Article ; Online: Mucosal microbiome of surgically treated terminal ileal Crohn's disease.
Frontiers in cellular and infection microbiology
2024 Volume 13, Page(s) 1324668
Abstract: Crohn's disease (CD) is associated with changes in the microbiome. The role of these changes and their precise association with disease course and activity remain ambiguous. In this prospective single-center study, the mucosal microbiome of surgical CD ... ...
Abstract | Crohn's disease (CD) is associated with changes in the microbiome. The role of these changes and their precise association with disease course and activity remain ambiguous. In this prospective single-center study, the mucosal microbiome of surgical CD and non-CD patients was compared at the time of surgery. Microbial analyses were individually performed for ileal and colonic tissue samples obtained during surgery using 16S-rRNA-gene amplicon sequencing. Three groups out of the 46 included patients were formed: 1) a study group of CD of patients who received ileocecal resection due to CD involvement (CD study, n=10); 2) a control group of non-CD of patients who received intestinal resection due to indications other than CD (non-CD control, n=27); and 3) a second control group of CD who underwent resection of the intestine not affected by CD (CD non-affected control, n=9). Species richness and Shannon diversity were not different between all formed groups and regions analyzed (p>0.05). Several significant taxonomic differences were seen at the phylum-, order-, and genus-levels between the formed groups, such as a decrease of |
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MeSH term(s) | Humans ; Crohn Disease/surgery ; Prospective Studies ; Intestinal Mucosa ; Gastrointestinal Microbiome ; Microbiota |
Language | English |
Publishing date | 2024-01-12 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2619676-1 |
ISSN | 2235-2988 ; 2235-2988 |
ISSN (online) | 2235-2988 |
ISSN | 2235-2988 |
DOI | 10.3389/fcimb.2023.1324668 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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