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Article ; Online: Pilot‐scale photocatalytic detoxification and disinfection of hazardous medical wastewater

Berberidou, Chrysanthi / Tsoumachidou, Sophia / Paspaltsis, Ioannis / Kitsiou, Vasiliki / Kanata, Eirini / Xanthopoulos, Kōstas / Sklaviadis, Theodoros / Arsenakis, Athansios / Poulios, Ioannis

Journal of Chemical Technology & Biotechnology. 2023 Sept., v. 98, no. 9 p.2235-2246

2023

Abstract: BACKGROUND: Treatment of liquid hazardous medical wastewater produced by healthcare laboratories is a global matter that has been inadequately addressed. In this study, the potential of heterogeneous and homogeneous photocatalytic oxidation to detoxify ... ...

Abstract	BACKGROUND: Treatment of liquid hazardous medical wastewater produced by healthcare laboratories is a global matter that has been inadequately addressed. In this study, the potential of heterogeneous and homogeneous photocatalytic oxidation to detoxify and disinfect such effluents was investigated. Experiments were performed using two toxic effluents and one of simultaneous toxic and infectious composition in pilot scale, in a novel photocatalytic inactivation system. RESULTS: Photocatalytic experimental runs performed with both toxic effluents showed that photo‐Fenton‐assisted TiO₂ photocatalytic oxidation under optimal conditions was the most efficient process among the tested ones, when the initial dissolved organic carbon values (DOC₀) ranged from 100 to 1000 mg L⁻¹. Furthermore, the potential of catalyst reuse was examined and verified for five sequential runs. Moreover, phytotoxicity was either eliminated or significantly reduced after photocatalytic processing under optimal conditions in the case of the second wastewater of toxic composition, while ecotoxicity showed a similar trend, highlighting the importance of extended mineralization for the removal of toxicity. The performance of the pilot photocatalytic inactivation system concerning the inactivation of bio‐pollutants was tested on five different types of microbes. Four of them were completely inactivated in relatively short periods, while survival of the more resistant bacterial endospores was found to be decreased to >99% after 5 h of treatment. CONCLUSION: Toxic and infectious hazardous medical effluents are highly recalcitrant targets in terms of mineralization, detoxification and inactivation. However, photocatalytic oxidation may serve as an efficient processing tool, providing alternative or complementary solutions to this highly challenging issue. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Keywords	biotechnology ; catalysts ; disinfection ; ecotoxicology ; endospores ; health services ; liquids ; mineralization ; organic carbon ; oxidation ; photocatalysis ; phytotoxicity ; wastewater
Language	English
Dates of publication	2023-09
Size	p. 2235-2246.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1479465-2
ISSN	1097-4660 ; 0268-2575
ISSN (online)	1097-4660
ISSN	0268-2575
DOI	10.1002/jctb.7448
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning.

Founta, Kyriaki / Dafou, Dimitra / Kanata, Eirini / Sklaviadis, Theodoros / Zanos, Theodoros P / Gounaris, Anastasios / Xanthopoulos, Konstantinos

Molecular medicine (Cambridge, Mass.)

2023 Volume 29, Issue 1, Page(s) 12

Abstract: Background: Amyotrophic lateral sclerosis (ALS) is a rare progressive neurodegenerative disease that affects upper and lower motor neurons. As the molecular basis of the disease is still elusive, the development of high-throughput sequencing ... ...

Abstract	Background: Amyotrophic lateral sclerosis (ALS) is a rare progressive neurodegenerative disease that affects upper and lower motor neurons. As the molecular basis of the disease is still elusive, the development of high-throughput sequencing technologies, combined with data mining techniques and machine learning methods, could provide remarkable results in identifying pathogenetic mechanisms. High dimensionality is a major problem when applying machine learning techniques in biomedical data analysis, since a huge number of features is available for a limited number of samples. The aim of this study was to develop a methodology for training interpretable machine learning models in the classification of ALS and ALS-subtypes samples, using gene expression datasets. Methods: We performed dimensionality reduction in gene expression data using a semi-automated preprocessing systematic gene selection procedure using Statistically Equivalent Signature (SES), a causality-based feature selection algorithm, followed by Boosted Regression Trees (XGBoost) and Random Forest to train the machine learning classifiers. The SHapley Additive exPlanations (SHAP values) were used for interpretation of the machine learning classifiers. The methodology was developed and tested using two distinct publicly available ALS RNA-seq datasets. We evaluated the performance of SES as a dimensionality reduction method against: (a) Least Absolute Shrinkage and Selection Operator (LASSO), and (b) Local Outlier Factor (LOF). Results: The proposed methodology achieved 85.18% accuracy for the classification of cerebellum or frontal cortex samples as C9orf72-related familial ALS, sporadic ALS or healthy samples. Importantly, the genes identified as the most determinative have also been reported as disease-associated in ALS literature. When tested in the evaluation dataset, the methodology achieved 88.89% accuracy for the classification of sporadic ALS motor neuron samples. When LASSO was used as feature selection method instead of SES, the accuracy of the machine learning classifiers ranged from 74.07 to 96.30%, depending on tissue assessed, while LOF underperformed significantly (77.78% accuracy for the classification of pooled cerebellum and frontal cortex samples). Conclusions: Using SES, we addressed the challenge of high dimensionality in gene expression data analysis, and we trained accurate machine learning ALS classifiers, specific for the gene expression patterns of different disease subtypes and tissue samples, while identifying disease-associated genes.
MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/genetics ; Neurodegenerative Diseases ; Machine Learning ; Gene Targeting
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-023-00603-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Αnti-prion effects of anthocyanins.

Christoudia, Nikoletta / Bekas, Nikolaos / Kanata, Eirini / Chatziefsthathiou, Athanasia / Pettas, Spyros / Karagianni, Korina / Da Silva Correia, Susana Margarida / Schmitz, Matthias / Zerr, Inga / Tsamesidis, Ioannis / Xanthopoulos, Konstantinos / Dafou, Dimitra / Sklaviadis, Theodoros

Redox biology

2024 Volume 72, Page(s) 103133

Abstract: Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are characterized by the conformational conversion of the normal cellular prion protein, ...

Abstract	Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are characterized by the conformational conversion of the normal cellular prion protein, PrP
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2024.103133
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Systematic Review of Common and Brain-Disease-Specific RNA Editing Alterations Providing Novel Insights into Neurological and Neurodegenerative Disease Manifestations.

Karagianni, Korina / Pettas, Spyros / Christoforidou, Georgia / Kanata, Eirini / Bekas, Nikolaos / Xanthopoulos, Konstantinos / Dafou, Dimitra / Sklaviadis, Theodoros

Biomolecules

2022 Volume 12, Issue 3

Abstract: RNA editing contributes to transcriptome diversification through RNA modifications in relation to genome-encoded information (RNA-DNA differences, RDDs). The deamination of Adenosine (A) to Inosine (I) or Cytidine (C) to Uridine (U) is the most common ... ...

Abstract	RNA editing contributes to transcriptome diversification through RNA modifications in relation to genome-encoded information (RNA-DNA differences, RDDs). The deamination of Adenosine (A) to Inosine (I) or Cytidine (C) to Uridine (U) is the most common type of mammalian RNA editing. It occurs as a nuclear co- and/or post-transcriptional event catalyzed by ADARs (Adenosine deaminases acting on RNA) and APOBECs (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like genes). RNA editing may modify the structure, stability, and processing of a transcript. This review focuses on RNA editing in psychiatric, neurological, neurodegenerative (NDs), and autoimmune brain disorders in humans and rodent models. We discuss targeted studies that focus on RNA editing in specific neuron-enriched transcripts with well-established functions in neuronal activity, and transcriptome-wide studies, enabled by recent technological advances. We provide comparative editome analyses between human disease and corresponding animal models. Data suggest RNA editing to be an emerging mechanism in disease development, displaying common and disease-specific patterns. Commonly edited RNAs represent potential disease-associated targets for therapeutic and diagnostic values. Currently available data are primarily descriptive, calling for additional research to expand global editing profiles and to provide disease mechanistic insights. The potential use of RNA editing events as disease biomarkers and available tools for RNA editing identification, classification, ranking, and functional characterization that are being developed will enable comprehensive analyses for a better understanding of disease(s) pathogenesis and potential cures.
MeSH term(s)	Adenosine/genetics ; Adenosine/metabolism ; Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Animals ; Brain/metabolism ; Brain Diseases ; Mammals/metabolism ; Neurodegenerative Diseases/genetics ; RNA ; RNA Editing/genetics
Chemical Substances	RNA (63231-63-0) ; Adenosine Deaminase (EC 3.5.4.4) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12030465
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Profiling Microglia through Single-Cell RNA Sequencing over the Course of Development, Aging, and Disease.

Pettas, Spyros / Karagianni, Korina / Kanata, Eirini / Chatziefstathiou, Athanasia / Christoudia, Nikoletta / Xanthopoulos, Konstantinos / Sklaviadis, Theodoros / Dafou, Dimitra

Cells

2022 Volume 11, Issue 15

Abstract: Microglia are macrophages present in the brain that function as the primary and most important source of immune response in the central nervous system (CNS). Regardless of their multitasking role, our knowledge regarding their molecular heterogeneity is ... ...

Abstract	Microglia are macrophages present in the brain that function as the primary and most important source of immune response in the central nervous system (CNS). Regardless of their multitasking role, our knowledge regarding their molecular heterogeneity is limited; due to technical restrictions, it is only possible to measure gene expression in cell populations, not individual cells, with the results reflecting average mRNA levels. Therefore, recent scientific approaches have focused on single-cell techniques such as single-cell RNA sequencing (scRNAseq), a powerful technique that enables the delineation of transcriptomic cell-to-cell differences, revealing subpopulations with distinct molecular and functional characteristics. Here, we summarize recent studies that focused on transcriptomic microglial subpopulation clustering and classify them into three distinct groups based on age, spatial distribution, and disease. Additionally, we cross-compare populations from different studies to identify expressional and functional overlaps between them.
MeSH term(s)	Central Nervous System ; Microglia/metabolism ; Sequence Analysis, RNA ; Transcriptome/genetics
Language	English
Publishing date	2022-08-02
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11152383
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photo-Fenton and TiO

Kanata, Eirini / Paspaltsis, Ioannis / Sotiriadis, Sotiris / Berberidou, Chrysanthi / Tsoumachidou, Sophia / Dafou, Dimitra / Xanthopoulos, Konstantinos / Arsenakis, Minas / Arsenakis, Athanasios / Poulios, Ioannis / Sklaviadis, Theodoros

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 3

Abstract: Photocatalytic inactivation of pathogens in aqueous waste is gaining increasing attention. Several homogeneous and heterogeneous photocatalytic protocols exist using the Fenton's reagent and ... ...

Abstract	Photocatalytic inactivation of pathogens in aqueous waste is gaining increasing attention. Several homogeneous and heterogeneous photocatalytic protocols exist using the Fenton's reagent and TiO
MeSH term(s)	Hydrogen Peroxide ; Titanium/pharmacology ; Catalysis
Chemical Substances	titanium dioxide (15FIX9V2JP) ; Hydrogen Peroxide (BBX060AN9V) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28031199
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Article ; Online: Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells.

Kanata, Eirini / Arsenakis, Minas / Sklaviadis, Theodoros

Prion

2016 Volume 10, Issue 5, Page(s) 391–408

Abstract: Scrapie, the prion disease of sheep and goats, is a devastating malady of small ruminants. Due to its infectious nature, epidemic outbreaks may occur in flocks/herds consisting of highly susceptible animals. Field studies identified scrapie-protective ... ...

Abstract	Scrapie, the prion disease of sheep and goats, is a devastating malady of small ruminants. Due to its infectious nature, epidemic outbreaks may occur in flocks/herds consisting of highly susceptible animals. Field studies identified scrapie-protective caprine PrP variants, harboring specific single amino acid changes (Met-142, Arg-143, Asp-146, Ser-146, His-154, Gln-211 and Lys-222). Their effects are under further evaluation, and aim to determine the most protective allele. We assessed some of these variants (Asp-146, His-154, Gln-211 and Lys-222), after their exogenous expression as murine-caprine chimeras in a scrapie- infected murine cell line. We report that exogenously expressed PrPs undergo conformational conversion upon interaction with the endogenous pathological murine prion protein (PrP
MeSH term(s)	Alleles ; Animals ; Asparagine/genetics ; Cell Line ; Glycine/genetics ; Goats ; Histidine/genetics ; Mice ; Prion Proteins/chemistry ; Prion Proteins/genetics ; Prion Proteins/metabolism ; Protein Binding ; Protein Conformation ; Scrapie/metabolism ; Scrapie/pathology
Chemical Substances	Prion Proteins ; Histidine (4QD397987E) ; Asparagine (7006-34-0) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2016--02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1933-690X
ISSN (online)	1933-690X
DOI	10.1080/19336896.2016.1199312
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Carnosic Acid and Carnosol Display Antioxidant and Anti-Prion Properties in In Vitro and Cell-Free Models of Prion Diseases.

Karagianni, Korina / Pettas, Spyros / Kanata, Eirini / Lioulia, Elisavet / Thune, Katrin / Schmitz, Matthias / Tsamesidis, Ioannis / Lymperaki, Evgenia / Xanthopoulos, Konstantinos / Sklaviadis, Theodoros / Dafou, Dimitra

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract: Prion diseases are transmissible encephalopathies associated with the conversion of the physiological form of the prion protein ( ... ...

Abstract	Prion diseases are transmissible encephalopathies associated with the conversion of the physiological form of the prion protein (PrP
Language	English
Publishing date	2022-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11040726
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: RNA Editing Alterations Define Disease Manifestations in the Progression of Experimental Autoimmune Encephalomyelitis (EAE).

Dafou, Dimitra / Kanata, Eirini / Pettas, Spyros / Bekas, Nikolaos / Dimitriadis, Athanasios / Kempapidou, Garyfalia / Lagoudaki, Roza / Theotokis, Paschalis / Touloumi, Olga / Delivanoglou, Nikoleta / Kesidou, Evangelia / Xanthopoulos, Konstantinos / Grigoriadis, Nikolaos / Papavasiliou, Fotini Nina / Sklaviadis, Theodoros

Cells

2022 Volume 11, Issue 22

Abstract: RNA editing is an epitranscriptomic modification, leading to targeted changes in RNA transcripts. It is mediated by the action of ADAR (adenosine deaminases acting on double-stranded (ds) RNA and APOBEC (apolipoprotein B mRNA editing enzyme catalytic ... ...

Abstract	RNA editing is an epitranscriptomic modification, leading to targeted changes in RNA transcripts. It is mediated by the action of ADAR (adenosine deaminases acting on double-stranded (ds) RNA and APOBEC (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like) deaminases and appears to play a major role in the pathogenesis of many diseases. Here, we assessed its role in experimental autoimmune encephalomyelitis (EAE), a widely used non-clinical model of autoimmune inflammatory diseases of the central nervous system (CNS), which resembles many aspects of human multiple sclerosis (MS). We have analyzed in silico data from microglia isolated at different timepoints through disease progression to identify the global editing events and validated the selected targets in murine tissue samples. To further evaluate the functional role of RNA editing, we induced EAE in transgenic animals lacking expression of APOBEC-1. We found that RNA-editing events, mediated by the APOBEC and ADAR deaminases, are significantly reduced throughout the course of disease, possibly affecting the protein expression necessary for normal neurological function. Moreover, the severity of the EAE model was significantly higher in APOBEC-1 knock-out mice, compared to wild-type controls. Our results implicate regulatory epitranscriptomic mechanisms in EAE pathogenesis that could be extrapolated to MS and other neurodegenerative disorders (NDs) with common clinical and molecular features.
MeSH term(s)	Humans ; Mice ; Animals ; RNA Editing/genetics ; APOBEC-1 Deaminase/genetics ; Encephalomyelitis, Autoimmune, Experimental/genetics ; RNA, Double-Stranded ; Mutagenesis, Site-Directed ; Mice, Knockout
Chemical Substances	APOBEC-1 Deaminase (EC 3.5.4.36) ; RNA, Double-Stranded
Language	English
Publishing date	2022-11-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11223582
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Closed Chemobrionic System as a Biochemical Delivery Platform.

Angelis, Georgios / Zayed, Dimitris Nabil / Karioti, Anastasia / Lazari, Diamanto / Kanata, Eirini / Sklaviadis, Theodoros / Pampalakis, Georgios

Chemistry (Weinheim an der Bergstrasse, Germany)

2019 Volume 25, Issue 56, Page(s) 12916–12919

Abstract: Inorganic cells bearing calcium silicate membranes were prepared and resembled closed chemical gardens. It was demonstrated that these inorganic cells can successfully be loaded with natural products, proteins and plasmid DNA, and their cargo can be ... ...

Abstract	Inorganic cells bearing calcium silicate membranes were prepared and resembled closed chemical gardens. It was demonstrated that these inorganic cells can successfully be loaded with natural products, proteins and plasmid DNA, and their cargo can be released in a controlled manner. These cells demonstrated the ability of chemical gardens to act as platforms for the sustained delivery of biomolecules and are expected to introduce chemical gardens in the field of biosciences.
MeSH term(s)	Animals ; Calcium Compounds/chemistry ; Cattle ; Drug Carriers/chemistry ; Plasmids/chemistry ; Plasmids/metabolism ; Rutin/chemistry ; Rutin/metabolism ; Serum Albumin, Bovine/chemistry ; Serum Albumin, Bovine/metabolism ; Silicates/chemistry
Chemical Substances	Calcium Compounds ; Drug Carriers ; Silicates ; Serum Albumin, Bovine (27432CM55Q) ; Rutin (5G06TVY3R7) ; calcium silicate (S4255P4G5M)
Language	English
Publishing date	2019-09-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.201903255
Database	MEDical Literature Analysis and Retrieval System OnLINE

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