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Article ; Online: Letter to the Editor concerning "Alterations of 3D acetabular and lower limb parameters in adolescent idiopathic scoliosis" by Karam M, et al. (Eur Spine J [2020]; 29(8):2010-2017): Does windswept deformity of the knee exist in 274 participants with adolescent idiopathic scoliosis?

Sugita, Takehiko / Aizawa, Toshimi / Sasaki, Akira / Miyamoto, Seiya / Miyatake, Naohisa / Kamimura, Masayuki / Yahata, Kenichirou

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2023 Volume 32, Issue 11, Page(s) 4073

MeSH term(s)	Humans ; Adolescent ; Scoliosis/surgery ; Kyphosis ; Lower Extremity ; Knee Joint ; Acetabulum
Language	English
Publishing date	2023-09-13
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-023-07862-7
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Zs.A 3437: Show issues

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Article ; Online: Evaluation of the usefulness of the Synovasure alpha-defensin lateral flow test kit for the diagnosis of periprosthetic joint infection in Japanese patients.

Mori, Yu / Kanabuchi, Ryuichi / Baba, Kazayoshi / Chiba, Daisuke / Kamimura, Masayuki / Mori, Naoko / Aizawa, Toshimi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2022 Volume 27, Issue 4, Page(s) 935–938

MeSH term(s)	Arthritis, Infectious ; Biomarkers ; Humans ; Japan ; Knee Prosthesis ; Prosthesis-Related Infections/diagnosis ; Sensitivity and Specificity ; Synovial Fluid ; alpha-Defensins
Chemical Substances	Biomarkers ; alpha-Defensins
Language	English
Publishing date	2022-05-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2022.05.001
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Article: Two-stage revision knee arthroplasty for metallosis in a patient with rheumatoid arthritis: A case report.

Koyama, Tomoki / Mori, Yu / Kamimura, Masayuki / Aki, Takashi / Izumiyama, Takuya / Mori, Naoko / Chiba, Daisuke / Hashimoto, Ko / Yamamoto, Nobuyuki / Aizawa, Toshimi

SAGE open medical case reports

2023 Volume 11, Page(s) 2050313X231177752

Abstract: We report a successful case of two-stage revision total knee arthroplasty performed for treating painless metallosis after total knee arthroplasty with a metal-backed patella. A 63-year-old woman diagnosed with rheumatoid arthritis underwent left total ... ...

Abstract	We report a successful case of two-stage revision total knee arthroplasty performed for treating painless metallosis after total knee arthroplasty with a metal-backed patella. A 63-year-old woman diagnosed with rheumatoid arthritis underwent left total knee arthroplasty with a metal-backed patella at 32 years of age. The patient did not have knee pain; however, knee joint swelling, a strange noise, and pigmentation were reported 4 years ago. Radiographs showed cloud and metal-line signs anteriorly and posteriorly at the femoral condyle. Therefore, a two-stage surgery was performed for infection prevention and ease of performing posterior synovectomy. The patient underwent initial synovectomy via a posterior approach, followed by anterior synovectomy and revision total knee arthroplasty. Synovectomy was performed well without perioperative infection or failure of wound healing. In cases with metallosis after total knee arthroplasty, the two-stage revision total knee arthroplasty should be considered, depending on the degree of synovial proliferation and the risk of complications.
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X231177752
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Article ; Online: Low Young's Modulus TiNbSn Alloy Locking Plates Accelerate Osteosynthesis in Rabbit Tibiae.

Koguchi, Masashi / Mori, Yu / Kamimura, Masayuki / Ito, Kentaro / Tanaka, Hidetatsu / Kurishima, Hiroaki / Koyama, Tomoki / Mori, Naoko / Masahashi, Naoya / Aizawa, Toshimi

The Tohoku journal of experimental medicine

2023 Volume 261, Issue 3, Page(s) 199–209

Abstract: A new beta TiNbSn alloy with a low Young's modulus of approximately 40 GPa has been developed to resolve the stress shielding by Young's modulus divergence. In this study, the efficacy of TiNbSn alloy locking plates on bone repair is compared to that of ... ...

Abstract	A new beta TiNbSn alloy with a low Young's modulus of approximately 40 GPa has been developed to resolve the stress shielding by Young's modulus divergence. In this study, the efficacy of TiNbSn alloy locking plates on bone repair is compared to that of commercially pure titanium (CP-Ti). The TiNbSn alloy and CP-Ti, which have Young's moduli of 49.1 GPa and 107 GPa, respectively, were compared. Male Japanese white rabbits were anesthetized, and osteotomy and osteosynthesis with locking plates were performed on the right tibia. The bone repair was assessed using micro-computed tomography (CT), histomorphometry, immunohistochemistry, and mechanical testing. Micro-CT, histomorphometry, immunohistochemistry, and mechanical testing were performed four weeks after osteotomy. Six weeks after surgery, micro-CT and mechanical testing were performed. Micro-CT analysis at four weeks after surgery showed that the intramedullary fracture callus in the TiNbSn alloy group had more bone volume and numerous bridging structures compared to the CP-Ti group (CP-Ti vs. TiNbSn alloy, 34.3 ± 13.1 mm
MeSH term(s)	Male ; Animals ; Rabbits ; Elastic Modulus ; Tibia/diagnostic imaging ; Tibia/surgery ; X-Ray Microtomography ; Fracture Fixation, Internal ; Alloys
Chemical Substances	Alloys
Language	English
Publishing date	2023-09-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	123477-8
ISSN	1349-3329 ; 0040-8727
ISSN (online)	1349-3329
ISSN	0040-8727
DOI	10.1620/tjem.2023.J075
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Ua VI Zs.155: Show issues

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Article ; Online: A case of 49,XXXYY followed-up from infancy to adulthood with review of literature.

Kanno, Junko / Miura, Akinobu / Kawashima, Sayaka / Shima, Hirohito / Suzuki, Dai / Kamimura, Miki / Fujiwara, Ikuma / Kamimura, Masayuki / Uematsu, Mitsugu / Kudo, Masataka / Kikuchi, Atsuo

Endocrine journal

2024

Abstract: 49,XXXYY is an extremely rare sex chromosomal aneuploidy (SCA), with only seven cases reported worldwide to date. Among these cases, only three have been documented into adulthood. Moreover, no cases of 49,XXXYY have been reported in Japan. This SCA has ... ...

Abstract	49,XXXYY is an extremely rare sex chromosomal aneuploidy (SCA), with only seven cases reported worldwide to date. Among these cases, only three have been documented into adulthood. Moreover, no cases of 49,XXXYY have been reported in Japan. This SCA has been identified in two scenarios: in vitro fertilization and abortion. Similar to 47,XXY, this aneuploidy is a type of Klinefelter syndrome. Aneuploidy of the X chromosome can lead to various progressive complications due to excess X chromosomes. Herein, we present the case of a Japanese man with 49,XXXYY. He exhibited developmental delays and external genitalia abnormalities since early infancy but was not closely monitored for these symptoms until the age of 3 years old. At that time, a chromosome test revealed his karyotype to be 49,XXXYY. Subsequent examinations were conducted due to various symptoms, including delayed motor development, intellectual disability, facial dysmorphisms, forearm deformities, hip dysplasia, cryptorchidism, micropenis, primary hypogonadism, and essential tremor. Since reaching puberty, he has undergone testosterone replacement therapy for primary hypogonadism, experiencing no complications related to androgen deficiency to date. He has maintained normal lipid and glucose metabolism, as well as bone density, for a prolonged period. There are no other reports on the long-term effects of testosterone treatment for the SCA. Appropriate testosterone replacement therapy is recommended for individuals with 49,XXXYY to prevent complications. This report will contribute to an enhanced understanding of the 49,XXXYY phenotype, aiding in the diagnosis, treatment, and genetic counseling of future cases.
Language	English
Publishing date	2024-04-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1151918-6
ISSN	1348-4540 ; 0918-8959
ISSN (online)	1348-4540
ISSN	0918-8959
DOI	10.1507/endocrj.EJ24-0015
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Uh III Zs.207: Show issues

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Article ; Online: Differences in kinematic parameters during gait between the patients with knee osteoarthritis and healthy controls using an insole with a single inertial measurement unit: A case-control study.

Yaguchi, Haruki / Honda, Keita / Sekiguchi, Yusuke / Huang, Chenhui / Fukushi, Kenichiro / Wang, Zhenwei / Nakahara, Kentaro / Kamimura, Masayuki / Aki, Takashi / Ogura, Ken / Izumi, Shin-Ichi

Clinical biomechanics (Bristol, Avon)

2024 Volume 112, Page(s) 106191

Abstract: Background: An inertial measurement unit is small and lightweight, allowing patient measurements without physical constraints. This study aimed to determine the differences in kinematic parameters during gait using an insole with a single inertial ... ...

Abstract	Background: An inertial measurement unit is small and lightweight, allowing patient measurements without physical constraints. This study aimed to determine the differences in kinematic parameters during gait using an insole with a single inertial measurement unit in healthy controls and on both sides in patients with knee osteoarthritis. Methods: Twenty patients with knee osteoarthritis and 13 age-matched controls were included in this study. The participants walked at a self-selected speed and foot kinematics were measured during gait using an insole with a single inertial measurement unit. The right side of the healthy controls and both the affected and contralateral sides of patients with KOA were analyzed separately. Findings: The foot extension angular velocity at toe-off was significantly reduced on the affected side than on the contralateral side (P < 0.001) and in healthy controls (P < 0.001). During the swing phase, foot posterior-anterior acceleration was significantly lower on the affected side than on the healthy controls (P = 0.005). Furthermore, despite a decrease in walking speed, foot superior-inferior acceleration at initial contact in patients was significantly lower on the contralateral side than in healthy controls (P = 0.0167), but not on the affected side (P = 0.344). Interpretation: An insole with a single inertial measurement unit can detect differences in foot kinematics during gait between healthy controls and patients with knee osteoarthritis. Our findings indicate that patients with knee osteoarthritis exhibit dysfunction of push-off at toe-off and shock absorption at initial contact on the affected side.
MeSH term(s)	Humans ; Osteoarthritis, Knee ; Knee Joint ; Biomechanical Phenomena ; Case-Control Studies ; Gait ; Walking
Language	English
Publishing date	2024-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632747-3
ISSN	1879-1271 ; 0268-0033
ISSN (online)	1879-1271
ISSN	0268-0033
DOI	10.1016/j.clinbiomech.2024.106191
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Zs.B 2876: Show issues

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Article ; Online: Obesity is a risk factor for osteoarthritis progression and spontaneous osteoporosis is a risk for the development of spontaneous osteonecrosis in patients with medial meniscus posterior root tear.

Takahashi, Atsushi / Umehara, Jutaro / Kamimura, Masayuki / Aizawa, Toshimi / Itoi, Eiji

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2020 Volume 26, Issue 5, Page(s) 844–849

Abstract: Background: Obesity is a representative risk factor for osteoarthritis (OA). The relationship between osteoporosis and executed osteonecrosis has been reported. The primary aim of this study was to determine the influence of obesity and osteoporosis on ... ...

Abstract	Background: Obesity is a representative risk factor for osteoarthritis (OA). The relationship between osteoporosis and executed osteonecrosis has been reported. The primary aim of this study was to determine the influence of obesity and osteoporosis on disease progression in patients with medial meniscus posterior root tear (MMPRT). Methods: We included 41 knees with MMPRT in this study. MMPRT was diagnosed based on the presence of both a meniscus ghost sign and a vertical linear defect on MRI. OA progression and development of osteonecrosis were evaluated using plain radiographs obtained at the initial visit and the final follow-up. The follow-up period for all knees was 30 ± 8 (mean ± standard deviation) months. Patients' physical attributes were assessed at initial visits; these attributes included body mass index (BMI) and the clinical risk for osteoporotic fracture, as determined by the World Health Organization fracture risk assessment tool (FRAX). Patients with a BMI ≥25 kg/m Results: OA progression evaluated by Kellgren-Lawrence grading scale was observed in 75% patients in the obesity group (1 grade in 38%, 2 grades in 31%, and 3 grades in 6%) and 58% in the control group (1 grade in 58%). Patients in the obesity group showed significantly greater OA progression. Spontaneous osteonecrosis was observed in no knees at the initial visit and six knees at the final follow-up. All six lesions were observed in the high FRAX group, which was statistically significant. Conclusions: OA progression and development of osteonecrosis were the two representative deterioration patterns in patients with MMPRT. High BMI was related with OA progression, and FRAX score of ≥10% with the development of osteonecrosis.
MeSH term(s)	Humans ; Magnetic Resonance Imaging ; Menisci, Tibial ; Obesity/complications ; Osteoarthritis ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/epidemiology ; Osteonecrosis/diagnostic imaging ; Osteonecrosis/epidemiology ; Osteonecrosis/etiology ; Osteoporosis/complications ; Osteoporosis/diagnostic imaging ; Osteoporosis/epidemiology ; Retrospective Studies ; Risk Factors ; Tibial Meniscus Injuries/complications ; Tibial Meniscus Injuries/diagnostic imaging
Language	English
Publishing date	2020-10-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2020.09.001
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Article ; Online: Effect of denosumab switched from bisphosphonates in preventing joint destruction in postmenopausal rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies.

Mori, Yu / Izumiyama, Takuya / Kurishima, Hiroaki / Kamimura, Masayuki / Baba, Kazuyoshi / Mori, Naoko / Itoi, Eiji

Journal of orthopaedic surgery and research

2021 Volume 16, Issue 1, Page(s) 107

Abstract: Introduction: This study aimed to determine the effects of denosumab treatment on the joint destruction of Japanese females with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibodies.: Materials and methods: This ... ...

Abstract	Introduction: This study aimed to determine the effects of denosumab treatment on the joint destruction of Japanese females with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibodies. Materials and methods: This retrospective longitudinal study included 56 patients treated with denosumab and 50 patients treated with bisphosphonate. All participants were positive for anti-CCP antibodies. All patients also had a history of osteoporosis treatment with bisphosphonate, which was either continued or switched to 60 mg of subcutaneous denosumab injection every 6 months. To assess the progression of joint destruction, hand and foot radiographs were taken, and changes in modified total Sharp score (mTSS), erosion score (ERO), and joint space narrowing score (JSN) were evaluated at 12 months and 24 months. The changes in BMD of the lumbar spine and hip were also assessed at 12 months. Results: At 12 months, there were significant differences in the change of ERO (p = 0.015) and mTSS (p = 0.01). Similarly, there were significant differences in the change of ERO (p = 0.013) and mTSS (p = 0.003) at 24 months. In contrast, no significant difference was observed in the changes of JSN and clinical parameters. There were significant differences in the changes in BMD in the femoral neck (p = 0.011) and total hip (p = 0.012). Conclusion: Denosumab treatment might be effective for the inhibition of bone erosion progression in the patients with RA, and it potentially contributes to the treatment of osteoporosis and prevention of destructive arthritis in patients with switching treatment from bisphosphonate.
MeSH term(s)	Aged ; Anti-Citrullinated Protein Antibodies ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Bone Density ; Bone Density Conservation Agents/administration & dosage ; Denosumab/administration & dosage ; Diphosphonates/administration & dosage ; Disease Progression ; Drug Substitution ; Female ; Humans ; Joint Deformities, Acquired/etiology ; Joint Deformities, Acquired/prevention & control ; Longitudinal Studies ; Middle Aged ; Osteoporosis, Postmenopausal/complications ; Osteoporosis, Postmenopausal/drug therapy ; Postmenopause ; Retrospective Studies
Chemical Substances	Anti-Citrullinated Protein Antibodies ; Bone Density Conservation Agents ; Diphosphonates ; Denosumab (4EQZ6YO2HI)
Language	English
Publishing date	2021-02-04
Publishing country	England
Document type	Journal Article
ISSN	1749-799X
ISSN (online)	1749-799X
DOI	10.1186/s13018-021-02271-2
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Article ; Online: How much force is acting on the shoulder joint to create a Hill-Sachs Lesion or reverse Hill-Sachs Lesion?

Etoh, Toshimitsu / Yamamoto, Nobuyuki / Kawakami, Jun / Kamimura, Masayuki / Chiba, Daisuke / Mori, Yu / Hashimoto, Ko / Aizawa, Toshimi / Itoi, Eiji

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2022 Volume 28, Issue 6, Page(s) 1252–1257

Abstract: Background: It has not been clarified yet how much force is acting on the shoulder joint to create Hill-Sachs/reverse Hill-Sachs lesions which are commonly observed in patients with anterior or posterior shoulder instability. The purpose of this study ... ...

Abstract	Background: It has not been clarified yet how much force is acting on the shoulder joint to create Hill-Sachs/reverse Hill-Sachs lesions which are commonly observed in patients with anterior or posterior shoulder instability. The purpose of this study was to determine the magnitude of force to create these bony lesions using cadaveric shoulders. Methods: Fourteen fresh-frozen cadaveric shoulders were used. Compression tests were performed using the universal testing machine. The specimens were randomly divided into two groups. In group A, the posterior humeral head (the bare area and articular cartilage) was first compressed against the anterior glenoid rim to simulate a Hill-Sachs lesion, followed by the anterior humeral head being compressed against the posterior glenoid rim. In group B, the same procedure was repeated in the reverse order. X-ray microcomputed tomography (microCT) was also performed. Results: The maximum compression force to create a Hill-Sachs lesion was 771 ± 214 N (mean ± SD) on the articular cartilage of the posterior humeral head, which was significantly greater than the force of 447 ± 215 N to create it on the bare area (P = 0.0086). Regarding the reverse Hill-Sachs lesions, the maximum compression force was 840 ± 198 N when it was created on the articular cartilage of the anterior humeral head, which was significantly greater than the force of 471 ± 100 N when it was created at the footprint of the subscapularis tendon (P = 0.0238). MicroCT showed multiple breakage of the trabecular bone. Conclusion: A force to create a Hill-Sachs lesion or a reverse Hill-Sachs lesion was significantly greater when it was created on the humeral articular cartilage than at the non-cartilage area. Also, the force to create a reverse Hill-Sachs lesion was significantly greater than the one to create a Hill-Sachs lesion.
MeSH term(s)	Humans ; Shoulder Joint/diagnostic imaging ; Shoulder Joint/pathology ; Bankart Lesions ; Shoulder Dislocation ; Joint Instability/diagnostic imaging ; Joint Instability/pathology ; X-Ray Microtomography ; Humeral Head/diagnostic imaging ; Bone Diseases ; Cartilage Diseases/pathology ; Cadaver
Language	English
Publishing date	2022-10-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2022.09.016
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Article ; Online: TiNbSn stems with gradient changes of Young's modulus and stiffness reduce stress shielding compared to the standard fit-and-fill stems.

Baba, Kazuyoshi / Mori, Yu / Chiba, Daisuke / Kuwahara, Yoshiyuki / Kurishima, Hiroaki / Tanaka, Hidetatsu / Kogure, Atsushi / Kamimura, Masayuki / Yamada, Norikazu / Ohtsu, Susumu / Oyama, Masamizu / Masahashi, Naoya / Hanada, Shuji / Itoi, Eiji / Aizawa, Toshimi

European journal of medical research

2023 Volume 28, Issue 1, Page(s) 214

Abstract: Background: The difference between Young's moduli of the femur and the stem causes stress shielding (SS). TiNbSn (TNS) stem has a low Young's modulus and strength with gradient functional properties during the change in elastic modulus with heat ... ...

Abstract	Background: The difference between Young's moduli of the femur and the stem causes stress shielding (SS). TiNbSn (TNS) stem has a low Young's modulus and strength with gradient functional properties during the change in elastic modulus with heat treatment. The aim of this study was to investigate the inhibitory effect of TNS stems on SS and their clinical outcomes compared to conventional stems. Methods: This study was a clinical trial. Primary THA was performed using a TNS stem from April 2016 to September 2017 for patients in the TNS group. Unilateral THA was performed using a Ti6Al4V alloy stem from January 2007 to February 2011 for patients in the control group. The TNS and Ti6Al4V stems were matched in shape. Radiographs were obtained at the 1- and 3-year follow-ups. Two surgeons independently checked the SS grade and appearance of cortical hypertrophy (CH). The Japanese Orthopaedic Association (JOA) scores before and 1 year after surgery were assessed as clinical scores. Results: None of the patients in the TNS group had grade 3 or 4 SS. In contrast, in the control group, 24% and 40% of patients had grade 3 and 4 SS at the 1- and 3-year follow-ups, respectively. The SS grade was lower in the TNS group than in the control group at the 1- and 3-year follow-ups (p < 0.001). The frequencies of CH in both groups were no significant difference at the 1- and 3-year follow-ups. The JOA scores of the TNS group significantly improved at 1 year after surgery and were comparable to control group. Conclusion: The TNS stem reduced SS at 1 and 3 years after THA compared to the proximal-engaging cementless stem, although the shapes of the stems matched. The TNS stem could reduce SS, stem loosening, and periprosthetic fractures. Trial registration: Current Controlled Trials. ISRCTN21241251. https://www.isrctn.com/search?q=21241251 . The date of registration was October 26, 2021. Retrospectively registered.
MeSH term(s)	Humans ; Alloys ; Arthroplasty, Replacement, Hip ; Elastic Modulus ; Femur/surgery ; Hip Prosthesis
Chemical Substances	Alloys ; titanium alloy (TiAl6V4) (12743-70-3)
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-023-01199-z
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