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  1. Article: Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens

    Karakas Alkan, Kubra / Alkan, Hasan / Tez, Gizem / Kanca, Halit

    Journal of feline medicine and surgery. 2020 Oct., v. 22, no. 10

    2020  

    Abstract: Termination rates for the highly recommended aglepristone (AGL) treatment are low in late-term pregnancy in queens. We studied the effects of an AGL and cloprostenol (CLO) combination in the termination of late-term pregnancy. Pregnant queens were ... ...

    Abstract Termination rates for the highly recommended aglepristone (AGL) treatment are low in late-term pregnancy in queens. We studied the effects of an AGL and cloprostenol (CLO) combination in the termination of late-term pregnancy. Pregnant queens were assigned to two groups. Queens in the AGL group (n = 10) received AGL 10 mg/kg, twice, 24 h apart. Queens in the AGL-CLO group (n = 9) were additionally injected with a single dose of CLO (5 μg/kg) 24 h after the second dose of AGL. Progesterone, 17beta(β)-oestradiol, cortisol, oxytocin and prostaglandin F2alpha (PGF2α) metabolite were measured in sera obtained at days 0, 1 and 2, and on the day of abortion. Average gestational age in both groups was similar (AGL 38.61 ± 0.91 days vs AGL-CLO 39.39 ± 1.35 days; P >0.05). Termination rates were 80% and 100% in the AGL and AGL-CLO groups, respectively (P <0.05). Fetal expulsion time was significantly longer (P <0.001) in the AGL group (96.9 ± 6 h) compared with the AGL-CLO group (69.8 ± 3.3 h). Duration of abortion was 19.8 ± 2.6 h and 12.6 ± 1.4 h in the AGL and AGL-CLO groups, respectively (P <0.05). Both treatments were well tolerated. Significantly (P <0.05) lower serum progesterone concentrations were observed in both groups at the day of abortion and concentrations in the AGL-CLO group (4.19 ± 0.80 ng/ml) were lower than in the AGL group (9.89 ± 2.21 ng/ml; P <0.05). AGL and CLO combination increases pregnancy termination rate in late-term pregnant queens. In addition, CLO contributes to a decrease in luteal function in AGL-treated late-term pregnant queens.
    Keywords blood serum ; cats ; cloprostenol ; cortisol ; dosage ; duration ; gestational age ; medicine ; metabolites ; oxytocin ; pregnancy ; progesterone ; surgery
    Language English
    Dates of publication 2020-10
    Size p. 907-915.
    Publishing place SAGE Publications
    Document type Article
    Note NAL-light
    ZDB-ID 2049047-1
    ISSN 1532-2750 ; 1098-612X
    ISSN (online) 1532-2750
    ISSN 1098-612X
    DOI 10.1177/1098612X19892087
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Live in same region, respond differently: Canine and human response to pollutants in placental accumulation

    Yurdakok-Dikmen, Begum / Kuzukiran, Ozgur / Uyar, Recep / Boztepe, Ummu Gulsum / Çelik, Hasan Tolga / Ozyuncu, Ozgur / Turgut, Yagmur / Kanca, Halit / Karakas-Alkan, Kubra / Filazi, Ayhan

    Chemosphere. 2022 Mar. 28,

    2022  

    Abstract: Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) are endocrine-disrupting chemicals (EDCs). Their presence in the environment is particularly ... ...

    Abstract Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) are endocrine-disrupting chemicals (EDCs). Their presence in the environment is particularly concerning in cases of fetal exposure, which is the most vulnerable period of life for both human and animals who share the same environment. Placenta, as a sample collected using noninvasive methods to screen EDCs, is a good indicator for potential fetal exposure. Although recent studies indicate that companion animal may correspond to human exposure, species-specific anatomo-morphological and metabolic differences are controversial. In this study, placenta samples of 60 women and 25 dogs living and giving birth within the same region were evaluated for the presence of PCB, OCP, PBDE, and PAH residues; where, socio-demographic factors were also assessed to identify the possible sources. Gas chromatography-mass spectrometry method was validated for the matrix, and among 45 screened and targeted pollutants, only 18 were found in human placentas. While the most frequently detected pollutants were DDTs, followed by PAHs and PCBs in decreasing order, the pollutants with the highest concentrations were PAHs, followed by PCBs and DDTs. Only five of the target contaminants were detected in the dog placentas. These results indicate that; as dogs have different bioaccumulation capacities and higher excretion rates than humans, the life-long effects of exposure to endocrine compound and possible consequences related to adverse health outcomes are expected to vary and concentrations cannot be directly correlated.
    Keywords bioaccumulation ; biphenyl ; dogs ; excretion ; gas chromatography-mass spectrometry ; humans ; pets ; placenta ; polychlorinated biphenyls
    Language English
    Dates of publication 2022-0328
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2022.134470
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
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  3. Article ; Online: Aglepristone and cloprostenol combination in the termination of late-term pregnancy in queens.

    Karakas Alkan, Kubra / Alkan, Hasan / Tez, Gizem / Kanca, Halit

    Journal of feline medicine and surgery

    2019  Volume 22, Issue 10, Page(s) 907–915

    Abstract: Objectives: Termination rates for the highly recommended aglepristone (AGL) treatment are low in late-term pregnancy in queens. We studied the effects of an AGL and cloprostenol (CLO) combination in the termination of late-term pregnancy.: Methods: ... ...

    Abstract Objectives: Termination rates for the highly recommended aglepristone (AGL) treatment are low in late-term pregnancy in queens. We studied the effects of an AGL and cloprostenol (CLO) combination in the termination of late-term pregnancy.
    Methods: Pregnant queens were assigned to two groups. Queens in the AGL group (n = 10) received AGL 10 mg/kg, twice, 24 h apart. Queens in the AGL-CLO group (n = 9) were additionally injected with a single dose of CLO (5 μg/kg) 24 h after the second dose of AGL. Progesterone, 17beta(β)-oestradiol, cortisol, oxytocin and prostaglandin F2alpha (PGF2α) metabolite were measured in sera obtained at days 0, 1 and 2, and on the day of abortion.
    Results: Average gestational age in both groups was similar (AGL 38.61 ± 0.91 days vs AGL-CLO 39.39 ± 1.35 days;
    Conclusions and relevance: AGL and CLO combination increases pregnancy termination rate in late-term pregnant queens. In addition, CLO contributes to a decrease in luteal function in AGL-treated late-term pregnant queens.
    MeSH term(s) Abortifacient Agents/administration & dosage ; Abortion, Induced/methods ; Abortion, Induced/veterinary ; Animals ; Cats ; Cloprostenol/administration & dosage ; Drug Combinations ; Estrenes/administration & dosage ; Female
    Chemical Substances Abortifacient Agents ; Drug Combinations ; Estrenes ; aglepristone (0UT4JLE1CM) ; Cloprostenol (4208238832)
    Language English
    Publishing date 2019-12-13
    Publishing country England
    Document type Clinical Trial, Veterinary ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2049047-1
    ISSN 1532-2750 ; 1098-612X
    ISSN (online) 1532-2750
    ISSN 1098-612X
    DOI 10.1177/1098612X19892087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Live in same region, respond differently: Canine and human response to pollutants in placental accumulation.

    Yurdakok-Dikmen, Begum / Kuzukiran, Ozgur / Uyar, Recep / Boztepe, Ummu Gulsum / Çelik, Hasan Tolga / Ozyuncu, Ozgur / Turgut, Yagmur / Kanca, Halit / Karakas-Alkan, Kubra / Filazi, Ayhan

    Chemosphere

    2022  Volume 301, Page(s) 134470

    Abstract: Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) are endocrine-disrupting chemicals (EDCs). Their presence in the environment is particularly ... ...

    Abstract Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) are endocrine-disrupting chemicals (EDCs). Their presence in the environment is particularly concerning in cases of fetal exposure, which is the most vulnerable period of life for both human and animals who share the same environment. Placenta, as a sample collected using noninvasive methods to screen EDCs, is a good indicator for potential fetal exposure. Although recent studies indicate that companion animal may correspond to human exposure, species-specific anatomo-morphological and metabolic differences are controversial. In this study, placenta samples of 60 women and 25 dogs living and giving birth within the same region were evaluated for the presence of PCB, OCP, PBDE, and PAH residues; where, socio-demographic factors were also assessed to identify the possible sources. Gas chromatography-mass spectrometry method was validated for the matrix, and among 45 screened and targeted pollutants, only 18 were found in human placentas. While the most frequently detected pollutants were DDTs, followed by PAHs and PCBs in decreasing order, the pollutants with the highest concentrations were PAHs, followed by PCBs and DDTs. Only five of the target contaminants were detected in the dog placentas. These results indicate that; as dogs have different bioaccumulation capacities and higher excretion rates than humans, the life-long effects of exposure to endocrine compound and possible consequences related to adverse health outcomes are expected to vary and concentrations cannot be directly correlated.
    MeSH term(s) Animals ; Dogs ; Environmental Pollutants/analysis ; Environmental Pollutants/toxicity ; Female ; Halogenated Diphenyl Ethers/analysis ; Halogenated Diphenyl Ethers/toxicity ; Humans ; Hydrocarbons, Chlorinated/analysis ; Pesticides/analysis ; Pesticides/toxicity ; Placenta/metabolism ; Polychlorinated Biphenyls/analysis ; Polychlorinated Biphenyls/toxicity ; Polycyclic Aromatic Hydrocarbons/analysis ; Polycyclic Aromatic Hydrocarbons/toxicity ; Pregnancy
    Chemical Substances Environmental Pollutants ; Halogenated Diphenyl Ethers ; Hydrocarbons, Chlorinated ; Pesticides ; Polycyclic Aromatic Hydrocarbons ; Polychlorinated Biphenyls (DFC2HB4I0K)
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2022.134470
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Intratumoral recombinant human interferon alpha-2a and vincristine combination therapy in canine transmissible venereal tumour.

    Kanca, Halit / Tez, Gizem / Bal, Kazim / Ozen, Dogukan / Alcigir, Eray / Atalay Vural, Sevil

    Veterinary medicine and science

    2018  Volume 4, Issue 4, Page(s) 364–372

    Abstract: Canine transmissible venereal tumour (CTVT) is a naturally occurring contagious neoplasm of dogs located mainly on the external genitalia of both sexes. The course of vincristine chemotherapy, the most effective and practical therapy, is affected by the ... ...

    Abstract Canine transmissible venereal tumour (CTVT) is a naturally occurring contagious neoplasm of dogs located mainly on the external genitalia of both sexes. The course of vincristine chemotherapy, the most effective and practical therapy, is affected by the immune status of the host. The aim was to investigate recombinant human interferon alpha-2a (rhIFNα-2a) and vincristine for treatment of CTVT. A total of 21 female dogs were included. In group I (n = 9), vincristine (0.025 mg/kg, IV) was administered weekly. In group II (n = 6), dogs were injected intratumorally weekly with 1.5 million IU rhIFNα-2a. In group III (n = 6), rhIFNα-2a and vincristine were combined. No tumour regression was observed after three injections of rhIFNα-2a in group II and weekly vincristine was administered. The number of tumour infiltrating lymphocytes (TILs), mitotic figures and apoptotic cells were counted in subsequent incisional tumour biopsies. The Kaplan-Meier Method was used to analyse survival using complete tumour regression as the outcome and Breslow Test was used for comparison of survival curves. Differences in TILs, cell proliferation and apoptosis between groups were assessed by analysis of covariance. Complete regression was observed in all animals included. Mean duration of vincristine treatment for complete regression was shorter in group II (3.50 weeks, 95% CI, 3.06-3.94, P < 0.05) and group III (3.17 weeks, 95% CI, 2.84-3.49, P < 0.01) compared to group I (5.11 weeks, 95% CI, 4.42-5.80). Vincristine and rhIFNα-2a combination increased TILs in CTVT biopsies compared to vincristine treatment (P = 0.017) and vincristine treatment after rhIFNα-2a (P = 0.049). Vincristine treatment after rhIFNα-2a (Group II; P < 0.001) and rhIFNα-2a and vincristine combination (Group III; P < 0.001) decreased apoptosis. The results indicate that intratumoral rhIFNα-2a treatment alone is not effective in CTVT. However, combination of rhIFNα-2a and vincristine shortens the duration of treatment compared to vincristine therapy.
    MeSH term(s) Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Dog Diseases/drug therapy ; Dogs ; Drug Therapy, Combination ; Female ; Interferon alpha-2/administration & dosage ; Interferon alpha-2/therapeutic use ; Venereal Tumors, Veterinary/drug therapy ; Vincristine/administration & dosage ; Vincristine/therapeutic use
    Chemical Substances Antineoplastic Agents ; Interferon alpha-2 ; Vincristine (5J49Q6B70F)
    Language English
    Publishing date 2018-08-17
    Publishing country England
    Document type Clinical Trial, Veterinary ; Journal Article
    ZDB-ID 2819409-3
    ISSN 2053-1095 ; 2053-1095
    ISSN (online) 2053-1095
    ISSN 2053-1095
    DOI 10.1002/vms3.119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade.

    Anadol, Elvan / Yar Saglam, Atiye Seda / Gultiken, Nilgun / Karakas, Kubra / Alcigir, Eray / Alkan, Hasan / Kanca, Halit

    Acta veterinaria Hungarica

    2017  Volume 65, Issue 3, Page(s) 382–393

    Abstract: The aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, ... ...

    Abstract The aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, aged 6-10 years and representing different breeds, were used. The expressions of iNOS, COX-2 and VEGF mRNA levels were significantly higher in both benign and malignant tumours than in the adjacent nonneoplastic mammary glands (P < 0.05). The iNOS, COX-2 and VEGF mRNA expression levels of grade 2 tumours were higher than those of grade 1 tumours; however, the highest expression levels were detected in grade 3 tumours. Thus, increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.
    Language English
    Publishing date 2017
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 605742-1
    ISSN 1588-2705 ; 0236-6290 ; 0365-8198
    ISSN (online) 1588-2705
    ISSN 0236-6290 ; 0365-8198
    DOI 10.1556/004.2017.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 483: Show issues Location:
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  7. Article ; Online: The evaluation of xenotransplantation of feline ovarian tissue vitrified by needle immersed vitrification technique into male immunodeficient mice.

    Demirel, Mürşide Ayşe / Acar, Duygu Baki / Ekim, Burcu / Çelikkan, Ferda Topal / Alkan, Kübra Karakaş / Salar, Seçkin / Erdemli, Esra Atabenli / Özkavukçu, Sinan / Yar, Seda Sağlam / Kanca, Halit / Baştan, Ayhan

    Cell and tissue banking

    2017  Volume 19, Issue 1, Page(s) 133–147

    Abstract: In this study, the efficiency of the "Needle Immersed Vitrification" technique was tested on cryopreserved feline ovarian tissue. For vitrification, ovarian fragments (0.5-1.5 ... ...

    Abstract In this study, the efficiency of the "Needle Immersed Vitrification" technique was tested on cryopreserved feline ovarian tissue. For vitrification, ovarian fragments (0.5-1.5 mm
    MeSH term(s) Animals ; Apoptosis ; Cats ; Cell Survival ; Cryopreservation/methods ; Cryopreservation/veterinary ; Female ; Male ; Mice ; Mice, Nude ; Ovary/cytology ; Ovary/transplantation ; Ovary/ultrastructure ; Transplantation, Heterologous/methods ; Transplantation, Heterologous/veterinary ; Vitrification
    Language English
    Publishing date 2017-10-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170897-6
    ISSN 1573-6814 ; 1389-9333
    ISSN (online) 1573-6814
    ISSN 1389-9333
    DOI 10.1007/s10561-017-9663-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5972: Show issues Location:
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  8. Article ; Online: Prostaglandin F receptor expression in intrauterine tissues of pregnant rats.

    Anadol, Elvan / Kanca, Halit / Yar, Atiye Seda / Helvacioğlu, Fatma / Menevşe, Sevda / Calgüner, Engin / Erdoğan, Deniz

    Journal of veterinary science

    2013  Volume 15, Issue 1, Page(s) 125–131

    Abstract: In this investigation, we studied the expression and localization of rat prostaglandin F (FP) receptor in uterine tissues of rats on gestational Days 10, 15, 18, 20, 21, 21.5 and postpartal Days 1 and 3 using Western blotting analysis, real-time PCR, and ...

    Abstract In this investigation, we studied the expression and localization of rat prostaglandin F (FP) receptor in uterine tissues of rats on gestational Days 10, 15, 18, 20, 21, 21.5 and postpartal Days 1 and 3 using Western blotting analysis, real-time PCR, and immunohistochemistry. A high level of immunoreactivity was observed on gestational Days 20, 21, and 21.5 with the most significant signals found on Day 20. FP receptor protein was expressed starting on gestational Day 15, and a fluctuating unsteady increase was observed until delivery. Uterine FP receptor mRNA levels were low between Days 10 and 18 of gestation (p < 0.05). The transcript level increased significantly on Day 20 and peaked on Day 21.5 just before labor (p < 0.05). There was a positive correlation between FP receptor mRNA expression and serum estradiol levels (rs = 0.78; p < 0.01) along with serum estradiol/progesterone ratios (rs = 0.79; p < 0.01). In summary, we observed an increase FP receptor expression in rat uterus with advancing gestation, a marked elevation of expression at term, and a concominant decrease during the postpartum period. These findings indicate a role for uterine FP receptors in the mediation of uterine contractility at term.
    MeSH term(s) Animals ; Blotting, Western ; Female ; Gene Expression Regulation ; Gestational Age ; Immunoglobulin G/blood ; Immunohistochemistry ; Postpartum Period/metabolism ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Receptors, Prostaglandin/genetics ; Receptors, Prostaglandin/metabolism ; Uterus/metabolism
    Chemical Substances Immunoglobulin G ; Receptors, Prostaglandin ; prostaglandin F2alpha receptor
    Language English
    Publishing date 2013-10-18
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2125308-0
    ISSN 1976-555X ; 1229-845X
    ISSN (online) 1976-555X
    ISSN 1229-845X
    DOI 10.4142/jvs.2014.15.1.125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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