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  1. Article ; Online: Effects of

    Mohajeranirad, Maryam / Saeidi, Naser / Kamali Nejad, Mohammad / Almasi-Hashiani, Amir / Salehi, Mehdi / Latifi, Seyed Amirhossein

    Hormone molecular biology and clinical investigation

    2021  Volume 43, Issue 2, Page(s) 211–218

    Abstract: Objectives: Anorexia, fatigue and pruritus are common complications of hemodialysis (HD) patients. Today, the use of medicinal plants is more than synthetic drugs due to their safety. Therefore, we designed a randomized controlled clinical trial to ... ...

    Abstract Objectives: Anorexia, fatigue and pruritus are common complications of hemodialysis (HD) patients. Today, the use of medicinal plants is more than synthetic drugs due to their safety. Therefore, we designed a randomized controlled clinical trial to evaluate the effects of
    Methods: This randomized, double-blind, placebo-controlled trial was performed on 50 subjects with, aged 55-65 years old. HD patients were randomly divided into two groups. Intervention group received 250 mg/day of
    Results: The results showed that the
    Conclusions: According to the results of this study,
    MeSH term(s) Humans ; Middle Aged ; Aged ; Quality of Life ; Helichrysum ; Anorexia/complications ; Creatinine ; Renal Dialysis/adverse effects ; Pruritus/drug therapy ; Pruritus/etiology ; Fatigue/drug therapy ; Fatigue/etiology ; Double-Blind Method ; Dietary Supplements ; Urea/therapeutic use ; Albumins/therapeutic use
    Chemical Substances Creatinine (AYI8EX34EU) ; Urea (8W8T17847W) ; Albumins
    Language English
    Publishing date 2021-12-02
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2536635-X
    ISSN 1868-1891 ; 1868-1883
    ISSN (online) 1868-1891
    ISSN 1868-1883
    DOI 10.1515/hmbci-2021-0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Water Extract of Juglans Regia L. And Diabetes Mellitus in Iranian Traditional Medicine

    Sarahroodi S. / Rasekh H.R. / Kamali-Nejad M. / Safaeian L.

    Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 3, Iss 3, Pp 19-

    2009  Volume 24

    Abstract: AbstractBackground and Objectives: There are many reports about the glucose lowering effects of medicinal plants in animal models. There are a some reports in Iranian traditional medicine about glucose lowering effect of septum water extract of Juglans ... ...

    Abstract AbstractBackground and Objectives: There are many reports about the glucose lowering effects of medicinal plants in animal models. There are a some reports in Iranian traditional medicine about glucose lowering effect of septum water extract of Juglans Regia L. In the present study, effect of aqueous extract of the septum of Juglans Regia L. on plasma glucose is assessed. Methods: After preparing the water extract of Juglans Regia L. and concentrating of it the lyophilized extract, was tested in diabetic (ip injection of streptozocin) and normal rats. Comparison between groups was made by analysis of variance (ANOVA) and the differences between the means assessed using student’s t test. Results: In an oral glucose tolerance test (OGGT), a single oral administration of the water extract at doses of 50, 250 and 750 mg/kg body weight didn’t lowered the plasma glucose level in the normal rats. Although that insulin administration (5IU/kg) caused a reduction of serum glucose(P<0.001), none of the extract doses (1000, 750, 500, 250mg/Kg) could cause a significant reduction in such level (P>0.005). Conclusion: These results demonstrated that the water extract of the septum of Juglans regia's fruit didn’t have a significant hypoglycemic effect in rats.Keywords: Diabetes Mellitus; Juglans Regia L.; Rat.
    Keywords Diabetes Mellitus ; Juglans Regia L ; Rat ; Medicine (General) ; R5-920
    Language Persian
    Publishing date 2009-11-01T00:00:00Z
    Publisher Qom University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Search for Proteins in the Liquid Extract of Edible Mushroom, Agaricusbisporus, and Studying their Antibacterial Effects.

    Houshdar Tehrani, Mohammad Hassan / Fakhrehoseini, Elham / Kamali Nejad, Mohammad / Mehregan, Hadi / Hakemi-Vala, Mojdeh

    Iranian journal of pharmaceutical research : IJPR

    2013  Volume 11, Issue 1, Page(s) 145–150

    Abstract: The edible mushrooms (basidomycetes) have high nutritional value, promote the immune system, and as a source of natural antimicrobial substances have been used to cure bacterial infections since ancient times.Various kinds of proteins with several ... ...

    Abstract The edible mushrooms (basidomycetes) have high nutritional value, promote the immune system, and as a source of natural antimicrobial substances have been used to cure bacterial infections since ancient times.Various kinds of proteins with several biological activities are produced by mushrooms. In this research, in order to evaluate antibacterial activity of edible mushrooms, we isolated proteins of Agaricus bisporus and examined their effects on gr + and gr- bacteria. Protein extract of the mushroom was first discriminated by homogenation of the chopped fruiting bodies in tris buffer with pH 7.3 and then centrifuged. The Protein concentration was determined by Bradford method. Gel filtration of the proteins was performed by Sephadex G-100 using UV spectrophotometer as detector.Three fractions were collected and their purity level were defined by SDS-PAGE . In order to reach to a more purification level, isolated proteins from the G-100 column were fractionated by the DEAE ion exchange column. Antibacterial activity of total extact proteins as well as protein fractions was evaluated by the method of microdilution against gr+ and gr- bacteria. This study showed that the isolated proteins from the mushroom, Agaricus bisporus fruiting bodies were effective against Staphylococcus aureus and MRSA. The proteins of edible mushrooms like Agaricus bisporus, maybe viewed as a natural source of antibacterial agents.
    Language English
    Publishing date 2013-10-22
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2578271-X
    ISSN 1726-6890 ; 1735-0328 ; 1735-0328
    ISSN (online) 1726-6890 ; 1735-0328
    ISSN 1735-0328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acute and subchronic toxicological evaluation of Echinophora platyloba DC (Apiaceae) total extract in Wistar rats.

    Mirghazanfari, Sayid Mahdi / Hosseinzadeh, Leila / Shokoohinia, Yalda / Aslany, Majid / Kamali-Nejad, Mohammad

    Clinics (Sao Paulo, Brazil)

    2007  Volume 67, Issue 5, Page(s) 497–502

    Abstract: Objective: Echinophora platyloba DC is a widely used herbal medicine and food seasoning in Iran. It is claimed to exert antimicrobial, antifungal, and antispasmodic effects. Despite the prevalent use of this plant as a food and medicine, there are no ... ...

    Abstract Objective: Echinophora platyloba DC is a widely used herbal medicine and food seasoning in Iran. It is claimed to exert antimicrobial, antifungal, and antispasmodic effects. Despite the prevalent use of this plant as a food and medicine, there are no reports on its possible toxic effects. To evaluate the safety of E. platyloba, we tested its acute and sub-chronic toxicity in male and female Wistar rats.
    Methods: Rats were orally treated with four different single doses of E. platyloba total extract and screened for signs of toxicity two weeks after administration. In the sub-chronic toxicity study, E. platyloba was administered for 45 days. Mortality, clinical signs, body weight changes, hematological and biochemical parameters, gross findings, organ weights, and histological markers were monitored during the study.
    Results: We found no mortality and no abnormality in clinical signs, body weight, or necropsy findings in any of the animals in the acute study. The results of the subchronic study showed no significant difference in hematological parameters in either sex. There was a significant increase in lactate dehydrogenase in the female groups. A significant increase in the relative lung weight of female rats was noted at 500 mg/kg. Histopathological examinations revealed intra-alveolar hemorrhage in the male rats (500 mg/kg). In the females, congestion of the alveolar capillaries (at 500 mg/kg) and liver bridging necrosis (at 200 mg/kg) were significantly increased.
    Conclusion: The no observed adverse effect level of E. platyloba was determined to be 200 and 50 mg/kg for male and female rats, respectively.
    MeSH term(s) Animals ; Apiaceae/classification ; Apiaceae/toxicity ; Body Weight/drug effects ; Capillaries/drug effects ; Dose-Response Relationship, Drug ; Female ; Liver/drug effects ; Liver/pathology ; Male ; No-Observed-Adverse-Effect Level ; Plant Extracts/toxicity ; Plants, Medicinal ; Pulmonary Alveoli/drug effects ; Pulmonary Alveoli/pathology ; Rats ; Rats, Wistar ; Toxicity Tests, Acute ; Toxicity Tests, Subchronic
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2007-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2012(05)15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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