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  1. Article ; Online: Japanese encephalitis in children from an endemic district of West Bengal, India

    Abhishek Gupta / Sumanta Laha / Kanai Lal Barik

    Asian Journal of Medical Sciences, Vol 12, Iss 10, Pp 34-

    A hospital based observational study

    2021  Volume 38

    Abstract: Background: Japanese encephalitis (JE) is an important cause of viral encephalitis in children in South East Asian countries including India. Aims and Objective: We have done this study in an JE endemic district of India to know the demographic profile, ... ...

    Abstract Background: Japanese encephalitis (JE) is an important cause of viral encephalitis in children in South East Asian countries including India. Aims and Objective: We have done this study in an JE endemic district of India to know the demographic profile, clinical presentation, seasonal variation, outcome and about the vaccination status of the JE cases. Materials and Methods: This observational, cross sectional study was done for a period of one year in the Pediatric department of Burdwan Medical College, West Bengal in children up to the age of 12 year, presented with acute encephalitis syndrome (AES). Demographic data, clinical presentation and JE vaccination status were recorded and confirmed JE cases were detected by either serum or CSF JE IgM antibody. Outcome of the JE cases were noted as discharge, death or leave against medical advice (LAMA). Results: We have found confirmed JE in 18 children out of total 125 AES cases (14.4%). 61.1% of them were within 6 to 12 year age, mostly from low socioeconomic status and 100% case occurred during monsoon and post monsoon period. History, was of JE vaccination were present in only 11.1% case of JE. Most common presenting symptoms were high fever (100%), convulsion (94.4%) and altered sensorium (72.2%). 77.8% JE case were discharged and 11.1% expired. Conclusion: We must consider JE whenever a child from any endemic district comes with AES and we should try to bring every child under the JE vaccination coverage in the endemic regions globally to reduce the burden of this preventable encephalitis.
    Keywords japanese encephalitis ; children ; west bengal ; Medicine ; R
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Usefulness of Urine Uric Acid/Creatinine Ratio in Neonate as an Early Detector of Perinatal Hypoxia

    Saikat Mondal / Kanai Lal Barik / Sudipto Paul / Sumanta Laha* / Sayan Bera

    SVU - International Journal of Medical Sciences, Vol 6, Iss 2, Pp 206-

    A Hospital-Based Observational Study

    2023  Volume 214

    Abstract: Background: When a neonate is born under a hypoxic state, there is increased production of uric acid due to hypoxic tissue damage, which is excreted via the kidney, and the ratio of uric acid and creatinine (UA/Cr) in urine is used as an early predictor ... ...

    Abstract Background: When a neonate is born under a hypoxic state, there is increased production of uric acid due to hypoxic tissue damage, which is excreted via the kidney, and the ratio of uric acid and creatinine (UA/Cr) in urine is used as an early predictor of perinatal hypoxia. Objectives: We conducted this study to compare urine UA/Cr ratio between normal and asphyxiated newborns and between different stages of HIE to evaluate its usefulness as a diagnostic and prognostic marker of perinatal asphyxia. Patients and method: This observational cross-sectional study is conducted for one year with 75 asphyxiated neonates in different stages of HIE and 75 healthy neonates as control. Uric acid and creatinine values are measured with an auto-analyzer from a single urine sample taken between 6 to 24 hours of birth. Results: We found urine UA(38 ±2.81 mg/dl vs 19.24±0.75 mg/dl ) and urine UA/Cr value (2.81±0.32 vs 1.40±0.13 ) significantly high in cases compared to control. Also, the urine UA and UA/Cr values are increasing with advanced stages of HIE (p <0.001). The optimal cut point value to predict HIE was at urine UA/Cr ratio of >2.45 with an AUC of 0.96, accuracy of 90%, sensitivity of 98.07% , specificity of 85.70% , PPV 78.46%, and NPV 98.82%. Conclusion: Urine UA/Cr appears to be a simple, inexpensive and reliable indicator of perinatal hypoxia for risk stratification based on functional impairment in the HIE babies.
    Keywords hypoxic ischemic encephalopathy ; neonate ; perinatal hypoxia ; uric acid ; creatinine ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher South Valley University, Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: An observational study to evaluate the outcome of patients admitted in pediatric intensive care unit (PICU) using pediatric risk of mortality (PRISM-III) score in a tertiary care hospital of West Bengal

    Sudipto Paul / Kanai Lal Barik / Nilanjan Ghosh / Sumanta Laha / Sayan Bera / Sukanya Nath

    Asian Journal of Medical Sciences, Vol 14, Iss 7, Pp 171-

    2023  Volume 177

    Abstract: Background: Pediatric risk of mortality (PRISM III) score is used across the globe to predict the mortality of hospitalized children by an objective method based on 17 variables measured during first 24 h of admission in pediatric intensive care unit ( ... ...

    Abstract Background: Pediatric risk of mortality (PRISM III) score is used across the globe to predict the mortality of hospitalized children by an objective method based on 17 variables measured during first 24 h of admission in pediatric intensive care unit (PICU). Aims and Objectives: We have done this study to evaluate the cause, management and outcome of PICU admissions and also to find out the statistical significance of PRISM III score in predicting mortality. Materials and Methods: This observational prospective study was conducted for a period of 1 year in the PICU of a district Medical College of West Bengal among children 1–12 years age. They were divided into 4 groups according to the PRISM III scores of 1–10, 11–20, 21–30, and >30 and outcome in all the groups were recorded and analyzed. Results: Respiratory (25%), neurological (20.1%), and infectious (17.3%) etiology were major cause of PICU admission. About 17.4% patients needed mechanical ventilation, 31.2% Continuous Positive Airway Pressure and 66% patients inotropic support. Out of 144 cases, 117 discharged and 27 expired. Percentage of death is 100%, 44.4%, 21.6%, and 4.6% among child with PRISM III score of >30, 21–30, 11–21, and ≤10, respectively. Significant increase in mortality noted with increase in number of organ failures. Specificity and positive predictive value increases with higher PRISM III score and sensitivity and negative predictive value is more with low PRISM III score. Conclusion: PRISM III score can be used as a triage tool in limited resource settings for early initiation of intense management to high risk and salvageable cases.
    Keywords child mortality ; pediatric intensive care units ; pediatric risk of mortality score ; Medicine ; R
    Subject code 310
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis

    Kanai Lal Barik / Projesh Biswas / Kuntal Kanti Das / Sumanta Laha / Sudipto Paul / Saikat Mondal

    Asian Journal of Medical Sciences, Vol 13, Iss 1, Pp 93-

    A cross-sectional hospital-based study from West Bengal

    2022  Volume 98

    Abstract: Background: Neonatal sepsis and meningitis is an important cause of neonatal mortality and morbidity especially in the developing countries. Bacteriological profile of meningitis and antibiotic sensitivity pattern may vary from one region to another. ... ...

    Abstract Background: Neonatal sepsis and meningitis is an important cause of neonatal mortality and morbidity especially in the developing countries. Bacteriological profile of meningitis and antibiotic sensitivity pattern may vary from one region to another. Aims and Objectives: We have planned this study to know the etiological agent of neonatal meningitis with its antibiotic sensitivity profile and to evaluate some other associated risk factors of meningitis. Materials and Methods: This observational, cross-sectional study was done for a period of 1 year in the SNCU and NICU of a district Medical College of West Bengal in neonates presented with clinical sepsis and meningitis. Sepsis screen, blood culture, cerebrospinal fluid (CSF) study, and culture sensitivity was done and recorded along with demographic data, clinical presentation, outcome, and other associated factors. Results: We found meningitis in 55 neonates out of 250 clinical sepsis. CSF culture was positive in 42 cases with Escherichia coli (30.9%), Klebsiella (26.1%), Staphylococcus aureus (16.6%), Acinetobacter (14.2%) and Coagulase negative Staphylococcus (CoNS 11.9%) as prevalent organism. E. coli and Klebsiella were mostly sensitive to Amikacin, Levofloxacin, and Colistin whereas less sensitive to Cefotaxime, Pipercilin-tazobactam or Meropenem and Acinetobacter showed good sensitivity only to Levofloxacin. Among the gram-positive organism, S. aureus and CoNS were only sensitive to Linezolid, Vancomycin, and Teicoplanin. Conclusion: This type of study should help to make a proper antibiotic policy for an institution so that the empirical first-line antibiotic can be started with good effect in cases of neonatal sepsis and meningitis before the arrival of culture sensitivity report.
    Keywords antimicrobial susceptibility ; etiology ; meningitis ; neonates ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A comparative study between glucose 6-phosphate dehydrogenase deficient and normal term neonates with indirect hyperbilirubinemia in a rural tertiary care hospital of Eastern India

    Kanai Lal Barik / Puja Kumari Singh / Sudipto Paul / Sumanta Laha / Saikat Mondal

    Asian Journal of Medical Sciences, Vol 13, Iss 9, Pp 77-

    2022  Volume 82

    Abstract: Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important cause of neonatal indirect hyperbilirubinemia or even kernicterus leading to long-term neurological sequelae specially in countries like India where G6PD deficiency is quite ... ...

    Abstract Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important cause of neonatal indirect hyperbilirubinemia or even kernicterus leading to long-term neurological sequelae specially in countries like India where G6PD deficiency is quite prevalent. Aims and Objectives: We have planned this study to know the prevalence of G6PD deficiency among cases of neonatal jaundice and also to evaluate the difference between G6PD deficient and normal neonates with indirect hyperbilirubinemia in terms of laboratory parameters and need of phototherapy or exchange transfusion. Materials and Methods: This observational and cross-sectional study was done for a period of 1 year in the SNCU and NICU of a district Medical College of West Bengal among 200 term neonates presented with indirect hyperbilirubinemia. Birth weight, sex, hemoglobin, G6PD level, serum bilirubin at admission, phototherapy duration, and need for exchange transfusion were recorded along with other necessary parameters. Results: We found G6PD deficiency in 24 neonates (12%) out of 200 cases of neonatal jaundice, 20 of whom were male. There is a statistically significant difference in hemoglobin and serum bilirubin level between two groups. Difference in early presentation of jaundice within 24–48 h (66.7% vs. 34.1%) and need of prolonged phototherapy 72–96 h (45.83% vs. 7.4%) between G6PD deficient and normal group were statistically significant. Difference in requirement of exchange transfusion is not statistically significant. Conclusion: Early screening for G6PD deficiency should be considered in every neonates of G6PD deficient endemic countries so that we can predict the natural course of the jaundice in those G6PD deficient neonate and prevent complication by early initiation of phototherapy or exchange transfusion.
    Keywords glucose-6-phosphate dehydrogenase ; hyperbilirubinemia ; jaundice ; neonates ; Medicine ; R
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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