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  1. Article ; Online: Association between the early repolarization pattern and nocturnal suicide attempts.

    Kameyama, Hiroshi / Sugimoto, Kenichi / Kodaka, Fumitoshi / Okuno, Kenji / Masaki, Takahiro / Nukariya, Kazutaka / Shigeta, Masahiro

    Neuropsychopharmacology reports

    2024  

    Abstract: Aim: Numerous recent reports have highlighted the association between mental disorders and electrocardiographic findings. The early repolarization pattern (ERP) on electrocardiogram has been linked with a history of suicide attempts and attention ... ...

    Abstract Aim: Numerous recent reports have highlighted the association between mental disorders and electrocardiographic findings. The early repolarization pattern (ERP) on electrocardiogram has been linked with a history of suicide attempts and attention deficit hyperactivity disorder, and associations with impulsivity have also been reported. It is known that suicidal intent is more common at night. Patients who have a mental disorder and ERP may have a higher likelihood of impulsivity, potentially increasing the risk of suicide at night.
    Methods: The subjects were 43 patients with a history of suicide attempts who had undergone electrocardiographic examination at Jikei University School of Medicine Kashiwa Hospital and received intervention from our department. Due to the diurnal variation in electrocardiographic findings, only patients who underwent the examination during the daytime were included. Patients' clinical backgrounds were compared according to the presence or absence of ERP, and the association between nocturnal suicide attempts and ERP was examined using multivariate analysis.
    Results: The frequency of nocturnal suicidal behavior was 76.2% in patients with ERP and 31.8% in those without ERP, but the difference was not significant after Bonferroni correction. In the multivariate analysis, there was a significant association of ERP with nocturnal suicide attempts (p = 0.018).
    Conclusion: The finding of an association between ERP and nocturnal suicide attempts indicates that ERP is a biological indicator that can predict nocturnal suicide attempts.
    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Journal Article
    ISSN 2574-173X
    ISSN (online) 2574-173X
    DOI 10.1002/npr2.12433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Relationship between the early repolarization pattern and a history of suicide attempts among drug-free psychiatric patients.

    Kameyama, Hiroshi / Sugimoto, Kenichi / Kodaka, Fumitoshi / Ito, Kyoko / Nukariya, Kazutaka / Kato, Tomohiro / Shigeta, Masahiro

    Neuropsychopharmacology reports

    2022  Volume 42, Issue 3, Page(s) 256–262

    Abstract: Aim: Suicide attempts are an important severe psychiatric symptom and a clear outcome for mental disorders. Although the relationship between the early repolarization pattern in electrocardiogram and psychiatric disorders has recently been reported, ... ...

    Abstract Aim: Suicide attempts are an important severe psychiatric symptom and a clear outcome for mental disorders. Although the relationship between the early repolarization pattern in electrocardiogram and psychiatric disorders has recently been reported, these reports have not been able to exclude the influence of psychiatric drugs. This study aimed to investigate the relationship between the early repolarization pattern and a history of suicide attempts among patients not receiving psychiatric medication.
    Methods: A total of 71 patients with a history of suicide attempts were investigated, 38 of whom were analyzed for this study. We compared the frequency of the early repolarization pattern between a suicide attempt group and a control group. Then, we investigated the association between the early repolarization pattern and the suicide attempt group by logistic regression analysis, including electrocardiographic findings associated with psychiatric disorders.
    Results: The findings indicated that the frequency of the early repolarization pattern was significantly higher in the suicide attempt group (n = 20; 52.6%) than in the control group (n = 4; 10.5%) (P < 0.001), and the results of the logistic regression analysis indicated that the early repolarization pattern was associated with suicide attempts.
    Conclusions: These findings suggest that the early repolarization pattern is associated with a history of suicide attempts.
    MeSH term(s) Humans ; Mental Disorders/drug therapy ; Mental Disorders/epidemiology ; Risk Factors ; Suicide, Attempted/psychology
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article
    ISSN 2574-173X
    ISSN (online) 2574-173X
    DOI 10.1002/npr2.12254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Examining Frontal Lobe Asymmetry and Its Potential Role in Aggressive Behaviors in Early Alzheimer's Disease.

    Kameyama, Hiroshi / Tagai, Kenji / Takasaki, Emi / Kashibayashi, Tetsuo / Takahashi, Ryuichi / Kanemoto, Hideki / Ishii, Kazunari / Ikeda, Manabu / Shigeta, Masatoshi / Shinagawa, Shunichiro / Kazui, Hiroaki

    Journal of Alzheimer's disease : JAD

    2024  Volume 98, Issue 2, Page(s) 539–547

    Abstract: Background: Neuropsychiatric symptoms (NPS) in patients with dementia lead to caregiver burdens and worsen the patient's prognosis. Although many neuroimaging studies have been conducted, the etiology of NPS remains complex. We hypothesize that brain ... ...

    Abstract Background: Neuropsychiatric symptoms (NPS) in patients with dementia lead to caregiver burdens and worsen the patient's prognosis. Although many neuroimaging studies have been conducted, the etiology of NPS remains complex. We hypothesize that brain structural asymmetry could play a role in the appearance of NPS.
    Objective: This study explores the relationship between NPS and brain asymmetry in patients with Alzheimer's disease (AD).
    Methods: Demographic and MRI data for 121 mild AD cases were extracted from a multicenter Japanese database. Brain asymmetry was assessed by comparing the volumes of gray matter in the left and right brain regions. NPS was evaluated using the Neuropsychiatric Inventory (NPI). Subsequently, a comprehensive assessment of the correlation between brain asymmetry and NPS was conducted.
    Results: Among each NPS, aggressive NPS showed a significant correlation with asymmetry in the frontal lobe, indicative of right-side atrophy (r = 0.235, p = 0.009). This correlation remained statistically significant even after adjustments for multiple comparisons (p < 0.01). Post-hoc analysis further confirmed this association (p < 0.05). In contrast, no significant correlations were found for other NPS subtypes, including affective and apathetic symptoms.
    Conclusions: The study suggests frontal lobe asymmetry, particularly relative atrophy in the right hemisphere, may be linked to aggressive behaviors in early AD. These findings shed light on the neurobiological underpinnings of NPS, contributing to the development of potential interventions.
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Atrophy/pathology ; Brain/pathology ; Frontal Lobe/diagnostic imaging ; Frontal Lobe/pathology ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-02-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-231306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Detection of alpha radionuclides in air from patients during Ra-223 alpha radionuclide therapy.

    Yamamoto, Seiichi / Kato, Katsuhiko / Fujita, Naotoshi / Yamashita, Masato / Nishimoto, Takuya / Kameyama, Hiroshi / Abe, Shinji

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 10976

    Abstract: Ra-223 has recently been introduced to alpha radionuclide therapy. According to the decay scheme of Ra-223, an inert gas, Rn-219 is released from patients during alpha radionuclide therapy and its daughter radionuclides may accumulate around the patient. ...

    Abstract Ra-223 has recently been introduced to alpha radionuclide therapy. According to the decay scheme of Ra-223, an inert gas, Rn-219 is released from patients during alpha radionuclide therapy and its daughter radionuclides may accumulate around the patient. However, the concentration of these radon daughters during alpha radionuclide therapy was not obvious. Here, we first detected the radon daughters of Rn-219 around patients during alpha radionuclide therapy. While the Ra-223-administered patients were in a room for ~1.5 hours, the radon daughter concentration increased to 4 to 5 times higher than without the patients. When the patients were in the room, the energy spectra of the alpha particles in the air showed the peak of the radon daughter of Rn-219, Bi-211 (6.6 MeV), which was different from that without the patients. We conclude that the daughter radionuclides of Rn-219 are accumulated around the patient, and the concentration was higher than that of the natural radon daughters. However, the increase in levels of alpha emitters, while detectable, is lower than the daily variations and thus is likely not a source of concern for radiation exposure.
    MeSH term(s) Air Pollutants, Radioactive/analysis ; Alpha Particles/adverse effects ; Alpha Particles/therapeutic use ; Humans ; Radiation Exposure ; Radiotherapy/adverse effects ; Radium/analysis ; Radium/therapeutic use ; Radon Daughters/analysis
    Chemical Substances Air Pollutants, Radioactive ; Radon Daughters ; Radium-223 (8BR2SOL3L1) ; Radium (W90AYD6R3Q)
    Language English
    Publishing date 2018-07-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-29449-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CONTRACT BROILER FARMING

    Todsadee Areerat / Kameyama Hiroshi / Ngamsomsuk Kamol / Yamauchi Koh-En

    American Journal of Economics and Business Administration, Vol 4, Iss 3, Pp 166-

    2012  Volume 171

    Abstract: In Thailand, poultry sector is the main economic growth of livestock sector, especially broiler production. The rapid expansion in broiler production has been made possible by the increase in the number of commercial farms or contract farming. The ... ...

    Abstract In Thailand, poultry sector is the main economic growth of livestock sector, especially broiler production. The rapid expansion in broiler production has been made possible by the increase in the number of commercial farms or contract farming. The objective of this research was to understand better how contract farming works, who gets involved and why and who benefits from the agreement. The study is based on the broiler file survey in Chiang Mai province of Thailand. As the results, contract farming looks quite attractive for farmers as well as for private companies but most of the farmers complained about long waiting until the delivery of the next cycle of chicks have started.
    Keywords Broiler Production ; Contract Farming ; Benefit ; Agreement ; Farmer ; Business ; HF5001-6182 ; Commerce ; HF1-6182 ; Social Sciences ; H
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Science Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds.

    Kameyama, Hiroshi / Udagawa, Orie / Hoshi, Tomoaki / Toukairin, Yoko / Arai, Tomomi / Nogami, Makoto

    Legal medicine (Tokyo, Japan)

    2015  Volume 17, Issue 4, Page(s) 255–260

    Abstract: Wound healing evaluation is important in forensic pathology, in which angiogenesis plays an important role. We have already shown that vascular endothelial growth factor A (VEGF) is produced in the rat skin incision wounds by neutrophils, endothelial ... ...

    Abstract Wound healing evaluation is important in forensic pathology, in which angiogenesis plays an important role. We have already shown that vascular endothelial growth factor A (VEGF) is produced in the rat skin incision wounds by neutrophils, endothelial cells, and fibroblasts. In this study, we assessed the changes in the mRNA expressions of various factors possibly involved in angiogenesis including angiopoietin (ANGPT) 1 and 2, cadherin 5 (CDH5), granulocyte-macrophage colony stimulating factor (CSF2/GM-CSF), granulocyte colony stimulating factor (CSF3/G-CSF), chemokine (C-X-C motif) ligand 2 (CXCL2), chemokine (C-X-C motif) ligand12 (CXCL12/SDF1), endothelin 1 (ET1), fibroblast growth factor 1 (FGF 1), hepatocyte growth factor (HGF), hypoxia inducible factor 1 alpha (HIF1a), leptin, matrix metallopepitidase 9 (MMP9), serpine/plasminogen activator inhibitor1 (PAI1), platelet-derived growth factor-A (PDGF-A), transforming growth factor alpha and beta 1 (TGFa and b1), tenomodulin (TNMD), and troponin I type 2 (TNNI2) in the early stage of the rat skin incision wounds by real time RT-PCR. Factors reported to be involved in lymphangiogenesis such as fibroblast growth factor 2 (FGF 2), c-fos induced growth factor (FIGF/VEGF-D), forkhead box C2 (FOXC2), and prospero homeobox 1 (PROX1) were also studied. One and 3 days after the dorsal skin incisions, wounds on male Sprague-Dawley rats showed the statistically significant increases in the mRNA expressions for CXCL2, CSF3, MMP9, PAI1, and CSF2, whereas TGFa, TNNI2, FGF1, TNMD, leptin, and CXCL12 showed the statistically significant decreases. Interestingly, lymphgangiogenic factors FOXC2, PROX1, and FGF2 also showed the statistically significant decreases. In situ hybridization and immunohistochemistry showed the mRNA and protein positivity in endothelial cells, fibroblasts, and some leukocytes at the bottom of the wound tissue for PAI1, CSF3, and MMP9, 1 day after the skin incisions. Our novel findings show the possible involvement of several factors involved in angiogenesis and lymphangiogenesis in the early stage of wound healing process, which may be useful for forensic wound evaluations.
    MeSH term(s) Animals ; Disease Models, Animal ; Forensic Pathology/methods ; Gene Expression Regulation/physiology ; Humans ; Immunohistochemistry/methods ; Lymphangiogenesis/physiology ; Male ; Neovascularization, Physiologic ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Skin/blood supply ; Skin/injuries ; Skin/metabolism ; Statistics, Nonparametric ; Vascular Endothelial Growth Factors/metabolism ; Wound Healing/physiology
    Chemical Substances RNA, Messenger ; Vascular Endothelial Growth Factors
    Language English
    Publishing date 2015-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2019555-2
    ISSN 1873-4162 ; 1344-6223
    ISSN (online) 1873-4162
    ISSN 1344-6223
    DOI 10.1016/j.legalmed.2015.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pin-photodiode array for the measurement of fan-beam energy and air kerma distributions of X-ray CT scanners.

    Haba, Tomonobu / Koyama, Shuji / Aoyama, Takahiko / Kinomura, Yutaka / Ida, Yoshihiro / Kobayashi, Masanao / Kameyama, Hiroshi / Tsutsumi, Yoshinori

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2016  Volume 32, Issue 7, Page(s) 905–913

    Abstract: Purpose: Patient dose estimation in X-ray computed tomography (CT) is generally performed by Monte Carlo simulation of photon interactions within anthropomorphic or cylindrical phantoms. An accurate Monte Carlo simulation requires an understanding of ... ...

    Abstract Purpose: Patient dose estimation in X-ray computed tomography (CT) is generally performed by Monte Carlo simulation of photon interactions within anthropomorphic or cylindrical phantoms. An accurate Monte Carlo simulation requires an understanding of the effects of the bow-tie filter equipped in a CT scanner, i.e. the change of X-ray energy and air kerma along the fan-beam arc of the CT scanner. To measure the effective energy and air kerma distributions, we devised a pin-photodiode array utilizing eight channels of X-ray sensors arranged at regular intervals along the fan-beam arc of the CT scanner.
    Methods: Each X-ray sensor consisted of two plate type of pin silicon photodiodes in tandem - front and rear photodiodes - and of a lead collimator, which only allowed X-rays to impinge vertically to the silicon surface of the photodiodes. The effective energy of the X-rays was calculated from the ratio of the output voltages of the photodiodes and the dose was calculated from the output voltage of the front photodiode using the energy and dose calibration curves respectively.
    Results: The pin-photodiode array allowed the calculation of X-ray effective energies and relative doses, at eight points simultaneously along the fan-beam arc of a CT scanner during a single rotation of the scanner.
    Conclusions: The fan-beam energy and air kerma distributions of CT scanners can be effectively measured using this pin-photodiode array.
    MeSH term(s) Calibration ; Radiation Dosage ; Semiconductors ; Tomography Scanners, X-Ray Computed
    Language English
    Publishing date 2016-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2016.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neurovascular coupling in primary auditory cortex investigated with voltage-sensitive dye imaging and laser-Doppler flowmetry.

    Kameyama, Hiroshi / Masamoto, Kazuto / Imaizumi, Yoichi / Omura, Tetsuro / Katura, Takusige / Maki, Atsushi / Tanishita, Kazuo

    Brain research

    2008  Volume 1244, Page(s) 82–88

    Abstract: The spatiotemporal dynamics of the neurovascular response to brief acoustic stimuli were investigated in guinea pig primary auditory cortex. Neural activity and cortical tonotopic organization were measured with a voltage-sensitive dye (VSD) technique, ... ...

    Abstract The spatiotemporal dynamics of the neurovascular response to brief acoustic stimuli were investigated in guinea pig primary auditory cortex. Neural activity and cortical tonotopic organization were measured with a voltage-sensitive dye (VSD) technique, whereas cerebral blood flow (CBF) response to neural stimulation was measured with laser-Doppler flowmetry (LDF). The acoustic stimulus was given as a wide band sound (click), which induced global activation or as one of two pure tones (1 kHz and 12 kHz), which induced distinct localizations in the auditory cortex. The VSD imaging showed that the sound-induced activation area varied dynamically, and that the spatial extent had peaks at 37+/-3 ms and 38+/-8 ms after the onset of stimulation during 1-kHz and 12-kHz tones, respectively. We observed that the average CBF response had a similar peak intensity irrespective of the type of stimuli: 16+/-9%, 18+/-11%, and 16+/-8% for click, 1-kHz, and 12-kHz tones, respectively. No significant differences in the CBF time course, time-to-onset (approximately 0.6 s), or time-to-peak (approximately 3.3 s) were found across the recording sites and stimulus types. These results showed that the CBF response measured with LDF produced a less specific spatial pattern relative to the neural map determined with VSD. The findings can be explained by the methodological limitations of LDF and/or neurovascular regulatory systems in the auditory cortex.
    MeSH term(s) Acoustic Stimulation/methods ; Animals ; Auditory Cortex/blood supply ; Auditory Cortex/cytology ; Cerebrovascular Circulation/physiology ; Guinea Pigs ; Laser-Doppler Flowmetry/methods ; Neurons/cytology ; Neurons/physiology ; Regional Blood Flow/physiology ; Time Factors
    Language English
    Publishing date 2008-12-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2008.09.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Stereoselective dialkylation of the proximal hydroxy groups of calix- and thiacalix[4]arenes.

    Narumi, Fumitaka / Hattori, Tetsutaro / Morohashi, Naoya / Matsumura, Nobuji / Yamabuki, Waka / Kameyama, Hiroshi / Miyano, Sotaro

    Organic & biomolecular chemistry

    2004  Volume 2, Issue 6, Page(s) 890–898

    Abstract: Treatment of p-tert-butylcalix[4]arene (C1) and its sulfur-bridged analog T1 with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane in the presence of imidazole gives proximally O,O'-disiloxane-1,3-diyl-bridged calixarenes C2 and T2 in excellent yields, ... ...

    Abstract Treatment of p-tert-butylcalix[4]arene (C1) and its sulfur-bridged analog T1 with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane in the presence of imidazole gives proximally O,O'-disiloxane-1,3-diyl-bridged calixarenes C2 and T2 in excellent yields, respectively. Subsequent base-catalyzed etherification of the remaining hydroxy groups with alkyl halides gives syn- and anti-O'',O'''-dialkylated products, the stereoselectivity of which varies depending on the nature of the macrocycle, as well as the metal cation of the base employed. Thus, conventional calixarene C2 preferentially affords syn compounds of 1,2-alternate conformation (C3) with the aid of tert-BuOK and K(2)CO(3) and anti counterparts of partial-cone conformation (C4) with Cs(2)CO(3). On the other hand, thiacalixarene T2 affords syn compounds of 1,2-alternate conformation (T3) with any of the bases. The disiloxanediyl bridge of the resulting products can readily be removed by treatment with tetrabutylammonium fluoride. Thus, the net process provides an efficient method for the regio- and stereoselective synthesis of proximally dialkylated calix[4]arenes.
    Language English
    Publishing date 2004-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/b315867e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Y-chromosomal STR loci data in Japanese using the Y-PLEX5 and Y-PLEX6 PCR amplification kits.

    Kido, Akira / Hara, Masaaki / Kameyama, Hiroshi / Yamamoto, Yasuhisa / Susukida, Rie / Oya, Masakazu

    Journal of forensic sciences

    2004  Volume 49, Issue 4, Page(s) 849–851

    MeSH term(s) Asian Continental Ancestry Group/genetics ; Chromosomes, Human, Y ; DNA Fingerprinting/methods ; Gene Frequency ; Genetics, Population ; Humans ; Japan ; Male ; Polymerase Chain Reaction/methods ; Tandem Repeat Sequences
    Language English
    Publishing date 2004-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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