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Article ; Online: Near-infrared light-actuated on-demand botanicals release and hyperthermia by an antibiotic-free polysaccharide-based hydrogel dressing for the synergistic treatment of wound infections.

Sun, Shuwen / Lin, Wenbo / Yang, Lu / Zhang, Chenhao / Kan, Hong / Xu, Chen / Dong, Kai

2024 Volume 12, Issue 5, Page(s) 1307–1316

Abstract: Bacterial infection is a key factor affecting wound healing. Conventional treatments might lead to the widespread emergence of drug-resistant bacteria due to the long-term and excessive use of antibiotics. It is necessary to develop an antibiotic-free ... ...

Abstract	Bacterial infection is a key factor affecting wound healing. Conventional treatments might lead to the widespread emergence of drug-resistant bacteria due to the long-term and excessive use of antibiotics. It is necessary to develop an antibiotic-free method for effective treatment of bacterial wound infections. In this work, we constructed an antibiotic-free polysaccharide-based hydrogel dressing (ATB) with near-infrared light-actuated on-demand botanicals release and hyperthermia for the synergistic treatment of wound infections. The ATB hydrogel dressing was made up of agarose as a support matrix, berberine hydrochloride as the active botanicals and TA-Fe(III) nanoparticles as NIR laser-activated photothermal reagents. The ATB hydrogel dressing showed spatiotemporal botanicals release and excellent photothermal properties with NIR irradiation. With the results of
MeSH term(s)	Humans ; Hydrogels/pharmacology ; Ferric Compounds ; Hyperthermia ; Polysaccharides/pharmacology ; Infrared Rays ; Bandages ; Anti-Bacterial Agents/pharmacology ; Wound Infection/drug therapy ; Hyperthermia, Induced
Chemical Substances	Hydrogels ; Ferric Compounds ; Polysaccharides ; Anti-Bacterial Agents
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02714g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolomics and pharmacodynamic analysis unveil the therapeutic role of icaritin on osteoporosis rats.

Zhang, Dongxue / Liang, Jinjing / Qu, Shuai / Xu, Chen / Kan, Hong / Dong, Kai / Wang, Yingping

Journal of pharmaceutical and biomedical analysis

2024 Volume 241, Page(s) 115979

Abstract: Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass resulting from multifactorial causes. Icaritin (ICT), a flavonoid glycoside, exhibits a multitude of effects on bone tissue. To examine the influence of ICT on ... ...

Abstract	Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass resulting from multifactorial causes. Icaritin (ICT), a flavonoid glycoside, exhibits a multitude of effects on bone tissue. To examine the influence of ICT on bone trabecular loss in vivo, ovariectomized (OVX) rats were utilized. The ability of ICT to mitigate bone trabecular loss and the underlying anti-osteoporotic pathways were assessed using ovariectomy-induced osteoporosis rats. Furthermore, we gain insights into the osteoprotective mechanisms of ICT on osteoporosis by conducting UPLC-Orbitrap-MS-based metabolomics of rat urine. The results of experiments demonstrated a significant attenuation of bone trabecular loss, as well as improvements in biochemical indices, biomechanical parameters, and microstructure in the ICT administered group compared to the OVX group. Moreover, metabolomics results suggested that the ICT treatment adjusted 33 different metabolites, which associated with the metabolism of amino acids, lipids, and energy. The findings suggest that the anti-osteoporosis effect of ICT may be related to the activation of PI3K/AKT signal and the inhibition of TLR4 pathway regulated by metabonomics. These results contribute to a better understanding of the therapeutic potential of ICT in the treatment of osteoporosis.
MeSH term(s)	Female ; Rats ; Animals ; Rats, Sprague-Dawley ; Phosphatidylinositol 3-Kinases/therapeutic use ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Metabolomics
Chemical Substances	icaritin (UFE666UELY) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Flavonoids
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.115979
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Article ; Online: Survival processing advantage demonstrated with virtual reality-based survival environment: A promising tool for survival processing research.

Wang, Yamin / Zhang, Leran / Kan, Hong / Gao, Jidong

Memory & cognition

2022 Volume 51, Issue 1, Page(s) 129–142

Abstract: Many studies have been conducted to demonstrate the survival processing advantage (SPA) as an evolutionary-oriented memory effect. But few studies were conducted to demonstrate this effect in real-life or simulated survival environments. This study ... ...

Abstract	Many studies have been conducted to demonstrate the survival processing advantage (SPA) as an evolutionary-oriented memory effect. But few studies were conducted to demonstrate this effect in real-life or simulated survival environments. This study tested whether the SPA could be replicated in a survival virtual reality environment (VRE). In Experiment 1, the SPAs were measured in VREs (survival grasslands, survival battlefield, nonsurvival moving) in which Experiment 1A used the standard long instructions and Experiment 1B used the modified short instructions. In Experiment 2, the SPAs were measured again with the scenarios corresponding to the VREs used in Experiment 1A. All experiments demonstrated typical SPAs, suggesting that the survival VRE is a reliable tool in designing and delivering a survival situation. The potential problems of applying survival VRE to survival processing research are discussed at the end.
MeSH term(s)	Humans ; Virtual Reality ; Biological Evolution ; Survival
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	185691-1
ISSN	1532-5946 ; 0090-502X
ISSN (online)	1532-5946
ISSN	0090-502X
DOI	10.3758/s13421-022-01341-y
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Zs.A 4560: Show issues

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Article ; Online: Integrated Metabolome and Transcriptome Analysis Unveils the Underlying Molecular Response of Panax ginseng Plants to the Phytophthora cactorum Infection

Kan, Hong / Qu, Shuai / Dong, Kai / Wang, Shihan / Xu, Chen / Wang, Yingping / Hua, Shuang

Agriculture. 2023 Feb. 20, v. 13, no. 2

2023

Abstract: Due to at least 3 years of cultivation, Panax ginseng (ginseng) is susceptible to being attacked by pathogens which severely affect its quality and yield. Compared with other diseases of ginseng, Phytophthora blight caused by Phytophthora cactorum (P. ... ...

Abstract	Due to at least 3 years of cultivation, Panax ginseng (ginseng) is susceptible to being attacked by pathogens which severely affect its quality and yield. Compared with other diseases of ginseng, Phytophthora blight caused by Phytophthora cactorum (P. cactorum) can spread rapidly and destroy almost the entire plant of ginseng, such as leaves, stems, and roots. However, little research was focused on this area, and how P. cactorum affected the metabolic profile of ginseng is still obscure. In the current study, we conducted a comprehensive analysis of metabolomics and transcriptomics to compare the differences in health and P. cactorum-affected ginseng leaves and stems. Metabolome analysis revealed that 110 and 113 significant differential metabolites were observably disturbed separately in ginseng leaves and stems. Transcriptome analysis demonstrated that 6424 and 9508 genes had remarkable variation in ginseng leaves and stems. Using conjoint analysis, we also revealed the changes in pathways “Alanine, aspartate and glutamate metabolism”, “Glycine, serine and threonine metabolism”, and “Biosynthesis of unsaturated fatty acids” and “Plant hormone signal transduction” in ginseng response to the P. cactorum. The current work provides an overview of the alteration of metabolic profile and gene expression profiles in ginseng leaves and stems in response to P. cactorum affection, which may help to further screen out the mechanism of plant-pathogen interaction at the molecular level.
Keywords	Panax ginseng ; Phytophthora cactorum ; agriculture ; alanine ; aspartic acid ; biosynthesis ; blight ; glutamic acid ; host-pathogen relationships ; metabolites ; metabolome ; metabolomics ; plant hormones ; serine ; signal transduction ; threonine ; transcriptomics
Language	English
Dates of publication	2023-0220
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture13020509
Database	NAL-Catalogue (AGRICOLA)

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Article: Bilateral common carotid artery mycotic aneurysms in the setting of intravenous drug abuse.

Randhawa, Darshan / Zheng, Kan Hong / Stanziale, Stephen / Chin, Jason

Journal of vascular surgery cases and innovative techniques

2022 Volume 9, Issue 1, Page(s) 101068

Abstract: Carotid mycotic aneurysms are rare, and fewer than five case reports have described carotid mycotic aneurysms due to intravenous drug abuse. Rare bilateral intracranial mycotic carotid aneurysms have been reported, although a review of literature ... ...

Abstract	Carotid mycotic aneurysms are rare, and fewer than five case reports have described carotid mycotic aneurysms due to intravenous drug abuse. Rare bilateral intracranial mycotic carotid aneurysms have been reported, although a review of literature revealed no cases of bilateral extracranial carotid aneurysms. We have reported the case of a 41-year-old man who had presented with intermittent fevers, headaches, and myalgias of 2 weeks' duration. He was found to have bilateral carotid artery mycotic aneurysms after intravenous drug abuse with neck injections. We used a management strategy entailing unilateral endovascular balloon control with open surgical resection followed by placement of a saphenous vein graft. The contralateral aneurysm was managed nonoperatively with antibiotics.
Language	English
Publishing date	2022-11-25
Publishing country	United States
Document type	Case Reports
ISSN	2468-4287
ISSN	2468-4287
DOI	10.1016/j.jvscit.2022.11.006
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Article ; Online: Metabolomics-derived biomarkers for biosafety assessment of Gd-based nanoparticle magnetic resonance imaging contrast agents.

Xu, Chen / Sun, Jie / Zhang, Chenhao / Yang, Lu / Kan, Hong / Zhang, Daguang / Xue, Guan / Dong, Kai

The Analyst

2024 Volume 149, Issue 4, Page(s) 1169–1178

Abstract: With the rapid development of nanotechnology and biomedicine, numerous gadolinium (Gd)-based nanoparticle MRI contrast agents have been widely investigated. Due to the unique physicochemical properties of nanoparticles and the complexity of biological ... ...

Abstract	With the rapid development of nanotechnology and biomedicine, numerous gadolinium (Gd)-based nanoparticle MRI contrast agents have been widely investigated. Due to the unique physicochemical properties of nanoparticles and the complexity of biological systems, the biosafety of Gd-based nanoparticle MRI contrast agents has been paid more and more attention. Herein, for the first time, we employed an ultra-high performance liquid chromatography-electrospray ionization quadrupole time-of-flight/mass spectrometry (UPLC-ESI-QTOF/MS)-based metabolomics approach to investigate the potential toxicity of Gd-based nanoparticle MRI contrast agents. In this work, NaGdF
MeSH term(s)	Contrast Media/toxicity ; Contrast Media/chemistry ; Containment of Biohazards ; Gadolinium/chemistry ; Nanoparticles/toxicity ; Nanoparticles/chemistry ; Magnetic Resonance Imaging/methods ; Biomarkers
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT) ; Biomarkers
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an01641b
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Zs.A 2423: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Application of three-dimensional material CZIF-8/CS-MS as adsorbents for the determination of plant growth regulators in Schisandra chinensis.

Zhang, Dong-Xue / Qu, Shuai / Liu, Yu-Han / Xu, Chen / Liu, Xiao-Ying / Kan, Hong / Dong, Kai / Wang, Ying-Ping

Journal of chromatography. A

2024 Volume 1718, Page(s) 464727

Abstract: In this study, we employed a melamine sponge (MS) as the skeleton material and utilized carbonized ZIF-8 (CZIF-8) and chitosan (CS) as the raw materials to prepare CZIF-8/CS-MS, a novel material featuring a three-dimensional interconnected porous network. ...

Abstract	In this study, we employed a melamine sponge (MS) as the skeleton material and utilized carbonized ZIF-8 (CZIF-8) and chitosan (CS) as the raw materials to prepare CZIF-8/CS-MS, a novel material featuring a three-dimensional interconnected porous network. The resulting CZIF-8/CS-MS material possesses a unique porous structure, significant specific surface area and abundant active sites. These characteristics make CZIF-8/CS-MS a promising absorbent for selective purification of plant growth regulators (PGRs) including 1-naphthlcetic acid (NAA), naphthoxyacetic acid (NOA), 4-chlorophenoxyacetic acid (4-CPA), 2,4-dichlorophenoxyacetic acid (2,4-D). After optimizing the extraction conditions, excellent linearity (r > 0.9994) was observed within a wide linear range of 1-100 ng/mL using ultra high performance liquid chromatography-tandem quadrupole mass spectrometry. The detection limits (LODs) and limits of quantification (LOQs) were found to be in the range of 0.013-0.154 ng/mL and 0.044-0.515 ng/mL, respectively. Additionally, the relative recovery of Schisandra chinensis fruit samples was determined to be 89.7-99.4 %, with a relative standard deviation (RSDs) of ≤ 8.4 % (n = 3). Compared to other methods, this approach offers a multitude of benefits, which include but are not limited to exceptional sensitivity, reduced sample volume requirements, low LODs, a comparable linear range, and high reproducibility. The findings of this study pave the way for exploring novel functionalized sponge columns, which leverage the integration of nano-sorbent materials and coating agents, for the purpose of analyzing PGRs within intricate matrix samples.
MeSH term(s)	Plant Growth Regulators/analysis ; Schisandra ; Chitosan ; Reproducibility of Results ; Tandem Mass Spectrometry/methods ; Chromatography, High Pressure Liquid/methods ; Solid Phase Extraction/methods ; Triazines
Chemical Substances	Plant Growth Regulators ; melamine (N3GP2YSD88) ; Chitosan (9012-76-4) ; Triazines
Language	English
Publishing date	2024-02-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2024.464727
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Zs.A 813: Show issues

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Article: Skin-permissible NIR-actuated hyperthermia using a photothermally responsive hydrogel membrane for the effective treatment of antibiotic-resistant bacterial infection

Yu, Zhongpeng / Sun, Jie / Deng, Hongling / Kan, Hong / Xu, Chen / Dong, Kai

Biomaterials science. 2022 Feb. 15, v. 10, no. 4

2022

Abstract: With the long-term widespread overuse of antibiotics, a large number of antibiotic-resistant bacteria have emerged and become a serious threat to healthcare systems. As an alternative strategy, near-infrared light (NIR)-actuated photothermal treatment ... ...

Abstract	With the long-term widespread overuse of antibiotics, a large number of antibiotic-resistant bacteria have emerged and become a serious threat to healthcare systems. As an alternative strategy, near-infrared light (NIR)-actuated photothermal treatment has been developed for killing antibiotic-resistant bacteria. Although promising, the widespread applications of photothermal antibacterial platforms face great challenges due to the skin-harmful high laser irradiation. In this work, a novel NIR-responsive hydrogel membrane for effective photothermal sterilization upon light irradiation at skin-permissible intensity has been successfully prepared using a sodium alginate-based hydrogel membrane containing tannic acid–Fe(iii) compounds (STF). The as-prepared STF displayed excellent mechanical capacity and fabricability. More importantly, the as-prepared STF revealed superior photothermal efficiency under a low-intensity NIR irradiation (0.3 W cm⁻²), which was below the maximum permissible exposure of skin (0.33 W cm⁻²). In addition, the STF showed the excellent performance of photothermal sterilization for MRSA both in vitro and in vivo. Furthermore, the STF showed good biocompatibility. Based on the simple synthesis method, outstanding mechanical properties, excellent photothermal sterilization performance and good biocompatibility, the STF could be a promising wound dressing for antibiotic-resistant bacterial infections.
Keywords	antibiotic resistance ; bacterial infections ; biocompatibility ; biocompatible materials ; fever ; health services ; hydrogels ; irradiation ; methicillin-resistant Staphylococcus aureus ; sodium
Language	English
Dates of publication	2022-0215
Size	p. 960-969.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d1bm01819a
Database	NAL-Catalogue (AGRICOLA)

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Article: Nanoporous Copper Catalysts for the Fluidized Electrocatalytic Hydrogenation of Furfural to Furfuryl Alcohol

Yang, Zhenhao / Chou, Xiaoyu / Kan, HongYin / Xiao, Zihui / Ding, Yi

ACS sustainable chemistry & engineering. 2022 May 23, v. 10, no. 22

2022

Abstract: Electrocatalytic hydrogenation is an efficient and environmentally friendly way to convert biomass derivatives into high-value-added chemicals and biofuels, although in most cases, the Faraday efficiency (FE) is low. Herein, Cu electrocatalysts with a ... ...

Abstract	Electrocatalytic hydrogenation is an efficient and environmentally friendly way to convert biomass derivatives into high-value-added chemicals and biofuels, although in most cases, the Faraday efficiency (FE) is low. Herein, Cu electrocatalysts with a bicontinuous nanoporous structure and high specific surface area were fabricated by chemical dealloying of CuAl alloy. For the electrocatalytic hydrogenation of furfural to furfuryl alcohol, as a biomass-derived platform molecule reaction, the nanoporous Cu (NP-Cu) exhibited excellent selectivity and high Faraday efficiency by fluidized electrocatalysis. Compared with a commercial Cu sheet electrode, the selectivity of furfuryl alcohol increased from 22 to 96%, and FE increased from 17 to 95%, respectively. The selectivity and FE of Cu nanoparticles for furfuryl alcohol were only about 44% under the same conditions as NP-Cu. It was indicated that the NP-Cu with a high specific surface area provided enough hydrogen adsorption sites (Hₐdₛ), leading to the enhancement of electrocatalytic hydrogenation and reduction of electrocondensation in the fluidization. Meanwhile, the hydrogen evolution as a side reaction was also restrained under a relatively low potential. These provide important basis and reference for the development of nanoporous catalysts and electrocatalytic conversion of biomass.
Keywords	adsorption ; alloys ; biofuels ; biomass ; copper nanoparticles ; electrodes ; furfural ; furfuryl alcohol ; green chemistry ; hydrogen ; hydrogen production ; hydrogenation ; nanopores ; surface area
Language	English
Dates of publication	2022-0523
Size	p. 7418-7425.
Publishing place	American Chemical Society
Document type	Article
ISSN	2168-0485
DOI	10.1021/acssuschemeng.2c02360
Database	NAL-Catalogue (AGRICOLA)

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Article: Virtual Reality Experiments on Emotional Face Recognition Find No Evidence of Mood-Congruent Effects.

Zhong, Lan / Wang, Yamin / Kan, Hong / Ding, Jinhong

Frontiers in psychology

2020 Volume 11, Page(s) 479

Abstract: Mood-congruent effects have been demonstrated many times, but few studies have managed to replicate the effect with natural moods. Additionally, the ecological validity of mood induction and real-time observation deficiency remain unresolved. Using a ... ...

Abstract	Mood-congruent effects have been demonstrated many times, but few studies have managed to replicate the effect with natural moods. Additionally, the ecological validity of mood induction and real-time observation deficiency remain unresolved. Using a newly developed, virtual-reality-based eye-tracking technique, the present study conducted real-time observations of mood effects on emotional face recognition with simulated "real-life" pleasant and grisly scenes. In experiment 1, participants performed an emotional face recognition task in both positive and negative virtual reality scenes. The recognition tests and gaze tracking results failed to support mood-congruent effects but did show a mood effect independent of a strong emotional face effect. In experiment 2, participants performed a neutral face recognition task in pleasant and grisly scenes that were matched for arousal levels, and the mood effect disappeared. The results also revealed a robust negativity bias in emotional face recognition, which was found to accompany a mood repair effect.
Language	English
Publishing date	2020-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2020.00479
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