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Article: Characteristics and Outcomes of Stem Cell Transplant Patients during the COVID-19 Era: A Systematic Review and Meta-Analysis.

Kamal, Mona / Baudo, Massimo / Joseph, Jacinth / Geng, Yimin / Mohamed, Omnia / Rahouma, Mohamed / Greenbaum, Uri

2024 Volume 12, Issue 5

Abstract: This systematic review and meta-analysis aims to identify the outcomes of stem cell transplant (SCT) patients during the COVID-19 era. Pooled event rates (PER) were calculated, and meta-regression was performed. A random effects model was utilized. In ... ...

Abstract	This systematic review and meta-analysis aims to identify the outcomes of stem cell transplant (SCT) patients during the COVID-19 era. Pooled event rates (PER) were calculated, and meta-regression was performed. A random effects model was utilized. In total, 36 eligible studies were included out of 290. The PER of COVID-19-related deaths and COVID-19-related hospital admissions were 21.1% and 55.2%, respectively. The PER of the use of hydroxychloroquine was 53.27%, of the receipt of immunosuppression it was 39.4%, and of the use of antivirals, antibiotics, and steroids it was 71.61%, 37.94%, and 18.46%, respectively. The PER of the time elapsed until COVID-19 infection after SCT of more than 6 months was 85.3%. The PER of fever, respiratory symptoms, and gastrointestinal symptoms were 70.9, 76.1, and 19.3%, respectively. The PER of acute and chronic GvHD were 40.2% and 60.9%, respectively. SCT patients are at a higher risk of severe COVID-19 infection and mortality. The use of dexamethasone improves the survival of hospitalized SCT patients with moderate to severe COVID-19 requiring supplemental oxygen or ventilation. The SCT patient group is a heterogeneous group with varying characteristics. The quality of reporting on these patients when infected with COVID-19 is not uniform and further prospective or registry studies are needed to better guide clinical care in this unique setting.
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12050530
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Retraction Note: Distance learning impact on the English language teaching during COVID-19.

Kamal, Mona Ibrahim / Zubanova, Svetlana / Isaeva, Anastasia / Movchun, Vasily

Education and information technologies

2022 Volume 27, Issue 9, Page(s) 13171

Abstract: This retracts the article DOI: 10.1007/s10639-021-10588-y.]. ...

Abstract	[This retracts the article DOI: 10.1007/s10639-021-10588-y.].
Language	English
Publishing date	2022-08-23
Publishing country	Netherlands
Document type	Retraction of Publication
ZDB-ID	2001930-0
ISSN	1573-7608 ; 1360-2357
ISSN (online)	1573-7608
ISSN	1360-2357
DOI	10.1007/s10639-022-11284-1
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Article: Distance learning impact on the English language teaching during COVID-19.

Kamal, Mona Ibrahim / Zubanova, Svetlana / Isaeva, Anastasia / Movchun, Vasily

publication RETRACTED

Education and information technologies

2021 Volume 26, Issue 6, Page(s) 7307–7319

Abstract: These days, distance learning has almost completely replaced traditional teaching methods due to the COVID-19 pandemic and the introduction of quarantine measures. A sharp rise in interest in distance learning methodology has raised a number of new ... ...

Abstract	These days, distance learning has almost completely replaced traditional teaching methods due to the COVID-19 pandemic and the introduction of quarantine measures. A sharp rise in interest in distance learning methodology has raised a number of new questions and challenges. This research examines changes in the training process and cognitive abilities and academic performance during the coronavirus pandemic. Students of the I.M. Sechenov University and Al Ain University were surveyed (103) during classroom and distance English learning before and during the COVID-19. Three samples of the average values of the respondents' self-assessment of academic performance, cognitive abilities (namely concentration and memory), progress in performing oral assignments, progress in performing written assignments, ability to absorb information while reading and by ear; general health condition during the training and were obtained and tested for the Gaussian distribution law compliance. All of the rates studied fell during distance learning during a pandemic compared to distance learning outside a pandemic. However, it should be noted that they still turned out to be higher than the marks obtained in classroom teaching. Students were interviewed for possible factors influencing the reviewed teaching modes effectiveness (the survey showed that these factors are an increase in the amount of leisure time, ability to take breaks more often, more comfortable learning environment, no need to spend time on the road to the university).
Language	English
Publishing date	2021-05-27
Publishing country	Netherlands
Document type	Journal Article ; Retracted Publication
ZDB-ID	2001930-0
ISSN	1573-7608 ; 1360-2357
ISSN (online)	1573-7608
ISSN	1360-2357
DOI	10.1007/s10639-021-10588-y
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Article: Utility of Patient-Reported Symptom and Functional Outcomes to Indicate Recovery after First 90 Days of Radical Cystectomy: A Longitudinal Study.

Wang, Xin Shelley / Bree, Kelly K / Navai, Neema / Kamal, Mona / Shen, Shu-En / Letona, Elizabeth / Cleeland, Charles S / Shi, Qiuling / Gottumukkala, Vijaya

Cancers

2023 Volume 15, Issue 11

Abstract: This is a longitudinal prospective study that tracked multiple symptom burden and functioning status for bladder cancer (BLC) patients for 3 months post-radical cystectomy at The University of Texas MD Anderson Cancer Center, using a validated disease- ... ...

Abstract	This is a longitudinal prospective study that tracked multiple symptom burden and functioning status for bladder cancer (BLC) patients for 3 months post-radical cystectomy at The University of Texas MD Anderson Cancer Center, using a validated disease-specific patient-reported outcome measure (PROM) tool, the MD Anderson Symptom Inventory (the MDASI-PeriOp-BLC). The feasibility of collecting an objective measure for physical functioning, using "Timed Up & Go test" (TUGT) and PRO scores at baseline, discharge and end of study, was tested. Patients (
Language	English
Publishing date	2023-06-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15113051
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Article ; Online: Novel quinoxaline-3-propanamides as VGFR-2 inhibitors and apoptosis inducers.

Ismail, Magda M F / Shawer, Taghreed Z / Ibrahim, Rabab S / Abusaif, Mostafa S / Kamal, Mona M / Allam, Rasha M / Ammar, Yousry A

RSC advances

2023 Volume 13, Issue 45, Page(s) 31908–31924

Abstract: Vascular endothelial growth factor receptor-2 is a vital target for therapeutic mediation in various types of cancer. This study was aimed at exploring the cytotoxic activity of seventeen novel quinoxaline-3-propanamides against colon cancer (HCT-116) ... ...

Abstract	Vascular endothelial growth factor receptor-2 is a vital target for therapeutic mediation in various types of cancer. This study was aimed at exploring the cytotoxic activity of seventeen novel quinoxaline-3-propanamides against colon cancer (HCT-116) and breast cancer (MCF-7) using MTT assay. Results revealed that compounds 8, 9, and 14 elicited higher cytotoxicity than the reference drugs, doxorubicin (DOX) and sorafenib. Interestingly, they are more selective for HCT-116 (SI 11.98-19.97) and MCF-7 (SI 12.44-23.87) compared to DOX (SI HCT-116 0.72 and MCF-7 0.9). These compounds effectively reduced vascular endothelial growth factor receptor-2; among them, compound 14 displayed similar VEGFR-2 inhibitory activity to sorafenib (IC
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra05066a
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Article ; Online: Patient-reported symptoms at discharge and risk of complications after gynecologic surgery.

Wang, Xin Shelley / Ramirez, Pedro T / Shi, Qiuling / Kamal, Mona / Garcia-Gonzalez, Araceli / Iniesta, Maria D / Cleeland, Charles S / Meyer, Larissa A

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023 Volume 33, Issue 2, Page(s) 271–277

Abstract: Objective: Current gaps in knowledge limit clinicians from fully implementing patient-reported outcomes in routine post-operative care.: Methods: This prospective study assessed symptoms via the gynecologic module of the MD Anderson Symptom Inventory ...

Abstract	Objective: Current gaps in knowledge limit clinicians from fully implementing patient-reported outcomes in routine post-operative care. Methods: This prospective study assessed symptoms via the gynecologic module of the MD Anderson Symptom Inventory (MDASI-PeriOp-GYN) in patients who underwent open laparotomy. Results: At discharge, patient-reported moderate to severe (≥4 on a 0-10 scale) abdominal bloating or abdominal cramping, combined with length of stay of ≥4 days, were found to be associated with a higher risk of 30-day post-operative grade II-IV complications by the Clavien-Dindo system (all p values <0.01). Also, length of stay of ≥4 days and moderate to severe urinary urgency at discharge were found to be associated with the need for re-admission (all p values <0.01). Conclusion: This study defined the clinically meaningful symptoms that related to the risk of developing important complications after discharge from major open gynecological surgery.These findings support the integration of assessment of patient-reported outcomes into patient-centered post-operative care.
MeSH term(s)	Humans ; Female ; Patient Discharge ; Prospective Studies ; Gynecologic Surgical Procedures/adverse effects ; Postoperative Complications/etiology ; Postoperative Complications/diagnosis ; Patient Reported Outcome Measures ; Length of Stay
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2022-004016
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Zs.A 3198: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats.

Elkiki, Shereen M / Mansour, Heba H / Anis, Lobna M / Gabr, Hanan M / Kamal, Mona M

Toxicology mechanisms and methods

2021 Volume 31, Issue 7, Page(s) 538–545

Abstract: Radiation-induced pulmonary fibrosis (RIPF) is a known complication in cancer patients after getting thoracic radiotherapy. Aromatase inhibitors (AIs) as anastrozole have been used instead of tamoxifen for adjuvant endocrine treatment of postmenopausal ... ...

Abstract	Radiation-induced pulmonary fibrosis (RIPF) is a known complication in cancer patients after getting thoracic radiotherapy. Aromatase inhibitors (AIs) as anastrozole have been used instead of tamoxifen for adjuvant endocrine treatment of postmenopausal women with hormone sensitive breast cancer. This study is to evaluate the concurrent treatment of anastrozole and RIPF in rats. Twenty four female Wistar rats were distributed into 4 groups: Control (C), Radiation group (R) (total dose 30 Gy in 10 fractions, 5 fractions/week), anastrozole group (A) (0.003 mg/200 g body weight) orally for 14 consecutive days, and Radiation + anastrozole group (R + A). Radiation exposure resulted in a significant increase (
MeSH term(s)	Animals ; Aromatase Inhibitors/toxicity ; Female ; Lung ; Platelet-Derived Growth Factor ; Pulmonary Fibrosis/chemically induced ; Rats ; Rats, Wistar ; Signal Transduction ; Smad3 Protein ; Transforming Growth Factor beta
Chemical Substances	Aromatase Inhibitors ; Platelet-Derived Growth Factor ; Smad3 Protein ; Smad3 protein, rat ; Transforming Growth Factor beta
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2081252-8
ISSN	1537-6524 ; 1537-6516 ; 1051-7235
ISSN (online)	1537-6524
ISSN	1537-6516 ; 1051-7235
DOI	10.1080/15376516.2021.1934765
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Zs.A 3215: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Estimating the optimal linear combination of predictors using spherically constrained optimization.

Das, Priyam / De, Debsurya / Maiti, Raju / Kamal, Mona / Hutcheson, Katherine A / Fuller, Clifton D / Chakraborty, Bibhas / Peterson, Christine B

BMC bioinformatics

2022 Volume 23, Issue Suppl 3, Page(s) 436

Abstract: Background: In the context of a binary classification problem, the optimal linear combination of continuous predictors can be estimated by maximizing the area under the receiver operating characteristic curve. For ordinal responses, the optimal ... ...

Abstract	Background: In the context of a binary classification problem, the optimal linear combination of continuous predictors can be estimated by maximizing the area under the receiver operating characteristic curve. For ordinal responses, the optimal predictor combination can similarly be obtained by maximization of the hypervolume under the manifold (HUM). Since the empirical HUM is discontinuous, non-differentiable, and possibly multi-modal, solving this maximization problem requires a global optimization technique. Estimation of the optimal coefficient vector using existing global optimization techniques is computationally expensive, becoming prohibitive as the number of predictors and the number of outcome categories increases. Results: We propose an efficient derivative-free black-box optimization technique based on pattern search to solve this problem, which we refer to as Spherically Constrained Optimization Routine (SCOR). Through extensive simulation studies, we demonstrate that the proposed method achieves better performance than existing methods including the step-down algorithm. Finally, we illustrate the proposed method to predict the severity of swallowing difficulty after radiation therapy for oropharyngeal cancer based on radiation dose to various structures in the head and neck. Conclusions: Our proposed method addresses an important challenge in combining multiple biomarkers to predict an ordinal outcome. This problem is particularly relevant to medical research, where it may be of interest to diagnose a disease with various stages of progression or a toxicity with multiple grades of severity. We provide the implementation of our proposed SCOR method as an R package, available online at https://CRAN.R-project.org/package=SCOR .
MeSH term(s)	ROC Curve ; Computer Simulation ; Algorithms ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-022-04953-y
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Article: Characteristics and Outcomes of Intracranial Hemorrhage in Cancer Patients Visiting the Emergency Department.

Qdaisat, Aiham / Yeung, Sai-Ching J / Rojas Hernandez, Cristhiam H / Samudrala, Pavani / Kamal, Mona / Li, Ziyi / Wechsler, Adriana H

Journal of clinical medicine

2022 Volume 11, Issue 3

Abstract: Intracranial hemorrhage (ICH) is a dreaded complication of both cancer and its treatment. To evaluate the characteristics and clinical outcomes of cancer patients with ICH, we identified all patients with ICH who visited The University of Texas MD ... ...

Abstract	Intracranial hemorrhage (ICH) is a dreaded complication of both cancer and its treatment. To evaluate the characteristics and clinical outcomes of cancer patients with ICH, we identified all patients with ICH who visited The University of Texas MD Anderson Cancer Center emergency department between 1 September 2006 and 16 February 2016. Clinical and radiologic data were collected and compared. Logistic regression analyses were used to determine the association between clinical variables and various outcomes. During the period studied, 704 confirmed acute ICH cases were identified. In-hospital, 7-day, and 30-day mortality rates were 15.1, 11.4, and 25.6%, respectively. Hypertension was most predictive of intensive care unit admission (OR = 1.52, 95% CI = 1.09-2.12,
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11030643
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Article: Validation and Application of MD Anderson Symptom Inventory Module for Patients with Bladder Cancer in the Perioperative Setting.

Kamal, Mona / Navai, Neema / Bree, Kelly K / Williams, Loretta A / Cleeland, Charles S / Shen, Shu-En / Wang, Xin Shelley

Cancers

2022 Volume 14, Issue 16

Abstract: Objectives: We developed and validated a disease-specific tool for perioperative patient-reported outcomes assessment for bladder cancer (BLC) patients undergoing radical cystectomy, The MD Anderson Symptom Inventory (the MDASI-PeriOp-BLC). Methods: ... ...

Abstract	Objectives: We developed and validated a disease-specific tool for perioperative patient-reported outcomes assessment for bladder cancer (BLC) patients undergoing radical cystectomy, The MD Anderson Symptom Inventory (the MDASI-PeriOp-BLC). Methods: Patients who underwent radical cystectomy were recruited. We used qualitative interviews and experts’ input to generate disease/treatment-specific items of the MDASI-PeriOp-BLC module; conducted item reduction; examined the psychometric properties of the resultant items for reliability, validity, and clinical interpretability; and conducted cognitive debriefing interviews to assess the tool’s performance. Results: A total of 150 BLC patients contributed to psychometric validation. We identified and defined eight BLC-specific module items (blood in urine, leaking urine, frequent urination, urinary urgency, burning with urination, constipation, changes in sexual function, and stomal problems). We included those 8 items in addition to 13 MDASI core symptoms and 6 interference items to form the MDASI-PeriOp-BLC module. Cronbach alphas were 0.89 and 0.90 for the 21 severity items and the 6 interference items, respectively. Test−retest reliability (intra-class correlation) was 0.92 for the 21 severity items. The MDASI-PeriOp-BLC module significantly differentiated the patients by performance status (p < 0.0001). Conclusions: The MDASI-PeriOp-BLC is a valid, reliable, and concise tool for monitoring symptom burden during perioperative care in BLC patients undergoing radical cystectomy.
Language	English
Publishing date	2022-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14163896
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