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  1. AU="Kamalraj, Pabiththa"
  2. AU="Buck, Anna"
  3. AU="Altermatt, Florian"

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  1. Article ; Online: Communication in home care: Understanding the lived experiences of formal caregivers communicating with persons living with dementia.

    Kamalraj, Pabiththa / Savundranayagam, Marie Y / Orange, J B / Kloseck, Marita

    International journal of older people nursing

    2021  Volume 16, Issue 6, Page(s) e12401

    Abstract: Background: Little is known about formal caregivers' lived experiences communicating with persons living with dementia (PLWD) who live in their own homes. Most information comes from research conducted in long-term care settings or home care settings ... ...

    Abstract Background: Little is known about formal caregivers' lived experiences communicating with persons living with dementia (PLWD) who live in their own homes. Most information comes from research conducted in long-term care settings or home care settings involving family care partners. Yet, there are expected needs and rising demands for formal caregivers to provide support within clients' homes.
    Objectives: Accordingly, this study aimed to understand the lived experiences of personal support workers (PSWs) regarding their communication with PLWD who live in their own homes.
    Methods: The study was grounded in a hermeneutic phenomenological research approach. Data were collected as part of the Be EPIC project, an evidence-informed, person-centred communication intervention for PSWs caring for PLWD. One, in-depth semi-structured interview was conducted with each of the PSWs (N = 15). Thematic analysis was completed on the interviews.
    Results: Three major themes emerged: (1) Challenged by dementia-related impairments; (2) Valuing communication in care; and (3) Home is a personal space. Findings revealed that PSWs experience difficulties communicating with PLWD because of dementia-related impairments, despite PSWs recognizing the importance of communication when they provide optimal care in the homes of PLWD. This suggests that PSWs view communication as a crucial component of quality care but do not possess the skills necessary to ensure effective interactions. Findings also demonstrated the importance, uniqueness and impact of the personal home space on PSWs' experiences with communication.
    Conclusion: Overall, findings indicate that PSWs acknowledge the importance of communication as an integral element of providing optimal care, but dementia-related impairments and the intimate, personal home-based care context can hinder successful communication between PSWs and PLWD. The implications of the findings are that additional and targeted education and training are required for PSWs, especially on how dementia-related impairments impact communication within the context of home care based services for PLWD.
    MeSH term(s) Caregivers ; Communication ; Dementia ; Home Care Services ; Humans
    Language English
    Publishing date 2021-08-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2250661-5
    ISSN 1748-3743 ; 1748-3735
    ISSN (online) 1748-3743
    ISSN 1748-3735
    DOI 10.1111/opn.12401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Changing Face of Cancer Surgery During Multiple Waves of COVID-19.

    Fu, Rui / Kamalraj, Pabiththa / Li, Qing / Hallet, Julie / Gomez, David / Sutradhar, Rinku / Eskander, Antoine

    JNCI cancer spectrum

    2022  Volume 6, Issue 5

    Abstract: COVID-19 has had a detrimental effect on the provision of cancer surgery, but its impact beyond the first 6 months of the pandemic remains unclear. We used data on 799 220 cancer surgeries performed in Ontario, Canada, during 2018-2021 and segmented ... ...

    Abstract COVID-19 has had a detrimental effect on the provision of cancer surgery, but its impact beyond the first 6 months of the pandemic remains unclear. We used data on 799 220 cancer surgeries performed in Ontario, Canada, during 2018-2021 and segmented regression to address this knowledge gap. With the arrival of the first COVID-19 wave (March 2020), mean cancer surgical volume decreased by 57%. Surgical volume then rose by 2.5% weekly and reached prepandemic levels in 8 months. The surgical backlog after the first wave was 47 639 cases. At the beginning of the second COVID-19 wave (January 2021), mean cancer surgical volume dropped by 22%. Afterward, surgical volume did not actively recover (2-sided P = .25), resulting in a cumulative backlog of 66 376 cases as of August 2021. These data urge the strengthening of the surgical system to quickly clear the backlog in anticipation of a tsunami of newly diagnosed cancer patients in need of surgery.
    MeSH term(s) COVID-19 ; Humans ; Neoplasms/epidemiology ; Ontario/epidemiology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2515-5091
    ISSN (online) 2515-5091
    DOI 10.1093/jncics/pkac062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nivolumab for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Retrospective Tertiary Centre's Real-World Experience.

    Du, Yue Jennifer / Fu, Rui / Levinsky, Justin T / Kamalraj, Pabiththa / Chan, Kelvin K W / Parmar, Ambica / Eskander, Antoine / Smoragiewicz, Martin

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 10, Page(s) 8928–8935

    Abstract: Nivolumab, a PD-1 checkpoint inhibitor, was approved in Canada in 2017 for the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) based on the phase 3 trial CHECKMATE-141. We aimed to examine the demographics and ... ...

    Abstract Nivolumab, a PD-1 checkpoint inhibitor, was approved in Canada in 2017 for the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) based on the phase 3 trial CHECKMATE-141. We aimed to examine the demographics and efficacy of nivolumab in a Canadian, real-world setting. A retrospective chart review was performed on patients who received nivolumab for R/M HNSCC from 2017 to 2020 at a high-volume cancer centre. Data were abstracted from 34 patients, based on physician notes and imaging reports. The median patient age at nivolumab initiation was 61, 24% were female, and 62% were current or former smokers. Prior to nivolumab, 44% of patients underwent surgery, 97% radiation, and 100% chemotherapy. Most (97%) therapies were for primary disease. Overall survival at 6 and 12 months following drug initiation was 38% and 23%, respectively. Progression-free survival at 6 and 12 months was 33% and 22%, respectively. Eighteen percent of patients experienced an immune-related adverse event, the most common of which was pneumonitis (3/8) and endocrine events (3/8). Seven out of eight of the immune adverse events were grade 1-2; 1/8 was grade 3. Nivolumab appears to have decreased survival rates in our single-centre Canadian population compared to CHECKMATE-141 and presented a manageable adverse event profile for R/M HNSCC.
    MeSH term(s) Humans ; Female ; Male ; Nivolumab/adverse effects ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Retrospective Studies ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Canada ; Head and Neck Neoplasms/drug therapy
    Chemical Substances Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30100645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A scoping assessment of dental services at designated head and neck cancer centres in Ontario, Canada.

    Levy, Ben B / Goodman, Jade / Watson, Erin / Gilbert, Melanie / Blanas, Nick / Noel, Christopher W / Kamalraj, Pabiththa / Wright, Frances C / Irish, Jonathan C / Conn, Lesley Gotlib / Eskander, Antoine

    BMC oral health

    2024  Volume 24, Issue 1, Page(s) 232

    Abstract: Background: Dentists serve a crucial role in managing treatment complications for patients with head and neck cancer, including post-radiation caries and oral infection. To date, dental services for head and neck cancer patients in Ontario, Canada have ... ...

    Abstract Background: Dentists serve a crucial role in managing treatment complications for patients with head and neck cancer, including post-radiation caries and oral infection. To date, dental services for head and neck cancer patients in Ontario, Canada have not been well characterized and considerable disparities in allocation, availability, and funding are thought to exist. The current study aims to describe and assess the provision of dental services for head and neck cancer patients in Ontario.
    Methods: A mixed methods scoping assessment was conducted. A purposive sample of dentist-in-chiefs at each of Ontario's 9 designated head and neck cancer centres (tertiary centres which meet provincially-set quality and safety standards) was invited to participate. Participants completed a 36-item online survey and 60-minute semi-structured interview which explored perceptions of dental services for head and neck cancer patients at their respective centres, including strengths, gaps, and inequities. If a centre did not have a dentist-in-chief, an alternative stakeholder who was knowledgeable on that centre's dental services participated instead. Thematic analysis of the interview data was completed using a mixed deductive-inductive approach.
    Results: Survey questionnaires were completed at 7 of 9 designated centres. A publicly funded dental clinic was present at 5 centres, but only 2 centres provided automatic dental assessment for all patients. Survey data from 2 centres were not captured due to these centres' lack of active dental services. Qualitative interviews were conducted at 9 of 9 designated centres and elicited 3 themes: (1) lack of financial resources; (2) heterogeneity in dentistry care provision; and (3) gaps in the continuity of care. Participants noted concerning under-resourcing and limitations/restrictions in funding for dental services across Ontario, resulting in worse health outcomes for vulnerable patients. Extensive advocacy efforts by champions of dental services who have sought to mitigate current disparities in dentistry care were also described.
    Conclusions: Inequities exist in the provision of dental services for head and neck cancer patients in Ontario. Data from the current study will broaden the foundation for evidence-based decision-making on the allocation and funding of dental services by government health care agencies.
    MeSH term(s) Humans ; Ontario ; Delivery of Health Care ; Head and Neck Neoplasms ; Mouth Diseases ; Dental Caries/therapy ; Dental Care
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-024-03992-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Early survival for patients newly diagnosed with cancer during COVID-19 in Ontario, Canada: A population-based cohort study.

    Fu, Rui / Sutradhar, Rinku / Li, Qing / Kamalraj, Pabiththa / Dare, Anna / Hanna, Timothy P / Chan, Kelvin K W / Irish, Jonathan C / Coburn, Natalie / Hallet, Julie / Singh, Simron / Parmar, Ambica / Earle, Craig C / Lapointe-Shaw, Lauren / Krzyzanowska, Monika K / Louie, Alexander V / Mahar, Alyson / Urbach, David R / McIsaac, Daniel I /
    Enepekides, Danny / Gomez, David / Look Hong, Nicole J / Tinmouth, Jill / Eskander, Antoine

    Cancer medicine

    2023  Volume 12, Issue 10, Page(s) 11849–11859

    Abstract: Background: Little is known about the association between the COVID-19 pandemic and early survival among newly diagnosed cancer patients.: Methods: This retrospective population-based cohort study used linked administrative datasets from Ontario, ... ...

    Abstract Background: Little is known about the association between the COVID-19 pandemic and early survival among newly diagnosed cancer patients.
    Methods: This retrospective population-based cohort study used linked administrative datasets from Ontario, Canada. Adults (≥18 years) who received a cancer diagnosis between March 15 and December 31, 2020, were included in a pandemic cohort, while those diagnosed during the same dates in 2018/2019 were included in a pre-pandemic cohort. All patients were followed for one full year after the date of diagnosis. Cox proportional hazards regression models were used to assess survival in relation to the pandemic, patient characteristics at diagnosis, and the modality of first cancer treatment as a time-varying covariate. Interaction terms were explored to measure the pandemic association with survival for each cancer type.
    Results: Among 179,746 patients, 53,387 (29.7%) were in the pandemic cohort and 37,741 (21.0%) died over the first post-diagnosis year. No association between the pandemic and survival was found when adjusting for patient characteristics at diagnosis (HR 0.99 [95% CI 0.96-1.01]), while marginally better survival was found for the pandemic cohort when the modality of treatment was additionally considered (HR 0.97 [95% CI 0.95-0.99]). When examining each cancer type, only a new melanoma diagnosis was associated with a worse survival in the pandemic cohort (HR 1.25 [95% CI 1.05-1.49]).
    Conclusions: Among patients able to receive a cancer diagnosis during the pandemic, one-year overall survival was not different than those diagnosed in the previous 2 years. This study highlights the complex nature of the COVID-19 pandemic impact on cancer care.
    MeSH term(s) Adult ; Humans ; Ontario/epidemiology ; Retrospective Studies ; Cohort Studies ; Pandemics ; COVID-19/epidemiology ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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