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  1. Article ; Online: Hypomagnesemia: A Rare Cause of Movement Disorders, Myopathy and Vertical Nystagmus.

    Ray, Somdattaa / Kamath, Vikram Varadaraya / Jadhav, Swati Ramkete / Rajesh, Karalumangala Nagarajaiah

    Movement disorders clinical practice

    2023  Volume 10, Issue 6, Page(s) 1001–1003

    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13735
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  2. Article: Brachial monomelic amyotrophy as an initial manifestation of stiff person syndrome.

    Ray, Somdattaa / Kamath, Vikram / Rajesh, K N

    Journal of neurosciences in rural practice

    2022  Volume 13, Issue 4, Page(s) 778–780

    Abstract: Stiff person syndrome (SPS) is characterized by rigidity of truncal and proximal muscles. The presence of abdominal and paraspinal rigidity is a defining clinical feature of SPS. It is rarely associated with the lower motor neuron (LMN) features. We ... ...

    Abstract Stiff person syndrome (SPS) is characterized by rigidity of truncal and proximal muscles. The presence of abdominal and paraspinal rigidity is a defining clinical feature of SPS. It is rarely associated with the lower motor neuron (LMN) features. We report a patient with SPS whose initial clinical presentation was that of brachial monomelic amyotrophy (BMA). A 24-year-old gentleman presented with a history of the left upper limb wasting and weakness. In addition, he reported stiffness of the lower limbs and abdomen while walking. On examination, patient had left upper limb monomelic amyotrophy and hypertonia, exaggerated deep tendon reflexes in all four limbs. He also had abdominal and paraspinal rigidity. Serum was strongly positive for GAD 65 antibodies suggestive of SPS. Patient showed dramatic improvement to immunomodulation. Patient presented with features of BMA. Symptoms related to SPS were mild. Abdominal rigidity was the clue to the diagnosis. LMN features have been reported previously in stiff person plus syndrome with an atypical course and progressive encephalomyelitis with myoclonus and rigidity, but not in classical SPS.
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.25259/JNRP-2022-3-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Malignant Hyperthermia Like Manifestations during Management of Refractory Status Epilepticus

    Srinivas, Deepti / Keshavan, Venkatesh / Kamath, Vikram / Manmadhan, Manju

    Journal of Neuroanaesthesiology and Critical Care

    2023  Volume 10, Issue 01, Page(s) 51–53

    Abstract: Management of refractory status epilepticus is challenging for a neurointensivist consequent to systemic complexities associated with various drugs and modalities involved in its treatment. We report one such case that manifested with multiple signs of ... ...

    Abstract Management of refractory status epilepticus is challenging for a neurointensivist consequent to systemic complexities associated with various drugs and modalities involved in its treatment. We report one such case that manifested with multiple signs of malignant hyperthermia following use of isoflurane to control seizures. However, the delayed and random occurrence of the signs and negative genetic test report raises doubts regarding the final diagnosis. Delayed presentation of malignant hyperthermia has been reported earlier. Unavailability of dantrolene sodium handily is a major hurdle in treating such cases. We enumerate management of the patient in our intensive care unit.
    Keywords status epilepticus ; malignant hyperthermia ; delayed malignant hyperthermia ; isoflurane
    Language English
    Publishing date 2023-03-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2937287-2
    ISSN 2348-926X ; 2348-0548
    ISSN (online) 2348-926X
    ISSN 2348-0548
    DOI 10.1055/s-0042-1756433
    Database Thieme publisher's database

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  4. Article ; Online: Response to letter to the Editor.

    Mathew, Thomas / K John, Saji / Kamath, Vikram / Sarma, G R K / J Parry, Gareth

    Epilepsy research

    2021  Volume 180, Page(s) 106661

    Language English
    Publishing date 2021-05-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2021.106661
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    Zs.A 2193: Show issues Location:
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  5. Article ; Online: Fulminant Reversible Cerebral Vasoconstriction Syndrome in Breakthrough COVID 19 Infection.

    Ray, Somdattaa / Kamath, Vikram V / Raju P, Arjun / Kn, Rajesh / N, Shalini

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2021  Volume 31, Issue 2, Page(s) 106238

    Abstract: COVID 19 infection continues to afflict people worldwide. Neurological complications of COVID infection are common. We report a case of fulminant reversible cerebrovascular constriction syndrome (RCVS) in a patient with breakthrough COVID 19 infection ... ...

    Abstract COVID 19 infection continues to afflict people worldwide. Neurological complications of COVID infection are common. We report a case of fulminant reversible cerebrovascular constriction syndrome (RCVS) in a patient with breakthrough COVID 19 infection who was fully vaccinated. A 64 year old lady, fully vaccinated 2 months back, presented with headache, drowsiness, partial seizures, visual impairment and quadriplegia. Her nasopharyngeal swab was tested positive for SARS COV2 on real time PCR assay. MRI brain FLAIR images showed multifocal hyperintensities with MR angiogram showing arterial vasoconstriction suggestive of RCVS. Despite initiation of nimodipine, patient's symptoms worsened and she succumbed to sepsis. RCVS following COVID infection has been reported to have a benign outcome. However, despite vaccination, fulminant RCVS following a breakthrough COVID infection was observed in our patient.
    MeSH term(s) COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; Cerebrovascular Disorders ; ChAdOx1 nCoV-19 ; Fatal Outcome ; Female ; Humans ; Middle Aged ; SARS-CoV-2 ; Sepsis/complications ; Sepsis/mortality ; Vasoconstriction ; Vasospasm, Intracranial/diagnostic imaging ; Vasospasm, Intracranial/drug therapy ; Vasospasm, Intracranial/etiology
    Chemical Substances COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2021-11-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2021.106238
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Delay in the diagnosis of dementia in urban India: Role of dementia subtype and age at onset.

    Ellajosyula, Ratnavalli / Narayanan, Jwala / Hegde, Soumya / Kamath, Vikram / Murgod, Uday / Easwaran, Vandhana / Seetharam, Raghavendra / Srinivasan, Murali / Watson, Peter

    International journal of geriatric psychiatry

    2022  Volume 37, Issue 12

    Abstract: Background: Early diagnosis of dementia is crucial for timely intervention. However, frequently, there is a substantial delay in diagnosis. Therefore, it is essential to recognise and address the barriers to early diagnosis. These have not been ... ...

    Abstract Background: Early diagnosis of dementia is crucial for timely intervention. However, frequently, there is a substantial delay in diagnosis. Therefore, it is essential to recognise and address the barriers to early diagnosis. These have not been systematically studied in India. We at a specialist memory clinic in India investigated the time from symptom onset to diagnosis of dementia and factors contributing to the delay.
    Methods: In this cross-sectional study, consecutive patients with dementia (n = 855) seen at a private hospital underwent a standard clinical assessment and investigations. The primary outcome variable was time from symptom onset to diagnosis (TTD). The association of age, education, gender, dementia subtype, and age of onset on TTD were examined using a univariate analysis of covariance.
    Results: The median TTD was 24 months; 43% were diagnosed after 24 months. There was a significant association between TTD and age at onset (young onset-median 36 months vs. late onset-24 months) and dementia subtype. Patients with vascular dementia were diagnosed significantly earlier as compared to patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) [median 18, 24, and 30 months, respectively]. There was no effect of gender or education on the TTD.
    Conclusion: About 40% of patients with dementia were diagnosed more than 2 years after symptom onset, particularly young onset dementias and FTD. Our study findings highlight the gaps in diagnosing patients with dementia in urban India and have significant implications for developing and implementing multifaceted interventions to improve the early diagnosis of dementia.
    MeSH term(s) Humans ; Frontotemporal Dementia ; Age of Onset ; Cross-Sectional Studies ; Alzheimer Disease/diagnosis ; Dementia, Vascular
    Language English
    Publishing date 2022-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.5843
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2208: Show issues Location:
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  7. Article: Comment on "The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review".

    Mathew, Thomas / John, Saji K / Kamath, Vikram / Shaji, Asha

    Evidence-based complementary and alternative medicine : eCAM

    2019  Volume 2019, Page(s) 6829428

    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2019/6829428
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    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Essential oil-related status epilepticus: A small case series study.

    Mathew, Thomas / John, Saji K / Kamath, Vikram / Kumar R, Shiva / Jadav, Rakesh / Shaji, Asha / Nadig, Raghunandan / Sarma, Gosala Raja Kukkuta / Parry, Gareth J

    Journal of the American College of Emergency Physicians open

    2020  Volume 1, Issue 5, Page(s) 918–921

    Abstract: Objective: Essential oils are plant-derived oils and are widely used as an over-the-counter remedy for common ailments. Many essential oils are found to have proconvulsant effects. Here we report a small case series of 3 adults with eseential oil- ... ...

    Abstract Objective: Essential oils are plant-derived oils and are widely used as an over-the-counter remedy for common ailments. Many essential oils are found to have proconvulsant effects. Here we report a small case series of 3 adults with eseential oil-related status epilepticus.
    Methods: This was an observational study conducted in a tertiary care hospital in south India from January 2018 to December 2019. We collected the demographic, clinical, and imaging features of all cases of status epilepticus resulting from exposure to essential oils. Cases of status epilepticus secondary to all other causes were excluded.
    Results: There were 3 young adults with essential oil-related status epilepticus. Two had de novo generalized tonic-clonic status epilepticus, and 1 with posttraumatic occipital lobe epilepsy had focal-impaired awareness status epilepticus. The first 2 cases presented with histories of ingestion of eucalyptus oil. The third case had focal-impaired awareness status epilepticus after topical application of various balms containing eucalyptus and camphor.
    Conclusions: Proconvulsant essential oils of eucalyptus and camphor can cause both generalized and focal status epilepticus. Physicians dealing with patients of status epilepticus should enquire about the exposure to proconvulsant essential oils.
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article
    ISSN 2688-1152
    ISSN (online) 2688-1152
    DOI 10.1002/emp2.12147
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  9. Article ; Online: Essential oil related seizures (EORS): A multi-center prospective study on essential oils and seizures in adults.

    Mathew, Thomas / K John, Saji / Kamath, Vikram / Kumar R, Shiva / Jadav, Rakesh / Swamy, Sreekanta / Adoor, Gurucharan / Shaji, Asha / Nadig, Raghunandan / Badachi, Sagar / D Souza, Delon / Therambil, Manjusha / Sarma, G R K / J Parry, Gareth

    Epilepsy research

    2021  Volume 173, Page(s) 106626

    Abstract: Objective: Essential oils (EOs) like eucalyptus and camphor have pro-convulsant properties. These EOs are present in many over- the- counter balms and oils. The effect of exposure to these EOs and occurrence of seizure is not systematically studied. The ...

    Abstract Objective: Essential oils (EOs) like eucalyptus and camphor have pro-convulsant properties. These EOs are present in many over- the- counter balms and oils. The effect of exposure to these EOs and occurrence of seizure is not systematically studied. The aim of this study was to evaluate the relationship between essential oils and the first episode of seizure and breakthrough seizures in known epileptic patients.
    Methods: This was a multi-center prospective study, conducted in four hospitals over four years. Every person presenting with the first episode of seizure or breakthrough seizure was asked about exposure to EOs, mode of exposure, time to onset of a seizure in relationship to exposure, duration of seizure, type of seizure, and antiepileptic drug therapy.
    Results: During the four-year period there were 55 patients with essential oil-related seizure (EORS). 22(40 %) had essential oil-induced seizures (EOIS) and 33(60 %) had essential oil-provoked seizures (EOPS). The female: male ratio was 1:1.1, the age of the patients ranged from 8 months to 77 years. In the EOIS group, 95 % had generalized tonic-clonic seizures and 5% had focal impaired awareness seizures. In the EOPS group, 42.4 % had focal impaired awareness seizures, 27.3 % generalized tonic-clonic seizures, 15 % focal to bilateral tonic-clonic seizures, and 15 % focal aware motor seizures. EOs implicated were preparations containing eucalyptus and camphor.
    Conclusion: Exposure to essential oils of eucalyptus and camphor is an under-recognized cause of the first and breakthrough seizure. Identifying the true causative factor will prevent unnecessary antiepileptic drug therapy and future recurrence.
    MeSH term(s) Adult ; Anticonvulsants/adverse effects ; Epilepsies, Partial/drug therapy ; Female ; Humans ; Infant ; Male ; Oils, Volatile/adverse effects ; Prospective Studies ; Seizures/chemically induced ; Seizures/drug therapy
    Chemical Substances Anticonvulsants ; Oils, Volatile
    Language English
    Publishing date 2021-03-26
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2021.106626
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    Zs.A 2193: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article: Eucalyptus oil inhalation-induced seizure: A novel, underrecognized, preventable cause of acute symptomatic seizure.

    Mathew, Thomas / Kamath, Vikram / Kumar, R Shiva / Srinivas, Meghana / Hareesh, Prarthana / Jadav, Rakesh / Swamy, Sreekanta

    Epilepsia open

    2017  Volume 2, Issue 3, Page(s) 350–354

    Abstract: Eucalyptus oil (EO) is an essential oil that is widely used across the globe as an over-the-counter remedy for common ailments. EO-induced seizure (EOIS) has not been recognized as an entity, and physicians rarely ask the history of exposure to ... ...

    Abstract Eucalyptus oil (EO) is an essential oil that is widely used across the globe as an over-the-counter remedy for common ailments. EO-induced seizure (EOIS) has not been recognized as an entity, and physicians rarely ask the history of exposure to eucalyptus oil when seeing a patient with first episode of seizure. Here we report 10 cases of EO inhalation-induced seizures seen over the past 2 years in three tertiary care hospitals. Eight patients had GTCS and two had CPS. We aim to raise awareness of seizures induced by exposure to eucalyptus oil.
    Language English
    Publishing date 2017-07-04
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9239
    ISSN 2470-9239
    DOI 10.1002/epi4.12065
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