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  1. Book ; Thesis: Klinische und sonographische Untersuchung der Auswirkungen des Golfspiels auf die Schulter

    Kamphues, Carsten Hendrik

    2006  

    Author's details Carsten Hendrik Kamphues
    Language German
    Size 99 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 2006
    HBZ-ID HT014722729
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 D 204 order for loan Magazin

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  2. Article ; Online: Mucosal microbiome of surgically treated terminal ileal Crohn's disease.

    Loch, Florian N / Kamphues, Carsten / Menzel, Peter / Schwarzer, Rolf / Beyer, Katharina / Schineis, Christian

    Frontiers in cellular and infection microbiology

    2024  Volume 13, Page(s) 1324668

    Abstract: Crohn's disease (CD) is associated with changes in the microbiome. The role of these changes and their precise association with disease course and activity remain ambiguous. In this prospective single-center study, the mucosal microbiome of surgical CD ... ...

    Abstract Crohn's disease (CD) is associated with changes in the microbiome. The role of these changes and their precise association with disease course and activity remain ambiguous. In this prospective single-center study, the mucosal microbiome of surgical CD and non-CD patients was compared at the time of surgery. Microbial analyses were individually performed for ileal and colonic tissue samples obtained during surgery using 16S-rRNA-gene amplicon sequencing. Three groups out of the 46 included patients were formed: 1) a study group of CD of patients who received ileocecal resection due to CD involvement (CD study, n=10); 2) a control group of non-CD of patients who received intestinal resection due to indications other than CD (non-CD control, n=27); and 3) a second control group of CD who underwent resection of the intestine not affected by CD (CD non-affected control, n=9). Species richness and Shannon diversity were not different between all formed groups and regions analyzed (p>0.05). Several significant taxonomic differences were seen at the phylum-, order-, and genus-levels between the formed groups, such as a decrease of
    MeSH term(s) Humans ; Crohn Disease/surgery ; Prospective Studies ; Intestinal Mucosa ; Gastrointestinal Microbiome ; Microbiota
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1324668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Prognostic and Therapeutic Implications of Tumor Biology in Colorectal Liver Metastases.

    Kamphues, Carsten / Beyer, Katharina / Margonis, Georgios Antonios

    Cancers

    2021  Volume 14, Issue 1

    Abstract: Prognostic models allow clinicians to predict survival outcomes, facilitate patient-physician discussions, and identify subgroups with potentially distinct prognoses [ ... ]. ...

    Abstract Prognostic models allow clinicians to predict survival outcomes, facilitate patient-physician discussions, and identify subgroups with potentially distinct prognoses [...].
    Language English
    Publishing date 2021-12-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14010088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Immune Checkpoint Landscape in Tumor Cells of Pancreatic Ductal Adenocarcinoma.

    Loch, Florian N / Kamphues, Carsten / Beyer, Katharina / Schineis, Christian / Rayya, Wael / Lauscher, Johannes C / Horst, David / Dragomir, Mihnea P / Schallenberg, Simon

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Immune checkpoint therapy (ICT) has shown promising potential in the treatment of multiple solid tumors. However, the role of ICT in pancreatic ductal adenocarcinoma (PDAC) remains limited. Patterns of immune checkpoints (ICs) in PDAC represent the basis ...

    Abstract Immune checkpoint therapy (ICT) has shown promising potential in the treatment of multiple solid tumors. However, the role of ICT in pancreatic ductal adenocarcinoma (PDAC) remains limited. Patterns of immune checkpoints (ICs) in PDAC represent the basis for establishing a potent ICT. The aim of this study is to create a profile of IC expression and its prognostic relevance in cancer cells of PDAC. Therefore, tumor cells from peripheral and central tissue microarray (TMA) spots from histologically confirmed PDAC of 68 patients after tumor resection were investigated in terms of expressions of TIM3, IDO, B7H4, LAG3, VISTA, and PD-L1 using immunohistochemistry. The presence of the respective ICs was compared to overall survival (OS). The presence of VISTA and PD-L1 significantly correlates with shorter OS (median OS: 22 months vs. 7 months and 22 months vs. 11 months, respectively,
    MeSH term(s) Humans ; B7-H1 Antigen/metabolism ; Hepatitis A Virus Cellular Receptor 2 ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/pathology ; Biomarkers, Tumor/metabolism ; Pancreatic Neoplasms
    Chemical Substances B7-H1 Antigen ; Hepatitis A Virus Cellular Receptor 2 ; Biomarkers, Tumor
    Language English
    Publishing date 2023-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Ex vivo

    Loch, Florian N / Kamphues, Carsten / Beyer, Katharina / Schineis, Christian / Asbach, Patrick / Reiter, Rolf / Sack, Ingolf / Braun, Jürgen

    Quantitative imaging in medicine and surgery

    2023  Volume 13, Issue 5, Page(s) 2895–2906

    Abstract: Background: Conventional magnetic resonance enterography is limited in differentiating active inflammation and fibrosis in lesions of Crohn's disease (CD), thus providing a restricted basis for therapeutic decision making. Magnetic resonance ... ...

    Abstract Background: Conventional magnetic resonance enterography is limited in differentiating active inflammation and fibrosis in lesions of Crohn's disease (CD), thus providing a restricted basis for therapeutic decision making. Magnetic resonance elastography (MRE) is an emerging imaging tool that differentiates soft tissues on the basis of their viscoelastic properties. The aim of this study was to demonstrate the feasibility of MRE in assessing the viscoelastic properties of small bowel samples and quantifying differences in viscoelastic properties between healthy ileum and ileum affected by CD.
    Methods: Twelve patients (median age: 48 years) were prospectively enrolled in this study between September 2019 and January 2021. Patients of the study group (n=7) underwent surgery for terminal ileal CD, while patients of the control group (n=5) underwent segmental resection of healthy ileum. MRE of ileal tissue samples of surgical specimens from both groups was performed in a compact tabletop MRI scanner. Penetration rate (
    Results: Penetration rate a was significantly lower in CD-affected ileum compared to healthy ileum for all vibration frequencies (P<0.05). Consistently, damping ratio
    Conclusions: MRE of surgical small bowel specimens is feasible, allowing determination of viscoelastic properties and reliable quantification of differences in viscoelastic properties between healthy and CD-affected ileum. Thus, the results presented here are an important prerequisite for future studies investigating comprehensive MRE mapping and exact histopathological correlation including characterization and quantification of inflammation and fibrosis in CD.
    Language English
    Publishing date 2023-04-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-22-1071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effektivität von Mukosa Muskel Flaps in der Behandlung von perianalen Fisteln bei Morbus Crohn und kryptoglandulären Fisteln – eine Langzeit-Follow-up-Studie.

    Schineis, Christian / Warschkow, René / Bruder, Leon / Lauscher, Johannes C / Kamphues, Carsten / Kreis, Martin / Weixler, Benjamin

    Zentralblatt fur Chirurgie

    2023  Volume 148, Issue 3, Page(s) 259–266

    Abstract: Aim: Surgical treatment of perianal fistulae originating from Crohn's Disease (CD) or cryptoglandular abscess (CGA) remains a challenge. Data on long-term healing rates are scarce. We aimed to evaluate the long-term success rate of mucosal advancement ... ...

    Title translation Effectiveness of Mucosal Advancement Flaps in Surgery of Perianal Fistulas from Crohn´s Disease and Cryptoglandular Fistulas - a Long-term Follow-up Study.
    Abstract Aim: Surgical treatment of perianal fistulae originating from Crohn's Disease (CD) or cryptoglandular abscess (CGA) remains a challenge. Data on long-term healing rates are scarce. We aimed to evaluate the long-term success rate of mucosal advancement flap (MAF) operations.
    Methods: This single centre retrospective analysis was performed at a tertiary referral centre (Charité University Hospital Berlin, Campus Benjamin Franklin) between March 1, 2010 and March 31, 2020. Patients with complex perianal fistulae originating from CD or CGA treated with MAF were included. Long-time healing rates of MAF in CGA and CD were compared. Regression analysis was used to identify predictive factors for definitive healing.
    Results: 83 patients (24 CD, 59 CGA,) were included. Median follow-up for CD was 5.4 and 1.9 years for CGA. Definitive healing of fistulae was achieved in 19 (79.2%) CD patients (p = 0.682) and in 44 (74.6%) CGA patients. Healing time was significantly shorter in CGA than in CD (9.3 months [standard deviation: SD= 11.3 months] vs. 30.9 months [SD = 23.5 months]; p < 0.001). Treatment with biologicals (hazard ratio: HR = 0.18, 95%-confidence interval: 95%-CI = 0.06-0.59, p = 0.004) and diverting ileostomy (HR = 0.29, 95%-CI = 0.10-0.85, p = 0.023) in CD were independent predictors for MAF success. Simultaneous medication with azathioprine in CD was an independent predictor for MAF failure (HR = 3.20, 95%-CI = 1.05-9.81, p = 0.041).
    Conclusion: This study demonstrates that surgical therapy of perianal fistulae with MAF is successful in about 75% of patients overall. Patients with MC benefit from biologicals and a diverting ileostomy. Treatment with azathioprine had a negative impact on recurrence rates. Repeated MAF operations did not increase the risk of failure in subsequent operations.
    MeSH term(s) Humans ; Crohn Disease/complications ; Crohn Disease/surgery ; Follow-Up Studies ; Treatment Outcome ; Azathioprine/therapeutic use ; Retrospective Studies ; Rectal Fistula/surgery
    Chemical Substances Azathioprine (MRK240IY2L)
    Language German
    Publishing date 2023-03-16
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200935-3
    ISSN 1438-9592 ; 0044-409X
    ISSN (online) 1438-9592
    ISSN 0044-409X
    DOI 10.1055/a-2039-2896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.25: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 95: Show issues

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  7. Article ; Online: Stepwise Analysis of Resection Margin Impact on Survival and Distant Metastasis in Pancreatic Head Ductal Adenocarcinoma.

    Loch, Florian N / Kamphues, Carsten / Rieger, Freschta / Beyer, Katharina / Rayya, Wael / Schineis, Christian / Klauschen, Frederick / Horst, David / Schallenberg, Simon / Dragomir, Mihnea P

    International journal of surgical pathology

    2024  , Page(s) 10668969241229342

    Abstract: The prognostic role of tumor cells in pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head with direct microscopic infiltration (DMI) or in close proximity (≤1 mm) to the resection margin (RM) remains unclear. This single-center, retrospective ... ...

    Abstract The prognostic role of tumor cells in pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head with direct microscopic infiltration (DMI) or in close proximity (≤1 mm) to the resection margin (RM) remains unclear. This single-center, retrospective study included specimens from 75 patients who underwent oncological resection of pancreatic head PDAC between February 2013 and July 2020. Two pathologists independently re-measured the distance between tumors and the multiple RMs. The impact of RM involvement for DMI, tumor cells within ≤1 mm, in general, and for individual RMs on overall survival (OS) and development of distant pulmonary (PM) and hepatic (HM) metastasis was analyzed. DMI of RMs was significantly associated with a shorter OS (median 5 vs 19 months,
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969241229342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Role of visceral fat on postoperative complications and relapse in patients with Crohn's disease after ileocecal resection: Is it overrated?

    Schineis, Christian Hans Wolfgang / Pozios, Ioannis / Boubaris, Katharina / Weixler, Benjamin / Kamphues, Carsten / Margonis, Georgios Antonios / Kreis, Martin Ernst / Strobel, Rahel Maria / Beyer, Katharina / Seifarth, Claudia / Luitjens, Jan / Kaufmann, David / Lauscher, Johannes Christian

    International journal of colorectal disease

    2024  Volume 39, Issue 1, Page(s) 20

    Abstract: Introduction: The role of visceral fat in disease development, particularly in Crohn´s disease (CD), is significant. However, its preoperative prognostic value for postoperative complications and CD relapse after ileocecal resection (ICR) remains ... ...

    Abstract Introduction: The role of visceral fat in disease development, particularly in Crohn´s disease (CD), is significant. However, its preoperative prognostic value for postoperative complications and CD relapse after ileocecal resection (ICR) remains unknown. This study aims to assess the predictive potential of preoperatively measured visceral and subcutaneous fat in postoperative complications and CD recurrence using magnetic resonance imaging (MRI). The primary endpoint was postoperative anastomotic leakage of the ileocolonic anastomosis, with secondary endpoints evaluating postoperative complications according to the Clavien Dindo classification and CD recurrence at the anastomosis.
    Methods: We conducted a retrospective analysis of 347 CD patients who underwent ICR at our tertiary referral center between 2010 and 2020. We included 223 patients with high-quality preoperative MRI scans, recording demographics, postoperative outcomes, and CD recurrence rates at the anastomosis. To assess adipose tissue distribution, we measured total fat area (TFA), visceral fat area (VFA), subcutaneous fat area (SFA), and abdominal circumference (AC) at the lumbar 3 (L3) level using MRI cross-sectional images. Ratios of these values were calculated.
    Results: None of the radiological variables showed an association with anastomotic leakage (TFA p = 0.932, VFA p = 0.982, SFA p = 0.951, SFA/TFA p = 0.422, VFA/TFA p = 0.422), postoperative complications, or CD recurrence (TFA p = 0.264, VFA p = 0.916, SFA p = 0.103, SFA/TFA p = 0.059, VFA/TFA p = 0.059).
    Conclusions: Radiological visceral obesity variables were associated with postoperative outcomes or clinical recurrence in CD patients undergoing ICR. Preoperative measurement of visceral fat measurement is not specific for predicting postoperative complications or CD relapse.
    MeSH term(s) Humans ; Crohn Disease/complications ; Crohn Disease/diagnostic imaging ; Crohn Disease/surgery ; Retrospective Studies ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/pathology ; Anastomotic Leak/pathology ; Recurrence ; Postoperative Complications/etiology ; Postoperative Complications/pathology
    Language English
    Publishing date 2024-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-023-04586-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Conference proceedings: Prognostischer Wert des DNA-Index auf das Überleben beim Adenokarzinom des Pankreaskopfes

    Kamphues, Carsten

    2013  , Page(s) 13dgch688

    Event/congress 130. Kongress der Deutschen Gesellschaft für Chirurgie; München; Deutsche Gesellschaft für Chirurgie; 2013
    Keywords Medizin, Gesundheit
    Publishing date 2013-04-26
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/13dgch688
    Database German Medical Science

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  10. Book ; Online ; Thesis: Evaluierung von Prognosemarkern und Untersuchung neuer zielgerichteter Therapiemodelle im biliopankreatischen Karzinom

    Kamphues, Carsten [Verfasser]

    2014  

    Author's details Carsten Kamphues
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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