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  1. Article ; Online: Risques infectieux après transplantation d’organes solides.

    Kamar, Nassim / Marion, Olivier / Del Bello, Arnaud

    La Revue du praticien

    2024  Volume 73, Issue 9, Page(s) 969–972

    Abstract: INFECTION AFTER SOLID-ORGAN-TRANSPLANTATION. Infections is one the most cause for hospitalization after solid-organ-transplantation. We distinguish donor-derived infections, reactivation of latent infection in recipients, nosocomial infections and ... ...

    Title translation Infectious risks after solid organ transplantation.
    Abstract INFECTION AFTER SOLID-ORGAN-TRANSPLANTATION. Infections is one the most cause for hospitalization after solid-organ-transplantation. We distinguish donor-derived infections, reactivation of latent infection in recipients, nosocomial infections and community infections. The first three types are observed mainly in the early period post-transplantation, while community infections can occur at any time after transplantation. Opportunistic infections and some specific infections should be assessed systematically and rapidly. This often requires invasive diagnostic procedures. Prevention altered the incidence and severity of post-transplant infections. It included vaccination, use of universal prophylaxis, systematic monitoring of some agents after transplantation and safer living.
    MeSH term(s) Humans ; Cross Infection ; Hospitalization ; Postoperative Complications ; Tissue Donors ; Organ Transplantation/adverse effects
    Language French
    Publishing date 2024-01-31
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  2. Article: New Insights on CMV Management in Solid Organ Transplant Patients: Prevention, Treatment, and Management of Resistant/Refractory Disease.

    Kotton, Camille Nelson / Kamar, Nassim

    Infectious diseases and therapy

    2022  Volume 12, Issue 2, Page(s) 333–342

    Abstract: Cytomegalovirus (CMV) infection can have both direct and indirect effects after solid-organ transplantation, with a significant impact on transplant outcomes. Prevention strategies decrease the risk of CMV disease, although CMV still occurs in up to 50% ... ...

    Abstract Cytomegalovirus (CMV) infection can have both direct and indirect effects after solid-organ transplantation, with a significant impact on transplant outcomes. Prevention strategies decrease the risk of CMV disease, although CMV still occurs in up to 50% of high-risk patients. Ganciclovir (GCV) and valganciclovir (VGCV) are the main drugs currently used for preventing and treating CMV. Emerging data suggest that letermovir is as effective as VGCV with fewer hematological side effects. Refractory and resistant CMV also still occur in solid-organ-transplant patients. Maribavir has been shown to be effective and have less toxicity in the treatment of refractory and resistant CMV. In this review paper, we discuss prevention strategies, refractory and resistant CMV, and drug-related side effects and their impact, as well as optimal use of novel anti-CMV therapies.
    Language English
    Publishing date 2022-12-30
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-022-00746-1
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  3. Article ; Online: Omicron breakthrough infection in a kidney-transplant patient given pre-exposition casirivimab and imdevimab monoclonal antibodies.

    Kamar, Nassim / Gouin, Anna / Izopet, Jacques

    Transplant infectious disease : an official journal of the Transplantation Society

    2022  Volume 24, Issue 2, Page(s) e13803

    MeSH term(s) Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Neutralizing ; Humans ; Kidney
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; imdevimab (2Z3DQD2JHM) ; casirivimab (J0FI6WE1QN)
    Language English
    Publishing date 2022-03-02
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13803
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    Zs.A 5100: Show issues Location:
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  4. Article ; Online: Resistance mutations in SARS-CoV-2 omicron variant after tixagevimab-cilgavimab treatment.

    Vellas, Camille / Kamar, Nassim / Izopet, Jacques

    The Journal of infection

    2022  Volume 85, Issue 5, Page(s) e162–e163

    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Humans ; Mutation ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; tixagevimab ; cilgavimab (1KUR4BN70F)
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.07.014
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    Zs.MG 48: Show issues

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  5. Article ; Online: BK Polyomavirus Consensus.

    Hirsch, Hans H / Mengel, Michael / Kamar, Nassim

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 11, Page(s) 2046–2047

    MeSH term(s) Humans ; BK Virus ; Consensus ; Polyomavirus Infections ; Kidney Transplantation
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac594
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  6. Article ; Online: Can the COVID-19 Pandemic Improve the Management of Solid Organ Transplant Recipients?

    Del Bello, Arnaud / Marion, Olivier / Izopet, Jacques / Kamar, Nassim

    Viruses

    2022  Volume 14, Issue 9

    Abstract: Increased mortality due to SARS-CoV-2 infection was observed among solid organ transplant patients. During the pandemic, in order to prevent and treat COVID-19 infections in this context, several innovative procedures and therapies were initiated within ... ...

    Abstract Increased mortality due to SARS-CoV-2 infection was observed among solid organ transplant patients. During the pandemic, in order to prevent and treat COVID-19 infections in this context, several innovative procedures and therapies were initiated within a short period of time. A large number of these innovations can be applied and expanded to improve the management of non-COVID-19 infectious diseases in solid organ transplant patients and in the case of a future pandemic. In this vein, the present paper reviews and discusses medical care system adaptation, modification of immunosuppression, adjuvant innovative therapies, the role of laboratory expertise, and the prevention of infections as examples of such innovations.
    MeSH term(s) COVID-19/epidemiology ; Humans ; Organ Transplantation/adverse effects ; Organ Transplantation/methods ; Pandemics/prevention & control ; SARS-CoV-2 ; Transplant Recipients
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14091860
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  7. Article ; Online: Chronic hepatitis E: Advancing research and patient care.

    Ma, Zhongren / de Man, Robert A / Kamar, Nassim / Pan, Qiuwei

    Journal of hepatology

    2022  Volume 77, Issue 4, Page(s) 1109–1123

    Abstract: The hepatitis E virus (HEV) was initially thought to exclusively cause acute hepatitis. However, the first diagnosis of chronic hepatitis E in transplant recipients in 2008 profoundly changed our understanding of this pathogen. We have now begun to ... ...

    Abstract The hepatitis E virus (HEV) was initially thought to exclusively cause acute hepatitis. However, the first diagnosis of chronic hepatitis E in transplant recipients in 2008 profoundly changed our understanding of this pathogen. We have now begun to understand that specific HEV genotypes can cause chronic infection in certain immunocompromised populations. Over the past decade, dedicated clinical and experimental research has substantiated knowledge on the epidemiology, transmission routes, pathophysiological mechanisms, diagnosis, clinical features and treatment of chronic HEV infection. Nevertheless, many gaps and major challenges remain, particularly regarding the translation of knowledge into disease prevention and improvement of clinical outcomes. This article aims to highlight the latest developments in the understanding and management of chronic hepatitis E. More importantly, we attempt to identify major knowledge gaps and discuss strategies for further advancing both research and patient care.
    MeSH term(s) Hepatitis E/diagnosis ; Hepatitis E/epidemiology ; Hepatitis E/prevention & control ; Hepatitis E virus/genetics ; Hepatitis, Chronic/diagnosis ; Hepatitis, Chronic/epidemiology ; Hepatitis, Chronic/therapy ; Humans ; Immunocompromised Host ; Patient Care ; Persistent Infection
    Language English
    Publishing date 2022-05-21
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.05.006
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    Zs.A 2027: Show issues Location:
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  8. Article ; Online: Acute and Persistent Hepatitis E Virus Genotype 3 and 4 Infection: Clinical Features, Pathogenesis, and Treatment.

    Kamar, Nassim / Pischke, Sven

    Cold Spring Harbor perspectives in medicine

    2019  Volume 9, Issue 7

    Abstract: Hepatitis E virus (HEV) genotype (gt)3 and 4 infections are prevalent in industrialized and high-income countries. Although most HEV gt3 and gt4 infections are clinically silent, acute infection may be symptomatic in some patients. In persons with ... ...

    Abstract Hepatitis E virus (HEV) genotype (gt)3 and 4 infections are prevalent in industrialized and high-income countries. Although most HEV gt3 and gt4 infections are clinically silent, acute infection may be symptomatic in some patients. In persons with underlying liver disease and in elderly men, HEV infections may present as acute or acute-on-chronic liver failure. Chronic hepatitis may develop in immunosuppressed individuals, including transplant recipients, human immunodeficiency virus (HIV)-infected patients, and persons with hematologic malignancy undergoing chemotherapy, and may progress to life-threatening liver cirrhosis. Extrahepatic manifestations of infection may include neurological and renal disease. Although there is no approved specific therapy for the treatment of acute or chronic HEV gt3 or gt4 infection, off-label use of ribavirin appears to be capable of eliminating chronic HEV infection, and may reduce disease severity in patients suffering from acute liver failure.
    MeSH term(s) Acute Disease ; Age Factors ; Animals ; Antiviral Agents/therapeutic use ; Chronic Disease ; Disease Transmission, Infectious ; Genotype ; Hepatitis E/drug therapy ; Hepatitis E/epidemiology ; Hepatitis E/pathology ; Hepatitis E virus/genetics ; Humans ; Immunocompromised Host ; Ribavirin/therapeutic use ; Sex Factors ; Transplant Recipients
    Chemical Substances Antiviral Agents ; Ribavirin (49717AWG6K)
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a031872
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  9. Article ; Online: Anti-CD38 Monoclonal Antibodies Interfere With Isoagglutinin Detection.

    Del Bello, Arnaud / Kamar, Nassim / Cointault, Olivier / Vieu, Guillaume / Gauthier, Katia

    Transplantation

    2023  Volume 107, Issue 3, Page(s) e74–e75

    MeSH term(s) Humans ; Antibodies, Monoclonal ; Antineoplastic Agents ; Multiple Myeloma
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004453
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    Zs.MO 509: Show issues

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  10. Article: CAR T-Cell Therapy for Refractory Posttransplantation Lymphoproliferative Disorder in a Kidney Transplant Patient.

    Guy, Pierre / Marion, Olivier / Oberic, Lucie / Darres, Amandine / Cointault, Olivier / Del Bello, Arnaud / Kamar, Nassim

    Transplantation direct

    2024  Volume 10, Issue 3, Page(s) e1584

    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001584
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