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  1. Article ; Online: Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report.

    Al-Maqbali, Ali / Kamble, Bina / Al-Qassabi, Salim / Elgalib, Ali

    Sultan Qaboos University medical journal

    2017  Volume 17, Issue 3, Page(s) e339–e342

    Abstract: Ritonavir is a powerful inhibitor of the cytochrome P450 3A4 (CYP3A4) isoenzyme. It is used as a pharmaceutical enhancer in the management of HIV-positive patients. However, when co-administered with other drugs that are metabolised via the CYP3A4 ... ...

    Abstract Ritonavir is a powerful inhibitor of the cytochrome P450 3A4 (CYP3A4) isoenzyme. It is used as a pharmaceutical enhancer in the management of HIV-positive patients. However, when co-administered with other drugs that are metabolised via the CYP3A4 pathway, ritonavir can potentially cause serious drug-drug interactions. Inhaled fluticasone propionate, which is used to treat asthma and chronic obstructive airway disease, is particularly prone to such interactions due to its physiological attributes. We report a HIV-positive 48-year-old male patient who presented to Al Nahdha Hospital, Muscat, Oman, in 2012 with weight loss, generalised weakness and fatigue and diagnosed with secondary adrenal insufficiency as a result of concomitant ritonavir and inhaled fluticasone.
    MeSH term(s) Administration, Inhalation ; Adrenal Insufficiency/chemically induced ; Asthma/drug therapy ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/adverse effects ; Cytochrome P-450 CYP3A Inhibitors/administration & dosage ; Cytochrome P-450 CYP3A Inhibitors/adverse effects ; Drug Interactions ; Fluticasone/administration & dosage ; Fluticasone/adverse effects ; HIV Infections/drug therapy ; HIV Protease Inhibitors/administration & dosage ; HIV Protease Inhibitors/adverse effects ; Humans ; Male ; Middle Aged ; Oman ; Ritonavir/administration & dosage ; Ritonavir/adverse effects
    Chemical Substances Bronchodilator Agents ; Cytochrome P-450 CYP3A Inhibitors ; HIV Protease Inhibitors ; Fluticasone (CUT2W21N7U) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2017-10-10
    Publishing country Oman
    Document type Case Reports ; Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-051X
    ISSN (online) 2075-0528
    ISSN 2075-051X
    DOI 10.18295/squmj.2017.17.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multidisciplinary care model for HIV improves treatment outcome: a single-centre experience from the Middle East.

    Elgalib, Ali / Al-Sawafi, Halima / Kamble, Bina / Al-Harthy, Saud / Al-Sariri, Qamra

    AIDS care

    2018  Volume 30, Issue 9, Page(s) 1114–1119

    Abstract: Multidisciplinary team (MDT) care models have been shown to improve clinical outcomes among HIV patients. We aim to assess the impact of adopting MDT approach in a tertiary HIV clinic in Muscat, Sultanate of Oman. We introduced MDT approach in our HIV ... ...

    Abstract Multidisciplinary team (MDT) care models have been shown to improve clinical outcomes among HIV patients. We aim to assess the impact of adopting MDT approach in a tertiary HIV clinic in Muscat, Sultanate of Oman. We introduced MDT approach in our HIV centre in January 2016 where existing team members (counsellors, nurses, social workers, pharmacists and doctors) worked together, through care pathways, to support patients as they go through the HIV care continuum from diagnosis to viral suppression. Notes were reviewed for demographics and clinical data. The primary outcome was HIV viral load (VL) suppression (<20, < 200 and < 1000 copies/ml) in measurements by December 2015 and June 2017. In December 2015, 253 patients were in care; 98.4% (249/253) were on antiretroviral therapy (ART). Median age was 41 years and 70% were males. Median baseline CD4 was 204. In June 2017, 294 were in care with similar patient characteristics to those in care in 2015. The majority, 95.9% (282/294), were on ART; 8 of whom started ART within 3 months, hence excluded from the VL analysis. Overall, VL < 200 and < 1000 rates increased from 71.9% and 78.7% in 2015 to 90.5% and 95.6% in 2017, with relative risk (RR) (95% CI) of 1.26 (1.15-1.37) and 1.21 (1.13-1.30), respectively; p value < 0.0001 for both. In a sub-analysis of 214 patients who were in care in 2015 and remained in care in 2017, VL < 200 and < 1000 rates increased from 78.5% and 85% in 2015 to 90.2% and 94.4% in 2016, with RR (95% CI) of 1.15 (1.06 to 1.25) and 1.11 (1.04-1.18), respectively; p values of 0.0010 for both. MDT approach has significantly improved treatment outcome for existing patients and those who have attended our services since the introduction of the MDT model.
    MeSH term(s) Adult ; Anti-HIV Agents/therapeutic use ; CD4 Lymphocyte Count ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Male ; Medication Adherence ; Middle Aged ; Middle East ; Retrospective Studies ; Treatment Outcome ; Viral Load
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2018-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/09540121.2018.1479028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2799: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Clinical Characteristics of Confirmed Cases of COVID-19 Admitted at Al Nahdha Hospital, Oman: A Cross-Sectional Descriptive Study.

    Al Harthi, Saud / Al Osali, Magdi / Al Ismaili, Ruwaida / Al Lawati, Sultan / Kamble, Bina / Al Shaaibi, Mustafa / Al Kindi, Nasser / Al Qasabi, Salim / Alhinai, Mohammed / Al Harthi, Hamad / Al Ghafri, Thamra S

    Cureus

    2021  Volume 13, Issue 8, Page(s) e17343

    Abstract: Background and objective Coronavirus disease 2019 (COVID-19) has become a public health emergency of international concern. Several characteristics of hospitalised cases, including variations in symptoms as well as radiological and laboratory findings, ... ...

    Abstract Background and objective Coronavirus disease 2019 (COVID-19) has become a public health emergency of international concern. Several characteristics of hospitalised cases, including variations in symptoms as well as radiological and laboratory findings, have been described. However, the exact clinical spectrum of hospitalised patients with COVID-19 in Oman is currently unclear. The objective of this paper was to describe the sociodemographic, clinical, laboratory, and radiological characteristics, as well as the treatment and clinical outcomes of the confirmed cases of COVID-19 at Al Nahdha Hospital, Oman. Additionally, factors associated with the severity of the disease were identified. Methodology This was a cross-sectional descriptive study of hospitalised COVID-19 patients. The required data were retrieved from the electronic health information system for the period from 3rd March to 9th May 2020. Information was recorded in a bespoke sheet and exported to SPSS Statistics (IBM, Armonk, NY) for analysis. Results A total of 102 admissions were included in this study. The mean age of the cohort was 49.9 (14.7) years. The majority were males (77.5%), and more than half were expatriates (56.9%). Diabetes and hypertension were found in 39.2% and 36.3% of the study population, respectively. Common symptoms encountered were dry cough (78.3%), fever (76.5%), and shortness of breath (SOB) (69.6%). Radiologically, bilateral infiltrations were present in 73.5% of the patients. Only 19 cases required critical care (18.6%), and those were mostly older [54.1 (13.4) years], males (89.5%), and non-nationals (63.2%). Significant factors associated with requiring critical care were symptoms of SOB (89.5% vs 65.1%, p=0.03), diabetes (68.4% vs 32.5%, OR=1.5, p=0.004), chronic artery disease (15.8% vs 3.6%, OR=1.7, p=0.04), and diagnosis of acute respiratory distress symptoms (63.2% vs 6.0%, p<0.001). Additionally, the mean ferritin levels were significantly higher in cases requiring critical care [2350.4 (423.8) vs 795.7 (554.3), p=0.005]. Depending on disease severity, the treatment included antibacterials, antivirals, heparin, and steroids. The utilisation of steroids was significantly higher in the cases requiring critical care (63.2% vs 26.5%, p=0.001). Among cases that required critical care (n=19), nine died (death rate=47.4%). Conclusions This study has provided fundamental information about the clinical characteristics of confirmed COVID-19 cases in Oman, including factors associated with the disease's severity. Results from this study can be utilised to update the COVID-19 management guidelines for hospitalised patients.
    Language English
    Publishing date 2021-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A rare cause for painful fingers--erythromelalgia.

    Saifudeen, A / Kamble, Bina / Nada, A / Gokhale, U

    The Journal of the Association of Physicians of India

    2002  Volume 50, Page(s) 859

    MeSH term(s) Erythromelalgia/complications ; Erythromelalgia/diagnosis ; Female ; Fingers ; Humans ; Middle Aged ; Pain/etiology
    Language English
    Publishing date 2002-06
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 313: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: HIV viral suppression in Oman: Encouraging progress toward achieving the United Nations 'third 90'.

    Elgalib, Ali / Shah, Samir / Al-Habsi, Zeyana / Al-Fouri, Maha / Al-Sawafi, Halima / Al-Noumani, Jalila / Al-Baloushi, Adil / Al-Alawi, Saad / Al-Badi, Salma / Mohammed, Zainab / Al-Ghafri, Jokha / Suleimani, Asma / Al-Mashani, Huda / Raju, Jyothish / Al-Riyami, Saada / Al-Shukri, Muna / Wahab, Abdul / Hussain, Bilal / Al-Naabi, Khalifa /
    Narayan, Anantha / Oliveros, Noreen / Prasad, George / Hussein, Ahmed / Kashyp, Rajeev / Al-Shardi, Khalid / Nada, Ahmed / Akhwand, Shakil / Kamble, Bina / Al-Aamri, Kawthar / Al-Mukhaini, Suad / Al-Kindi, Hanan / Khamis, Faryal / Al-Maani, Amal / Al-Abaidani, Idris / Al-Abri, Seif

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2018  Volume 71, Page(s) 94–99

    Abstract: Objective: To assess the impact of capacity-building interventions introduced by the Oman National AIDS Programme on the quality of HIV care in the country.: Methods: HIV viral load (VL) suppression and loss to follow-up (LTFU) rates were calculated ... ...

    Abstract Objective: To assess the impact of capacity-building interventions introduced by the Oman National AIDS Programme on the quality of HIV care in the country.
    Methods: HIV viral load (VL) suppression and loss to follow-up (LTFU) rates were calculated for the period before (in December 2015; n=1098) and after (in June 2017; n=1185) the introduction of the interventions: training, support, and care pathway development. Three HIV VL cuts-offs at last measurement in the year of interest were used to define VL suppression.
    Results: In the intention-to-treat (ITT) analysis, rates of VL <200 copies/ml and <1000 copies/ml increased from 51.9% in 2015 to 65.5% in 2017 (relative risk (RR) 1.26, 95% confidence interval (CI) 1.17-1.36) and from 58.1% in 2015 to 70.9% in 2017 (RR 1.22, 95% CI 1.14-1.30), respectively; p<0.0001 for both. Similarly, in the on-treatment analysis, rates of VL <200 copies/ml and <1000copies/ml increased from 64.2% in 2015 to 76.9% in 2017 (RR 1.20, 95% CI 1.12-1.28) and from 71.9% in 2015 to 83.2% in 2017 (RR 1.16, 95% CI 1.10-1.22), respectively. Fewer patients were LTFU in 2017 than in 2015 (14.7% (157/1061) vs. 19.2% (188/981); RR 0.77, 95% CI 0.64-0.94).
    Conclusions: Achieving the UNAIDS target of 90% of HIV patients on treatment having VL suppression by 2020 is feasible in Oman.
    MeSH term(s) Adult ; Anti-HIV Agents/therapeutic use ; Female ; HIV Infections/drug therapy ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Oman ; United Nations ; Viral Load
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2018-05-26
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2018.04.795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
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