact on the world’s population in the years 2020−2022. The rapid development of vaccines enabled a reduction in the mortality and morbidity of COVID-19, but there are limited data about their effects on immunocompromised children. The aim of this prospective study was to evaluate the safety and efficacy of the mRNA BNT162b2 (Pfizer/Biontech) vaccine in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Material and methods: Two cohorts of 34 children after allo-HSCT and 35 healthy children aged 5−11 years were vaccinated with two doses of the mRNA BNT162b2 (10 µg) vaccine. All children were evaluated for adverse effects with electronic surveys and the immunogenicity of the vaccine was assessed with anti-SARS-CoV-2 IgG titer measurements. Results: All reported adverse events (AEs) were classified as mild. The most common AE was pain at the injection site. All the other AEs (both local and systemic) were rarely reported (<15% patients). Both groups showed a similar response in anti-SARS-CoV-2 IgG production. Patients after allo-HSCT that were undergoing immunosuppressive treatment presented a poorer immunological response than patients off of treatment. Time since HSCT, patient age, lymphocyte count, and total IgG concentration did not correlate with initial/post-vaccination anti-SARS-CoV-2 IgG titers. Most patients who were eligible for a third dose of the vaccine had an excellent humoral response observed after two vaccine doses. Conclusions: The COVID-19 mRNA BNT162b2 vaccine is very well tolerated and highly immunogenic in 5−11-year-old children after HSCT. Children >2 years of age after HSCT who did not receive immunosuppressive treatment presented excellent antibody production after two doses of the vaccine, but children on immunosuppression may require a more intense vaccination schedule.
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11010195
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