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  1. Article: A modular map of Bradykinin-mediated inflammatory signaling network.

    Rex, D A B / Deepak, K / Vaid, Neelanchal / Dagamajalu, Shobha / Kandasamy, Richard Kumaran / Flo, Trude Helen / Keshava Prasad, T S

    Journal of cell communication and signaling

    2021  Volume 16, Issue 2, Page(s) 301–310

    Abstract: Bradykinin, a member of the kallikrein-kinin system (KKS), is associated with an inflammatory response pathway with diverse vascular permeability functions, including thrombosis and blood coagulation. In majority, bradykinin signals through Bradykinin ... ...

    Abstract Bradykinin, a member of the kallikrein-kinin system (KKS), is associated with an inflammatory response pathway with diverse vascular permeability functions, including thrombosis and blood coagulation. In majority, bradykinin signals through Bradykinin Receptor B2 (B2R). B2R is a G protein-coupled receptor (GPCR) coupled to G protein family such as Gα
    Language English
    Publishing date 2021-10-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2299380-0
    ISSN 1873-961X ; 1873-9601
    ISSN (online) 1873-961X
    ISSN 1873-9601
    DOI 10.1007/s12079-021-00652-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Toward effective sharing of high-dimensional immunology data.

    Snijder, Berend / Kandasamy, Richard Kumaran / Superti-Furga, Giulio

    Nature biotechnology

    2014  Volume 32, Issue 8, Page(s) 755–759

    MeSH term(s) Allergy and Immunology ; Database Management Systems ; Laboratories ; Technology Transfer
    Language English
    Publishing date 2014-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/nbt.2974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

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  3. Article: Protein interaction networks in innate immunity

    Rebsamen, Manuele / Kandasamy, Richard Kumaran / Superti-Furga, Giulio

    Trends in immunology. 2013 Dec., v. 34, no. 12

    2013  

    Abstract: The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host–pathogen interactions at a systems level. ... ...

    Abstract The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host–pathogen interactions at a systems level. Protein complexes are key players in pathogen recognition and integrate much of the host molecular responses that occur at the transcriptional and translational level. The ability to monitor protein complex abundance, dynamics, and composition is therefore important to understand the ability of cells to mount the appropriate immune response. Here, we focus on current proteomics technologies applied to identify the protein complexes involved, and highlight recent studies illustrating the power of these approaches to unravel how the dedicated molecular machinery is integrated with other cellular processes to safeguard homeostasis.
    Keywords homeostasis ; immune response ; innate immunity ; pathogens ; proteomics ; transcription (genetics)
    Language English
    Dates of publication 2013-12
    Size p. 610-619.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2013.05.002
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: Protein interaction networks in innate immunity.

    Rebsamen, Manuele / Kandasamy, Richard Kumaran / Superti-Furga, Giulio

    Trends in immunology

    2013  Volume 34, Issue 12, Page(s) 610–619

    Abstract: The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host-pathogen interactions at a systems level. ... ...

    Abstract The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host-pathogen interactions at a systems level. Protein complexes are key players in pathogen recognition and integrate much of the host molecular responses that occur at the transcriptional and translational level. The ability to monitor protein complex abundance, dynamics, and composition is therefore important to understand the ability of cells to mount the appropriate immune response. Here, we focus on current proteomics technologies applied to identify the protein complexes involved, and highlight recent studies illustrating the power of these approaches to unravel how the dedicated molecular machinery is integrated with other cellular processes to safeguard homeostasis.
    MeSH term(s) Humans ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Protein Interaction Maps/genetics ; Protein Interaction Maps/immunology ; Proteome/genetics ; Proteome/immunology ; Proteomics/methods ; Signal Transduction/genetics ; Signal Transduction/immunology
    Chemical Substances Proteome
    Language English
    Publishing date 2013-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2013.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 2: Show issues

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  5. Article ; Online: MultiOMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells

    Pinto, Sneha M. / Subbannayya, Yashwanth / Kim, Hera / Hagen, Lars / Gorna, Maria W / Nieminen, Anni I. / Bjoras, Magnar / Espevik, Terje / Kainov, Denis E. / Kandasamy, Richard Kumaran

    bioRxiv

    Abstract: Despite the availability of vaccines and approved therapeutics, the COVID-19 pandemic continues to rise owing to the emergence of newer variants. Several multi-omics studies have made available extensive evidence on host-pathogen interactions and ... ...

    Abstract Despite the availability of vaccines and approved therapeutics, the COVID-19 pandemic continues to rise owing to the emergence of newer variants. Several multi-omics studies have made available extensive evidence on host-pathogen interactions and potential therapeutic targets. Nonetheless, an increased understanding of host signaling networks regulated by post-translational modifications and their ensuing effect on the biochemical and cellular dynamics is critical to expanding the current knowledge on the host response to SARS-CoV-2 infections. Here, employing unbiased global transcriptomics, proteomics, acetylomics, phosphoproteomics, and exometabolome analysis of a lung-derived human cell line, we show that SARS-CoV-2 Norway/Trondheim-S15 strain induces time-dependent alterations in the induction of type I IFN response, activation of DNA damage response, dysregulated Hippo signaling, among others. We provide evidence for the interplay of phosphorylation and acetylation dynamics on host proteins and its effect on the altered release of metabolites, especially organic acids and ketone bodies. Together, our findings serve as a resource of potential targets that can aid in designing novel host-directed therapeutic strategies.
    Keywords covid19
    Language English
    Publishing date 2022-09-07
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2022.09.06.506768
    Database COVID19

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  6. Article ; Online: SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages.

    Yurchenko, Maria / Skjesol, Astrid / Ryan, Liv / Richard, Gabriel Mary / Kandasamy, Richard Kumaran / Wang, Ninghai / Terhorst, Cox / Husebye, Harald / Espevik, Terje

    The Journal of cell biology

    2018  Volume 217, Issue 4, Page(s) 1411–1429

    Abstract: Signaling lymphocytic activation molecule family 1 (SLAMF1) is an Ig-like receptor and a costimulatory molecule that initiates signal transduction networks in a variety of immune cells. In this study, we report that SLAMF1 is required for Toll-like ... ...

    Abstract Signaling lymphocytic activation molecule family 1 (SLAMF1) is an Ig-like receptor and a costimulatory molecule that initiates signal transduction networks in a variety of immune cells. In this study, we report that SLAMF1 is required for Toll-like receptor 4 (TLR4)-mediated induction of interferon β (IFNβ) and for killing of Gram-negative bacteria by human macrophages. We found that SLAMF1 controls trafficking of the Toll receptor-associated molecule (TRAM) from the endocytic recycling compartment (ERC) to
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Vesicular Transport/genetics ; Adaptor Proteins, Vesicular Transport/immunology ; Adaptor Proteins, Vesicular Transport/metabolism ; Animals ; Endosomes/drug effects ; Endosomes/immunology ; Endosomes/metabolism ; Endosomes/microbiology ; Escherichia coli/metabolism ; Escherichia coli/pathogenicity ; HEK293 Cells ; Host-Pathogen Interactions ; Humans ; Interferon Regulatory Factor-3/metabolism ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Lipopolysaccharides/pharmacology ; Macrophage Activation/drug effects ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/microbiology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Phagosomes/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Transport ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Signaling Lymphocytic Activation Molecule Family Member 1/genetics ; Signaling Lymphocytic Activation Molecule Family Member 1/immunology ; Signaling Lymphocytic Activation Molecule Family Member 1/metabolism ; THP-1 Cells ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology ; Toll-Like Receptor 4/metabolism ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Adaptor Proteins, Vesicular Transport ; IRF3 protein, human ; Interferon Regulatory Factor-3 ; Lipopolysaccharides ; SLAMF1 protein, human ; Slamf1 protein, mouse ; TICAM1 protein, human ; TICAM2 protein, human ; TLR4 protein, human ; Toll-Like Receptor 4 ; lipopolysaccharide, Escherichia coli O111 B4 ; Signaling Lymphocytic Activation Molecule Family Member 1 (169535-43-7) ; Interferon-beta (77238-31-4) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1) ; rab11 protein (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2018-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201707027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ub I Zs.190: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Single-cell transcriptome identifies

    Nassir, Nasna / Tambi, Richa / Bankapur, Asma / Al Heialy, Saba / Karuvantevida, Noushad / Khansaheb, Hamda Hassan / Zehra, Binte / Begum, Ghausia / Hameid, Reem Abdel / Ahmed, Awab / Deesi, Zulfa / Alkhajeh, Abdulmajeed / Uddin, K M Furkan / Akter, Hosneara / Safizadeh Shabestari, Seyed Ali / Almidani, Omar / Islam, Amirul / Gaudet, Mellissa / Kandasamy, Richard Kumaran /
    Loney, Tom / Tayoun, Ahmad Abou / Nowotny, Norbert / Woodbury-Smith, Marc / Rahman, Proton / Kuebler, Wolfgang M / Yaseen Hachim, Mahmood / Casanova, Jean-Laurent / Berdiev, Bakhrom K / Alsheikh-Ali, Alawi / Uddin, Mohammed

    iScience

    2021  Volume 24, Issue 9, Page(s) 103030

    Abstract: Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening COVID-19 pneumonia, compared with healthy ... ...

    Abstract Understanding host cell heterogeneity is critical for unraveling disease mechanism. Utilizing large-scale single-cell transcriptomics, we analyzed multiple tissue specimens from patients with life-threatening COVID-19 pneumonia, compared with healthy controls. We identified a subtype of monocyte-derived alveolar macrophages (MoAMs) where genes associated with severe COVID-19 comorbidities are significantly upregulated in bronchoalveolar lavage fluid of critical cases.
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.103030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Protein interaction networks in innate immunity

    Rebsamen, Manuele / Kandasamy, Richard Kumaran / Superti-Furga, Giulio

    Trends in immunology

    Volume v. 34,, Issue no. 1

    Abstract: The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host–pathogen interactions at a systems level. ... ...

    Abstract The immune response to pathogens is controlled by complex and tightly regulated molecular networks. Recent technological advances have empowered approaches to investigate innate immune signaling and monitor host–pathogen interactions at a systems level. Protein complexes are key players in pathogen recognition and integrate much of the host molecular responses that occur at the transcriptional and translational level. The ability to monitor protein complex abundance, dynamics, and composition is therefore important to understand the ability of cells to mount the appropriate immune response. Here, we focus on current proteomics technologies applied to identify the protein complexes involved, and highlight recent studies illustrating the power of these approaches to unravel how the dedicated molecular machinery is integrated with other cellular processes to safeguard homeostasis.
    Keywords homeostasis ; innate immunity ; immune response ; proteomics ; pathogens ; transcription (genetics)
    Language English
    Document type Article
    ISSN 1471-4906
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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