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Article: Enhancing oleic acid and oil content in low oil and oleic type Indian safflower (Carthamus tinctorius L.)

Kammili, Anjani / Yadav, Praduman

Industrial crops and products. 2022 Jan., v. 175

2022

Abstract: Indian safflower (Carthamus tinctorius L.), an oilseed crop, is low in oleic acid (14–20%) and oil (26–32%) levels. An attempt was made to improve oleic acid and oil levels in Indian safflower considering the high global demand for oleic oils. A parent ... ...

Abstract	Indian safflower (Carthamus tinctorius L.), an oilseed crop, is low in oleic acid (14–20%) and oil (26–32%) levels. An attempt was made to improve oleic acid and oil levels in Indian safflower considering the high global demand for oleic oils. A parent possessing low oil (30%) and high oleic acid (74%) contents was crossed to two parents having low levels of oil (28% and 30%) and oleic acid (18% and 14%) contents. Progenies possessing high oil and high oleic acid were selected in F₃-F₄, and the best were advanced to F₆. Fifty eight high oil and high oleic F₆ lines were tested for three years for oil and oleic acid levels and two years for seed yield under unirrigated conditions. Ten inbred lines possessing 36.11–41.01% oil and 77.01–82.56% oleic acid were finally shortlisted. One line, ISF-1264 (Ole) gave seed yield (2480 kg/ha) comparable to the high yielding variety check, A1 (2460 kg/ha) with a 56% increase in oil yield (992 kg/ha) and 6.71 times increase in oleic acid yield (805 kg/ha) over A1 while the remaining nine lines could not compete with A1 for seed yield but gave 13–32% higher oil yield and 4.65–5.7 times higher oleic acid yield than A1. These lines would help in increasing safflower oil and oleic acid production in India, and make safflower cultivation more rewarding to farmers besides increasing the market value of Indian safflower oil once released as varieties for commercial cultivation.
Keywords	Carthamus tinctorius ; lipid content ; market value ; oilseed crops ; oleic acid ; safflower oil ; seed yield ; India
Language	English
Dates of publication	2022-01
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2021.114254
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Remoteness from urban centre does not affect gastric cancer outcomes with established care pathway to specialist centre.

Kammili, Anitha / Morency, Dominique / Cools-Lartigue, Jonathan / Ferri, Lorenzo E / Mueller, Carmen L

Canadian journal of surgery. Journal canadien de chirurgie

2023 Volume 66, Issue 3, Page(s) E219–E227

Abstract: Background: Patients living in rural communities experience difficulty accessing specialized medical care. Rural patients with cancer present with more advanced disease, have reduced access to treatment and have poorer overall survival than urban ... ...

Abstract	Background: Patients living in rural communities experience difficulty accessing specialized medical care. Rural patients with cancer present with more advanced disease, have reduced access to treatment and have poorer overall survival than urban patients. This study's aim was to evaluate outcomes of patients with gastric cancer living in rural and remote areas versus urban and suburban communities in the context of an established care corridor to a tertiary care centre. Methods: All patients treated for gastric cancer at the McGill University Health Centre during 2010-2018 were included. Travel, lodging and cancer care coordination were provided for patients from remote and rural areas and coordinated centrally by dedicated nurse navigators servicing these regions. Statistics Canada's remoteness index was used to categorize patients into a rural and remote group and an urban and suburban group. Results: A total of 274 patients were included. Compared with patients from urban and suburban areas, patients from rural and remote areas were younger and their clinical tumour stage was higher at presentation. The number of curative resections and palliative surgeries and rate of nonresection were comparable ( Conclusion: Although patients with gastric cancer from rural and remote areas had more advanced disease at presentation, their treatment patterns and survival were comparable to those of patients from urbanized areas in the context of a publicly funded care corridor to a multidisciplinary specialist cancer centre. Equitable access to health care is necessary to diminish any preexisting disparities among patients with gastric cancer.
MeSH term(s)	Humans ; Stomach Neoplasms/therapy ; Critical Pathways ; Health Services Accessibility ; Rural Population
Language	English
Publishing date	2023-05-02
Publishing country	Canada
Document type	Journal Article
ZDB-ID	410651-9
ISSN	1488-2310 ; 0008-428X
ISSN (online)	1488-2310
ISSN	0008-428X
DOI	10.1503/cjs.019420
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Article ; Online: Enhanced recovery after surgery after radical gastrectomy: Improved compliance over time is associated with a shorter postoperative hospital stay.

Tankel, James / Kammili, Anitha / Meng, Andrew / Dehghani, Mehrnoush / Sakalla, Rawan / Spicer, Jonathan / Najmeh, Sara / Cools-Lartigue, Jonathan / Ferri, Lorenzo / Mueller, Carmen

World journal of surgery

2024 Volume 48, Issue 2, Page(s) 261–270

Abstract: Background: Changing adherence over time to enhanced recovery after surgery (ERAS) protocols following radical gastrectomy and the impact this has on length of stay (LoS) is not well described. This study aimed to explore the changes in adherence to ... ...

Abstract	Background: Changing adherence over time to enhanced recovery after surgery (ERAS) protocols following radical gastrectomy and the impact this has on length of stay (LoS) is not well described. This study aimed to explore the changes in adherence to core ERAS elements over time and the relationship between compliance and LoS. Methods: A retrospective, single center cohort study was performed between 01/2016-12/2021. An ad hoc analysis revealed the point at which a significant difference in the number of patients being discharge on postoperative day (PoD) 3 was noted allowing allocation of patients to Group A (01/2016-12/2019) or B (01/2020-12/2021). Compliance with core ERAS elements was compared and the relationship between compliance and discharge by (PoD) 3 assessed. Variables significant on univariate analysis were assessed using binary multivariate regression. Results: Of the 268 patients identified, 187 met the inclusion criteria (Group A 112 and Group B 75). More patients in Group B mobilized on PoD 1 (60.0 vs. 31.3%, p = <0.001), tolerated postgastrectomy diet by PoD 3 (84.6 vs. 62.5%, p = 0.049), and were discharged by PoD 3 (34.7 vs. 20.5%, p = 0.002). Protocol compliance of >75% was associated with discharge on PoD 3 (area under the curve, 0.726). Active mobilization on PoD 1 (OR 3.5, p = 0.009), compliance ≥75% (OR 3.3, p = 0.036), and preoperative nutritional consult (OR 0.2, p = 0.002) were independently associated with discharge on PoD 3. Discharge on PoD 3 did not increase readmission or representation to hospital. Conclusion: Early mobilization, protocol compliance >75%, and preoperative nutritional consult were associated with discharge on PoD 3 after radical gastrectomy.
MeSH term(s)	Humans ; Gastrectomy/methods ; Male ; Female ; Length of Stay/statistics & numerical data ; Retrospective Studies ; Middle Aged ; Enhanced Recovery After Surgery/standards ; Aged ; Patient Compliance/statistics & numerical data ; Stomach Neoplasms/surgery ; Guideline Adherence/statistics & numerical data ; Time Factors ; Patient Discharge/statistics & numerical data
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1002/wjs.12055
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Article: Introgression of resistance to Alternaria leaf spot from wild species into susceptible cultivated safflower

Kammili, Anjani / Mandalapu, Pallavi / Ponukumatla, Bhavana / Ruvulapalli, Durga Prasad / Sarada, Chunduri

Plant breeding. 2020 Apr., v. 139, no. 2

2020

Abstract: Alternaria leaf spot (ALS) caused by Alternaria carthami Chowdhury can cause yield loss up to 90% in safflower (Carthamus tinctorius L.) under severe conditions. Even though a definite source of ALS resistance is not available in cultivated species, a ... ...

Abstract	Alternaria leaf spot (ALS) caused by Alternaria carthami Chowdhury can cause yield loss up to 90% in safflower (Carthamus tinctorius L.) under severe conditions. Even though a definite source of ALS resistance is not available in cultivated species, a few of the wild species, viz. C. palaestinus and C. lantaus, are known to be tolerant to ALS. Therefore, an attempt was made to introgress Alternaria resistance from these species into cultivated species. F₁‐F₈ generations of crosses (PI537632 × C. palaestinus), (C. palaestinus × PI537632), (“Nira” × C. palaestinus) and ([MS 6(O) × C. lanatus] × C. palaestinus) were screened against ALS. ALS infection (%) was recorded in field and quantified using Windias Leaf Image Analysis system. Detached leaf technique was used in laboratory to confirm resistance in interspecific selections. Six resistant and 29 moderately resistant interspecific lines resembling mostly cultivated species were developed. Inheritance of ALS resistance indicated involvement of multiple minor alleles having small effects on resistance. The identified resistant lines could provide potential source of resistance to ALS for safflower breeding programmes.
Keywords	Alternaria carthami ; Carthamus lanatus ; Carthamus tinctorius ; cultivars ; disease resistance ; fungal diseases of plants ; genetic resistance ; interspecific hybridization ; introgression ; leaf spot ; plant breeding ; wild relatives
Language	English
Dates of publication	2020-04
Size	p. 368-374.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	golden set ; JOURNAL ARTICLE
ZDB-ID	232853-7
ISSN	0179-9541
ISSN	0179-9541
DOI	10.1111/pbr.12775
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Article ; Online: The Role of Palliative Surgery in Stage IV Gastric Cancer: A Retrospective Study.

Nevo, Yehonatan / Morency, Dominque / Kammili, Anitha / Abdrabo, Lina / Zullo, Kyle / Almatar, Saleh / Cools-Lartigue, Jonathan / Ferri, Lorenzo / Mueller, Carmen

Journal of palliative care

2022 Volume 37, Issue 2, Page(s) 152–158

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Gastrectomy ; Humans ; Palliative Care ; Retrospective Studies ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
Language	English
Publishing date	2022-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	639326-3
ISSN	2369-5293 ; 0825-8597
ISSN (online)	2369-5293
ISSN	0825-8597
DOI	10.1177/08258597221078382
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Article ; Online: The association between video-based assessment of intraoperative technical performance and patient outcomes: a systematic review.

Balvardi, Saba / Kammili, Anitha / Hanson, Melissa / Mueller, Carmen / Vassiliou, Melina / Lee, Lawrence / Schwartzman, Kevin / Fiore, Julio F / Feldman, Liane S

Surgical endoscopy

2022 Volume 36, Issue 11, Page(s) 7938–7948

Abstract: Background: Efforts to improve surgical safety and outcomes have traditionally placed little emphasis on intraoperative performance, partly due to difficulties in measurement. Video-based assessment (VBA) provides an opportunity for blinded and unbiased ...

Abstract	Background: Efforts to improve surgical safety and outcomes have traditionally placed little emphasis on intraoperative performance, partly due to difficulties in measurement. Video-based assessment (VBA) provides an opportunity for blinded and unbiased appraisal of surgeon performance. Therefore, we aimed to systematically review the existing literature on the association between intraoperative technical performance, measured using VBA, and patient outcomes. Methods: Major databases (Medline, Embase, Cochrane Database, and Web of Science) were systematically searched for studies assessing the association of intraoperative technical performance measured by tools supported by validity evidence with short-term (≤ 30 days) and/or long-term postoperative outcomes. Study quality was assessed using the Newcastle-Ottawa Scale. Results were appraised descriptively as study heterogeneity precluded meta-analysis. Results: A total of 11 observational studies were identified involving 8 different procedures in foregut/bariatric (n = 4), colorectal (n = 4), urologic (n = 2), and hepatobiliary surgery (n = 1). The number of surgeons assessed ranged from 1 to 34; patient sample size ranged from 47 to 10,242. High risk of bias was present in 5 of 8 studies assessing short-term outcomes and 2 of 6 studies assessing long-term outcomes. Short-term outcomes were reported in 8 studies (i.e., morbidity, mortality, and readmission), while 6 reported long-term outcomes (i.e., cancer outcomes, weight loss, and urinary continence). Better intraoperative performance was associated with fewer postoperative complications (6 of 7 studies), reoperations (3 of 4 studies), and readmissions (1 of 4 studies). Long-term outcomes were less commonly investigated, with mixed results. Conclusion: Current evidence supports an association between superior intraoperative technical performance measured using surgical videos and improved short-term postoperative outcomes. Intraoperative performance analysis using video-based assessment represents a promising approach to surgical quality-improvement.
MeSH term(s)	Humans ; Postoperative Complications/etiology ; Surgeons ; Weight Loss
Language	English
Publishing date	2022-05-12
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-022-09296-6
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Article ; Online: Perioperative Transfusions for Gastroesophageal Cancers: Risk Factors and Short- and Long-Term Outcomes.

Kammili, Anitha / Kaneva, Pepa / Lee, Lawrence / Cools-Lartigue, Jonathan / Ferri, Lorenzo Edwin / Mueller, Carmen Leandra

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2020 Volume 25, Issue 1, Page(s) 48–57

Abstract: Background: Perioperative blood transfusions have been associated with increased morbidity and poorer oncologic outcomes for numerous surgical procedures. However, this issue is understudied among patients with gastroesophageal malignancies. The ... ...

Abstract	Background: Perioperative blood transfusions have been associated with increased morbidity and poorer oncologic outcomes for numerous surgical procedures. However, this issue is understudied among patients with gastroesophageal malignancies. The objective was to clarify the risk factors and impact of perioperative transfusions on quality of life and surgical and oncologic outcomes among patients undergoing gastric and esophageal cancer surgery. Methods: Patients undergoing curative-intent resections for gastroesophageal cancers between 2010 and 2018 were included. Perioperative blood transfusion was defined as any transfusion within 24 h pre-operatively, during surgery, or the primary post-operative hospitalization period. Patient and tumor characteristics, surgical and oncological outcomes, and quality of life were compared. Results: A total of 435 patients were included. Perioperative transfusions occurred in 184 (42%). Anemia, blood loss, female sex, open surgical approach, and operative time emerged as independent risk factors for transfusions. Factors found to be independently associated with overall survival were neoadjuvant therapy, tumor size and stage, major complications, and mortality. Transfusions did not independently impact overall survival, disease-free survival, or quality of life. Conclusions: Perioperative transfusions did not impact oncologic outcomes or quality of life among patients undergoing curative-intent surgery for gastroesophageal cancers.
MeSH term(s)	Blood Transfusion ; Esophageal Neoplasms/surgery ; Female ; Humans ; Quality of Life ; Risk Factors ; Stomach Neoplasms/surgery
Language	English
Publishing date	2020-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-020-04845-7
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Article ; Online: Endoscopic pyloromyotomy in minimally invasive esophagectomy: a novel approach.

Nevo, Yehonatan / Calderone, Alexander / Kammili, Anitha / Boulila, Cyril / Renaud, Stephane / Cools-Lartigue, Jonathan / Spicer, Jonathan / Mueller, Carmen / Ferri, Lorenzo

Surgical endoscopy

2021 Volume 36, Issue 4, Page(s) 2341–2348

Abstract: Background: Pyloric drainage procedures, namely pyloromyotomy or pyloroplasty, have long been considered an integral aspect of esophagectomy. However, the requirement of pyloric drainage in the era of minimally invasive esophagectomy (MIE) has been ... ...

Abstract	Background: Pyloric drainage procedures, namely pyloromyotomy or pyloroplasty, have long been considered an integral aspect of esophagectomy. However, the requirement of pyloric drainage in the era of minimally invasive esophagectomy (MIE) has been brought into question. This is in part because of the technical challenges of performing the pyloric drainage laparoscopically, leading many surgical teams to explore other options or to abandon this procedure entirely. We have developed a novel, technically facile, endoscopic approach to pyloromyotomy, and sought to assess the efficacy of this new approach compared to the standard surgical pyloromyotomy. Methods: Patients who underwent MIE for cancer from 01/2010 to 12/2019 were identified from a prospectively maintained institutional database and were divided into two groups according to the pyloric drainage procedure: endoscopic or surgical pyloric drainage. 30-day outcomes (complications, length of stay, readmissions) and pyloric drainage-related outcomes [conduit distension/width, nasogastric tube (NGT) duration and re-insertion, gastric stasis] were compared between groups. Results: 94 patients were identified of these 52 patients underwent endoscopic PM and 42 patients underwent surgical PM. The groups were similar with respect to age, gender and comorbidities. There were more Ivor-Lewis esophagectomies in the endoscopic PM group than the surgical PM group [45 (86%), 15 (36%) p < 0.001]. There was no significant difference in the rate of complications and readmissions. Gastric stasis requiring NGT re-insertion was rare in the endoscopic PM group and did not differ significantly from the surgical PM group (1.9-4.7% p = 0.58). Conclusions: Endoscopic pyloromyotomy using a novel approach is a safe, quick and reproducible technique with comparable results to a surgical PM in the setting of MIE.
MeSH term(s)	Esophageal Neoplasms/complications ; Esophageal Neoplasms/surgery ; Esophagectomy/methods ; Gastroparesis/surgery ; Humans ; Minimally Invasive Surgical Procedures/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Pyloromyotomy/adverse effects ; Pylorus/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-05-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-021-08511-0
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Article ; Online: RpoN-Based stapled peptides with improved DNA binding suppress

Paquette, André R / Payne, Sterling R / McKay, Geoffrey A / Brazeau-Henrie, Jordan T / Darnowski, Micheal G / Kammili, Anitha / Bernal, Federico / Mah, Thien-Fah / Gruenheid, Samantha / Nguyen, Dao / Boddy, Christopher N

RSC medicinal chemistry

2022 Volume 13, Issue 4, Page(s) 445–455

Abstract: Stapled peptides have the ability to mimic α-helices involved in protein binding and have proved to be effective pharmacological agents for disrupting protein-protein interactions. DNA-binding proteins such as transcription factors bind their cognate DNA ...

Abstract	Stapled peptides have the ability to mimic α-helices involved in protein binding and have proved to be effective pharmacological agents for disrupting protein-protein interactions. DNA-binding proteins such as transcription factors bind their cognate DNA sequences
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d1md00371b
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Article ; Online: Transition from open to minimally invasive en bloc esophagectomy can be achieved without compromising surgical quality.

Kammili, Anitha / Cools-Lartigue, Jonathan / Mulder, David / Feldman, Liane S / Ferri, Lorenzo E / Mueller, Carmen L

Surgical endoscopy

2020 Volume 35, Issue 6, Page(s) 3067–3076

Abstract: Background: En bloc esophagectomy results in higher lymph node (LN) retrieval than standard esophagectomy. Minimally invasive esophagectomy (MIE) has gained traction due to improved short-term outcomes, but many large series report LN yields well below ... ...

Abstract	Background: En bloc esophagectomy results in higher lymph node (LN) retrieval than standard esophagectomy. Minimally invasive esophagectomy (MIE) has gained traction due to improved short-term outcomes, but many large series report LN yields well below the international benchmark of 23. We sought to determine if an established approach to open en bloc resection can be safely transferred to MIE using LN yield as a quality benchmark. Methods: An open approach to en bloc esophagectomy (OE) was established over 5 years (~ 300 cases) before en bloc MIE was introduced in 2010. Patients undergoing curative-intent en bloc Ivor-Lewis and McKeown esophagectomy for cancer from 2010 to 2019 by a single surgeon with formal minimally invasive surgery training were identified from a prospectively collected database. Mann-Whitney U and χ Results: A total of 269 esophageal resections met inclusion criteria [193(72%) OE; 76(28%) MIE]. Age, sex, BMI and comorbidities were comparable between groups. Tumors were larger and more often locally advanced in OE. Median LN retrieval was sufficient by international standards in both groups [OE:34(27-46); MIE:28(22-39); p = 0.01]. "Failures" occurred in 33(17%) of OE and 12(16%) MIE cases (p = 0.63). No learning effect was observed for LN yield. R0 resection rate was comparable [OE:191(99%); MIE:73(96%); p = 0.90]. Operative time was longer for MIE [275(246-300)] than OE [240(210-270) minutes], p < 0.0001, while estimated blood loss (OE:350(250-500)mL; MIE:300(200-400)mL; p = 0.02] and length of stay [OE:8(6-13); MIE7(6-9) days; p = 0.02] were higher for OE. Morbidity and mortality were comparable between groups and LN yield did not impact survival. Conclusions: Under appropriate conditions, an established approach to open en bloc esophagectomy can be safely transferred to MIE without compromising surgical quality.
MeSH term(s)	Esophageal Neoplasms/surgery ; Esophagectomy ; Humans ; Minimally Invasive Surgical Procedures ; Postoperative Complications ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2020-06-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-020-07696-0
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