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  1. Article ; Online: Pharmacogenomic Biomarkers and Their Applications in Psychiatry.

    Kam, Heejin / Jeong, Hotcherl

    Genes

    2020  Volume 11, Issue 12

    Abstract: Realizing the promise of precision medicine in psychiatry is a laudable and beneficial endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the economic and social burden of psychiatric disorders. This review aims ... ...

    Abstract Realizing the promise of precision medicine in psychiatry is a laudable and beneficial endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the economic and social burden of psychiatric disorders. This review aims to summarize important issues on pharmacogenomics in psychiatry that have laid the foundation towards personalized pharmacotherapy and, in a broader sense, precision medicine. We present major pharmacogenomic biomarkers and their applications in a variety of psychiatric disorders, such as depression, attention-deficit/hyperactivity disorder (ADHD), narcolepsy, schizophrenia, and bipolar disorder. In addition, we extend the scope into epilepsy, since antiepileptic drugs are widely used to treat psychiatric disorders, although epilepsy is conventionally considered to be a neurological disorder.
    MeSH term(s) Anticonvulsants/therapeutic use ; Biomarkers/metabolism ; Epilepsy/drug therapy ; Humans ; Mental Disorders/drug therapy ; Mental Disorders/metabolism ; Pharmacogenetics/methods ; Precision Medicine/methods ; Psychiatry/methods
    Chemical Substances Anticonvulsants ; Biomarkers
    Language English
    Publishing date 2020-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11121445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pharmacogenomic Biomarkers and Their Applications in Psychiatry

    Kam, Heejin / Jeong, Hotcherl

    Genes. 2020 Nov. 30, v. 11, no. 12

    2020  

    Abstract: Realizing the promise of precision medicine in psychiatry is a laudable and beneficial endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the economic and social burden of psychiatric disorders. This review aims ... ...

    Abstract Realizing the promise of precision medicine in psychiatry is a laudable and beneficial endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the economic and social burden of psychiatric disorders. This review aims to summarize important issues on pharmacogenomics in psychiatry that have laid the foundation towards personalized pharmacotherapy and, in a broader sense, precision medicine. We present major pharmacogenomic biomarkers and their applications in a variety of psychiatric disorders, such as depression, attention-deficit/hyperactivity disorder (ADHD), narcolepsy, schizophrenia, and bipolar disorder. In addition, we extend the scope into epilepsy, since antiepileptic drugs are widely used to treat psychiatric disorders, although epilepsy is conventionally considered to be a neurological disorder.
    Keywords biomarkers ; bipolar disorder ; drug therapy ; epilepsy ; morbidity ; mortality ; narcolepsy ; pharmacogenomics ; precision medicine ; schizophrenia
    Language English
    Dates of publication 2020-1130
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11121445
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Amentoflavone, a potent natural matrix metalloproteinase 2 inhibitor.

    Jo, Seri / Kim, Mi-Sun / Kim, Hwa-Young / Kim, Suwon / Kam, Heejin / Choi, Haein / Shin, Dong Hae

    Natural product research

    2023  , Page(s) 1–8

    Abstract: Gelatinase A (MMP-2) has been studied and proven to play a vital role in the intrusion and metastasis of cancer. Flavonoids influence on molecular and cellular functions of MMP-2 and thus a systematic investigation of flavonoids against the ... ...

    Abstract Gelatinase A (MMP-2) has been studied and proven to play a vital role in the intrusion and metastasis of cancer. Flavonoids influence on molecular and cellular functions of MMP-2 and thus a systematic investigation of flavonoids against the metalloproteolytic activity of MMP-2 has been performed in this study. A fluorescence resonance energy transfer method was used to investigate the inhibitory activities of various flavonoids. Flavone, flavonol and isobavachalcone derivatives showed their inhibitory activity against MMP-2. Surprisingly, the most effective inhibitor was Amentoflavone and its blocking function was superior to other flavonoids. Its IC50 value was 0.689 μM. An induced-fit docking study was carried out to survey its extraordinary activity. The binding mode of Amentoflavone is quite similar to that of (2 ∼ {S})-2-[2-[4-(4-methoxyphenyl) phenyl] sulfanylphenyl] pentanedioic acid complexed with MMP-9. Amentoflavone interacts with the functional zinc and catalytic residue, Glu202. Therefore, the docking study reasonably confirmed the strong inhibitory activity of Amentoflavone.
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2294108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inhibition of d-glycero-β-d-manno-heptose 1-phosphate adenylyltransferase from Burkholderia pseudomallei by epigallocatechin gallate and myricetin.

    Kim, Suwon / Jo, Seri / Kim, Mi-Sun / Kam, Heejin / Shin, Dong Hae

    The Biochemical journal

    2020  Volume 478, Issue 1, Page(s) 235–245

    Abstract: Flavonoids play beneficial roles in various human diseases. In this study, a flavonoid library was employed to probe inhibitors of d-glycero-β-d-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei (BpHldC) and two flavonoids, ... ...

    Abstract Flavonoids play beneficial roles in various human diseases. In this study, a flavonoid library was employed to probe inhibitors of d-glycero-β-d-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei (BpHldC) and two flavonoids, epigallocatechin gallate (EGCG) and myricetin, have been discovered. BpHldC is one of the essential enzymes in the ADP-l-glycero-β-d-manno-heptose biosynthesis pathway constructing lipopolysaccharide of B. pseudomallei. Enzyme kinetics study showed that two flavonoids work through different mechanisms to block the catalytic activity of BpHldC. Among them, a docking study of EGCG was performed and the binding mode could explain its competitive inhibitory mode for both ATP and βG1P. Analyses with EGCG homologs could reveal the important functional moieties, too. This study is the first example of uncovering the inhibitory activity of flavonoids against the ADP-l-glycero-β-d-manno-heptose biosynthesis pathway and especially targeting HldC. Since there are no therapeutic agents and vaccines available against melioidosis, EGCG and myricetin can be used as templates to develop antibiotics over B. pseudomallei.
    MeSH term(s) Adenosine Triphosphate/chemistry ; Burkholderia pseudomallei/enzymology ; Catechin/analogs & derivatives ; Catechin/chemistry ; Crystallography, X-Ray ; Escherichia coli/metabolism ; Flavonoids/chemistry ; Inhibitory Concentration 50 ; Kinetics ; Ligands ; Mannose/chemistry ; Molecular Docking Simulation ; Nucleotidyltransferases/antagonists & inhibitors ; Nucleotidyltransferases/chemistry ; Nucleotidyltransferases/metabolism ; Pyrans/chemistry
    Chemical Substances Flavonoids ; Ligands ; Pyrans ; d-glycero-beta-d-manno-heptose 1-phosphate ; myricetin (76XC01FTOJ) ; Adenosine Triphosphate (8L70Q75FXE) ; Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL) ; Nucleotidyltransferases (EC 2.7.7.-) ; glutamine-synthetase adenylyltransferase (EC 2.7.7.42) ; Mannose (PHA4727WTP)
    Language English
    Publishing date 2020-12-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20200677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?

    Choi, Seul-Ki / Kam, Heejin / Kim, Kye-Young / Park, Suk In / Lee, Yun-Sil

    Cancers

    2019  Volume 11, Issue 8

    Abstract: Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and ... ...

    Abstract Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.
    Language English
    Publishing date 2019-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11081195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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