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  1. Article ; Online: Time-Resolved Luminescent Sensing and Imaging for Enzyme Catalytic Activity Based on Responsive Probes.

    Wang, Jiawei / Jin, Yibiao / Li, Mingdang / Liu, Shujuan / Kam-Wing Lo, Kenneth / Zhao, Qiang

    Chemistry, an Asian journal

    2022  Volume 17, Issue 16, Page(s) e202200429

    Abstract: Enzymes, as a kind of biomacromolecules, play an important role in many physiological processes and relate directly to various diseases. Developing an efficient detection method for enzyme activity is important to achieve early diagnosis of enzyme- ... ...

    Abstract Enzymes, as a kind of biomacromolecules, play an important role in many physiological processes and relate directly to various diseases. Developing an efficient detection method for enzyme activity is important to achieve early diagnosis of enzyme-relevant diseases and high throughput screening of potential enzyme-relevant drugs. Time-resolved luminescence assay provide a high accuracy and signal-to-noise ratios detection methods for enzyme activity, which has been widely used in high throughput screening of enzyme-relevant drugs and diagnosis of enzyme-relevant diseases. Inspired by these advantages, various responsive probes based on metal complexes and metal-free organic compounds have been developed for time-resolved bioimaging and biosensing of enzyme activity owing to their long luminescence lifetimes, high quantum yields and photostability. In this review, we comprehensively reviewed metal complex- and metal-free organic compound-based responsive probes applied to detect enzyme activity through time-resolved imaging, including their design strategies and sensing principles. Current challenges and future prospects in this rapidly growing field are also discussed.
    MeSH term(s) Coordination Complexes ; Diagnostic Imaging ; Luminescence ; Luminescent Measurements
    Chemical Substances Coordination Complexes
    Language English
    Publishing date 2022-07-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202200429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Iridium(iii) polypyridine complexes with a disulfide linker as biological sensors and cytotoxic agents.

    Li, Steve Po-Yam / Yim, Vicki Man-Wai / Shum, Justin / Kam-Wing Lo, Kenneth

    Dalton transactions (Cambridge, England : 2003)

    2019  Volume 48, Issue 26, Page(s) 9831

    Abstract: Correction for 'Iridium(iii) polypyridine complexes with a disulfide linker as biological sensors and cytotoxic agents' by Steve Po-Yam Li et al., Dalton Trans., 2019, DOI: 10.1039/c9dt00793h. ...

    Abstract Correction for 'Iridium(iii) polypyridine complexes with a disulfide linker as biological sensors and cytotoxic agents' by Steve Po-Yam Li et al., Dalton Trans., 2019, DOI: 10.1039/c9dt00793h.
    Language English
    Publishing date 2019-04-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c9dt90095k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Luminescent and photoactive transition metal complexes as biomolecular probes and cellular reagents

    Alonso-de Castro, S / Kam-Wing Lo, Kenneth

    (Structure and bonding ; 165)

    2015  

    Abstract: The series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the ...

    Author's details Kenneth Kam-Wing Lo, ed. With contributions by S. Alonso-de Castro
    Series title Structure and bonding ; 165
    Abstract The series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. The individual volumes in the series are thematic. The goal of each volume is to give the reader, whether at a university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience. Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the physical basis of the experimental techniques that have been used to provide the primary data may also be appropriate, if it has not been covered in detail elsewhere. The coverage need not be exhaustive in data, but should rather be conceptual, concentrating on the new principles being developed that will allow the reader, who is not a specialist in the area covered, to understand the data presented. Discussion of possible future research directions in the area is welcomed. Review articles for the individual volumes are invited by the volume editors. Readership: research scientists at universities or in industry, graduate students Special offer For all customers who have a standing order to the print version of Structure and Bonding, we offer free access to the electronic volumes of the Series published in the current year via SpringerLink
    Keywords Chemistry ; Chemistry, inorganic
    Language English
    Size IX, 260 S., 235 mm x 155 mm
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    ISBN 3662467178 ; 9783662467176 ; 9783662467183 ; 3662467186
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article ; Online: Photo- and Electrochemical Dual-Responsive Iridium Probe for Saccharide Detection.

    Carrod, Andrew J / Graglia, Francesco / Male, Louise / Le Duff, Cécile / Simpson, Peter / Elsherif, Mohamed / Ahmed, Zubair / Butt, Haider / Xu, Guang-Xi / Kam-Wing Lo, Kenneth / Bertoncello, Paolo / Pikramenou, Zoe

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Volume 28, Issue 4, Page(s) e202103541

    Abstract: Dual detection systems are of interest for rapid, accurate data collection in sensing systems and in vitro testing. We introduce an ... ...

    Abstract Dual detection systems are of interest for rapid, accurate data collection in sensing systems and in vitro testing. We introduce an Ir
    MeSH term(s) Boronic Acids ; Carbohydrates ; Iridium ; Luminescence ; Water
    Chemical Substances Boronic Acids ; Carbohydrates ; Water (059QF0KO0R) ; Iridium (44448S9773)
    Language English
    Publishing date 2021-12-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202103541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Silver nanoclusters capped silica nanoparticles as a ratiometric photoluminescence nanosensor for the selective detection of I

    Huang, Xinan / Shahzad, Sohail Anjum / Li, Yongxin / Zhang, Yunyi / Sang, Lijia / Zhou, Huipeng / Jiang, Hong / Kam-Wing Lo, Kenneth / Yu, Cong

    Analytica chimica acta

    2017  Volume 988, Page(s) 74–80

    Abstract: A novel and efficient approach has been established for the synthesis of silver nanoclusters capped silica nanoparticles ( ... ...

    Abstract A novel and efficient approach has been established for the synthesis of silver nanoclusters capped silica nanoparticles (SiO
    Language English
    Publishing date 2017-10-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2017.07.056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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